Gene Symbol: CYP83B1
Description: cytochrome P450, family 83, subfamily B, polypeptide 1
Alias: ''cytochrome P450, ALTERED TRYPTOPHAN REGULATION 4, ATR4, CYTOCHROME P450 MONOOXYGENASE 83B1, F3L17.70, F3L17_70, RED ELONGATED 1, RED1, RNT1, RUNT 1, SUPERROOT 2, SUR2, cytochrome P450, family 83, polypeptide 1, polypeptide 1'', subfamily B, cytochrome P450, family 83, subfamily B, polypeptide 1
Species: thale cress

Top Publications

  1. Barlier I, Kowalczyk M, Marchant A, Ljung K, Bhalerao R, Bennett M, et al. The SUR2 gene of Arabidopsis thaliana encodes the cytochrome P450 CYP83B1, a modulator of auxin homeostasis. Proc Natl Acad Sci U S A. 2000;97:14819-24 pubmed
    ..The SUR2 gene was cloned and shown to encode the CYP83B1 protein, which belongs to the large family of the P450-dependent monooxygenases...
  2. Bak S, Feyereisen R. The involvement of two p450 enzymes, CYP83B1 and CYP83A1, in auxin homeostasis and glucosinolate biosynthesis. Plant Physiol. 2001;127:108-18 pubmed
    ..The initial step in this conversion is catalyzed by CYP83B1 in Arabidopsis (S. Bak, F.E. Tax, K.A. Feldmann, D.A. Galbraith, R. Feyereisen [2001] Plant Cell 13: 101-111)...
  3. Smolen G, Bender J. Arabidopsis cytochrome P450 cyp83B1 mutations activate the tryptophan biosynthetic pathway. Genetics. 2002;160:323-32 pubmed
    ..One atr complementation group consisted of mutations in the cytochrome P450 gene CYP83B1...
  4. Sorin C, Negroni L, Balliau T, Corti H, Jacquemot M, Davanture M, et al. Proteomic analysis of different mutant genotypes of Arabidopsis led to the identification of 11 proteins correlating with adventitious root development. Plant Physiol. 2006;140:349-64 pubmed
    ..The results identify regulatory pathways associated with adventitious root formation and represent valuable markers that might be used for the future identification of genotypes with better rooting abilities. ..
  5. Naur P, Petersen B, Mikkelsen M, Bak S, Rasmussen H, Olsen C, et al. CYP83A1 and CYP83B1, two nonredundant cytochrome P450 enzymes metabolizing oximes in the biosynthesis of glucosinolates in Arabidopsis. Plant Physiol. 2003;133:63-72 pubmed
    ..Here, we provide biochemical evidence for the functional role of the two cytochromes P450, CYP83A1 and CYP83B1, from Arabidopsis in oxime metabolism in the biosynthesis of glucosinolates...
  6. Clay N, Adio A, Denoux C, Jander G, Ausubel F. Glucosinolate metabolites required for an Arabidopsis innate immune response. Science. 2009;323:95-101 pubmed publisher
    ..Our study shows that well-studied plant metabolites, previously identified as important in avoiding damage by herbivores, are also required as a component of the plant defense response against microbial pathogens...
  7. Griffiths J, Murase K, Rieu I, Zentella R, Zhang Z, Powers S, et al. Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis. Plant Cell. 2006;18:3399-414 pubmed
    ..Furthermore, yeast three-hybrid assays showed that the GA-GID1 complex promotes the interaction between RGA and the F-box protein SLY1, a component of the SCF(SLY1) E3 ubiquitin ligase that targets the DELLA protein for degradation. ..
  8. Truman W, Bennett M, Turnbull C, Grant M. Arabidopsis auxin mutants are compromised in systemic acquired resistance and exhibit aberrant accumulation of various indolic compounds. Plant Physiol. 2010;152:1562-73 pubmed publisher
    ..Linking together transcriptional and targeted metabolite studies, our data provide compelling evidence for a role of indole-derived compounds, but not auxin itself, in the establishment and maintenance of systemic immunity. ..
  9. Kiyohara S, Honda H, Shimizu N, Ejima C, Hamasaki R, Sawa S. Tryptophan auxotroph mutants suppress the superroot2 phenotypes, modulating IAA biosynthesis in arabidopsis. Plant Signal Behav. 2011;6:1351-5 pubmed
    ..b>SUR2 is considered to modulate Trp dependent pathway, resulting IAA accumulation in Arabidopsis...

More Information


  1. Wagner D, Hoecker U, Quail P. RED1 is necessary for phytochrome B-mediated red light-specific signal transduction in Arabidopsis. Plant Cell. 1997;9:731-43 pubmed
    ..One recessive, red light-specific extragenic revertant, designated red1, was isolated...
  2. Mikkelsen M, Fuller V, Hansen B, Nafisi M, Olsen C, Nielsen H, et al. Controlled indole-3-acetaldoxime production through ethanol-induced expression of CYP79B2. Planta. 2009;229:1209-17 pubmed publisher
    ..The cytochrome P450s CYP79B2 and CYP79B3 catalyze the conversion of tryptophan to IAOx. CYP83B1 channels IAOx into I-GLS biosynthesis, CYP71A13 channels IAOx into camalexin biosynthesis, whereas the IAOx-..
  3. Morant M, Ekstrøm C, Ulvskov P, Kristensen C, Rudemo M, Olsen C, et al. Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2. Mol Plant. 2010;3:192-211 pubmed publisher
    ..Subsequently, SUR2 was identified as CYP83B1, a cytochrome P450 positioned at the metabolic branch point between auxin and indole glucosinolate metabolism...
  4. Zou H, Zhang Y, Wei W, Chen H, Song Q, Liu Y, et al. The transcription factor AtDOF4.2 regulates shoot branching and seed coat formation in Arabidopsis. Biochem J. 2013;449:373-88 pubmed publisher
    ..thaliana SHOOT MERISTEMLESS), AtTFL1 (A. thaliana TERMINAL FLOWER1) and AtCYP83B1 (A. thaliana CYTOCHROME P450 83B1). The seeds of an AtDOF4...
  5. Clausen M, Kannangara R, Olsen C, Blomstedt C, Gleadow R, Jørgensen K, et al. The bifurcation of the cyanogenic glucoside and glucosinolate biosynthetic pathways. Plant J. 2015;84:558-73 pubmed publisher
    ..We demonstrate that CYP83B1 from Arabidopsis thaliana cannot convert the (E)-p-hydroxyphenylacetaldoxime to the (Z)-isomer, which blocks ..
  6. Maharjan P, Dilkes B, Fujioka S, Pěnčík A, Ljung K, Burow M, et al. Arabidopsis gulliver1/SUPERROOT2-7 identifies a metabolic basis for auxin and brassinosteroid synergy. Plant J. 2014;80:797-808 pubmed publisher
    ..that gul1 was a missense mutation, resulting in a glycine to arginine change at amino acid 116 in SUPERROOT2 (CYP83B1), which converts indole acetaldoxime to an S-alkyl thiohydroximate adduct in the indole glucosinolate pathway...
  7. Kim J, Dolan W, Anderson N, Chapple C. Indole Glucosinolate Biosynthesis Limits Phenylpropanoid Accumulation in Arabidopsis thaliana. Plant Cell. 2015;27:1529-46 pubmed publisher a screen for plants with defects in soluble phenylpropanoid accumulation, has a missense mutation in CYP83B1 and displays defects in glucosinolate biosynthesis and in phenylpropanoid accumulation...