Gene Symbol: DRD1
Description: SNF2 domain-containing protein / helicase domain-containing protein
Alias: CHR35, DEFECTIVE IN MERISTEM SILENCING 1, DEFECTIVE IN RNA-DIRECTED DNA METHYLATION 1, DMS1, F16F14.11, F16F14_11, SNF2 domain-containing protein / helicase domain-containing protein
Species: thale cress

Top Publications

  1. Kanno T, Mette M, Kreil D, Aufsatz W, Matzke M, Matzke A. Involvement of putative SNF2 chromatin remodeling protein DRD1 in RNA-directed DNA methylation. Curr Biol. 2004;14:801-5 pubmed
    ..for mutants defective in RNA-directed DNA methylation identified a novel putative chromatin-remodeling protein, DRD1. This protein belongs to a previously undefined, plant-specific subfamily of SWI2/SNF2-like proteins most similar ..
  2. Pontes O, Costa Nunes P, Vithayathil P, Pikaard C. RNA polymerase V functions in Arabidopsis interphase heterochromatin organization independently of the 24-nt siRNA-directed DNA methylation pathway. Mol Plant. 2009;2:700-710 pubmed publisher
    ..Nuclear RNA polymerase V (Pol V) collaborates with DRD1 (DEFICIENT IN RNA-DEPENDENT DNA METHYLATION 1) to generate transcripts at heterochromatic loci that are ..
  3. Law J, Ausin I, Johnson L, Vashisht A, Zhu J, Wohlschlegel J, et al. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. Curr Biol. 2010;20:951-6 pubmed publisher
    ..Through affinity purification of two known RdDM components, DEFECTIVE IN RNA-DIRECTED DNA METHYLATION 1 (DRD1) and DEFECTIVE IN MERISTEM SILENCING 3 (DMS3), we found that they copurify with each other and with a novel protein,..
  4. Huettel B, Kanno T, Daxinger L, Aufsatz W, Matzke A, Matzke M. Endogenous targets of RNA-directed DNA methylation and Pol IV in Arabidopsis. EMBO J. 2006;25:2828-36 pubmed
    b>DRD1 is a SWI/SNF-like protein that cooperates with a plant-specific RNA polymerase, Pol IVb, to facilitate RNA-directed de novo methylation and silencing of homologous DNA...
  5. Zhong X, Hale C, Law J, Johnson L, Feng S, Tu A, et al. DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons. Nat Struct Mol Biol. 2012;19:870-5 pubmed publisher
    ..Furthermore, these findings suggest a role for Pol V and RNA-directed DNA methylation in genome surveillance and in responding to genome evolution. ..
  6. Wierzbicki A, Haag J, Pikaard C. Noncoding transcription by RNA polymerase Pol IVb/Pol V mediates transcriptional silencing of overlapping and adjacent genes. Cell. 2008;135:635-48 pubmed publisher
    ..Pol IVb/Pol V transcription requires the chromatin-remodeling protein DRD1 but is independent of siRNA biogenesis...
  7. Kanno T, Aufsatz W, Jaligot E, Mette M, Matzke M, Matzke A. A SNF2-like protein facilitates dynamic control of DNA methylation. EMBO Rep. 2005;6:649-55 pubmed
    b>DRD1 is a SNF2-like protein previously identified in a screen for mutants defective in RNA-directed DNA methylation of a seed promoter in Arabidopsis...
  8. He X, Hsu Y, Pontes O, Zhu J, Lu J, Bressan R, et al. NRPD4, a protein related to the RPB4 subunit of RNA polymerase II, is a component of RNA polymerases IV and V and is required for RNA-directed DNA methylation. Genes Dev. 2009;23:318-30 pubmed publisher
    ..a new component (referred to as RDM2) as well as seven known components (NRPD1, NRPE1, NRPD2a, AGO4, HEN1, DRD1, and HDA6) of the RdDM pathway...
  9. Chan S, Henderson I, Zhang X, Shah G, Chien J, Jacobsen S. RNAi, DRD1, and histone methylation actively target developmentally important non-CG DNA methylation in arabidopsis. PLoS Genet. 2006;2:e83 pubmed
    ..pathway as well as histone H3K9 methylation, both of which converge on the putative chromatin-remodeling protein DRD1. These signals act in at least three partially intersecting pathways that control the locus-specific patterning of ..

More Information


  1. Lopez A, Ramirez V, GarcĂ­a Andrade J, Flors V, Vera P. The RNA silencing enzyme RNA polymerase v is required for plant immunity. PLoS Genet. 2011;7:e1002434 pubmed publisher
    ..Studies were extended to other mutants affected in different steps of the RdDM pathway, such as nrpd1, nrpe1, ago4, drd1, rdr2, and drm1drm2 mutants...
  2. Johnson L, Du J, Hale C, Bischof S, Feng S, Chodavarapu R, et al. SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature. 2014;507:124-128 pubmed publisher
  3. Cho E, Choi S, Kim J, Kim J, Lee M, Chung B, et al. A Mutation in Plant-Specific SWI2/SNF2-Like Chromatin-Remodeling Proteins, DRD1 and DDM1, Delays Leaf Senescence in Arabidopsis thaliana. PLoS ONE. 2016;11:e0146826 pubmed publisher
    ..Therefore, we chose to examine the functions of DRD1, a SWI2/SNF2 chromatin remodeling protein, in epigenetic regulation of leaf senescence, particularly because drd1-6 ..
  4. Dong L, Liu M, Fang Y, Zhao J, He X, Ying X, et al. DRD1-Pol V-dependent self-silencing of an exogenous silencer restricts the non-cell autonomous silencing of an endogenous target gene. Plant J. 2011;68:633-45 pubmed publisher
    ..Mutations affecting nuclear proteins DRD1 and Pol V (NRPE1 or NRPD2) relieved exo-Pdsi self-silencing, resulting in higher levels of Pdsi transcripts, which ..
  5. Zhong X, Hale C, Nguyen M, Ausin I, Groth M, Hetzel J, et al. Domains rearranged methyltransferase3 controls DNA methylation and regulates RNA polymerase V transcript abundance in Arabidopsis. Proc Natl Acad Sci U S A. 2015;112:911-6 pubmed publisher
    ..This work sheds further light on the mechanism by which long noncoding RNAs facilitate RNA-directed DNA methylation. ..
  6. Liu Z, Shao C, Zhang C, Zhou J, Zhang S, Li L, et al. The SET domain proteins SUVH2 and SUVH9 are required for Pol V occupancy at RNA-directed DNA methylation loci. PLoS Genet. 2014;10:e1003948 pubmed publisher
    ..results indicated that SUVH2 and/or SUVH9 not only interact with the chromatin-remodeling complex termed DDR (DMS3, DRD1, and RDM1) but also with the newly characterized complex composed of two conserved Microrchidia (MORC) family ..
  7. Pontes O, Li C, Costa Nunes P, Haag J, Ream T, Vitins A, et al. The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center. Cell. 2006;126:79-92 pubmed
    ..Pol IVb), RNA-DEPENDENT RNA POLYMERASE 2 (RDR2), DICER-LIKE 3 (DCL3), ARGONAUTE4 (AGO4), the chromatin remodeler DRD1, and the de novo cytosine methyltransferase DRM2...