Gene Symbol: DDB1B
Description: damaged DNA binding protein 1B
Alias: F7J7.40, F7J7_40, damaged DNA binding protein 1B, damaged DNA binding protein 1B
Species: thale cress

Top Publications

  1. Bernhardt A, Lechner E, Hano P, Schade V, Dieterle M, Anders M, et al. CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana. Plant J. 2006;47:591-603 pubmed
    ..These results therefore assign an important function to CUL4 during plant development and provide strong evidence that CUL4 assembles together with RBX1 and DDB1 proteins to form a functional E3 ligase in Arabidopsis. ..
  2. Schroeder D, Gahrtz M, Maxwell B, Cook R, Kan J, Alonso J, et al. De-etiolated 1 and damaged DNA binding protein 1 interact to regulate Arabidopsis photomorphogenesis. Curr Biol. 2002;12:1462-72 pubmed
    ..The DET1/DDB1 complex may regulate gene expression in response to light via recruitment of HAT activity. Thus, DET1, whose sequence is conserved in both animals and plants, may play a direct role in the regulation of many genes. ..
  3. Lee J, Terzaghi W, Deng X. DWA3, an Arabidopsis DWD protein, acts as a negative regulator in ABA signal transduction. Plant Sci. 2011;180:352-7 pubmed publisher
    ..Taken together, we suggest that DWA3 is a negative regulator of ABA responses and may be involved in protein degradation mediated by CRL4. ..
  4. Bernhardt A, Mooney S, Hellmann H. Arabidopsis DDB1a and DDB1b are critical for embryo development. Planta. 2010;232:555-66 pubmed publisher
    ..Arabidopsis encodes for two closely related DDB1 proteins, named DDB1a and DDB1b. While loss-of DDB1a does not severely affect development, loss-of DDB1b has been reported to result in an embryo ..
  5. Al Khateeb W, Schroeder D. Overexpression of Arabidopsis damaged DNA binding protein 1A (DDB1A) enhances UV tolerance. Plant Mol Biol. 2009;70:371-83 pubmed publisher
    ..Arabidopsis has two homologues of DDB1: DDB1A and DDB1B. In this study we examine the role of DDB1A in Arabidopsis UV tolerance and DNA repair using a DDB1A null mutant (..
  6. Lee J, Yoon H, Terzaghi W, Martinez C, Dai M, Li J, et al. DWA1 and DWA2, two Arabidopsis DWD protein components of CUL4-based E3 ligases, act together as negative regulators in ABA signal transduction. Plant Cell. 2010;22:1716-32 pubmed publisher
    ..This report thus describes a previously unknown heterodimeric cooperation between two independent substrate receptors for CUL4-based E3 ligases. ..
  7. Pazhouhandeh M, Molinier J, Berr A, Genschik P. MSI4/FVE interacts with CUL4-DDB1 and a PRC2-like complex to control epigenetic regulation of flowering time in Arabidopsis. Proc Natl Acad Sci U S A. 2011;108:3430-5 pubmed publisher
    ..Overall our work provides evidence for a unique functional interaction between the cullin-RING ubiquitin ligase (CUL4-DDB1(MSI4)) and a CLF-PRC2 complex in the regulation of flowering timing in Arabidopsis. ..
  8. Chen H, Huang X, Gusmaroli G, Terzaghi W, Lau O, Yanagawa Y, et al. Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell. 2010;22:108-23 pubmed publisher
    ..Thus, a series of CUL4-DDB1-COP1-SPA E3 ligase complexes may mediate the repression of photomorphogenesis and, possibly, of flowering time. ..
  9. Irigoyen M, Iniesto E, Rodriguez L, Puga M, Yanagawa Y, Pick E, et al. Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis. Plant Cell. 2014;26:712-28 pubmed publisher
    ..Altogether, our data establish a function for DDA1 as a substrate receptor for CRL4-CDD complexes and uncover a mechanism for the desensitization of ABA signaling based on the regulation of ABA receptor stability...

More Information


  1. Bjerkan K, Jung Roméo S, Jurgens G, Genschik P, Grini P. Arabidopsis WD repeat domain55 Interacts with DNA damaged binding protein1 and is required for apical patterning in the embryo. Plant Cell. 2012;24:1013-33 pubmed publisher
    ..Interestingly, the observed embryo and endosperm phenotype is reminiscent of CUL4 or DDB1A/B loss of function and thus may support a regulatory role of a putative CRL4(WDR55) E3 ligase complex. ..
  2. Ganpudi A, Schroeder D. Genetic interactions of Arabidopsis thaliana damaged DNA binding protein 1B (DDB1B) with DDB1A, DET1, and COP1. G3 (Bethesda). 2013;3:493-503 pubmed publisher
    ..Arabidopsis thaliana encodes two homologs of DDB1, DDB1A, and DDB1B. In this study we use a viable partial loss of function allele of DDB1B, ddb1b-2, to examine genetic interactions ..
  3. Huang X, Ouyang X, Yang P, Lau O, Chen L, Wei N, et al. Conversion from CUL4-based COP1-SPA E3 apparatus to UVR8-COP1-SPA complexes underlies a distinct biochemical function of COP1 under UV-B. Proc Natl Acad Sci U S A. 2013;110:16669-74 pubmed publisher