COP9

Summary

Gene Symbol: COP9
Description: COP9 signalosome, subunit CSN8
Alias: CONSTITUTIVE PHOTOMORPHOGENIC 9, COP9 SIGNALOSOME SUBUNIT 8, CSN8, DL3095C, EMB143, EMBRYO DEFECTIVE 143, FCAALL.131, FUS7, FUSCA 7, FUSCA PROTEIN FUS7, COP9 signalosome, subunit CSN8
Species: thale cress
Products:     COP9

Top Publications

  1. Feng S, Ma L, Wang X, Xie D, Dinesh Kumar S, Wei N, et al. The COP9 signalosome interacts physically with SCF COI1 and modulates jasmonate responses. Plant Cell. 2003;15:1083-94 pubmed
    The COP9 signalosome (CSN) is an evolutionarily conserved, nucleus-enriched multiprotein complex...
  2. Chamovitz D, Wei N, Osterlund M, von Arnim A, Staub J, Matsui M, et al. The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch. Cell. 1996;86:115-21 pubmed
    Arabidopsis COP9 is a component of a large protein complex that is essential for the light control of a developmental switch and whose conformation or size is modulated by light...
  3. Wei N, Deng X. The COP9 signalosome. Annu Rev Cell Dev Biol. 2003;19:261-86 pubmed
    The COP9 signalosome (CSN) is composed of eight distinct subunits and is highly homologous to the lid sub-complex of the 26S proteasome...
  4. Kwok S, Solano R, Tsuge T, Chamovitz D, Ecker J, Matsui M, et al. Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations. Plant Cell. 1998;10:1779-90 pubmed
    The CONSTITUTIVE PHOTOMORPHOGENIC9 (COP9) complex is a nuclear localized, multisubunit protein complex essential for repression of light-mediated development in Arabidopsis...
  5. Gusmaroli G, Figueroa P, Serino G, Deng X. Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases. Plant Cell. 2007;19:564-81 pubmed
    The COP9 signalosome (CSN) is an evolutionarily conserved multisubunit protein complex that regulates a variety of biological processes...
  6. Serino G, Tsuge T, Kwok S, Matsui M, Wei N, Deng X. Arabidopsis cop8 and fus4 mutations define the same gene that encodes subunit 4 of the COP9 signalosome. Plant Cell. 1999;11:1967-80 pubmed
    ..Cloning and biochemical analysis of COP9 have revealed that it is a component of a multiprotein complex, the COP9 signalosome (previously known as the COP9 ..
  7. Rubio V, Shen Y, Saijo Y, Liu Y, Gusmaroli G, Dinesh Kumar S, et al. An alternative tandem affinity purification strategy applied to Arabidopsis protein complex isolation. Plant J. 2005;41:767-78 pubmed
    ..procedure we generated a C-terminal fusion between the TAPa tag and CSN3, a component of the multi-protein COP9 signalosome (CSN) complex...
  8. Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, et al. Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell. 2003;15:719-31 pubmed
    The COP9 signalosome (CSN) is an evolutionarily conserved protein complex that resembles the lid subcomplex of proteasomes...
  9. Stuttmann J, Lechner E, Guerois R, Parker J, Nussaume L, Genschik P, et al. COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis. J Biol Chem. 2009;284:7920-30 pubmed publisher
    ..RUB modification is antagonized by the COP9 signalosome (CSN), an evolutionarily conserved eight-subunit complex that is essential in most eukaryotes and ..

More Information

Publications33

  1. Peng Z, Serino G, Deng X. Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted developmental processes in Arabidopsis. Plant Cell. 2001;13:2393-407 pubmed
    The COP9 signalosome is a highly conserved protein complex initially identified as a repressor of photomorphogenesis...
  2. Chen H, Shen Y, Tang X, Yu L, Wang J, Guo L, et al. Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development. Plant Cell. 2006;18:1991-2004 pubmed
    Repression of photomorphogenesis in Arabidopsis thaliana requires activity of the COP9 signalosome (CSN), CDD, and COP1 complexes, but how these three complexes work in concert to accomplish this important developmental switch has ..
  3. Gusmaroli G, Feng S, Deng X. The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development. Plant Cell. 2004;16:2984-3001 pubmed
    The COP9 signalosome (CSN) is an evolutionarily conserved multisubunit protein complex involved in a variety of signaling and developmental processes through the regulation of protein ubiquitination and degradation...
  4. Paz Aviram T, Yahalom A, Chamovitz D. Arabidopsis eIF3e interacts with subunits of the ribosome, Cop9 signalosome and proteasome. Plant Signal Behav. 2008;3:409-11 pubmed
    ..eIF3e interacts in yeast with subunits of the ribosome, COP9 signalosome and 26S proteasome...
  5. Spoel S, Mou Z, Tada Y, Spivey N, Genschik P, Dong X. Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity. Cell. 2009;137:860-72 pubmed publisher
    ..These in vivo data demonstrate dual roles for coactivator turnover in both preventing and stimulating gene transcription to regulate plant immunity. ..
  6. Suzuki G, Yanagawa Y, Kwok S, Matsui M, Deng X. Arabidopsis COP10 is a ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis. Genes Dev. 2002;16:554-9 pubmed
    ..Among them, COP1 and the COP9 signalosome have been hypothesized to fulfill the roles as an ubiquitin ligase (E3) and an essential E3 modulator...
  7. Staub J, Wei N, Deng X. Evidence for FUS6 as a component of the nuclear-localized COP9 complex in Arabidopsis. Plant Cell. 1996;8:2047-56 pubmed
    ..Although COP1, DET1, COP9, and FUS6 (also called COP11) have been cloned, their biochemical activities and interactions remain elusive...
  8. Dessau M, Halimi Y, Erez T, Chomsky Hecht O, Chamovitz D, Hirsch J. The Arabidopsis COP9 signalosome subunit 7 is a model PCI domain protein with subdomains involved in COP9 signalosome assembly. Plant Cell. 2008;20:2815-34 pubmed publisher
    The COP9 Signalosome (CSN) is a multiprotein complex that was originally identified in Arabidopsis thaliana as a negative regulator of photomorphogenesis and subsequently shown to be a general eukaryotic regulator of developmental ..
  9. Wang X, Kang D, Feng S, Serino G, Schwechheimer C, Wei N. CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome. Mol Biol Cell. 2002;13:646-55 pubmed
    The COP9 signalosome (CSN) is a multifunctional protein complex essential for arabidopsis development. One of its functions is to promote Rub1/Nedd8 deconjugation from the cullin subunit of the Skp1-cullin-F-box ubiquitin ligase...
  10. Karniol B, Yahalom A, Kwok S, Tsuge T, Matsui M, Deng X, et al. The Arabidopsis homologue of an eIF3 complex subunit associates with the COP9 complex. FEBS Lett. 1998;439:173-9 pubmed
    The Arabidopsis COP9 complex is a multi-subunit repressor of photomorphogenesis which is conserved among multicellular organisms. Approximately 12 proteins copurify with the COP9 complex...
  11. Yahalom A, Kim T, Roy B, Singer R, von Arnim A, Chamovitz D. Arabidopsis eIF3e is regulated by the COP9 signalosome and has an impact on development and protein translation. Plant J. 2008;53:300-11 pubmed
    ..eIF3e associates with the COP9 signalosome, and localizes to the nucleus in certain tissues...
  12. Kim T, Kim B, Yahalom A, Chamovitz D, von Arnim A. Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h. Plant Cell. 2004;16:3341-56 pubmed
    ..Moreover, eIF3h could physically interact with subunits of the COP9 signalosome, a protein complex implicated primarily in the regulation of protein ubiquitination, supporting a ..
  13. Halimi Y, Dessau M, Pollak S, Ast T, Erez T, Livnat Levanon N, et al. COP9 signalosome subunit 7 from Arabidopsis interacts with and regulates the small subunit of ribonucleotide reductase (RNR2). Plant Mol Biol. 2011;77:77-89 pubmed publisher
    The COP9 Signalosome protein complex (CSN) is a pleiotropic regulator of plant development and contains eight-subunits...
  14. Wang X, Feng S, Nakayama N, Crosby W, Irish V, Deng X, et al. The COP9 signalosome interacts with SCF UFO and participates in Arabidopsis flower development. Plant Cell. 2003;15:1071-82 pubmed
    The COP9 signalosome (CSN) is involved in multiple developmental processes. It interacts with SCF ubiquitin ligases and deconjugates Nedd8/Rub1 from cullins (deneddylation). CSN is highly expressed in Arabidopsis floral tissues...
  15. Karniol B, Malec P, Chamovitz D. Arabidopsis FUSCA5 encodes a novel phosphoprotein that is a component of the COP9 complex. Plant Cell. 1999;11:839-48 pubmed
    The COP9 complex is a regulator essential for repression of light-mediated development in Arabidopsis...
  16. Stratmann J, Gusmaroli G. Many jobs for one good cop - the COP9 signalosome guards development and defense. Plant Sci. 2012;185-186:50-64 pubmed publisher
    The COP9 signalosome (CSN) is a multiprotein complex that regulates the activity of CULLIN-RING E3 ubiquitin ligases (CRLs). CRLs ubiquitinate substrate proteins and thus target them for proteasomal degradation...
  17. Huang H, Quint M, Gray W. The eta7/csn3-3 auxin response mutant of Arabidopsis defines a novel function for the CSN3 subunit of the COP9 signalosome. PLoS ONE. 2013;8:e66578 pubmed publisher
    The COP9 signalosome (CSN) is an eight subunit protein complex conserved in all higher eukaryotes...
  18. Yahalom A, Kim T, Winter E, Karniol B, von Arnim A, Chamovitz D. Arabidopsis eIF3e (INT-6) associates with both eIF3c and the COP9 signalosome subunit CSN7. J Biol Chem. 2001;276:334-40 pubmed
    ..Here we describe the association between components of the COP9 signalosome (CSN1, CSN7, and CSN8) and two subunits of eukaryotic translation initiation factor 3 (eIF3), eIF3e (p48, known also as INT-6) and eIF3c (..
  19. Wei N, Deng X. COP9: a new genetic locus involved in light-regulated development and gene expression in arabidopsis. Plant Cell. 1992;4:1507-18 pubmed
    We report here the identification and characterization of a new Arabidopsis light-regulatory locus, COP9, mutation that leads to a constitutive photomorphogenic phenotype...
  20. Kwok S, Staub J, Deng X. Characterization of two subunits of Arabidopsis 19S proteasome regulatory complex and its possible interaction with the COP9 complex. J Mol Biol. 1999;285:85-95 pubmed
    The nuclear localized, multi-subunit COP9 complex (or COP9 signalosome) is a key developmental modulator involved in repression of photomorphogenesis...
  21. Karniol B, Chamovitz D. The COP9 signalosome: from light signaling to general developmental regulation and back. Curr Opin Plant Biol. 2000;3:387-93 pubmed
    The COP9 signalosome has eight core subunits that are highly conserved between plants and animals. Some of the subunits in Arabidopsis are found in forms that are independent of the complex...
  22. Nakasone A, Fujiwara M, Fukao Y, Biswas K, Rahman A, Kawai Yamada M, et al. SMALL ACIDIC PROTEIN1 acts with RUB modification components, the COP9 signalosome, and AXR1 to regulate growth and development of Arabidopsis. Plant Physiol. 2012;160:93-105 pubmed publisher
    ..Our findings suggest that SMAP1 is involved in the auxin response and possibly in other cullin-RING ubiquitin ligase-regulated signaling processes via its interaction with components associated with RELATED TO UBIQUITIN modification. ..
  23. Franciosini A, Moubayidin L, Du K, Matari N, Boccaccini A, Butera S, et al. The COP9 SIGNALOSOME Is Required for Postembryonic Meristem Maintenance in Arabidopsis thaliana. Mol Plant. 2015;8:1623-34 pubmed publisher
    ..The constitutively photomorphogenic9 (COP9) signalosome (CSN) acts as a molecular switch of CRLs activity by reverting their neddylation status, but its ..
  24. Christians M, Robles L, Zeller S, Larsen P. The eer5 mutation, which affects a novel proteasome-related subunit, indicates a prominent role for the COP9 signalosome in resetting the ethylene-signaling pathway in Arabidopsis. Plant J. 2008;55:467-77 pubmed publisher
    ..an amino acid substitution in a previously uncharacterized gene, which encodes a protein with a PAM [proteasome COP9 initiation factor (PCI/PINT)-associated module] domain similar to those found in components of the COP9 signalosome ..