Gene Symbol: COR15A
Description: cold-regulated 15a
Alias: AtCOR15A, COR15, F14N22.19, F14N22_19, cold-regulated 15a, cold-regulated 15a
Species: thale cress

Top Publications

  1. Bremer A, Kent B, Hauß T, Thalhammer A, Yepuri N, Darwish T, et al. Intrinsically Disordered Stress Protein COR15A Resides at the Membrane Surface during Dehydration. Biophys J. 2017;113:572-579 pubmed publisher
    ..During this process, several cold-regulated (COR) proteins are accumulated in the cells. One of them is COR15A, a small, intrinsically disordered protein that contributes to leaf freezing tolerance by stabilizing cellular ..
  2. Wang Y, Hua J. A moderate decrease in temperature induces COR15a expression through the CBF signaling cascade and enhances freezing tolerance. Plant J. 2009;60:340-9 pubmed publisher
    ..The cooling response involves a weaker and more transient induction of cold-induced genes, such as COR15a, than cold response...
  3. Kwon C, Lee D, Choi G, Chung W. Histone occupancy-dependent and -independent removal of H3K27 trimethylation at cold-responsive genes in Arabidopsis. Plant J. 2009;60:112-21 pubmed publisher
    ..Here we show that H3K27me3 in two cold-responsive genes, COR15A and ATGOLS3, decreases gradually in Arabidopsis during exposure to cold temperatures...
  4. Dong M, Farré E, Thomashow M. Circadian clock-associated 1 and late elongated hypocotyl regulate expression of the C-repeat binding factor (CBF) pathway in Arabidopsis. Proc Natl Acad Sci U S A. 2011;108:7241-6 pubmed publisher
    ..Circadian regulation and cold induction of three CBF regulon genes, i.e., COld-regulated Gene15a (COR15A), COR47, and COR78, also were greatly diminished in plants carrying the cca1-11/lhy-21 double mutation...
  5. Vergnolle C, Vaultier M, Taconnat L, Renou J, Kader J, Zachowski A, et al. The cold-induced early activation of phospholipase C and D pathways determines the response of two distinct clusters of genes in Arabidopsis cell suspensions. Plant Physiol. 2005;139:1217-33 pubmed
    ..The connection of these pathways with the CBF pathway, currently the most understood genetic system playing a role in cold acclimation, is discussed. ..
  6. Rayirath P, Benkel B, Mark Hodges D, Allan Wojtas P, MacKinnon S, Critchley A, et al. Lipophilic components of the brown seaweed, Ascophyllum nodosum, enhance freezing tolerance in Arabidopsis thaliana. Planta. 2009;230:135-47 pubmed publisher
    ..Further, the A. nodosum extract treatment modulated the expression of the cold response genes, COR15A, RD29A, and CBF3, resulting in enhanced tolerance to freezing temperatures. More than 2...
  7. Thalhammer A, Hincha D. A mechanistic model of COR15 protein function in plant freezing tolerance: integration of structural and functional characteristics. Plant Signal Behav. 2014;9:e977722 pubmed publisher
    ..We recently reported a comprehensive study of 2 intrinsically disordered cold regulated chloroplast proteins, COR15A and COR15B from Arabidopsis thaliana. They are necessary for full cold acclimation...
  8. Nakayama K, Okawa K, Kakizaki T, Honma T, Itoh H, Inaba T. Arabidopsis Cor15am is a chloroplast stromal protein that has cryoprotective activity and forms oligomers. Plant Physiol. 2007;144:513-23 pubmed
    ..A wide variety of polypeptides are induced during cold acclimation, among which is one encoded by COR15A in Arabidopsis (Arabidopsis thaliana)...
  9. Kim H, Kim Y, Park J, Kim J. Light signalling mediated by phytochrome plays an important role in cold-induced gene expression through the C-repeat/dehydration responsive element (C/DRE) in Arabidopsis thaliana. Plant J. 2002;29:693-704 pubmed
    ..pathways, the transgenic Arabidopsis plants were generated containing several copies of the C/DRE derived from cor15a gene with a minimal promoter fused to a GUS reporter gene...

More Information


  1. Bremer A, Wolff M, Thalhammer A, Hincha D. Folding of intrinsically disordered plant LEA proteins is driven by glycerol-induced crowding and the presence of membranes. FEBS J. 2017;284:919-936 pubmed publisher
    ..In the model plant Arabidopsis thaliana, the LEA proteins COR15A and COR15B are highly induced upon cold treatment and are necessary for the plants to attain full freezing ..
  2. Yang S, Seo P, Yoon H, Park C. The Arabidopsis NAC transcription factor VNI2 integrates abscisic acid signals into leaf senescence via the COR/RD genes. Plant Cell. 2011;23:2155-68 pubmed publisher
    ..These observations indicate that the VNI2 transcription factor serves as a molecular link that integrates plant responses to environmental stresses into modulation of leaf longevity. ..
  3. Lin C, Thomashow M. A cold-regulated Arabidopsis gene encodes a polypeptide having potent cryoprotective activity. Biochem Biophys Res Commun. 1992;183:1103-8 pubmed
    We previously showed that cor15, a cold-regulated gene from Arabidopsis thaliana, encodes a 15 kDa polypeptide designated COR15. Here we report that COR15 has potent cryoprotective activity in an in vitro cryoprotection assay...
  4. Ishitani M, Xiong L, Lee H, Stevenson B, Zhu J. HOS1, a genetic locus involved in cold-responsive gene expression in arabidopsis. Plant Cell. 1998;10:1151-61 pubmed
    ..mutation identified by luciferase imaging causes superinduction of cold-responsive genes, such as RD29A, COR47, COR15A, KIN1, and ADH...
  5. Nakayama K, Okawa K, Kakizaki T, Inaba T. Evaluation of the protective activities of a late embryogenesis abundant (LEA) related protein, Cor15am, during various stresses in vitro. Biosci Biotechnol Biochem. 2008;72:1642-5 pubmed
    ..This might be attributable to the activity of Cor15am in attenuating the aggregation of the substrates. Our data indicate that Cor15am functions as a protectant against various stresses by preventing protein aggregation. ..
  6. Song C, Je J, Hong J, Lim C. Ectopic expression of an Arabidopsis dehydration-responsive element-binding factor DREB2C improves salt stress tolerance in crucifers. Plant Cell Rep. 2014;33:1239-54 pubmed publisher
    ..Basal expression of the stress-responsive genes COLD-REGULATED 15A (COR15A), RESPONSIVE TO DEHYDRATION (RD) 29A and RD29B, was higher in transgenic DREB2C-overexpressing Arabidopsis plants ..
  7. Kimura M, Yamamoto Y, Seki M, Sakurai T, Sato M, Abe T, et al. Identification of Arabidopsis genes regulated by high light-stress using cDNA microarray. Photochem Photobiol. 2003;77:226-33 pubmed
    ..These genes include RD29A, ERD7, ERD10, KIN1, LEA14 and COR15a, most of which are thought to be involved in the protection of cellular components.
  8. Franklin K, Whitelam G. Light-quality regulation of freezing tolerance in Arabidopsis thaliana. Nat Genet. 2007;39:1410-3 pubmed
  9. Xiong L, Lee H, Ishitani M, Zhu J. Regulation of osmotic stress-responsive gene expression by the LOS6/ABA1 locus in Arabidopsis. J Biol Chem. 2002;277:8588-96 pubmed
    ..blot analysis indicates that under osmotic stress the transcript levels for stress-responsive genes such as RD29A, COR15A, KIN1, COR47, RD19, and ADH are lower in los6 plants than in wild type plants...
  10. Lin C, Thomashow M. DNA Sequence Analysis of a Complementary DNA for Cold-Regulated Arabidopsis Gene cor15 and Characterization of the COR 15 Polypeptide. Plant Physiol. 1992;99:519-25 pubmed
    ..we identify a cDNA clone for a cold-regulated gene encoding one of the "boiling-stable" polypeptides, COR15. DNA sequence analysis indicated that the gene, designated cor15, encodes a 14...
  11. Baker S, Wilhelm K, Thomashow M. The 5'-region of Arabidopsis thaliana cor15a has cis-acting elements that confer cold-, drought- and ABA-regulated gene expression. Plant Mol Biol. 1994;24:701-13 pubmed
    Previous nuclear run-on experiments indicated that the cor15a (cold-regulated) gene of Arabidopsis thaliana L. (Heyn) has a cold-inducible promoter (Hajela et al., Plant Physiol 93: 1246-1252, 1990)...
  12. Thalhammer A, Hundertmark M, Popova A, Seckler R, Hincha D. Interaction of two intrinsically disordered plant stress proteins (COR15A and COR15B) with lipid membranes in the dry state. Biochim Biophys Acta. 2010;1798:1812-20 pubmed publisher
    b>COR15A and COR15B form a tandem repeat of highly homologous genes in Arabidopsis thaliana...
  13. Wan F, Pan Y, Li J, Chen X, Pan Y, Wang Y, et al. Heterologous expression of Arabidopsis C-repeat binding factor 3 (AtCBF3) and cold-regulated 15A (AtCOR15A) enhanced chilling tolerance in transgenic eggplant (Solanum melongena L.). Plant Cell Rep. 2014;33:1951-61 pubmed publisher
    Our study shows that the expression of AtCBF3 and AtCOR15A improved the chilling tolerance in transgenic eggplant...
  14. Wang X, Li Q, Chen H, Zhang W, Ma B, Chen S, et al. Trihelix transcription factor GT-4 mediates salt tolerance via interaction with TEM2 in Arabidopsis. BMC Plant Biol. 2014;14:339 pubmed publisher
    ..confers enhanced salt tolerance in Arabidopsis likely through direct binding to the promoter and activation of Cor15A, in addition to possible regulation of other relevant genes. The gt-4 mutant shows salt sensitivity...
  15. Thalhammer A, Bryant G, Sulpice R, Hincha D. Disordered cold regulated15 proteins protect chloroplast membranes during freezing through binding and folding, but do not stabilize chloroplast enzymes in vivo. Plant Physiol. 2014;166:190-201 pubmed publisher
    ..Here we report that the chloroplast proteins COR15A and COR15B are necessary for full cold acclimation in Arabidopsis (Arabidopsis thaliana)...
  16. Artus N, Uemura M, Steponkus P, Gilmour S, Lin C, Thomashow M. Constitutive expression of the cold-regulated Arabidopsis thaliana COR15a gene affects both chloroplast and protoplast freezing tolerance. Proc Natl Acad Sci U S A. 1996;93:13404-9 pubmed
    ..Here we provide direct evidence in support of this hypothesis. We show that constitutive expression of COR15a, a cold-regulated gene of Arabidopsis thaliana that encodes a chloroplast-targeted polypeptide, enhances the in ..
  17. Steponkus P, Uemura M, Joseph R, Gilmour S, Thomashow M. Mode of action of the COR15a gene on the freezing tolerance of Arabidopsis thaliana. Proc Natl Acad Sci U S A. 1998;95:14570-5 pubmed
    Constitutive expression of the cold-regulated COR15a gene of Arabidopsis thaliana results in a significant increase in the survival of isolated protoplasts frozen over the range of -4.5 to -7 degreesC...