Gene Symbol: DDB1A
Description: damaged DNA binding protein 1A
Alias: C6L9.100, C6L9_100, damaged DNA binding protein 1A, damaged DNA binding protein 1A
Species: thale cress

Top Publications

  1. Chen H, Shen Y, Tang X, Yu L, Wang J, Guo L, et al. Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development. Plant Cell. 2006;18:1991-2004 pubmed
    ..Thus, this study suggests a biochemical activity connection between CSN and CDD complexes in their cooperation with COP1 in orchestrating the repression of photomorphogenesis. ..
  2. Lee J, Terzaghi W, Deng X. DWA3, an Arabidopsis DWD protein, acts as a negative regulator in ABA signal transduction. Plant Sci. 2011;180:352-7 pubmed publisher
    ..Taken together, we suggest that DWA3 is a negative regulator of ABA responses and may be involved in protein degradation mediated by CRL4. ..
  3. Yanagawa Y, Sullivan J, Komatsu S, Gusmaroli G, Suzuki G, Yin J, et al. Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes. Genes Dev. 2004;18:2172-81 pubmed
    ..Furthermore, we show that COP10 forms a complex with UV-damaged DNA-binding protein 1a (DDB1a) and de-etiolated 1 (DET1), and physically interacts with COP1 and the CSN...
  4. Seo K, Lee J, Nezames C, Zhong S, Song E, Byun M, et al. ABD1 is an Arabidopsis DCAF substrate receptor for CUL4-DDB1-based E3 ligases that acts as a negative regulator of abscisic acid signaling. Plant Cell. 2014;26:695-711 pubmed publisher
    ..Taken together, these data suggest that the DCAF-CUL4 E3 ubiquitin ligase assembled with ABD1 is a negative regulator of ABA responses by directly binding to and affecting the stability of ABI5 in the nucleus. ..
  5. Pazhouhandeh M, Molinier J, Berr A, Genschik P. MSI4/FVE interacts with CUL4-DDB1 and a PRC2-like complex to control epigenetic regulation of flowering time in Arabidopsis. Proc Natl Acad Sci U S A. 2011;108:3430-5 pubmed publisher
    ..Overall our work provides evidence for a unique functional interaction between the cullin-RING ubiquitin ligase (CUL4-DDB1(MSI4)) and a CLF-PRC2 complex in the regulation of flowering timing in Arabidopsis. ..
  6. Lee J, Yoon H, Terzaghi W, Martinez C, Dai M, Li J, et al. DWA1 and DWA2, two Arabidopsis DWD protein components of CUL4-based E3 ligases, act together as negative regulators in ABA signal transduction. Plant Cell. 2010;22:1716-32 pubmed publisher
    ..This report thus describes a previously unknown heterodimeric cooperation between two independent substrate receptors for CUL4-based E3 ligases. ..
  7. Biedermann S, Hellmann H. The DDB1a interacting proteins ATCSA-1 and DDB2 are critical factors for UV-B tolerance and genomic integrity in Arabidopsis thaliana. Plant J. 2010;62:404-15 pubmed publisher
    ..Overall, the results presented here form a functional description of a plant Cockayne syndrome factor A (CSA) ortholog, and demonstrate the importance of ATCSA-1 for UV-B tolerance. ..
  8. Dumbliauskas E, Lechner E, Jaciubek M, Berr A, Pazhouhandeh M, Alioua M, et al. The Arabidopsis CUL4-DDB1 complex interacts with MSI1 and is required to maintain MEDEA parental imprinting. EMBO J. 2011;30:731-43 pubmed publisher
    ..Here, we provide evidence that Arabidopsis MSI1 physically interacts with DDB1A and is part of a multimeric protein complex including CUL4...
  9. Bernhardt A, Mooney S, Hellmann H. Arabidopsis DDB1a and DDB1b are critical for embryo development. Planta. 2010;232:555-66 pubmed publisher
    ..Arabidopsis encodes for two closely related DDB1 proteins, named DDB1a and DDB1b...

More Information


  1. Al Khateeb W, Schroeder D. Overexpression of Arabidopsis damaged DNA binding protein 1A (DDB1A) enhances UV tolerance. Plant Mol Biol. 2009;70:371-83 pubmed publisher
    ..Arabidopsis has two homologues of DDB1: DDB1A and DDB1B...
  2. Schroeder D, Gahrtz M, Maxwell B, Cook R, Kan J, Alonso J, et al. De-etiolated 1 and damaged DNA binding protein 1 interact to regulate Arabidopsis photomorphogenesis. Curr Biol. 2002;12:1462-72 pubmed
    ..A null mutation in Arabidopsis DDB1A results in no obvious phenotype on its own, yet it enhances the phenotype of a weak det1 allele...
  3. Bernhardt A, Lechner E, Hano P, Schade V, Dieterle M, Anders M, et al. CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana. Plant J. 2006;47:591-603 pubmed
    ..These results therefore assign an important function to CUL4 during plant development and provide strong evidence that CUL4 assembles together with RBX1 and DDB1 proteins to form a functional E3 ligase in Arabidopsis. ..
  4. Zhang C, Guo H, Zhang J, Guo G, Schumaker K, Guo Y. Arabidopsis cockayne syndrome A-like proteins 1A and 1B form a complex with CULLIN4 and damage DNA binding protein 1A and regulate the response to UV irradiation. Plant Cell. 2010;22:2353-69 pubmed publisher
    ..Yeast two-hybrid analysis indicated that both CSAat1A and B interact with DDB1A (UV-Damage DNA Binding Protein1)...
  5. Al Khateeb W, Schroeder D. DDB2, DDB1A and DET1 exhibit complex interactions during Arabidopsis development. Genetics. 2007;176:231-42 pubmed
    ..Arabidopsis has two DDB1 homologs, DDB1A and DDB1B. ddb1a single mutants have no visible phenotype while ddb1b mutants are lethal...
  6. Chen H, Huang X, Gusmaroli G, Terzaghi W, Lau O, Yanagawa Y, et al. Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell. 2010;22:108-23 pubmed publisher
    ..Thus, a series of CUL4-DDB1-COP1-SPA E3 ligase complexes may mediate the repression of photomorphogenesis and, possibly, of flowering time. ..
  7. Molinier J, Lechner E, Dumbliauskas E, Genschik P. Regulation and role of Arabidopsis CUL4-DDB1A-DDB2 in maintaining genome integrity upon UV stress. PLoS Genet. 2008;4:e1000093 pubmed publisher
    ..Interestingly, we found that DDB1A shuttles from the cytoplasm to the nucleus in an ATR-dependent manner, highlighting an upstream level of control ..
  8. Ganpudi A, Schroeder D. Genetic interactions of Arabidopsis thaliana damaged DNA binding protein 1B (DDB1B) with DDB1A, DET1, and COP1. G3 (Bethesda). 2013;3:493-503 pubmed publisher
    ..Arabidopsis thaliana encodes two homologs of DDB1, DDB1A, and DDB1B...
  9. Kim S, Lee J, Seo K, Ryu B, Sung Y, Chung T, et al. Characterization of a Novel DWD protein that participates in heat stress response in Arabidopsis. Mol Cells. 2014;37:833-40 pubmed publisher
    ..Additionally, HTD1 directly interacted with DDB1a in yeast two-hybrid assays and associated with DDB1b in vivo, supporting that it could be a part of a CRL4 complex...
  10. Hotton S, Castro M, Eigenheer R, Callis J. Recovery of DDB1a (damaged DNA binding protein1a) in a screen to identify novel RUB-modified proteins in Arabidopsis thaliana. Mol Plant. 2012;5:1163-6 pubmed publisher
  11. Beris D, Kapolas G, Livanos P, Roussis A, Milioni D, Haralampidis K. RNAi-mediated silencing of the Arabidopsis thaliana ULCS1 gene, encoding a WDR protein, results in cell wall modification impairment and plant infertility. Plant Sci. 2016;245:71-83 pubmed publisher
    ..AtULCS1 interacts with the E3Cullin Ring Ligase subunit DDB1a, regulating most likely the degradation of specific proteins involved in the manifestation of diverse ..
  12. Ly V, Collister D, Fonseca E, Liao T, Schroeder D. Light and COP1 regulate level of overexpressed DET1 protein. Plant Sci. 2015;231:114-23 pubmed publisher
    ..Arabidopsis has two DDB1 homologues, DDB1A and DDB1B, and DDB1A mutants enhance det1 phenotypes...
  13. Irigoyen M, Iniesto E, Rodriguez L, Puga M, Yanagawa Y, Pick E, et al. Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis. Plant Cell. 2014;26:712-28 pubmed publisher
    ..Altogether, our data establish a function for DDA1 as a substrate receptor for CRL4-CDD complexes and uncover a mechanism for the desensitization of ABA signaling based on the regulation of ABA receptor stability...
  14. Zhang Y, Schroeder D. Effect of overexpression of Arabidopsis damaged DNA-binding protein 1A on de-etiolated 1. Planta. 2010;231:337-48 pubmed publisher
    ..Arabidopsis has two DDB1 homologs: DDB1A and DDB1B. DDB1A mutation enhances det1 mutant phenotypes...
  15. Ly V, Hatherell A, Kim E, Chan A, Belmonte M, Schroeder D. Interactions between Arabidopsis DNA repair genes UVH6, DDB1A, and DDB2 during abiotic stress tolerance and floral development. Plant Sci. 2013;213:88-97 pubmed publisher
    ..For example, the sun is a source of heat, intense light, and DNA-damaging ultraviolet (UV) rays. Damaged DNA binding protein 1A (DDB1A), DDB2, and UV hypersensitive 6 (UVH6)/XPD are all involved in the repair of UV-damaged DNA - ..
  16. Bjerkan K, Grini P. The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development. Plant Signal Behav. 2013;8: pubmed publisher
    ..We have previously reported that the WD40 protein WDR55 interacts with DDB1A and is thus a putative DCAF...
  17. Bjerkan K, Jung Roméo S, Jurgens G, Genschik P, Grini P. Arabidopsis WD repeat domain55 Interacts with DNA damaged binding protein1 and is required for apical patterning in the embryo. Plant Cell. 2012;24:1013-33 pubmed publisher
    ..We demonstrate that WDR55 physically interacts with Arabidopsis thaliana DDB1A in planta, suggesting that WDR55 may be a novel substrate recruiter of CRL4 complexes...