Gene Symbol: CKS1
Description: cyclin-dependent kinase-subunit 1
Alias: CATALYTIC SUBUNIT OF CYCLIN-DEPENDENT KINASE, CKS1AT, P10CKS1AT, T1E2.12, T1E2_12, cyclin-dependent kinase-subunit 1, cyclin-dependent kinase-subunit 1
Species: thale cress
De Veylder L, Segers G, Glab N, Casteels P, Van Montagu M, Inze D. The Arabidopsis Cks1At protein binds the cyclin-dependent kinases Cdc2aAt and Cdc2bAt. FEBS Lett. 1997;412:446-52 pubmed
..The functionality of the Arabidopsis Suc1/Cks1 homologue, designed Cks1At, was demonstrated by its ability to rescue the temperature-sensitive cdc2-L7 strain of fission yeast at low and ..
Boudolf V, Rombauts S, Naudts M, Inze D, De Veylder L. Identification of novel cyclin-dependent kinases interacting with the CKS1 protein of Arabidopsis. J Exp Bot. 2001;52:1381-2 pubmed
..With the Arabidopsis thaliana CKS1At protein as bait in a two-hybrid screen, two novel Arabidopsis CDKs, Arath;CDKB1;2 and Arath;CDKB2;1, were isolated...
Boruc J, Mylle E, Duda M, De Clercq R, Rombauts S, Geelen D, et al
. Systematic localization of the Arabidopsis core cell cycle proteins reveals novel cell division complexes. Plant Physiol. 2010;152:553-65 pubmed publisher
..Thus, we identified unknown spatiotemporal territories where functional cell cycle protein interactions are most likely to occur...
Pusch S, Harashima H, Schnittger A. Identification of kinase substrates by bimolecular complementation assays. Plant J. 2012;70:348-56 pubmed publisher
..As a proof of functionality, we present the identification and in vivo confirmation of substrates of the major cell-cycle kinase in Arabidopsis, revealing a direct link between cell proliferation and the control of the redox state. ..
Van Leene J, Eeckhout D, Cannoot B, De Winne N, Persiau G, Van De Slijke E, et al
. An improved toolbox to unravel the plant cellular machinery by tandem affinity purification of Arabidopsis protein complexes. Nat Protoc. 2015;10:169-87 pubmed publisher
..The value of the provided protocols is illustrated through numerous applications described in recent literature. ..
Jacqmard A, De Veylder L, Segers G, de Almeida Engler J, Bernier G, Van Montagu M, et al
. Expression of CKS1At in Arabidopsis thaliana indicates a role for the protein in both the mitotic and the endoreduplication cycle. Planta. 1999;207:496-504 pubmed
..To investigate the role of the cell cycle genes CDC2aAt, CDC2bAt, CYCB1;1, and CKS1At in the process of endoreduplication, in-situ hybridizations were performed on the vegetative shoot apices...
Boudolf V, Lammens T, Boruc J, Van Leene J, Van Den Daele H, Maes S, et al
. CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset. Plant Physiol. 2009;150:1482-93 pubmed publisher
..We conclude that CCS52A1 participates in endocycle onset by down-regulating CDKB1;1 activity through the destruction of CYCA2;3. ..
De Veylder L, Beemster G, Beeckman T, Inze D. CKS1At overexpression in Arabidopsis thaliana inhibits growth by reducing meristem size and inhibiting cell-cycle progression. Plant J. 2001;25:617-26 pubmed
..Recently, an Arabidopsis thaliana SUC1/CKS1 homologous gene, designated CKS1At, has been cloned. Here, overexpression of CKS1At in Arabidopsis is shown to reduce leaf size and root growth rates...
De Veylder L, Beeckman T, Beemster G, Krols L, Terras F, Landrieu I, et al
. Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis. Plant Cell. 2001;13:1653-68 pubmed
..We conclude that KRP2 exerts a plant growth inhibitory activity by reducing cell proliferation in leaves, but, in contrast to its mammalian counterparts, it may not control the timing of cell cycle exit and differentiation. ..