Gene Symbol: CDKB1;1
Description: cyclin-dependent kinase B1;1
Alias: CDC2-LIKE GENE, CDC2B, CYCLIN-DEPENDENT KINASE B1;1, P34(CDC2)-LIKE PROTEIN, cyclin-dependent kinase B1;1, cyclin-dependent kinase B1;1
Species: thale cress

Top Publications

  1. Xie Z, Lee E, Lucas J, Morohashi K, Li D, Murray J, et al. Regulation of cell proliferation in the stomatal lineage by the Arabidopsis MYB FOUR LIPS via direct targeting of core cell cycle genes. Plant Cell. 2010;22:2306-21 pubmed publisher
    ..FLP recognizes a distinct cis-regulatory element that overlaps with that of the cell cycle activator E2F-DP in the CDKB1;1 promoter, suggesting that these MYBs may also modulate E2F-DP pathways. ..
  2. Boudolf V, Barr├┤co R, Engler J, Verkest A, Beeckman T, Naudts M, et al. B1-type cyclin-dependent kinases are essential for the formation of stomatal complexes in Arabidopsis thaliana. Plant Cell. 2004;16:945-55 pubmed
    ..Although division of stomatal precursors was inhibited, cells still acquired stomatal identity, illustrating that stomatal cell differentiation is independent of cellular and nuclear division. ..
  3. Boudolf V, Lammens T, Boruc J, Van Leene J, Van Den Daele H, Maes S, et al. CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset. Plant Physiol. 2009;150:1482-93 pubmed publisher
    ..We conclude that CCS52A1 participates in endocycle onset by down-regulating CDKB1;1 activity through the destruction of CYCA2;3. ..
  4. Boudolf V, Rombauts S, Naudts M, Inze D, De Veylder L. Identification of novel cyclin-dependent kinases interacting with the CKS1 protein of Arabidopsis. J Exp Bot. 2001;52:1381-2 pubmed
    ..Differences in the expression patterns in roots, leaves and stems suggest unique roles for each CDK. ..
  5. Lee E, Liu X, Eglit Y, Sack F. FOUR LIPS and MYB88 conditionally restrict the G1/S transition during stomatal formation. J Exp Bot. 2013;64:5207-19 pubmed publisher
  6. Kono A, Umeda Hara C, Lee J, Ito M, Uchimiya H, Umeda M. Arabidopsis D-type cyclin CYCD4;1 is a novel cyclin partner of B2-type cyclin-dependent kinase. Plant Physiol. 2003;132:1315-21 pubmed
    ..Our results suggest that CDKB2;1 and CYCD4;1 may form an active kinase complex during G2/M phase and control the development of particular tissues. ..
  7. Torres Acosta J, de Almeida Engler J, Raes J, Magyar Z, De Groodt R, Inze D, et al. Molecular characterization of Arabidopsis PHO80-like proteins, a novel class of CDKA;1-interacting cyclins. Cell Mol Life Sci. 2004;61:1485-97 pubmed
    ..The possible role of CYCPs in linking cell division, cell differentiation, and the nutritional status of the cell is discussed. ..
  8. Kono A, Ohno R, Umeda Hara C, Uchimiya H, Umeda M. A distinct type of cyclin D, CYCD4;2, involved in the activation of cell division in Arabidopsis. Plant Cell Rep. 2006;25:540-5 pubmed
    ..These results suggest that CYCD4;2 has a promotive function in cell division by interacting with CDKA;1 regardless of the unusual primary sequence. ..
  9. Verkest A, Manes C, Vercruysse S, Maes S, Van Der Schueren E, Beeckman T, et al. The cyclin-dependent kinase inhibitor KRP2 controls the onset of the endoreduplication cycle during Arabidopsis leaf development through inhibition of mitotic CDKA;1 kinase complexes. Plant Cell. 2005;17:1723-36 pubmed
    ..Moreover, the proposed model allowed a dynamical simulation of the in vivo observations, validating the sufficiency of the regulatory interactions between CDKA;1, KRP2, and CDKB1;1 in fine-tuning the mitosis-to-endocycle transition. ..

More Information


  1. Weimer A, Biedermann S, Harashima H, Roodbarkelari F, Takahashi N, Foreman J, et al. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J. 2016;35:2068-2086 pubmed
    ..Thus, while the major mitotic cell-cycle activity is blocked after DNA damage, CDKB1-CYCB1 complexes are specifically activated to mediate HR. ..
  2. Yoshizumi T, Nagata N, Shimada H, Matsui M. An Arabidopsis cell cycle -dependent kinase-related gene, CDC2b, plays a role in regulating seedling growth in darkness. Plant Cell. 1999;11:1883-96 pubmed
    The Arabidopsis CDC2b gene has been defined as a plant-specific cell cycle-dependent kinase-related gene, although it lacks the conserved cyclin binding motif, and its exact function is not known...
  3. Boudolf V, Inze D, De Veylder L. What if higher plants lack a CDC25 phosphatase?. Trends Plant Sci. 2006;11:474-9 pubmed
  4. Imajuku Y, Hirayama T, Endoh H, Oka A. Exon-intron organization of the Arabidopsis thaliana protein kinase genes CDC2a and CDC2b. FEBS Lett. 1992;304:73-7 pubmed
    ..shown by cDNA cloning that a higher plant, Arabidopsis thaliana, possesses at least two CDC2 genes (CDC2a and CDC2b) similar to the cell-cycle-controlling cdc2 gene of Schizosaccharomyces pombe...
  5. Wu S, Scheible W, Schindelasch D, Van Den Daele H, De Veylder L, Baskin T. A conditional mutation in Arabidopsis thaliana separase induces chromosome non-disjunction, aberrant morphogenesis and cyclin B1;1 stability. Development. 2010;137:953-61 pubmed publisher
    ..Our characterization of rsw4 leads us to hypothesize that plant separase, in addition to cleaving cohesin, regulates cyclin B1;1, with profound ramifications for morphogenesis. ..
  6. De Veylder L, Segers G, Glab N, Casteels P, Van Montagu M, Inze D. The Arabidopsis Cks1At protein binds the cyclin-dependent kinases Cdc2aAt and Cdc2bAt. FEBS Lett. 1997;412:446-52 pubmed
    ..Cks1At binds both Cdc2aAt and Cdc2bAt in vivo and in vitro. Furthermore, we demonstrate that the fission yeast Suc1 binds Cdc2aAt but only weakly Cdc2bAt, whereas the human CksHs1 associated exclusively with Cdc2aAt. ..
  7. Boruc J, Mylle E, Duda M, De Clercq R, Rombauts S, Geelen D, et al. Systematic localization of the Arabidopsis core cell cycle proteins reveals novel cell division complexes. Plant Physiol. 2010;152:553-65 pubmed publisher
    ..Thus, we identified unknown spatiotemporal territories where functional cell cycle protein interactions are most likely to occur...
  8. De Veylder L, Beeckman T, Beemster G, Krols L, Terras F, Landrieu I, et al. Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis. Plant Cell. 2001;13:1653-68 pubmed
    ..We conclude that KRP2 exerts a plant growth inhibitory activity by reducing cell proliferation in leaves, but, in contrast to its mammalian counterparts, it may not control the timing of cell cycle exit and differentiation. ..