Gene Symbol: DDB2
Description: damaged DNA binding 2
Alias: MZN1.20, MZN1_20, damaged DNA binding 2, damaged DNA binding 2
Species: thale cress
Koga A, Ishibashi T, Kimura S, Uchiyama Y, Sakaguchi K. Characterization of T-DNA insertion mutants and RNAi silenced plants of Arabidopsis thaliana UV-damaged DNA binding protein 2 (AtUV-DDB2). Plant Mol Biol. 2006;61:227-40 pubmed
..human UV-damaged DNA binding protein (UV-DDB), a heterodimeric protein composed of 127 kDa (UV-DDB1) and 48 kDa (UV-DDB2) subunits, has been shown to be involved in DNA repair...
Bernhardt A, Lechner E, Hano P, Schade V, Dieterle M, Anders M, et al
. CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana. Plant J. 2006;47:591-603 pubmed
..In this work Arabidopsis cullin 4 is shown to assemble with DDB1, RBX1, DET1 and DDB2 in vitro and in planta...
Al Khateeb W, Schroeder D. DDB2, DDB1A and DET1 exhibit complex interactions during Arabidopsis development. Genetics. 2007;176:231-42 pubmed
Damaged DNA-binding proteins 1 and 2 (DDB1 and DDB2) are subunits of the damaged DNA-binding protein complex (DDB)...
Al Khateeb W, Schroeder D. Overexpression of Arabidopsis damaged DNA binding protein 1A (DDB1A) enhances UV tolerance. Plant Mol Biol. 2009;70:371-83 pubmed publisher
..DDB1A and DDB1B mRNA levels increased 3 h after UV exposure and DDB1A is required for UV regulation of DDB1B and DDB2 mRNA levels...
Biedermann S, Hellmann H. The DDB1a interacting proteins ATCSA-1 and DDB2 are critical factors for UV-B tolerance and genomic integrity in Arabidopsis thaliana. Plant J. 2010;62:404-15 pubmed publisher
..initiating the repair of UV-B-induced DNA lesions, and, together with the damage-specific DNA binding protein 2 (DDB2), is necessary for light-independent repair processes in Arabidopsis...
Dumbliauskas E, Lechner E, Jaciubek M, Berr A, Pazhouhandeh M, Alioua M, et al
. The Arabidopsis CUL4-DDB1 complex interacts with MSI1 and is required to maintain MEDEA parental imprinting. EMBO J. 2011;30:731-43 pubmed publisher
..Overall, our work provides the first evidence of a physical and functional link between a CRL4 E3 ligase and a PRC2 complex, thus indicating a novel role of ubiquitylation in the repression of gene expression. ..
Molinier J, Lechner E, Dumbliauskas E, Genschik P. Regulation and role of Arabidopsis CUL4-DDB1A-DDB2 in maintaining genome integrity upon UV stress. PLoS Genet. 2008;4:e1000093 pubmed publisher
..Here we investigated the regulation and the function of the recently described CUL4-DDB1-DDB2 E3 ligase in the maintenance of genome integrity upon UV-stress using the model plant Arabidopsis...
Castells E, Molinier J, Benvenuto G, Bourbousse C, Zabulon G, Zalc A, et al
. The conserved factor DE-ETIOLATED 1 cooperates with CUL4-DDB1DDB2 to maintain genome integrity upon UV stress. EMBO J. 2011;30:1162-72 pubmed publisher
..Moreover, DET1 is required for CULLIN4-dependent targeted degradation of the UV-lesion recognition factor DDB2. Finally, DET1 protein is degraded concomitantly with DDB2 upon UV irradiation in a CUL4-dependent mechanism...
Ly V, Hatherell A, Kim E, Chan A, Belmonte M, Schroeder D. Interactions between Arabidopsis DNA repair genes UVH6, DDB1A, and DDB2 during abiotic stress tolerance and floral development. Plant Sci. 2013;213:88-97 pubmed publisher
..Damaged DNA binding protein 1A (DDB1A), DDB2, and UV hypersensitive 6 (UVH6)/XPD are all involved in the repair of UV-damaged DNA - DDB1A and DDB2 in the ..