Gene Symbol: CDPK6
Description: calcium-dependent protein kinase 6
Alias: AtCDPK6, CALCIUM-DEPENDENT PROTEIN KINASE 6, CPK3, Calcium dependent protein kinase 3, F9D16.120, F9D16_120, calcium-dependent protein kinase 6, calcium-dependent protein kinase 6
Species: thale cress

Top Publications

  1. Qi Q, Rajala R, Anderson W, Jiang C, Rozwadowski K, Selvaraj G, et al. Molecular cloning, genomic organization, and biochemical characterization of myristoyl-CoA:protein N-myristoyltransferase from Arabidopsis thaliana. J Biol Chem. 2000;275:9673-83 pubmed
    ..coli exhibited a high catalytic efficiency for the peptides derived from putative plant myristoylated proteins AtCDPK6 and Fen kinase...
  2. Geiger D, Scherzer S, Mumm P, Marten I, Ache P, Matschi S, et al. Guard cell anion channel SLAC1 is regulated by CDPK protein kinases with distinct Ca2+ affinities. Proc Natl Acad Sci U S A. 2010;107:8023-8 pubmed publisher
    ..Thus the CPK and OST1 branch of ABA signal transduction in guard cells seem to converge on the level of SLAC1 under the control of the ABI1/ABA-receptor complex. ..
  3. Kanchiswamy C, Takahashi H, Quadro S, Maffei M, Bossi S, Bertea C, et al. Regulation of Arabidopsis defense responses against Spodoptera littoralis by CPK-mediated calcium signaling. BMC Plant Biol. 2010;10:97 pubmed publisher
    ..Ca2+-binding sensory proteins such as Ca2+-dependent protein kinases (CPKs) have been predicted to mediate the signaling following Ca2+ influx after insect herbivory. However, until now this prediction was not testable...
  4. Mori I, Murata Y, Yang Y, Munemasa S, Wang Y, Andreoli S, et al. CDPKs CPK6 and CPK3 function in ABA regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure. PLoS Biol. 2006;4:e327 pubmed
    ..Two Arabidopsis guard cell-expressed CDPK genes, CPK3 and CPK6, showed gene disruption phenotypes...
  5. Latz A, Mehlmer N, Zapf S, Mueller T, Wurzinger B, Pfister B, et al. Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium-dependent protein kinases (CDPKs). Mol Plant. 2013;6:1274-1289 pubmed publisher
    ..Focusing on the stress-activated kinase CPK3, we visualized direct and specific interaction of TPK1 with the kinase at the tonoplast in vivo...
  6. Dong C, Hong Y. Arabidopsis CDPK6 phosphorylates ADF1 at N-terminal serine 6 predominantly. Plant Cell Rep. 2013;32:1715-28 pubmed publisher
    We found that Arabidopsis AtADF1 was phosphorylated by AtCDPK6 at serine 6 predominantly and the phosphoregulation plays a key role in the regulation of ADF1-mediated depolymerization of actin filaments...
  7. Popescu S, Popescu G, Bachan S, Zhang Z, Seay M, Gerstein M, et al. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Proc Natl Acad Sci U S A. 2007;104:4730-5 pubmed
    ..Our results suggest that calcium functions through distinct CaM/CML proteins to regulate a wide range of targets and cellular activities. ..
  8. Berendzen K, Böhmer M, Wallmeroth N, Peter S, Vesić M, Zhou Y, et al. Screening for in planta protein-protein interactions combining bimolecular fluorescence complementation with flow cytometry. Plant Methods. 2012;8:25 pubmed
    ..From this work, we show that the well characterized protein Calcium Dependent Protein Kinase 3 (CPK3) interacts with APX3, HMGB5, ORP2A and a ricin B-related lectin domain containing protein ..
  9. Wu Y, Zhao S, Tian H, He Y, Xiong W, Guo L, et al. CPK3-phosphorylated RhoGDI1 is essential in the development of Arabidopsis seedlings and leaf epidermal cells. J Exp Bot. 2013;64:3327-38 pubmed publisher
    ..GDI1 could be phosphorylated by CPK3. Three conserved Ser/Thr residues in GDI1 were determined as targeted amino acids for CPK3...

More Information


  1. Mehlmer N, Wurzinger B, Stael S, Hofmann Rodrigues D, Csaszar E, Pfister B, et al. The Ca(2+) -dependent protein kinase CPK3 is required for MAPK-independent salt-stress acclimation in Arabidopsis. Plant J. 2010;63:484-98 pubmed publisher
    ..Here, we show the essential function of the CDPK CPK3 (At4g23650) for salt stress acclimation in Arabidopsis thaliana, and test crosstalk between CPK3 and the major salt-..
  2. Fàbregas N, Li N, Boeren S, Nash T, Goshe M, Clouse S, et al. The brassinosteroid insensitive1-like3 signalosome complex regulates Arabidopsis root development. Plant Cell. 2013;25:3377-88 pubmed publisher