Research TopicsGenomes and GenesSpecies | DDB1ASummaryGene Symbol: DDB1A Description: damaged DNA binding protein 1A Alias: C6L9.100, C6L9_100, damaged DNA binding protein 1A, damaged DNA binding protein 1A Species: thale cress Top Publications
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- Al Khateeb W, Schroeder D. Overexpression of Arabidopsis damaged DNA binding protein 1A (DDB1A) enhances UV tolerance. Plant Mol Biol. 2009;70:371-83 pubmed publisher..Arabidopsis has two homologues of DDB1: DDB1A and DDB1B...
- Schroeder D, Gahrtz M, Maxwell B, Cook R, Kan J, Alonso J, et al. De-etiolated 1 and damaged DNA binding protein 1 interact to regulate Arabidopsis photomorphogenesis. Curr Biol. 2002;12:1462-72 pubmed..A null mutation in Arabidopsis DDB1A results in no obvious phenotype on its own, yet it enhances the phenotype of a weak det1 allele...
- Bernhardt A, Lechner E, Hano P, Schade V, Dieterle M, Anders M, et al. CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana. Plant J. 2006;47:591-603 pubmed..These results therefore assign an important function to CUL4 during plant development and provide strong evidence that CUL4 assembles together with RBX1 and DDB1 proteins to form a functional E3 ligase in Arabidopsis. ..
- Zhang C, Guo H, Zhang J, Guo G, Schumaker K, Guo Y. Arabidopsis cockayne syndrome A-like proteins 1A and 1B form a complex with CULLIN4 and damage DNA binding protein 1A and regulate the response to UV irradiation. Plant Cell. 2010;22:2353-69 pubmed publisher..Yeast two-hybrid analysis indicated that both CSAat1A and B interact with DDB1A (UV-Damage DNA Binding Protein1)...
- Al Khateeb W, Schroeder D. DDB2, DDB1A and DET1 exhibit complex interactions during Arabidopsis development. Genetics. 2007;176:231-42 pubmed..Arabidopsis has two DDB1 homologs, DDB1A and DDB1B. ddb1a single mutants have no visible phenotype while ddb1b mutants are lethal...
- Chen H, Huang X, Gusmaroli G, Terzaghi W, Lau O, Yanagawa Y, et al. Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell. 2010;22:108-23 pubmed publisher..Thus, a series of CUL4-DDB1-COP1-SPA E3 ligase complexes may mediate the repression of photomorphogenesis and, possibly, of flowering time. ..
- Molinier J, Lechner E, Dumbliauskas E, Genschik P. Regulation and role of Arabidopsis CUL4-DDB1A-DDB2 in maintaining genome integrity upon UV stress. PLoS Genet. 2008;4:e1000093 pubmed publisher..Interestingly, we found that DDB1A shuttles from the cytoplasm to the nucleus in an ATR-dependent manner, highlighting an upstream level of control ..
- Ganpudi A, Schroeder D. Genetic interactions of Arabidopsis thaliana damaged DNA binding protein 1B (DDB1B) with DDB1A, DET1, and COP1. G3 (Bethesda). 2013;3:493-503 pubmed publisher..Arabidopsis thaliana encodes two homologs of DDB1, DDB1A, and DDB1B...
- Kim S, Lee J, Seo K, Ryu B, Sung Y, Chung T, et al. Characterization of a Novel DWD protein that participates in heat stress response in Arabidopsis. Mol Cells. 2014;37:833-40 pubmed publisher..Additionally, HTD1 directly interacted with DDB1a in yeast two-hybrid assays and associated with DDB1b in vivo, supporting that it could be a part of a CRL4 complex...
- Beris D, Kapolas G, Livanos P, Roussis A, Milioni D, Haralampidis K. RNAi-mediated silencing of the Arabidopsis thaliana ULCS1 gene, encoding a WDR protein, results in cell wall modification impairment and plant infertility. Plant Sci. 2016;245:71-83 pubmed publisher..AtULCS1 interacts with the E3Cullin Ring Ligase subunit DDB1a, regulating most likely the degradation of specific proteins involved in the manifestation of diverse ..
- Ly V, Collister D, Fonseca E, Liao T, Schroeder D. Light and COP1 regulate level of overexpressed DET1 protein. Plant Sci. 2015;231:114-23 pubmed publisher..Arabidopsis has two DDB1 homologues, DDB1A and DDB1B, and DDB1A mutants enhance det1 phenotypes...
- Irigoyen M, Iniesto E, Rodriguez L, Puga M, Yanagawa Y, Pick E, et al. Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis. Plant Cell. 2014;26:712-28 pubmed publisher..Altogether, our data establish a function for DDA1 as a substrate receptor for CRL4-CDD complexes and uncover a mechanism for the desensitization of ABA signaling based on the regulation of ABA receptor stability...
- Zhang Y, Schroeder D. Effect of overexpression of Arabidopsis damaged DNA-binding protein 1A on de-etiolated 1. Planta. 2010;231:337-48 pubmed publisher..Arabidopsis has two DDB1 homologs: DDB1A and DDB1B. DDB1A mutation enhances det1 mutant phenotypes...
- Ly V, Hatherell A, Kim E, Chan A, Belmonte M, Schroeder D. Interactions between Arabidopsis DNA repair genes UVH6, DDB1A, and DDB2 during abiotic stress tolerance and floral development. Plant Sci. 2013;213:88-97 pubmed publisher..For example, the sun is a source of heat, intense light, and DNA-damaging ultraviolet (UV) rays. Damaged DNA binding protein 1A (DDB1A), DDB2, and UV hypersensitive 6 (UVH6)/XPD are all involved in the repair of UV-damaged DNA - ..
- Bjerkan K, Grini P. The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development. Plant Signal Behav. 2013;8: pubmed publisher..We have previously reported that the WD40 protein WDR55 interacts with DDB1A and is thus a putative DCAF...
- Bjerkan K, Jung Roméo S, Jurgens G, Genschik P, Grini P. Arabidopsis WD repeat domain55 Interacts with DNA damaged binding protein1 and is required for apical patterning in the embryo. Plant Cell. 2012;24:1013-33 pubmed publisher..We demonstrate that WDR55 physically interacts with Arabidopsis thaliana DDB1A in planta, suggesting that WDR55 may be a novel substrate recruiter of CRL4 complexes...