Gene Symbol: CDC48
Description: cell division cycle 48
Alias: ATCDC48, CDC48A, cell division cycle 48, cell division cycle 48
Species: thale cress

Top Publications

  1. Rancour D, Park S, Knight S, Bednarek S. Plant UBX domain-containing protein 1, PUX1, regulates the oligomeric structure and activity of arabidopsis CDC48. J Biol Chem. 2004;279:54264-74 pubmed
    ..protein, PUX1, which functions to regulate the oligomeric structure of the Arabidopsis homolog of p97/CDC48, AtCDC48, as well as mammalian p97...
  2. Gallois J, Drouaud J, Lecureuil A, Guyon Debast A, Bonhomme S, Guerche P. Functional characterization of the plant ubiquitin regulatory X (UBX) domain-containing protein AtPUX7 in Arabidopsis thaliana. Gene. 2013;526:299-308 pubmed publisher
    p97/CDC48 is a major AAA-ATPase that acts in many cellular events such as ubiquitin-dependent degradation and membrane fusion...
  3. Aker J, Borst J, Karlova R, de Vries S. The Arabidopsis thaliana AAA protein CDC48A interacts in vivo with the somatic embryogenesis receptor-like kinase 1 receptor at the plasma membrane. J Struct Biol. 2006;156:62-71 pubmed
    Fluorescent cell division cycle (CDC)48 proteins were studied in living plant protoplasts. CDC48A and somatic embryogenesis receptor like kinase 1 (SERK1) were found to co-localize in the endoplasmatic reticulum (ER) and at the plasma ..
  4. Han B, Bingman C, Mahnke D, Bannen R, Bednarek S, Sabina R, et al. Membrane association, mechanism of action, and structure of Arabidopsis embryonic factor 1 (FAC1). J Biol Chem. 2006;281:14939-47 pubmed
  5. Park S, Rancour D, Bednarek S. Protein domain-domain interactions and requirements for the negative regulation of Arabidopsis CDC48/p97 by the plant ubiquitin regulatory X (UBX) domain-containing protein, PUX1. J Biol Chem. 2007;282:5217-24 pubmed
    ..regulatory X (UBX)-containing protein, PUX1, functions to regulate the hexameric structure and ATPase activity of AtCDC48. To characterize the biochemical mechanism of PUX1 action on AtCDC48, we have defined domains of both PUX1 and ..
  6. Copeland C, Woloshen V, Huang Y, Li X. AtCDC48A is involved in the turnover of an NLR immune receptor. Plant J. 2016;88:294-305 pubmed publisher
    ..As an AAA-ATPase, AtCDC48A likely serves to process the poly-ubiquitinated NLR substrate for final protein degradation by the 26S proteasome. ..
  7. Rancour D, Dickey C, Park S, Bednarek S. Characterization of AtCDC48. Evidence for multiple membrane fusion mechanisms at the plane of cell division in plants. Plant Physiol. 2002;130:1241-53 pubmed
    ..Here, we show the plant ortholog of Cdc48p/p97, AtCDC48, colocalizes at the division plane in dividing Arabidopsis cells with KNOLLE and another SNARE, the plant ..
  8. Mérai Z, Chumak N, García Aguilar M, Hsieh T, Nishimura T, Schoft V, et al. The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes. Proc Natl Acad Sci U S A. 2014;111:16166-71 pubmed publisher that these processes are blocked by mutations in the evolutionarily conserved AAA-ATPase molecular chaperone, CDC48A, homologous to yeast Cdc48 and human p97 proteins, both of which are implicated in ubiquitin/small ubiquitin-like ..
  9. Rienties I, Vink J, Borst J, Russinova E, de Vries S. The Arabidopsis SERK1 protein interacts with the AAA-ATPase AtCDC48, the 14-3-3 protein GF14lambda and the PP2C phosphatase KAPP. Planta. 2005;221:394-405 pubmed
    ..By yeast two-hybrid screening we identified AtCDC48, a homologue of the mammalian AAA-ATPase p97 and GF14lambda, a member of the Arabidopsis family of 14-3-3 ..

More Information


  1. Aker J, Hesselink R, Engel R, Karlova R, Borst J, Visser A, et al. In vivo hexamerization and characterization of the Arabidopsis AAA ATPase CDC48A complex using forster resonance energy transfer-fluorescence lifetime imaging microscopy and fluorescence correlation spectroscopy. Plant Physiol. 2007;145:339-50 pubmed
    The Arabidopsis (Arabidopsis thaliana) AAA ATPase CDC48A was fused to cerulean fluorescent protein and yellow fluorescent protein. AAA ATPases like CDC48 are only active in hexameric form...
  2. Park S, Rancour D, Bednarek S. In planta analysis of the cell cycle-dependent localization of AtCDC48A and its critical roles in cell division, expansion, and differentiation. Plant Physiol. 2008;148:246-58 pubmed publisher
    ..These results demonstrate that CDC48A/p97 is critical for cytokinesis, cell expansion, and differentiation in plants.
  3. Niehl A, Amari K, Gereige D, Brandner K, M ly Y, Heinlein M. Control of Tobacco mosaic virus movement protein fate by CELL-DIVISION-CYCLE protein48. Plant Physiol. 2012;160:2093-108 pubmed publisher
    ..Here, we identify CELL-DIVISION-CYCLE protein48 (CDC48), a conserved chaperone controlling protein fate in yeast (Saccharomyces cerevisiae) and animal cells by ..
  4. Feiler H, Desprez T, Santoni V, Kronenberger J, Caboche M, Traas J. The higher plant Arabidopsis thaliana encodes a functional CDC48 homologue which is highly expressed in dividing and expanding cells. EMBO J. 1995;14:5626-37 pubmed
    ..Biochemical studies link VCP function to membrane trafficking and signal transduction. We have described the AtCDC48 expression pattern in a multicellular eukaryote; the zones of cell division, expansion and differentiation are ..
  5. Karlova R, Boeren S, Russinova E, Aker J, Vervoort J, de Vries S. The Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 protein complex includes BRASSINOSTEROID-INSENSITIVE1. Plant Cell. 2006;18:626-38 pubmed
    ..In addition, KINASE-ASSOCIATED PROTEIN PHOSPHATASE, CDC48A, and 14-3-3nu were found...