Gene Symbol: EFR
Description: EF-TU receptor
Alias: EF-TU receptor, F7C8.70, F7C8_70, EF-TU receptor
Species: thale cress
Products:     EFR

Top Publications

  1. Xiang T, Zong N, Zou Y, Wu Y, Zhang J, Xing W, et al. Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol. 2008;18:74-80 pubmed
    Plants use receptor kinases, such as FLS2 and EFR, to perceive bacterial pathogens and initiate innate immunity. This immunity is often suppressed by bacterial effectors, allowing pathogen propagation...
  2. Nekrasov V, Li J, Batoux M, Roux M, Chu Z, Lacombe S, et al. Control of the pattern-recognition receptor EFR by an ER protein complex in plant immunity. EMBO J. 2009;28:3428-38 pubmed publisher
    In plant innate immunity, the surface-exposed leucine-rich repeat receptor kinases EFR and FLS2 mediate recognition of the bacterial pathogen-associated molecular patterns EF-Tu and flagellin, respectively...
  3. Häweker H, Rips S, Koiwa H, Salomon S, Saijo Y, Chinchilla D, et al. Pattern recognition receptors require N-glycosylation to mediate plant immunity. J Biol Chem. 2010;285:4629-36 pubmed publisher
    ..N-glycans in receptor-mediated immune responses, we investigated the functionality of Arabidopsis receptor kinases EFR and FLS2, sensing bacterial translation elongation factor Tu (elf18) and flagellin (flg22), respectively, in N-..
  4. Nicaise V, Joe A, Jeong B, Korneli C, Boutrot F, Westedt I, et al. Pseudomonas HopU1 modulates plant immune receptor levels by blocking the interaction of their mRNAs with GRP7. EMBO J. 2013;32:701-12 pubmed publisher
    ..show that GRP7 associates with translational components, as well as with the pattern recognition receptors FLS2 and EFR. Moreover, GRP7 binds specifically FLS2 and EFR transcripts in vivo through its RNA recognition motif...
  5. Domínguez Ferreras A, Kiss Papp M, Jehle A, Felix G, Chinchilla D. An Overdose of the Arabidopsis Coreceptor BRASSINOSTEROID INSENSITIVE1-ASSOCIATED RECEPTOR KINASE1 or Its Ectodomain Causes Autoimmunity in a SUPPRESSOR OF BIR1-1-Dependent Manner. Plant Physiol. 2015;168:1106-21 pubmed publisher
    ..In conclusion, our findings unravel a new role for the BAK1 ectodomain in the tight regulation of Arabidopsis immune receptors necessary to avoid inappropriate activation of immunity. ..
  6. Kadota Y, Sklenar J, Derbyshire P, Stransfeld L, Asai S, Ntoukakis V, et al. Direct regulation of the NADPH oxidase RBOHD by the PRR-associated kinase BIK1 during plant immunity. Mol Cell. 2014;54:43-55 pubmed publisher
    ..Here, we show that RBOHD exists in complex with the receptor kinases EFR and FLS2, which are the PRRs for bacterial EF-Tu and flagellin, respectively...
  7. Albert M, Felix G. Chimeric receptors of the Arabidopsis thaliana pattern recognition receptors EFR and FLS2. Plant Signal Behav. 2010;5:1430-2 pubmed
    FLS2 and EFR are pattern recognition receptors in Arabidopsis thaliana perceiving the bacterial proteins flagellin and Elongation factor Tu (EF-Tu)...
  8. Yeh Y, Panzeri D, Kadota Y, Huang Y, Huang P, Tao C, et al. The Arabidopsis Malectin-Like/LRR-RLK IOS1 Is Critical for BAK1-Dependent and BAK1-Independent Pattern-Triggered Immunity. Plant Cell. 2016;28:1701-21 pubmed publisher
    Plasma membrane-localized pattern recognition receptors (PRRs) such as FLAGELLIN SENSING2 (FLS2), EF-TU RECEPTOR (EFR), and CHITIN ELICITOR RECEPTOR KINASE1 (CERK1) recognize microbe-associated molecular patterns (MAMPs) to activate ..
  9. Farid A, Malinovsky F, Veit C, Schoberer J, Zipfel C, Strasser R. Specialized roles of the conserved subunit OST3/6 of the oligosaccharyltransferase complex in innate immunity and tolerance to abiotic stresses. Plant Physiol. 2013;162:24-38 pubmed publisher

More Information


  1. Jeworutzki E, Roelfsema M, Anschütz U, Krol E, Elzenga J, Felix G, et al. Early signaling through the Arabidopsis pattern recognition receptors FLS2 and EFR involves Ca-associated opening of plasma membrane anion channels. Plant J. 2010;62:367-78 pubmed publisher
    ..The Arabidopsis pattern recognition receptors FLAGELLIN-SENSING 2 (FLS2) and EF-Tu receptor (EFR) represent genetically well studied paradigms that mediate defense against bacterial pathogens...
  2. Schoonbeek H, Wang H, Stefanato F, Craze M, Bowden S, Wallington E, et al. Arabidopsis EF-Tu receptor enhances bacterial disease resistance in transgenic wheat. New Phytol. 2015;206:606-13 pubmed publisher
    ..The Arabidopsis PRR EF-Tu receptor (EFR) recognizes the bacterial PAMP elongation factor Tu (EF-Tu) and its derived peptide elf18...
  3. Schwessinger B, Roux M, Kadota Y, Ntoukakis V, Sklenar J, Jones A, et al. Phosphorylation-dependent differential regulation of plant growth, cell death, and innate immunity by the regulatory receptor-like kinase BAK1. PLoS Genet. 2011;7:e1002046 pubmed publisher
    ..Innate immune signaling mediated by the BAK1-dependent RKs FLS2 and EFR is severely compromised in bak1-5 mutant plants...
  4. Malinovsky F, Batoux M, Schwessinger B, Youn J, Stransfeld L, Win J, et al. Antagonistic regulation of growth and immunity by the Arabidopsis basic helix-loop-helix transcription factor homolog of brassinosteroid enhanced expression2 interacting with increased leaf inclination1 binding bHLH1. Plant Physiol. 2014;164:1443-55 pubmed publisher
    ..This study identifies a novel component involved in the complex tradeoff between innate immunity and BR-regulated growth...
  5. Wang Y, Li Z, Liu D, Xu J, Wei X, Yan L, et al. Assessment of BAK1 activity in different plant receptor-like kinase complexes by quantitative profiling of phosphorylation patterns. J Proteomics. 2014;108:484-93 pubmed publisher
    ..BAK1), a member of the plant RLK family, forms receptor complexes with multiple RLK proteins including BRI1, FLS2, EFR and BIK1 to regulate responses to growth hormones or PAMPs...
  6. Zipfel C, Kunze G, Chinchilla D, Caniard A, Jones J, Boller T, et al. Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation. Cell. 2006;125:749-60 pubmed
    ..a targeted reverse-genetic approach to identify a receptor kinase essential for EF-Tu perception, which we called EFR. Nicotiana benthamiana, a plant unable to perceive EF-Tu, acquires EF-Tu binding sites and responsiveness upon ..
  7. Hok S, Danchin E, Allasia V, Panabières F, Attard A, Keller H. An Arabidopsis (malectin-like) leucine-rich repeat receptor-like kinase contributes to downy mildew disease. Plant Cell Environ. 2011;34:1944-57 pubmed publisher
    ..According to the mutant phenotype, we denominated it Impaired Oomycete Susceptibility 1 (IOS1). ..
  8. Macho A, Schwessinger B, Ntoukakis V, Brutus A, Segonzac C, Roy S, et al. A bacterial tyrosine phosphatase inhibits plant pattern recognition receptor activation. Science. 2014;343:1509-12 pubmed publisher
    ..Many plant PRRs are kinases. Here, we report that the Arabidopsis receptor kinase EF-TU RECEPTOR (EFR), which perceives the elf18 peptide derived from bacterial elongation factor Tu, is activated upon ligand binding ..
  9. Albert M, Jehle A, Fürst U, Chinchilla D, Boller T, Felix G. A two-hybrid-receptor assay demonstrates heteromer formation as switch-on for plant immune receptors. Plant Physiol. 2013;163:1504-9 pubmed publisher
  10. Saijo Y, Tintor N, Lu X, Rauf P, Pajerowska Mukhtar K, Häweker H, et al. Receptor quality control in the endoplasmic reticulum for plant innate immunity. EMBO J. 2009;28:3439-49 pubmed publisher
    ..The Leu-rich repeat receptor-like kinases FLS2 and EFR recognize the bacterial epitopes flg22 and elf18, derived from flagellin and elongation factor-Tu, respectively...
  11. Lu F, Wang H, Wang S, Jiang W, Shan C, Li B, et al. Enhancement of innate immune system in monocot rice by transferring the dicotyledonous elongation factor Tu receptor EFR. J Integr Plant Biol. 2015;57:641-52 pubmed publisher
    The elongation factor Tu (EF-Tu) receptor (EFR) in cruciferous plants specifically recognizes the N-terminal acetylated elf18 region of bacterial EF-Tu and thereby activates plant immunity...