CERK1

Summary

Gene Symbol: CERK1
Description: chitin elicitor receptor kinase 1
Alias: AtCERK1, AtLYK1, LYK1, LYSM DOMAIN RECEPTOR-LIKE KINASE 1, LYSM RLK1, LysM-containing receptor-like kinase 1, chitin elicitor receptor kinase 1, chitin elicitor receptor kinase 1
Species: thale cress
Products:     CERK1

Top Publications

  1. Wan J, Tanaka K, Zhang X, Son G, Brechenmacher L, Nguyen T, et al. LYK4, a lysin motif receptor-like kinase, is important for chitin signaling and plant innate immunity in Arabidopsis. Plant Physiol. 2012;160:396-406 pubmed publisher
    ..In Arabidopsis (Arabidopsis thaliana), the LYK1/CERK1 (for LysM-containing receptor-like kinase1/chitin elicitor receptor kinase1) was shown to be essential for chitin ..
  2. Wan J, Zhang X, Neece D, Ramonell K, Clough S, Kim S, et al. A LysM receptor-like kinase plays a critical role in chitin signaling and fungal resistance in Arabidopsis. Plant Cell. 2008;20:471-81 pubmed publisher
    ..We identified a LysM receptor-like protein (LysM RLK1) required for chitin signaling in Arabidopsis thaliana...
  3. Gimenez Ibanez S, Hann D, Ntoukakis V, Petutschnig E, Lipka V, Rathjen J. AvrPtoB targets the LysM receptor kinase CERK1 to promote bacterial virulence on plants. Curr Biol. 2009;19:423-9 pubmed publisher
    ..Here, we show that the Arabidopsis LysM receptor kinase CERK1, which is critical for chitin elicitor signaling and resistance to fungal pathogens, plays an essential role in ..
  4. Iizasa E, Mitsutomi M, Nagano Y. Direct binding of a plant LysM receptor-like kinase, LysM RLK1/CERK1, to chitin in vitro. J Biol Chem. 2010;285:2996-3004 pubmed publisher
    ..Recent studies have revealed that LysM receptor-like kinase 1/chitin elicitor receptor kinase 1 (LysM RLK1/CERK1) is a critical component for the immune responses to chitin in Arabidopsis thaliana...
  5. Petutschnig E, Jones A, Serazetdinova L, Lipka U, Lipka V. The lysin motif receptor-like kinase (LysM-RLK) CERK1 is a major chitin-binding protein in Arabidopsis thaliana and subject to chitin-induced phosphorylation. J Biol Chem. 2010;285:28902-11 pubmed publisher
    ..In the dicot model plant Arabidopsis, the lysin motif (LysM)-containing chitin elicitor receptor kinase 1 (CERK1) has been shown to be essential for perception of the fungal cell wall component chitin and ..
  6. Willmann R, Lajunen H, Erbs G, Newman M, Kolb D, Tsuda K, et al. Arabidopsis lysin-motif proteins LYM1 LYM3 CERK1 mediate bacterial peptidoglycan sensing and immunity to bacterial infection. Proc Natl Acad Sci U S A. 2011;108:19824-9 pubmed publisher
    ..We further show that deletion of CERK1, a LysM receptor kinase that had previously been implicated in chitin perception and immunity to fungal infection ..
  7. Liu T, Liu Z, Song C, Hu Y, Han Z, She J, et al. Chitin-induced dimerization activates a plant immune receptor. Science. 2012;336:1160-4 pubmed publisher
    ..The cell surface receptor chitin elicitor receptor kinase 1 of Arabidopsis (AtCERK1) directly binds chitin through its lysine motif (LysM)-containing ectodomain ..
  8. Miya A, Albert P, Shinya T, Desaki Y, Ichimura K, Shirasu K, et al. CERK1, a LysM receptor kinase, is essential for chitin elicitor signaling in Arabidopsis. Proc Natl Acad Sci U S A. 2007;104:19613-8 pubmed
    ..Here, we identified a receptor-like kinase, designated CERK1, which is essential for chitin elicitor signaling in Arabidopsis...
  9. Shinya T, Motoyama N, Ikeda A, Wada M, Kamiya K, Hayafune M, et al. Functional characterization of CEBiP and CERK1 homologs in arabidopsis and rice reveals the presence of different chitin receptor systems in plants. Plant Cell Physiol. 2012;53:1696-706 pubmed publisher
    ..Studies of the chitin binding properties of the ectodomains of At/OsCERK1 and the chimeric receptors consisting of ecto/cytosolic domains of these molecules indicated that AtCERK1 is sufficient for chitin perception by itself.

More Information

Publications25

  1. Zhang Z, Liu Y, Ding P, Li Y, Kong Q, Zhang Y. Splicing of receptor-like kinase-encoding SNC4 and CERK1 is regulated by two conserved splicing factors that are required for plant immunity. Mol Plant. 2014;7:1766-75 pubmed publisher
    ..Further analysis showed that SUA and RSN2 are also required for the proper splicing of CERK1 (CHITIN ELICITOR RECEPTOR KINASE1), which encodes another RLK that functions as a receptor for chitin...
  2. Yamada K, Yamaguchi K, Shirakawa T, Nakagami H, Mine A, Ishikawa K, et al. The Arabidopsis CERK1-associated kinase PBL27 connects chitin perception to MAPK activation. EMBO J. 2016;35:2468-2483 pubmed
    ..We found that the receptor-like cytoplasmic kinase PBL27 connects the chitin receptor complex CERK1-LYK5 and a MAPK cascade. PBL27 interacts with both CERK1 and the MAPK kinase kinase MAPKKK5 at the plasma membrane...
  3. Shinya T, Yamaguchi K, Desaki Y, Yamada K, Narisawa T, Kobayashi Y, et al. Selective regulation of the chitin-induced defense response by the Arabidopsis receptor-like cytoplasmic kinase PBL27. Plant J. 2014;79:56-66 pubmed publisher
    ..show that PBL27, an Arabidopsis ortholog of OsRLCK185, is an immediate downstream component of the chitin receptor CERK1 and contributes to the regulation of chitin-induced immunity in Arabidopsis...
  4. Aranda Sicilia M, Trusov Y, Maruta N, Chakravorty D, Zhang Y, Botella J. Heterotrimeric G proteins interact with defense-related receptor-like kinases in Arabidopsis. J Plant Physiol. 2015;188:44-8 pubmed publisher
    ..interaction between the Gα, Gγ1 and Gγ2 subunits, and the defense-related RD-type receptor like kinases CERK1, BAK1 and BIR1. At the same time, no interaction was detected with the non-RD RLK FLS2...
  5. Willmann R, Nürnberger T. How plant lysin motif receptors get activated: lessons learned from structural biology. Sci Signal. 2012;5:pe28 pubmed publisher
    ..The three-dimensional structure of the LysM receptor kinase CERK1 (chitin elicitor receptor kinase 1) from Arabidopsis thaliana has been reported...
  6. Genenncher B, Lipka V, Petutschnig E, Wiermer M. Nucleoporin NUP88/MOS7 is required for manifestation of phenotypes associated with the Arabidopsis CHITIN ELICITOR RECEPTOR KINASE1 mutant cerk1-4. Plant Signal Behav. 2017;12:e1313378 pubmed publisher
    ..Here, we extend our analyses of MOS7-dependent plant immune responses and report the genetic requirement of MOS7 for manifestation of phenotypes associated with the CHITIN ELICITOR RECEPTOR KINASE1 (CERK1) mutant cerk1-4.
  7. Cao Y, Liang Y, Tanaka K, Nguyen C, Jedrzejczak R, Joachimiak A, et al. The kinase LYK5 is a major chitin receptor in Arabidopsis and forms a chitin-induced complex with related kinase CERK1. elife. 2014;3: pubmed publisher
    ..a fungal microbe-associated molecular pattern recognized in Arabidopsis by a lysin motif receptor kinase (LYK), AtCERK1. Previous research suggested that AtCERK1 is the major chitin receptor and mediates chitin-induced signaling ..
  8. Narusaka Y, Shinya T, Narusaka M, Motoyama N, Shimada H, Murakami K, et al. Presence of LYM2 dependent but CERK1 independent disease resistance in Arabidopsis. Plant Signal Behav. 2013;8: pubmed publisher
    ..Plant chitin receptor consists of two types of plasma membrane proteins, CEBiP and CERK1. However, the contribution of these proteins to chitin signaling is different between Arabidopsis and rice...
  9. Petutschnig E, Stolze M, Lipka U, Kopischke M, Horlacher J, Valerius O, et al. A novel Arabidopsis CHITIN ELICITOR RECEPTOR KINASE 1 (CERK1) mutant with enhanced pathogen-induced cell death and altered receptor processing. New Phytol. 2014;204:955-67 pubmed publisher
    ..Here, we report isolation of cerk1-4, a novel mutant allele of the Arabidopsis chitin receptor CERK1 with enhanced defense responses...
  10. Gimenez Ibanez S, Ntoukakis V, Rathjen J. The LysM receptor kinase CERK1 mediates bacterial perception in Arabidopsis. Plant Signal Behav. 2009;4:539-41 pubmed
  11. Yamaguchi K, Mezaki H, Fujiwara M, Hara Y, Kawasaki T. Arabidopsis ubiquitin ligase PUB12 interacts with and negatively regulates Chitin Elicitor Receptor Kinase 1 (CERK1). PLoS ONE. 2017;12:e0188886 pubmed publisher
    ..molecular pattern (PAMP) by the chitin receptor complex containing the lysin-motif (LysM) receptor-like kinases CERK1 and LYK5...
  12. Yeh Y, Panzeri D, Kadota Y, Huang Y, Huang P, Tao C, et al. The Arabidopsis Malectin-Like/LRR-RLK IOS1 Is Critical for BAK1-Dependent and BAK1-Independent Pattern-Triggered Immunity. Plant Cell. 2016;28:1701-21 pubmed publisher
    ..receptors (PRRs) such as FLAGELLIN SENSING2 (FLS2), EF-TU RECEPTOR (EFR), and CHITIN ELICITOR RECEPTOR KINASE1 (CERK1) recognize microbe-associated molecular patterns (MAMPs) to activate pattern-triggered immunity (PTI)...
  13. Brotman Y, Landau U, Pnini S, Lisec J, Balazadeh S, Mueller Roeber B, et al. The LysM receptor-like kinase LysM RLK1 is required to activate defense and abiotic-stress responses induced by overexpression of fungal chitinases in Arabidopsis plants. Mol Plant. 2012;5:1113-24 pubmed publisher
    ..tolerance to salinity in wild-type but not in knockout mutants of the LysM Receptor-Like Kinase1 (CERK1/LysM RLK1) gene, known to play a critical role in signaling defense responses induced by exogenous chitin...
  14. Espinoza C, Liang Y, Stacey G. Chitin receptor CERK1 links salt stress and chitin-triggered innate immunity in Arabidopsis. Plant J. 2017;89:984-995 pubmed publisher
    ..Here, we show a unique link between chitin and salt signaling mediated by the chitin receptor CHITIN ELICITOR RECEPTOR KINASE 1 (CERK1)...
  15. Le M, Cao Y, Zhang X, Stacey G. LIK1, a CERK1-interacting kinase, regulates plant immune responses in Arabidopsis. PLoS ONE. 2014;9:e102245 pubmed publisher
    ..This LRR-RLK was named LysM RLK1-interacting kinase 1 (LIK1)...
  16. Suzuki M, Shibuya M, Shimada H, Motoyama N, Nakashima M, Takahashi S, et al. Autophosphorylation of Specific Threonine and Tyrosine Residues in Arabidopsis CERK1 is Essential for the Activation of Chitin-Induced Immune Signaling. Plant Cell Physiol. 2016;57:2312-2322 pubmed
    ..and 15 Ser/Thr residues were identified as in vitro and in vivo autophosphorylation sites of Arabidopsis CERK1, which is essential for chitin signaling...