Gene Symbol: COI1
Description: RNI-like superfamily protein
Alias: CORONATINE INSENSITIVE 1, T28M21.10, T28M21_10, RNI-like superfamily protein
Species: thale cress
Products:     COI1

Top Publications

  1. Munemasa S, Oda K, Watanabe Sugimoto M, Nakamura Y, Shimoishi Y, Murata Y. The coronatine-insensitive 1 mutation reveals the hormonal signaling interaction between abscisic acid and methyl jasmonate in Arabidopsis guard cells. Specific impairment of ion channel activation and second messenger production. Plant Physiol. 2007;143:1398-407 pubmed guard cells of wild-type Arabidopsis (Arabidopsis thaliana) and MeJA-insensitive coronatine-insensitive 1 (coi1) mutants. The coi1 mutation impaired MeJA-induced stomatal closing but not ABA-induced stomatal closing...
  2. Chini A, Fonseca S, Fernandez G, Adie B, Chico J, Lorenzo O, et al. The JAZ family of repressors is the missing link in jasmonate signalling. Nature. 2007;448:666-71 pubmed
    ..The identification more than a decade ago of COI1 as an F-box protein suggested the existence of a repressor of jasmonate responses that is targeted by the SCF(COI1) ..
  3. Armengaud P, Breitling R, Amtmann A. Coronatine-insensitive 1 (COI1) mediates transcriptional responses of Arabidopsis thaliana to external potassium supply. Mol Plant. 2010;3:390-405 pubmed publisher
    ..Using comparative microarray analysis of wild-type and coi1-16 mutant plants, we classified transcriptional responses to K with respect to their dependence on COI1, a central ..
  4. Devoto A, Nieto Rostro M, Xie D, Ellis C, Harmston R, Patrick E, et al. COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis. Plant J. 2002;32:457-66 pubmed
    ..Significantly, each of these responses requires COI1, an F-box protein...
  5. Feng S, Ma L, Wang X, Xie D, Dinesh Kumar S, Wei N, et al. The COP9 signalosome interacts physically with SCF COI1 and modulates jasmonate responses. Plant Cell. 2003;15:1083-94 pubmed
    ..b>COI1 encodes an F-box protein, which is a subunit of SCF(COI1) E3 ubiquitin ligase, and is required for jasmonate (JA) ..
  6. Adams E, Turner J. COI1, a jasmonate receptor, is involved in ethylene-induced inhibition of Arabidopsis root growth in the light. J Exp Bot. 2010;61:4373-86 pubmed publisher
    ..b>COI1 is a JA receptor and is required for the known responses to this hormone...
  7. Xie D, Feys B, James S, Nieto Rostro M, Turner J. COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility. Science. 1998;280:1091-4 pubmed
    The coi1 mutation defines an Arabidopsis gene required for response to jasmonates, which regulate defense against insects and pathogens, wound healing, and pollen fertility...
  8. Melotto M, Mecey C, Niu Y, Chung H, Katsir L, Yao J, et al. A critical role of two positively charged amino acids in the Jas motif of Arabidopsis JAZ proteins in mediating coronatine- and jasmonoyl isoleucine-dependent interactions with the COI1 F-box protein. Plant J. 2008;55:979-88 pubmed publisher
    ..An important step in JA signaling is the SCF(COI1) E3 ubiquitin ligase-dependent degradation of JAZ repressor proteins...
  9. Devoto A, Ellis C, Magusin A, Chang H, Chilcott C, Zhu T, et al. Expression profiling reveals COI1 to be a key regulator of genes involved in wound- and methyl jasmonate-induced secondary metabolism, defence, and hormone interactions. Plant Mol Biol. 2005;58:497-513 pubmed
    The Arabidopsis gene COI1 is required for jasmonic acid (JA)-induced growth inhibition, resistance to insect herbivory, and resistance to pathogens...

More Information


  1. Shan X, Zhang Y, Peng W, Wang Z, Xie D. Molecular mechanism for jasmonate-induction of anthocyanin accumulation in Arabidopsis. J Exp Bot. 2009;60:3849-60 pubmed publisher
    ..It was found that the F-box protein COI1 was required for JA-specific induced expression of the 'late' anthocyanin biosynthetic genes DFR, LDOX, and UF3GT...
  2. Ralhan A, Schöttle S, Thurow C, Iven T, Feussner I, Polle A, et al. The vascular pathogen Verticillium longisporum requires a jasmonic acid-independent COI1 function in roots to elicit disease symptoms in Arabidopsis shoots. Plant Physiol. 2012;159:1192-203 pubmed publisher plants that lack the receptor of the plant defense hormone jasmonic acid (JA), CORONATINE INSENSITIVE1 (COI1)...
  3. Thines B, Katsir L, Melotto M, Niu Y, Mandaokar A, Liu G, et al. JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling. Nature. 2007;448:661-5 pubmed
    ..Jasmonate treatment causes JAZ1 degradation and this degradation is dependent on activities of the SCF(COI1) ubiquitin ligase and the 26S proteasome...
  4. Yan J, Zhang C, Gu M, Bai Z, Zhang W, Qi T, et al. The Arabidopsis CORONATINE INSENSITIVE1 protein is a jasmonate receptor. Plant Cell. 2009;21:2220-36 pubmed publisher
    Jasmonates play a number of diverse roles in plant defense and development. CORONATINE INSENSITIVE1 (COI1), an F-box protein essential for all the jasmonate responses, interacts with multiple proteins to form the SCF(COI1) E3 ubiquitin ..
  5. Fernández Arbaizar A, Regalado J, Lorenzo O. Isolation and characterization of novel mutant loci suppressing the ABA hypersensitivity of the Arabidopsis coronatine insensitive 1-16 (coi1-16) mutant during germination and seedling growth. Plant Cell Physiol. 2012;53:53-63 pubmed publisher
    ..was to identify additional ABA response loci by suppressor screening of the jasmonate (JA)-insensitive coronatine insensitive 1-16 (coi1-16) mutant using its ABA-hypersensitive phenotype...
  6. Xu L, Liu F, Lechner E, Genschik P, Crosby W, Ma H, et al. The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell. 2002;14:1919-35 pubmed
    Xie and colleagues previously isolated the Arabidopsis COI1 gene that is required for response to jasmonates (JAs), which regulate root growth, pollen fertility, wound healing, and defense against insects and pathogens...
  7. Chini A, Fonseca S, Chico J, Fernández Calvo P, Solano R. The ZIM domain mediates homo- and heteromeric interactions between Arabidopsis JAZ proteins. Plant J. 2009;59:77-87 pubmed publisher
    Discovery of the jasmonate ZIM-domain (JAZ) repressors defined the core jasmonate (JA) signalling module as COI1-JAZ-MYC2, and allowed a full view of the JA signalling pathway from hormone perception to transcriptional reprogramming...
  8. Adie B, Pérez Pérez J, Perez Perez M, Godoy M, Sanchez Serrano J, Schmelz E, et al. ABA is an essential signal for plant resistance to pathogens affecting JA biosynthesis and the activation of defenses in Arabidopsis. Plant Cell. 2007;19:1665-81 pubmed
    ..Subsequent signaling of inducible defenses is predominantly mediated by jasmonic acid (JA), with insensitive coi1 mutants showing extreme susceptibility...
  9. Sheard L, Tan X, Mao H, Withers J, Ben Nissan G, Hinds T, et al. Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. Nature. 2010;468:400-5 pubmed publisher
    ..The F-box protein CORONATINE INSENSITIVE 1 (COI1) mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of ..
  10. Potuschak T, Lechner E, Parmentier Y, Yanagisawa S, Grava S, Koncz C, et al. EIN3-dependent regulation of plant ethylene hormone signaling by two arabidopsis F box proteins: EBF1 and EBF2. Cell. 2003;115:679-89 pubmed
    ..Our work places EBF1 and EBF2 within the genetic framework of the ethylene-response pathway and supports a model in which ethylene action depends on EIN3 protein stabilization. ..
  11. Shan X, Li C, Peng W, Gao B. New perspective of jasmonate function in leaf senescence. Plant Signal Behav. 2011;6:575-7 pubmed
    Jasmonates (JAs) induce leaf senescence in many plant species. The Arabidopsis F-box protein coronatine insensitive 1 (COI1) is required for various JA-regulated plant responses including plant fertility, defense responses and leaf ..
  12. Cerrudo I, Keller M, Cargnel M, Demkura P, de Wit M, Patitucci M, et al. Low red/far-red ratios reduce Arabidopsis resistance to Botrytis cinerea and jasmonate responses via a COI1-JAZ10-dependent, salicylic acid-independent mechanism. Plant Physiol. 2012;158:2042-52 pubmed publisher
    ..2 transcription was up-regulated by constitutive expression of ERF1 in a coronatine insensitive1 (coi1) mutant background (35S::ERF1/coi1)...
  13. Kim J, Dotson B, Rey C, Lindsey J, Bleecker A, Binder B, et al. New clothes for the jasmonic acid receptor COI1: delayed abscission, meristem arrest and apical dominance. PLoS ONE. 2013;8:e60505 pubmed publisher
    In a screen for delayed floral organ abscission in Arabidopsis, we have identified a novel mutant of CORONATINE INSENSITIVE 1 (COI1), the F-box protein that has been shown to be the jasmonic acid (JA) co-receptor...
  14. Mosblech A, Thurow C, Gatz C, Feussner I, Heilmann I. Jasmonic acid perception by COI1 involves inositol polyphosphates in Arabidopsis thaliana. Plant J. 2011;65:949-57 pubmed publisher
    ..Arabidopsis F-box proteins involved in the perception of JA-Ile (COI1) and auxin (TIR1) are structurally similar...
  15. Ralhan A, Thurow C, Gatz C. The tolerance of the Arabidopsis defense hormone receptor mutant coi1 against the vascular pathogen Verticillium longisporum is not due to increased levels of the active hormone jasmonoyl-isoleucine. Plant Signal Behav. 2013;8:e27008 pubmed publisher
    ..mutants should have the same phenotype, we found that plants that lack the JA-Ile receptor CORONATINE INSENSITIVE1 (COI1) are more tolerant to the disease...
  16. Zhang F, Yao J, Ke J, Zhang L, Lam V, Xin X, et al. Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. Nature. 2015;525:269-73 pubmed publisher
    ..of active jasmonate, JAZ proteins function as jasmonate co-receptors by forming a hormone-dependent complex with COI1, the F-box subunit of an SCF-type ubiquitin E3 ligase...
  17. Pauwels L, Barbero G, Geerinck J, Tilleman S, Grunewald W, Pérez A, et al. NINJA connects the co-repressor TOPLESS to jasmonate signalling. Nature. 2010;464:788-91 pubmed publisher
    ..This new insight reveals how stress-related and growth-related signalling cascades use common molecular mechanisms to regulate gene expression in plants. ..
  18. Consonni C, Humphry M, Hartmann H, Livaja M, Durner J, Westphal L, et al. Conserved requirement for a plant host cell protein in powdery mildew pathogenesis. Nat Genet. 2006;38:716-20 pubmed
  19. Yan J, Li H, Li S, Yao R, Deng H, Xie Q, et al. The Arabidopsis F-box protein CORONATINE INSENSITIVE1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway. Plant Cell. 2013;25:486-98 pubmed publisher
    Jasmonate regulates critical aspects of plant development and defense. The F-box protein CORONATINE INSENSITIVE1 (COI1) functions as a jasmonate receptor and forms Skp1/Cullin1/F-box protein COI1 (SCF(COI1)) complexes with Arabidopsis ..
  20. Zhai Q, Zhang X, Wu F, Feng H, Deng L, Xu L, et al. Transcriptional Mechanism of Jasmonate Receptor COI1-Mediated Delay of Flowering Time in Arabidopsis. Plant Cell. 2015;27:2814-28 pubmed publisher
    ..Here, we report that the CORONATINE INSENSITIVE1 (COI1)-dependent signaling pathway delays the flowering time of Arabidopsis thaliana by inhibiting the expression of the ..
  21. Withers J, Yao J, Mecey C, Howe G, Melotto M, He S. Transcription factor-dependent nuclear localization of a transcriptional repressor in jasmonate hormone signaling. Proc Natl Acad Sci U S A. 2012;109:20148-53 pubmed publisher
    ..A key step in JA signaling is ligand-dependent assembly of a coreceptor complex consisting of the F-box protein COI1 and JAZ transcriptional repressors...
  22. Jewell J, Browse J. Epidermal jasmonate perception is sufficient for all aspects of jasmonate-mediated male fertility in Arabidopsis. Plant J. 2016;85:634-47 pubmed publisher
    ..To this end we used targeted expression of a COI1-YFP transgene in the coi1-1 mutant background...
  23. Lee H, Seo J, Cho J, Jung H, Kim J, Lee J, et al. Oryza sativa COI homologues restore jasmonate signal transduction in Arabidopsis coi1-1 mutants. PLoS ONE. 2013;8:e52802 pubmed publisher
    b>CORONATINE INSENSITIVE 1 (COI1) encodes an E3 ubiquitin ligase complex component that interacts with JAZ proteins and targets them for degradation in response to JA signaling...
  24. Raya González J, Pelagio Flores R, López Bucio J. The jasmonate receptor COI1 plays a role in jasmonate-induced lateral root formation and lateral root positioning in Arabidopsis thaliana. J Plant Physiol. 2012;169:1348-58 pubmed publisher
    Jasmonic acid (JA) regulates a broad range of plant defense and developmental responses. COI1 has been recently found to act as JA receptor...
  25. Stotz H, Mueller S, Zoeller M, Mueller M, Berger S. TGA transcription factors and jasmonate-independent COI1 signalling regulate specific plant responses to reactive oxylipins. J Exp Bot. 2013;64:963-75 pubmed publisher
    ..Whereas JA-isoleucine signals through binding to COI1, the bZIP transcription factors TGA2, TGA5, and TGA6 are involved in regulation of gene expression in response to ..
  26. Dobon A, Wulff B, Canet J, Fort P, Tornero P. An allele of Arabidopsis COI1 with hypo- and hypermorphic phenotypes in plant growth, defence and fertility. PLoS ONE. 2013;8:e55115 pubmed publisher
    ..A key component of the JA signal transduction pathway is its receptor, the COI1 gene...
  27. Ruduś I, Terai H, Shimizu T, Kojima H, Hattori K, Nishimori Y, et al. Wound-induced expression of DEFECTIVE IN ANTHER DEHISCENCE1 and DAD1-like lipase genes is mediated by both CORONATINE INSENSITIVE1-dependent and independent pathways in Arabidopsis thaliana. Plant Cell Rep. 2014;33:849-60 pubmed publisher
    ..However, the JA-Ile receptor COI1 is often required for their JA-independent induction...
  28. Geng X, Cheng J, Gangadharan A, Mackey D. The coronatine toxin of Pseudomonas syringae is a multifunctional suppressor of Arabidopsis defense. Plant Cell. 2012;24:4763-74 pubmed publisher
    ..COR also suppresses callose deposition and promotes bacterial growth in coi1 mutant plants, indicating that COR may have multiple targets inside plant cells.
  29. Melotto M, Underwood W, Koczan J, Nomura K, He S. Plant stomata function in innate immunity against bacterial invasion. Cell. 2006;126:969-80 pubmed
    ..We provide evidence that supports a model in which stomata, as part of an integral innate immune system, act as a barrier against bacterial infection. ..
  30. Yan J, Li S, Gu M, Yao R, Li Y, Chen J, et al. Endogenous Bioactive Jasmonate Is Composed of a Set of (+)-7-iso-JA-Amino Acid Conjugates. Plant Physiol. 2016;172:2154-2164 pubmed
    ..The bioactive JA is perceived by its receptor COI1 to trigger the degradation of JASMONATE ZIM-DOMAIN (JAZ) proteins and subsequently derepress the JAZ-repressed ..
  31. Zhou Z, Wu Y, Yang Y, Du M, Zhang X, Guo Y, et al. An Arabidopsis Plasma Membrane Proton ATPase Modulates JA Signaling and Is Exploited by the Pseudomonas syringae Effector Protein AvrB for Stomatal Invasion. Plant Cell. 2015;27:2032-41 pubmed publisher
    ..Unexpectedly, AHA1 promotes the interaction between the jasmonate (JA) receptor CORONATINE INSENSITIVE1 (COI1) and JASMONATE ZIM-DOMAIN (JAZ) proteins and enhances JA signaling...
  32. Chung H, Cooke T, Depew C, Patel L, Ogawa N, Kobayashi Y, et al. Alternative splicing expands the repertoire of dominant JAZ repressors of jasmonate signaling. Plant J. 2010;63:613-22 pubmed publisher
    ..The F-box protein COI1 functions both as a receptor for jasmonoyl-l-isoleucine (JA-Ile) and as the component of an E3-ubiquitin ligase ..
  33. Ren C, Pan J, Peng W, Genschik P, Hobbie L, Hellmann H, et al. Point mutations in Arabidopsis Cullin1 reveal its essential role in jasmonate response. Plant J. 2005;42:514-24 pubmed
    ..AtCUL1 was demonstrated to assemble into SCF complexes containing COI1, an F-box protein required for response to jasmonates (JA) that regulate plant fertility and defense responses...
  34. Laluk K, Luo H, Chai M, Dhawan R, Lai Z, Mengiste T. Biochemical and genetic requirements for function of the immune response regulator BOTRYTIS-INDUCED KINASE1 in plant growth, ethylene signaling, and PAMP-triggered immunity in Arabidopsis. Plant Cell. 2011;23:2831-49 pubmed publisher
    ..BIK1-mediated PTI to Pseudomonas syringae is modulated by SA, ET, and jasmonate signaling. The coi1 mutation suppressed several bik1 phenotypes, suggesting that COI1 may act as a repressor of BIK1 function...
  35. García Andrade J, Ramirez V, Flors V, Vera P. Arabidopsis ocp3 mutant reveals a mechanism linking ABA and JA to pathogen-induced callose deposition. Plant J. 2011;67:783-94 pubmed publisher ocp3 plants, including enhanced disease resistance, also required jasmonic acid (JA) recognition though a COI1 receptor, however JA was not required for basal callose deposition following fungal infection...
  36. Dai L, Xu L, Huang D, Li X, Luo K, Guan C. ASK1 physically interacts with COI1 and is required for male fertility in Arabidopsis. Sci China C Life Sci. 2002;45:631-6 pubmed publisher
    Jasmonates are a new class of plant hormones that play important roles in plant development and plant defense. The COI1 gene was previously shown to be required for jasmonate-regulated plant fertility and defense...
  37. Glazebrook J. Genes controlling expression of defense responses in Arabidopsis--2001 status. Curr Opin Plant Biol. 2001;4:301-8 pubmed
    ..Genes required for jasmonic-acid-dependent signaling and for induced systemic resistance have also been identified. ..
  38. Gan Y, Li H, Xie Y, Wu W, Li M, Wang X, et al. THF1 mutations lead to increased basal and wound-induced levels of oxylipins that stimulate anthocyanin biosynthesis via COI1 signaling in Arabidopsis. J Integr Plant Biol. 2014;56:916-27 pubmed publisher
    ..genetic evidence showed that the increased level of anthocyanin in thf1 is dependent on coronatine-insensitive1 (COI1) signaling...
  39. Qi T, Huang H, Song S, Xie D. Regulation of Jasmonate-Mediated Stamen Development and Seed Production by a bHLH-MYB Complex in Arabidopsis. Plant Cell. 2015;27:1620-33 pubmed publisher
  40. Mewis I, Appel H, Hom A, Raina R, Schultz J. Major signaling pathways modulate Arabidopsis glucosinolate accumulation and response to both phloem-feeding and chewing insects. Plant Physiol. 2005;138:1149-62 pubmed
    ..Blocked JA signaling in coronatine-insensitive (coi1) and enhanced expression of SA-signaled disease resistance in hypersensitive response-like (hrl1) mutants reduced ..
  41. Geng X, Shen M, Kim J, Mackey D. The Pseudomonas syringae type III effectors AvrRpm1 and AvrRpt2 promote virulence dependent on the F-box protein COI1. Plant Cell Rep. 2016;35:921-32 pubmed publisher
    Type III effectors AvrRpm1 and AvrRpt2 promote bacterial growth dependent on a COI1-mediated pathway in the absence of the RPM1 and RPS2 resistance proteins...
  42. Robson F, Okamoto H, Patrick E, Harris S, Wasternack C, Brearley C, et al. Jasmonate and phytochrome A signaling in Arabidopsis wound and shade responses are integrated through JAZ1 stability. Plant Cell. 2010;22:1143-60 pubmed publisher
    ..that the FR light-induced expression of transcription factor genes is dependent on CORONATINE INSENSITIVE1 (COI1), a central component of JA signaling, and is suppressed by JA...
  43. Zhou W, Yao R, Li H, Li S, Yan J. New perspective on the stabilization and degradation of the F-box protein COI1 in Arabidopsis. Plant Signal Behav. 2013;8: pubmed publisher
    The F-box protein CORONATINE INSENSITIVE1 (COI1) assembles into SCF(COI1) complexes and recruits its substrate JAZ proteins for ubiquitination and degradation to regulate diverse aspects of jasmonate-regulated plant developmental ..
  44. Chua L, Shan X, Wang J, Peng W, Zhang G, Xie D. Proteomics study of COI1-regulated proteins in Arabidopsis flower. J Integr Plant Biol. 2010;52:410-9 pubmed publisher
    ..The Arabidopsis F-box protein COI1 is required for plant defense and male fertility in JA signal pathway...
  45. Takahashi N, Kuroda H, Kuromori T, Hirayama T, Seki M, Shinozaki K, et al. Expression and interaction analysis of Arabidopsis Skp1-related genes. Plant Cell Physiol. 2004;45:83-91 pubmed
    ..As a result, we found diverse binding specificities: ASK1, ASK2, ASK11 and ASK12 interacted well with COI1, FKF1, UFO-like protein, LRR-containing F-box proteins, and other F-box proteins with unknown C-terminal motifs...
  46. Pauwels L, Ritter A, Goossens J, Durand A, Liu H, Gu Y, et al. The RING E3 Ligase KEEP ON GOING Modulates JASMONATE ZIM-DOMAIN12 Stability. Plant Physiol. 2015;169:1405-17 pubmed publisher
    ..JA-isoleucine triggers the interaction of JAZ repressor proteins with the F-box protein CORONATINE INSENSITIVE1 (COI1), part of an S-phase kinase-associated protein1/Cullin1/F-box protein COI1 (SCF(COI1)) E3 ubiquitin ligase complex, ..