DET1

Summary

Gene Symbol: DET1
Description: light-mediated development protein 1 / deetiolated1 (DET1)
Alias: ATDET1, DE-ETIOLATED 1, FUS2, FUSCA 2, T9A4.17, light-mediated development protein 1 / deetiolated1 (DET1)
Species: thale cress

Top Publications

  1. Schroeder D, Gahrtz M, Maxwell B, Cook R, Kan J, Alonso J, et al. De-etiolated 1 and damaged DNA binding protein 1 interact to regulate Arabidopsis photomorphogenesis. Curr Biol. 2002;12:1462-72 pubmed
    ..Arabidopsis de-etiolated 1 (det1) mutants develop like light-grown seedlings even when grown in the dark...
  2. Bernhardt A, Lechner E, Hano P, Schade V, Dieterle M, Anders M, et al. CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana. Plant J. 2006;47:591-603 pubmed
    ..In this work Arabidopsis cullin 4 is shown to assemble with DDB1, RBX1, DET1 and DDB2 in vitro and in planta...
  3. Al Khateeb W, Schroeder D. DDB2, DDB1A and DET1 exhibit complex interactions during Arabidopsis development. Genetics. 2007;176:231-42 pubmed
    ..DDB1 is also found in the same complex as DE-ETIOLATED 1 (DET1), a negative regulator of light-mediated responses in plants. Arabidopsis has two DDB1 homologs, DDB1A and DDB1B...
  4. Lau O, Huang X, Charron J, Lee J, Li G, Deng X. Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock. Mol Cell. 2011;43:703-12 pubmed publisher
    The COP10-DET1-DDB1 (CDD) complex is an evolutionarily conserved protein complex discovered for its role in the repression of photomorphogenesis in Arabidopsis...
  5. Chen H, Huang X, Gusmaroli G, Terzaghi W, Lau O, Yanagawa Y, et al. Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell. 2010;22:108-23 pubmed publisher
    ..Thus, a series of CUL4-DDB1-COP1-SPA E3 ligase complexes may mediate the repression of photomorphogenesis and, possibly, of flowering time. ..
  6. Castells E, Molinier J, Benvenuto G, Bourbousse C, Zabulon G, Zalc A, et al. The conserved factor DE-ETIOLATED 1 cooperates with CUL4-DDB1DDB2 to maintain genome integrity upon UV stress. EMBO J. 2011;30:1162-72 pubmed publisher
    ..Here we investigated the involvement in NER of DE-ETIOLATED 1 (DET1), an evolutionarily conserved factor that associates with components of the ubiquitylation machinery in plants and ..
  7. Maxwell B, Andersson C, Poole D, Kay S, Chory J. HY5, Circadian Clock-Associated 1, and a cis-element, DET1 dark response element, mediate DET1 regulation of chlorophyll a/b-binding protein 2 expression. Plant Physiol. 2003;133:1565-77 pubmed
    b>DET1 is a pleiotropic regulator of Arabidopsis development and controls the expression of many light-regulated genes...
  8. Chen H, Shen Y, Tang X, Yu L, Wang J, Guo L, et al. Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development. Plant Cell. 2006;18:1991-2004 pubmed
    ..Furthermore, CUL4 exhibits a synergistic genetic interaction with COP10 and DET1. Therefore, this CUL4-based E3 ligase is essential for the repression of photomorphogenesis...
  9. Pepper A, Delaney T, Washburn T, Poole D, Chory J. DET1, a negative regulator of light-mediated development and gene expression in arabidopsis, encodes a novel nuclear-localized protein. Cell. 1994;78:109-16 pubmed
    ..for a signal transduction component that may integrate light with developmental pathways is the Arabidopsis DET1 gene product...

More Information

Publications24

  1. Song H, Carre I. DET1 regulates the proteasomal degradation of LHY, a component of the Arabidopsis circadian clock. Plant Mol Biol. 2005;57:761-71 pubmed
    ..Here we investigate the epistatic interaction between DE-ETIOLATED 1 (DET1), a negative regulator of light-regulated gene expression, and LATE ELONGATED HYPOCOTYL (LHY), one of the core ..
  2. Desai M, Kaur N, Hu J. Ectopic expression of the RING domain of the Arabidopsis peroxin2 protein partially suppresses the phenotype of the photomorphogenic mutant de-etiolated1. PLoS ONE. 2014;9:e108473 pubmed publisher
    The Arabidopsis constitutive photomorphogenic/de-etiolated 1/FUSCA (COP/DET1/FUS) proteins repress photomorphogenesis by degrading positive regulators of photomorphogenesis, such as the transcription factor long hypocotyl5 (HY5)...
  3. Dohmann E, Levesque M, De Veylder L, Reichardt I, Jurgens G, Schmid M, et al. The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability. Development. 2008;135:2013-22 pubmed publisher
    ..apparent in mutants of the NEDD8 conjugation pathway and in mutants of the E3 ligase subunits CULLIN4, COP1 and DET1, which share phenotypes with csn mutants...
  4. Nixdorf M, Hoecker U. SPA1 and DET1 act together to control photomorphogenesis throughout plant development. Planta. 2010;231:825-33 pubmed publisher
    The COP1/SPA complex and DET1 function to suppress photomorphogenesis in dark-grown Arabidopsis seedlings. Additionally, they inhibit flowering under non-inductive short-day conditions...
  5. Park B, Eo H, Jang I, Kang H, Song J, Seo H. Ubiquitination of LHY by SINAT5 regulates flowering time and is inhibited by DET1. Biochem Biophys Res Commun. 2010;398:242-6 pubmed publisher
    ..the Drosophila SINA RING-finger protein, interacts directly with LHY, a component of the circadian oscillator, and DET1, a negative regulator of light-regulated gene expression...
  6. Fernando V, Schroeder D. Genetic interactions between DET1 and intermediate genes in Arabidopsis ABA signalling. Plant Sci. 2015;239:166-79 pubmed publisher
    ..DE-ETIOLATED 1 (DET1) is a negative regulator of light signalling in Arabidopsis thaliana...
  7. Shi H, Wang X, Mo X, Tang C, Zhong S, Deng X. Arabidopsis DET1 degrades HFR1 but stabilizes PIF1 to precisely regulate seed germination. Proc Natl Acad Sci U S A. 2015;112:3817-22 pubmed publisher
    ..We identify that de-etiolated 1 (DET1), an evolutionarily conserved protein, is a central repressor of light-induced seed germination...
  8. Ganpudi A, Schroeder D. Genetic interactions of Arabidopsis thaliana damaged DNA binding protein 1B (DDB1B) with DDB1A, DET1, and COP1. G3 (Bethesda). 2013;3:493-503 pubmed publisher
    ..we use a viable partial loss of function allele of DDB1B, ddb1b-2, to examine genetic interactions with DDB1A, DET1 and COP1...
  9. Irigoyen M, Iniesto E, Rodriguez L, Puga M, Yanagawa Y, Pick E, et al. Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis. Plant Cell. 2014;26:712-28 pubmed publisher
    ..The latter involve COP10-DET1-DDB1 (CDD)-related complexes, which have been proposed to facilitate target recognition by CRL4, although the ..
  10. Dong J, Tang D, Gao Z, Yu R, Li K, He H, et al. Arabidopsis DE-ETIOLATED1 represses photomorphogenesis by positively regulating phytochrome-interacting factors in the dark. Plant Cell. 2014;26:3630-45 pubmed publisher
    ..thaliana seedlings undergo photomorphogenic development even in darkness when the function of DE-ETIOLATED1 (DET1), a repressor of photomorphogenesis, is disrupted...
  11. Kim E, Ly V, Hatherell A, Schroeder D. Genetic interactions between Arabidopsis DET1 and UVH6 during development and abiotic stress response. G3 (Bethesda). 2012;2:913-20 pubmed publisher
    ..In Arabidopsis thaliana, DE-ETIOLATED 1 (DET1) plays a role in visible light signaling, UV tolerance, and development...
  12. Kang M, Yoo S, Kwon H, Lee B, Cho J, Noh Y, et al. Negative regulatory roles of DE-ETIOLATED1 in flowering time in Arabidopsis. Sci Rep. 2015;5:9728 pubmed publisher
    ..The repressor of photomorphogenesis DE-ETIOLATED1 (DET1) delays flowering; det1-1 mutants flower early, especially under SD, but the molecular mechanism of DET1 regulation ..
  13. Ly V, Collister D, Fonseca E, Liao T, Schroeder D. Light and COP1 regulate level of overexpressed DET1 protein. Plant Sci. 2015;231:114-23 pubmed publisher
    de-etiolated 1 (det1) and constitutive photomorphogenic 1 (cop1) were initially identified as constitutively photomorphogenic Arabidopsis mutants, exhibiting light-grown phenotypes in the dark...
  14. Zhang Y, Schroeder D. Effect of overexpression of Arabidopsis damaged DNA-binding protein 1A on de-etiolated 1. Planta. 2010;231:337-48 pubmed publisher
    In Arabidopsis thaliana, de-etiolated 1 mutants (det1) grown in the dark resemble light-grown wild-type seedlings. Arabidopsis DET1 encodes a 62 kD protein, which is a negative regulator of light signaling...
  15. Gangappa S, Kumar S. DET1 and HY5 Control PIF4-Mediated Thermosensory Elongation Growth through Distinct Mechanisms. Cell Rep. 2017;18:344-351 pubmed publisher
    ..DE-ETIOLATED 1 (DET1) and CONSTITUTIVE PHOTOMORPHOGENESIS 1 (COP1), key regulators of light signaling, have been proposed to control ..