Gene Symbol: EIF4E
Description: eukaryotic translation initiation factor 4E
Alias: ARABIDOPSIS THALIANA EUKARYOTIC TRANSLATION INITATION FACTOR 4E1, AT.EIF4E1, CUCUMOVIRUS MULTIPLICATION 1, CUM1, EUKARYOTIC TRANSLATION INITATION FACTOR 4E, F15J5.10, F15J5_10, eIF4E1, eukaryotic translation Initiation Factor 4E1, eukaryotic translation initiation factor 4E, eukaryotic translation initiation factor 4E
Species: thale cress

Top Publications

  1. Nicaise V, Gallois J, Chafiai F, Allen L, Schurdi Levraud V, Browning K, et al. Coordinated and selective recruitment of eIF4E and eIF4G factors for potyvirus infection in Arabidopsis thaliana. FEBS Lett. 2007;581:1041-6 pubmed
    The translation initiation factors eIF4E and eIF(iso)4E play a key role during virus infection in plants. During mRNA translation, eIF4E provides the cap-binding function and is associated with the protein eIF4G to form the eIF4F complex...
  2. Freire M, Tourneur C, Granier F, Camonis J, El Amrani A, Browning K, et al. Plant lipoxygenase 2 is a translation initiation factor-4E-binding protein. Plant Mol Biol. 2000;44:129-40 pubmed
    The eukaryotic initiation factor 4E (eIF4E) emerged recently as a target for different types of regulation affecting translation. In animal and yeast cells, eIF4E-binding proteins modulate the availability of eIF4E...
  3. Sato M, Nakahara K, Yoshii M, Ishikawa M, Uyeda I. Selective involvement of members of the eukaryotic initiation factor 4E family in the infection of Arabidopsis thaliana by potyviruses. FEBS Lett. 2005;579:1167-71 pubmed
    Arabidopsis thaliana plants with mutations in the genes encoding eukaryotic initiation factor (eIF4E) or isoform of eIF4E (eIF(iso)4E) were tested for susceptibility to Clover yellow vein virus (ClYVV), a member of the genus Potyvirus...
  4. Yoshii M, Yoshioka N, Ishikawa M, Naito S. Isolation of an Arabidopsis thaliana mutant in which accumulation of cucumber mosaic virus coat protein is delayed. Plant J. 1998;13:211-9 pubmed
    ..accumulation of CMV CP in the mutant plants was caused by a single, nuclear and recessive mutation designated cum1-1, which was located on chromosome IV...
  5. Martínez Silva A, Aguirre Martínez C, Flores Tinoco C, Alejandri Ramírez N, Dinkova T. Translation initiation factor AteIF(iso)4E is involved in selective mRNA translation in Arabidopsis thaliana seedlings. PLoS ONE. 2012;7:e31606 pubmed publisher
    ..In eukaryotes, this step is mediated by the 5'end cap-binding factor eIF4E bound to the bridge protein eIF4G and forming the eIF4F complex...
  6. Gutiérrez Beltrán E, Moschou P, Smertenko A, Bozhkov P. Tudor staphylococcal nuclease links formation of stress granules and processing bodies with mRNA catabolism in Arabidopsis. Plant Cell. 2015;27:926-43 pubmed publisher
    ..Taken together, our results establish TSN as a key enzymatic component of the catabolic machinery responsible for the processing of mRNAs in the cytoplasmic mRNP complexes during stress. ..
  7. Xu J, Yang J, Niu Q, Chua N. Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development. Plant Cell. 2006;18:3386-98 pubmed
    ..We conclude that mRNA turnover mediated by the decapping complex is required for postembryonic development in Arabidopsis. ..
  8. Kropiwnicka A, Kuchta K, Lukaszewicz M, Kowalska J, Jemielity J, Ginalski K, et al. Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding. Biochem Biophys Res Commun. 2015;456:47-52 pubmed publisher
    The assembly of the ribosome on majority of eukaryotic mRNAs is initiated by the recruitment of eIF4E protein to the mRNA 5' end cap structure...