Gene Symbol: CKA1
Description: casein kinase alpha 1
Alias: ATCKA1, ATPK12D, K8K14.10, K8K14_10, casein kinase alpha 1, casein kinase alpha 1
Species: thale cress

Top Publications

  1. Lu S, Liu H, Knowles S, Li J, Ma L, Tobin E, et al. A role for protein kinase casein kinase2 ?-subunits in the Arabidopsis circadian clock. Plant Physiol. 2011;157:1537-45 pubmed publisher
    ..These data demonstrate that CK2? subunits are important components of the Arabidopsis circadian system and their effects on rhythms are in part due to their phosphorylation of CIRCADIAN CLOCK ASSOCIATED1. ..
  2. Mizoguchi T, Yamaguchi Shinozaki K, Hayashida N, Kamada H, Shinozaki K. Cloning and characterization of two cDNAs encoding casein kinase II catalytic subunits in Arabidopsis thaliana. Plant Mol Biol. 1993;21:279-89 pubmed
    Two cDNA clones, ATCKA1 and ATCKA2, encoding casein kinase II (CKII) catalytic subunits, were cloned from Arabidopsis thaliana and their nucleotide sequences were determined...
  3. Sugano S, Andronis C, Green R, Wang Z, Tobin E. Protein kinase CK2 interacts with and phosphorylates the Arabidopsis circadian clock-associated 1 protein. Proc Natl Acad Sci U S A. 1998;95:11020-5 pubmed
    ..These results suggest that CK2 can modulate CCA1 activity both by direct interaction and by phosphorylation of the CCA1 protein and that CK2 may play a role in the function of CCA1 in vivo. ..
  4. Collinge M, Walker J. Isolation of an Arabidopsis thaliana casein kinase II beta subunit by complementation in Saccharomyces cerevisiae. Plant Mol Biol. 1994;25:649-58 pubmed
    ..Simultaneous disruption of the genes for the alpha and alpha' subunits, CKA1 and CKA2, respectively, is lethal...
  5. Dennis M, Browning K. Differential phosphorylation of plant translation initiation factors by Arabidopsis thaliana CK2 holoenzymes. J Biol Chem. 2009;284:20602-14 pubmed publisher
  6. Mulekar J, Bu Q, Chen F, Huq E. Casein kinase II ? subunits affect multiple developmental and stress-responsive pathways in Arabidopsis. Plant J. 2012;69:343-54 pubmed publisher
    ..Moreover, CK2 ? subunit mutants are also hyposensitive to a NaCl-induced blockage of seed germination. Taken together, these data suggest that CK2 ? subunits affect diverse developmental and stress responsive pathways in Arabidopsis. ..
  7. Bu Q, Zhu L, Dennis M, Yu L, Lu S, Person M, et al. Phosphorylation by CK2 enhances the rapid light-induced degradation of phytochrome interacting factor 1 in Arabidopsis. J Biol Chem. 2011;286:12066-74 pubmed publisher
    ..Taken together, these data suggest that CK2-mediated phosphorylation enhances the light-induced degradation of PIF1 to promote photomorphogenesis. ..
  8. Moreno Romero J, Armengot L, Mar Marquès Bueno M, Britt A, Carmen Martínez M. CK2-defective Arabidopsis plants exhibit enhanced double-strand break repair rates and reduced survival after exposure to ionizing radiation. Plant J. 2012;71:627-38 pubmed publisher
    ..Our results suggest that CK2 is required in the maintenance and control of genomic stability and chromatin structure in plants, and that this process affects several functions, including the DNA damage response and DNA repair. ..
  9. Sugano S, Andronis C, Ong M, Green R, Tobin E. The protein kinase CK2 is involved in regulation of circadian rhythms in Arabidopsis. Proc Natl Acad Sci U S A. 1999;96:12362-6 pubmed
    ..These data demonstrate that CK2 is involved in regulation of the circadian clock in Arabidopsis. ..

More Information


  1. Daniel X, Sugano S, Tobin E. CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis. Proc Natl Acad Sci U S A. 2004;101:3292-7 pubmed
  2. Salinas P, Fuentes D, Vidal E, Jordana X, Echeverria M, Holuigue L. An extensive survey of CK2 alpha and beta subunits in Arabidopsis: multiple isoforms exhibit differential subcellular localization. Plant Cell Physiol. 2006;47:1295-308 pubmed
    ..This study represents a complete survey of the CK2 gene family in Arabidopsis and the first step for future studies on CK2 cellular function in this species. ..
  3. Moreno Romero J, Armengot L, Marquès Bueno M, Cadavid Ordóñez M, Martinez M. About the role of CK2 in plant signal transduction. Mol Cell Biochem. 2011;356:233-40 pubmed publisher
    ..The high pleiotropy of CK2 was sustained by analysis of global transcript profiles that showed a huge number of genes affected, involved in a wide variety of cellular processes. ..