Gene Symbol: DCP2
Description: decapping 2
Alias: ATDCP2, INCREASED TRANSGENE SILENCING 1, ITS1, T6I14.5, TDT, TRIDENT, decapping 2, decapping 2
Species: thale cress
Iwasaki S, Takeda A, Motose H, Watanabe Y. Characterization of Arabidopsis decapping proteins AtDCP1 and AtDCP2, which are essential for post-embryonic development. FEBS Lett. 2007;581:2455-9 pubmed
..Here, we identified Arabidopsis thaliana decapping proteins AtDCP1 and AtDCP2 and showed that (I) AtDCP2 is an active decapping enzyme, (II) AtDCP1 interacts with itself, (III) AtDCP1 and ..
Xu J, Yang J, Niu Q, Chua N. Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development. Plant Cell. 2006;18:3386-98 pubmed
..Here, we show that Arabidopsis thaliana DCP2 can generate from capped mRNAs, m7GDP, and 5'-phosphorylated mRNAs in vitro and that this decapping activity ..
Xu J, Chua N. Arabidopsis decapping 5 is required for mRNA decapping, P-body formation, and translational repression during postembryonic development. Plant Cell. 2009;21:3270-9 pubmed publisher
..We previously found that a decapping complex comprising Decapping 1 (DCP1), DCP2, and Varicose in Arabidopsis thaliana is essential for postembryonic development, but the underlying mechanism is ..
Motomura K, Le Q, Kumakura N, Fukaya T, Takeda A, Watanabe Y. The role of decapping proteins in the miRNA accumulation in Arabidopsis thaliana. RNA Biol. 2012;9:644-52 pubmed publisher
Decapping 1 (DCP1), Decapping 2 (DCP2) and VARICOSE (VCS) are components of the decapping complex that removes the 7-methyl-guanosine 5'-diphosphate from the 5' end of mRNAs...
Goeres D, Van Norman J, Zhang W, Fauver N, Spencer M, Sieburth L. Components of the Arabidopsis mRNA decapping complex are required for early seedling development. Plant Cell. 2007;19:1549-64 pubmed
..vein patterning in Arabidopsis thaliana, we analyzed two phenotypically similar mutants, varicose (vcs) and trident (tdt). We had previously identified VCS, and recently, human VCS was shown to function in mRNA decapping...
Thran M, Link K, Sonnewald U. The Arabidopsis DCP2 gene is required for proper mRNA turnover and prevents transgene silencing in Arabidopsis. Plant J. 2012;72:368-77 pubmed publisher
..Map-based cloning and subsequent complementation revealed that ITS1 encodes DECAPPING?2 (DCP2), which is crucial for decapping, a prerequisite for mRNA degradation...
Motomura K, Le Q, Hamada T, Kutsuna N, Mano S, Nishimura M, et al
. Diffuse decapping enzyme DCP2 accumulates in DCP1 foci under heat stress in Arabidopsis thaliana. Plant Cell Physiol. 2015;56:107-15 pubmed publisher
The decapping enzymes DCP1 and DCP2 are components of a decapping complex that degrades mRNAs. DCP2 is the catalytic core and DCP1 is an auxiliary subunit...
Xu J, Chua N. Dehydration stress activates Arabidopsis MPK6 to signal DCP1 phosphorylation. EMBO J. 2012;31:1975-84 pubmed publisher
..Our results suggest that mRNA decapping through MPK6-DCP1-DCP5 pathway serves as a rapid response to dehydration stress in Arabidopsis. ..
Ma X, Nicole M, Meteignier L, Hong N, Wang G, Moffett P. Different roles for RNA silencing and RNA processing components in virus recovery and virus-induced gene silencing in plants. J Exp Bot. 2015;66:919-32 pubmed publisher
..Consistent with this, we found that viral recovery induced increased PB formation and that a decapping mutant (DCP2) showed increased VIGS and virus RNA accumulation, indicating an important role for PBs in eliminating viral RNA.