EDS16

Summary

Gene Symbol: EDS16
Description: Isochorismate synthase 1
Alias: ARABIDOPSIS ISOCHORISMATE SYNTHASE 1, ATICS1, ENHANCED DISEASE SUSCEPTIBILITY TO ERYSIPHE ORONTII 16, F25A4.31, ICS1, ISOCHORISMATE SYNTHASE, ISOCHORISMATE SYNTHASE 1, SALICYLIC ACID INDUCTION DEFICIENT 2, SID2
Species: thale cress

Top Publications

  1. ncbi Isochorismate synthase is required to synthesize salicylic acid for plant defence
    M C Wildermuth
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 414:562-5. 2001
  2. pmc Characterization and biological function of the ISOCHORISMATE SYNTHASE2 gene of Arabidopsis
    Christophe Garcion
    UMR 1090, INRA Université Bordeaux 2, 33140 Villenave d Ornon, France
    Plant Physiol 147:1279-87. 2008
  3. pmc Genetic analysis of acd6-1 reveals complex defense networks and leads to identification of novel defense genes in Arabidopsis
    Hua Lu
    Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Plant J 58:401-12. 2009
  4. pmc Peroxisomal hydrogen peroxide is coupled to biotic defense responses by ISOCHORISMATE SYNTHASE1 in a daylength-related manner
    Sejir Chaouch
    Institut de Biologie des Plantes, UMR8618 CNRS, Universite de Paris Sud, 91405 Orsay Cedex, France
    Plant Physiol 153:1692-705. 2010
  5. pmc ETHYLENE INSENSITIVE3 and ETHYLENE INSENSITIVE3-LIKE1 repress SALICYLIC ACID INDUCTION DEFICIENT2 expression to negatively regulate plant innate immunity in Arabidopsis
    Huamin Chen
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China
    Plant Cell 21:2527-40. 2009
  6. pmc Salicylic acid deficiency in NahG transgenic lines and sid2 mutants increases seed yield in the annual plant Arabidopsis thaliana
    Maria Elizabeth Abreu
    Departament de Biologia Vegetal, Universitat de Barcelona, Facultat de Biologia, Avinguda Diagonal 645, E 08028 Barcelona, Spain
    J Exp Bot 60:1261-71. 2009
  7. pmc Signaling pathways that regulate the enhanced disease resistance of Arabidopsis "defense, no death" mutants
    Ruth K Genger
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Plant Microbe Interact 21:1285-96. 2008
  8. pmc ABA is an essential signal for plant resistance to pathogens affecting JA biosynthesis and the activation of defenses in Arabidopsis
    Bruce A T Adie
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 19:1665-81. 2007
  9. ncbi Pathogen-associated molecular pattern recognition rather than development of tissue necrosis contributes to bacterial induction of systemic acquired resistance in Arabidopsis
    Tatiana E Mishina
    Julius von Sachs Institute of Biological Sciences, University of Wurzburg, Julius von Sachs Platz 3, D 97082 Wurzburg, Germany
    Plant J 50:500-13. 2007
  10. ncbi MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis
    Kazuya Ichimura
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    J Biol Chem 281:36969-76. 2006

Scientific Experts

  • Hua Lu
  • Marcel C van Verk
  • Sejir Chaouch
  • Maria Elizabeth Abreu
  • Huamin Chen
  • Christophe Garcion
  • Ruth K Genger
  • Tatiana E Mishina
  • Bruce A T Adie
  • Kazuya Ichimura
  • Chiara Consonni
  • Kazuo Shinozaki
  • Jeferson Gross
  • Maeli Melotto
  • Balakrishnan Prithiviraj
  • M C Wildermuth
  • John F Bol
  • Huub J M Linthorst
  • Guillaume Queval
  • Frank Van Breusegem
  • Michaël Vandorpe
  • Patrick Saindrenan
  • Sandy Vanderauwera
  • Mathilde Langlois-Meurinne
  • Amna Mhamdi
  • Graham Noctor
  • Xiaoyan Tang
  • Jian Min Zhou
  • Haitao Cui
  • Hugo Germain
  • Jianru Zuo
  • Sergi Munne-Bosch
  • Satya Chintamanani
  • Hongwei Guo
  • Xin Li
  • Li Xue
  • Run Cai
  • Huiqiong Lin
  • Ho Won Jung
  • Antony Buchala
  • Jérémy Catinot
  • Peter Doermann
  • John M McDowell
  • Andrew F Bent
  • Grace I Jurkowski
  • Elisabeth Lamodière
  • Jean Pierre Metraux
  • Jean T Greenberg
  • Antje Lohmann
  • Jose J Sanchez-Serrano
  • Roberto Solano
  • Jürgen Zeier
  • Eric A Schmelz
  • Julián Pérez-Pérez
  • Manuel M Perez-Perez
  • Marta Godoy
  • Jörg Durner
  • Volker Lipka
  • Jessica Koczan
  • Ken Shirasu
  • Maren Livaja
  • Kinya Nomura
  • H Andreas Hartmann
  • Motoaki Seki
  • Reinhold G Herrmann
  • Lina Lezhneva
  • Jorg Meurer
  • Birgit Kemmerling
  • William Underwood
  • Matthew E Humphry
  • John Vogel
  • Shauna C Somerville
  • Won Kyong Cho
  • Lore Westphal
  • Ralph Panstruga
  • Scott C Peck
  • Jon Falk
  • Karin Krupinska
  • Paul Schulze-Lefert
  • Catarina Casais
  • Sheng Yang He
  • Harsh P Bais
  • Jorge M Vivanco
  • Ajay K Jha
  • F M Ausubel
  • G Wu
  • J Dewdney

Detail Information

Publications15

  1. ncbi Isochorismate synthase is required to synthesize salicylic acid for plant defence
    M C Wildermuth
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 414:562-5. 2001
    ..Some bacteria such as Pseudomonas aeruginosa synthesize SA using isochorismate synthase (ICS) and pyruvate lyase...
  2. pmc Characterization and biological function of the ISOCHORISMATE SYNTHASE2 gene of Arabidopsis
    Christophe Garcion
    UMR 1090, INRA Université Bordeaux 2, 33140 Villenave d Ornon, France
    Plant Physiol 147:1279-87. 2008
    ..derive mainly from isochorismate, itself produced from chorismate through the activity of ISOCHORISMATE SYNTHASE1 (ICS1)...
  3. pmc Genetic analysis of acd6-1 reveals complex defense networks and leads to identification of novel defense genes in Arabidopsis
    Hua Lu
    Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Plant J 58:401-12. 2009
    ..to identify two genes disrupted in acd6-1 suppressor (sup) mutants: one encodes a known SA biosynthetic component (SID2) and the other encodes an uncharacterized putative metalloprotease (At5g20660)...
  4. pmc Peroxisomal hydrogen peroxide is coupled to biotic defense responses by ISOCHORISMATE SYNTHASE1 in a daylength-related manner
    Sejir Chaouch
    Institut de Biologie des Plantes, UMR8618 CNRS, Universite de Paris Sud, 91405 Orsay Cedex, France
    Plant Physiol 153:1692-705. 2010
    ..H(2)O(2) was modified by introducing secondary mutations into the cat2 background and was completely absent in cat2 sid2 double mutants, in which ISOCHORISMATE SYNTHASE1 (ICS1) activity is defective...
  5. pmc ETHYLENE INSENSITIVE3 and ETHYLENE INSENSITIVE3-LIKE1 repress SALICYLIC ACID INDUCTION DEFICIENT2 expression to negatively regulate plant innate immunity in Arabidopsis
    Huamin Chen
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China
    Plant Cell 21:2527-40. 2009
    ..Further analyses indicated that SALICYLIC ACID INDUCTION DEFICIENT2 (SID2), which encodes isochorismate synthase required for pathogen-induced biosynthesis of salicylic acid (SA), is a key target of EIN3 and EIL1...
  6. pmc Salicylic acid deficiency in NahG transgenic lines and sid2 mutants increases seed yield in the annual plant Arabidopsis thaliana
    Maria Elizabeth Abreu
    Departament de Biologia Vegetal, Universitat de Barcelona, Facultat de Biologia, Avinguda Diagonal 645, E 08028 Barcelona, Spain
    J Exp Bot 60:1261-71. 2009
    ..It is concluded that (i) the sid2 gene, which encodes for isochorismate synthase, plays a central role in salicylic acid biosynthesis during plant development in A...
  7. pmc Signaling pathways that regulate the enhanced disease resistance of Arabidopsis "defense, no death" mutants
    Ruth K Genger
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Plant Microbe Interact 21:1285-96. 2008
    ..We examined the contributions of NPR1, SID2 (EDS16), NDR1, and EIN2 to dnd phenotypes...
  8. pmc ABA is an essential signal for plant resistance to pathogens affecting JA biosynthesis and the activation of defenses in Arabidopsis
    Bruce A T Adie
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 19:1665-81. 2007
    ..The results support a model for ABA affecting JA biosynthesis in the activation of defenses against this oomycete...
  9. ncbi Pathogen-associated molecular pattern recognition rather than development of tissue necrosis contributes to bacterial induction of systemic acquired resistance in Arabidopsis
    Tatiana E Mishina
    Julius von Sachs Institute of Biological Sciences, University of Wurzburg, Julius von Sachs Platz 3, D 97082 Wurzburg, Germany
    Plant J 50:500-13. 2007
    ..Our data indicate that PAMPs significantly contribute to SAR initiation in Arabidopsis and that tissue necroses at inoculation sites are dispensable for SAR activation...
  10. ncbi MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis
    Kazuya Ichimura
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    J Biol Chem 281:36969-76. 2006
    ..cell death and H(2)O(2) accumulation that are partly dependent on both RAR1, a key component in resistance protein function, and SID2, an isochorismate synthase required for salicylic acid production upon pathogen infection.
  11. ncbi Plant stomata function in innate immunity against bacterial invasion
    Maeli Melotto
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Cell 126:969-80. 2006
    ..We provide evidence that supports a model in which stomata, as part of an integral innate immune system, act as a barrier against bacterial infection...
  12. ncbi Conserved requirement for a plant host cell protein in powdery mildew pathogenesis
    Chiara Consonni
    Max Planck Institute for Plant Breeding Research, Department of Plant Microbe Interactions, Carl von Linne Weg 10, D 50829 Köln, Germany
    Nat Genet 38:716-20. 2006
    ....
  13. ncbi A plant locus essential for phylloquinone (vitamin K1) biosynthesis originated from a fusion of four eubacterial genes
    Jeferson Gross
    Department Biology I, Botany, Ludwig Maximilians University Munich, Menzinger Strasse 67, D 80638 Munich, Germany
    J Biol Chem 281:17189-96. 2006
    ..Therefore, gene fusion, duplication, and fission events adapted a eubacterial multienzymatic system to the metabolic requirements of plants...
  14. ncbi Staphylococcus aureus pathogenicity on Arabidopsis thaliana is mediated either by a direct effect of salicylic acid on the pathogen or by SA-dependent, NPR1-independent host responses
    Balakrishnan Prithiviraj
    Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, CO 80523 1173, USA
    Plant J 42:417-32. 2005
    ..SA) accumulation], and 35S-LOX2- (defective in jasmonic acid production and hyper-accumulator of SA), and mutants ics1 (depleted in SA accumulation), and npr1-1 (non-expressor of pathogenesis-related protein) we show that resistance ..
  15. pmc WRKY transcription factors involved in activation of SA biosynthesis genes
    Marcel C van Verk
    Institute of Biology, Leiden University, Leiden, The Netherlands
    BMC Plant Biol 11:89. 2011
    ..in SA biosynthesis in Arabidopsis is the conversion of chorismate to isochorismate through the action of isochorismate synthase, encoded by the ICS1 gene...