Gene Symbol: CSN5A
Description: COP9 signalosome 5A
Alias: AJH1, ARABIDOPSIS JAB1 HOMOLOG 1, COP9 signalosome 5A, CSN5, F19G10.12, F19G10_12, JAB1, PUTATIVE JUN KINASE ACTIVATOR, COP9 signalosome 5A
Species: thale cress

Top Publications

  1. Peng Z, Serino G, Deng X. Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted developmental processes in Arabidopsis. Plant Cell. 2001;13:2393-407 pubmed
    ..The CSN6 proteins share homology with CSN5 and belong to the Mov34 superfamily of proteins...
  2. Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, et al. Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell. 2003;15:719-31 pubmed
    ..Comparative analyses of the subunit interaction of CSN revealed a set of conserved subunit contacts and resulted in a model of CSN subunit topology, some aspects of which were substantiated by in vivo cross-link tests. ..
  3. Gusmaroli G, Feng S, Deng X. The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development. Plant Cell. 2004;16:2984-3001 pubmed
    ..catalytic center resides in its subunit 5, which in Arabidopsis thaliana is encoded by two homologous genes, CSN5A and CSN5B...
  4. Gusmaroli G, Figueroa P, Serino G, Deng X. Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases. Plant Cell. 2007;19:564-81 pubmed
    ..MPN (for Mpr1p and Pad1p N-terminal) domain and, in Arabidopsis thaliana, are each encoded by two genes: CSN5A, CSN5B and CSN6A, CSN6B, respectively...
  5. Serino G, Tsuge T, Kwok S, Matsui M, Wei N, Deng X. Arabidopsis cop8 and fus4 mutations define the same gene that encodes subunit 4 of the COP9 signalosome. Plant Cell. 1999;11:1967-80 pubmed
    ..that COP8 is capable of strong self-association as well as interaction with COP9, FUS6/COP11, FUS5, and Arabidopsis JAB1 homolog 1, the latter four proteins being previously defined subunits of the Arabidopsis COP9 signalosome...
  6. Dohmann E, Kuhnle C, Schwechheimer C. Loss of the CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome subunit 5 is sufficient to cause the cop/det/fus mutant phenotype in Arabidopsis. Plant Cell. 2005;17:1967-78 pubmed
    ..CSN is evolutionary conserved, and its subunit 5 (CSN5) mediates the deconjugation of NEDD8 from the cullin subunit of E3 ubiquitin ligases (deneddylation)...
  7. Kwok S, Solano R, Tsuge T, Chamovitz D, Ecker J, Matsui M, et al. Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations. Plant Cell. 1998;10:1779-90 pubmed
    ..Both AJH1 and AJH2 share high amino acid sequence identity (62 and 63%, respectively) with JAB1, a specific mammalian coactivator of AP-1 transcription...
  8. Ambroggio X, Rees D, Deshaies R. JAMM: a metalloprotease-like zinc site in the proteasome and signalosome. PLoS Biol. 2004;2:E2 pubmed publisher
    The JAMM (JAB1/MPN/Mov34 metalloenzyme) motif in Rpn11 and Csn5 underlies isopeptidase activities intrinsic to the proteasome and signalosome, respectively...
  9. Karniol B, Chamovitz D. The COP9 signalosome: from light signaling to general developmental regulation and back. Curr Opin Plant Biol. 2000;3:387-93 pubmed
    ..The COP9 complex is essential for animal development. The COP9 signalosome may have both an evolutionary and a physical relationship with both the regulatory lid of the proteasome and eIF3. ..

More Information


  1. Mukhtar M, Carvunis A, Dreze M, Epple P, Steinbrenner J, Moore J, et al. Independently evolved virulence effectors converge onto hubs in a plant immune system network. Science. 2011;333:596-601 pubmed publisher
    ..Thus, pathogens from different kingdoms deploy independently evolved virulence proteins that interact with a limited set of highly connected cellular hubs to facilitate their diverse life-cycle strategies. ..
  2. Wang X, Feng S, Nakayama N, Crosby W, Irish V, Deng X, et al. The COP9 signalosome interacts with SCF UFO and participates in Arabidopsis flower development. Plant Cell. 2003;15:1071-82 pubmed
    ..Compared with the previously reported csn5 antisense and csn1 null mutants, partial deficiency of CSN1 causes a reduction in the level of CUL1 in the mutant ..
  3. Yanagawa Y, Sullivan J, Komatsu S, Gusmaroli G, Suzuki G, Yin J, et al. Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes. Genes Dev. 2004;18:2172-81 pubmed
    ..Thus, the CDD complex may act as a ubiquitylation-promoting factor to regulate photomorphogenesis. ..
  4. Dohmann E, Levesque M, De Veylder L, Reichardt I, Jurgens G, Schmid M, et al. The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability. Development. 2008;135:2013-22 pubmed publisher
    ..In summary, our data suggest that Arabidopsis csn mutants undergo DNA damage, which might be the cause of the delay in G2 cell cycle progression...
  5. Mir R, Leon J. Pathogen and circadian controlled 1 (PCC1) protein is anchored to the plasma membrane and interacts with subunit 5 of COP9 signalosome in Arabidopsis. PLoS ONE. 2014;9:e87216 pubmed publisher
    ..The regulatory effect exerted by PCC1 on the transition to flowering as well as on other reported phenotypes might be explained by a mechanism involving the interaction with the subunit 5 of the COP9 signalosome (CSN). ..
  6. Kim T, Kim B, Yahalom A, Chamovitz D, von Arnim A. Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h. Plant Cell. 2004;16:3341-56 pubmed
  7. Nakasone A, Fujiwara M, Fukao Y, Biswas K, Rahman A, Kawai Yamada M, et al. SMALL ACIDIC PROTEIN1 acts with RUB modification components, the COP9 signalosome, and AXR1 to regulate growth and development of Arabidopsis. Plant Physiol. 2012;160:93-105 pubmed publisher
    ..The extremely dwarf phenotype of the aar1-1 csn5a-1 double mutant confirms the functional role of SMAP1 in plant growth and development under limiting CSN ..
  8. Jia X, Chanda B, Zhao M, Brunner A, Beers E. Instability of the Arabidopsis mutant csn5a-2 caused by epigenetic modification of intronic T-DNA. Plant Sci. 2015;238:53-63 pubmed publisher
    ..We studied the significance of protein-protein interactions between CSN5A and ROP11 by crossing three independent rop11 T-DNA insertion mutants with csn5a-2, a partial loss-of-function ..
  9. Spoel S, Mou Z, Tada Y, Spivey N, Genschik P, Dong X. Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity. Cell. 2009;137:860-72 pubmed publisher
    ..These in vivo data demonstrate dual roles for coactivator turnover in both preventing and stimulating gene transcription to regulate plant immunity. ..
  10. Kotiguda G, Weinberg D, Dessau M, Salvi C, Serino G, Chamovitz D, et al. The organization of a CSN5-containing subcomplex of the COP9 signalosome. J Biol Chem. 2012;287:42031-41 pubmed publisher
    ..intrinsic to the complex, deneddylation of the Cullin subunits from Cullin-RING ubiquitin ligases, is assigned to CSN5. As an essential step to understanding the structure and assembly of a CSN5-containing subcomplex of the CSN, we ..
  11. Wang X, Li W, Piqueras R, Cao K, Deng X, Wei N. Regulation of COP1 nuclear localization by the COP9 signalosome via direct interaction with CSN1. Plant J. 2009;58:655-67 pubmed publisher
    ..This study advances our understanding of COP1 localization, and the molecular interactions between COP1 and CSN. ..
  12. Huang H, Quint M, Gray W. The eta7/csn3-3 auxin response mutant of Arabidopsis defines a novel function for the CSN3 subunit of the COP9 signalosome. PLoS ONE. 2013;8:e66578 pubmed publisher
    ..We hypothesize that in addition to its role in the CSN as a cullin deneddylase, CSN3 functions in a distinct protein complex that is required for proper auxin signaling. ..