CBP20

Summary

Gene Symbol: CBP20
Description: CAP-binding protein 20
Alias: ATCBP20, CAP-binding protein 20, MLN1.12, MLN1_12, CAP-binding protein 20
Species: thale cress
Products:     CBP20

Top Publications

  1. Kmieciak M, Simpson C, Lewandowska D, Brown J, Jarmolowski A. Cloning and characterization of two subunits of Arabidopsis thaliana nuclear cap-binding complex. Gene. 2002;283:171-83 pubmed
    In this report we characterize two Arabidopsis thaliana proteins, named AtCBP20 and AtCBP80, that are homologues of human subunits of a nuclear cap-binding protein complex (CBC). AtCBP20 has a calculated molecular mass of 29...
  2. Hugouvieux V, Murata Y, Young J, Kwak J, Mackesy D, Schroeder J. Localization, ion channel regulation, and genetic interactions during abscisic acid signaling of the nuclear mRNA cap-binding protein, ABH1. Plant Physiol. 2002;130:1276-87 pubmed
    ..Here, we show that the dimeric ABH1 and AtCBP20 subunits are ubiquitously expressed...
  3. Bush M, Hutchins A, Jones A, Naldrett M, Jarmolowski A, Lloyd C, et al. Selective recruitment of proteins to 5' cap complexes during the growth cycle in Arabidopsis. Plant J. 2009;59:400-12 pubmed publisher
    ..These findings suggest that the dynamic and selective recruitment of various proteins to mRNA 5' cap complexes could play an important role in the regulation of gene expression. ..
  4. Laubinger S, Sachsenberg T, Zeller G, Busch W, Lohmann J, Rätsch G, et al. Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2008;105:8795-800 pubmed publisher
    ..that the morphological appearance of weak se mutants is reminiscent of plants with mutations in ABH1/CBP80 and CBP20, which encode the two subunits of the nuclear cap-binding complex...
  5. Kim S, Yang J, Xu J, Jang I, Prigge M, Chua N. Two cap-binding proteins CBP20 and CBP80 are involved in processing primary MicroRNAs. Plant Cell Physiol. 2008;49:1634-44 pubmed publisher
    ..Here, we show that cbp20 and cbp80 mutants have reduced miRNA levels and increased pri-miRNA levels...
  6. Raczynska K, Simpson C, Ciesiolka A, Szewc L, Lewandowska D, McNicol J, et al. Involvement of the nuclear cap-binding protein complex in alternative splicing in Arabidopsis thaliana. Nucleic Acids Res. 2010;38:265-78 pubmed publisher
    ..Splicing profiles were determined in wild type plants, the cbp20 and cbp80(abh1) single mutants and the cbp20/80 double mutant...
  7. Hugouvieux V, Kwak J, Schroeder J. An mRNA cap binding protein, ABH1, modulates early abscisic acid signal transduction in Arabidopsis. Cell. 2001;106:477-87 pubmed
    ..Thus, ABH1 represents a modulator of ABA signaling proposed to function by transcript alteration of early ABA signaling elements. ..
  8. Wang L, Song X, Gu L, Li X, Cao S, Chu C, et al. NOT2 proteins promote polymerase II-dependent transcription and interact with multiple MicroRNA biogenesis factors in Arabidopsis. Plant Cell. 2013;25:715-27 pubmed publisher
    ..interacts with polymerase II and other miRNA processing factors, including two cap binding proteins, CBP80/ABH1, CBP20, and SERRATE (SE). Finally, we found that the mRNA levels of some protein coding genes were also affected...
  9. Jager K, Fabian A, Tompa G, Deák C, Hohn M, Olmedilla A, et al. New phenotypes of the drought-tolerant cbp20 Arabidopsis thaliana mutant have changed epidermal morphology. Plant Biol (Stuttg). 2011;13:78-84 pubmed publisher
    This paper provides a detailed phenotypic analysis of the abscisic acid (ABA) hypersensitive Cap Binding Protein 20 (cbp20) mutant...

More Information

Publications15

  1. Geraldo N, Bäurle I, Kidou S, Hu X, Dean C. FRIGIDA delays flowering in Arabidopsis via a cotranscriptional mechanism involving direct interaction with the nuclear cap-binding complex. Plant Physiol. 2009;150:1611-8 pubmed publisher
    ..Mutations in the small subunit of the CBC (CBP20) also suppress FRI up-regulation of FLC...
  2. Liu J, Jung C, Xu J, Wang H, Deng S, Bernad L, et al. Genome-wide analysis uncovers regulation of long intergenic noncoding RNAs in Arabidopsis. Plant Cell. 2012;24:4333-45 pubmed publisher
    ..Further analysis of transcriptome data in 11 mutants uncovered SERRATE, CAP BINDING PROTEIN20 (CBP20), and CBP80 as regulators of lincRNA expression and biogenesis...
  3. Raczynska K, Stepien A, Kierzkowski D, Kalak M, Bajczyk M, McNicol J, et al. The SERRATE protein is involved in alternative splicing in Arabidopsis thaliana. Nucleic Acids Res. 2014;42:1224-44 pubmed publisher
    ..Here we show that both subunits of AtCBC (AtCBP20 and AtCBP80) interact with SERRATE (AtSE), a protein involved in the microRNA biogenesis pathway...
  4. Kierzkowski D, Kmieciak M, Piontek P, Wojtaszek P, Szweykowska Kulinska Z, Jarmolowski A. The Arabidopsis CBP20 targets the cap-binding complex to the nucleus, and is stabilized by CBP80. Plant J. 2009;59:814-25 pubmed publisher
    ..nuclear-cytoplasmic transport of two subunits of the Arabidopsis thaliana cap-binding protein complex (AtCBC): AtCBP20 and AtCBP80...
  5. Kong X, Ma L, Yang L, Chen Q, Xiang N, Yang Y, et al. Quantitative proteomics analysis reveals that the nuclear cap-binding complex proteins arabidopsis CBP20 and CBP80 modulate the salt stress response. J Proteome Res. 2014;13:2495-510 pubmed publisher
    The cap-binding proteins CBP20 and CBP80 have well-established roles in RNA metabolism and plant growth and development...
  6. Zhang F, Wang L, Lim J, Kim T, Pyo Y, Sung S, et al. Phosphorylation of CBP20 Links MicroRNA to Root Growth in the Ethylene Response. PLoS Genet. 2016;12:e1006437 pubmed publisher
    ..Here we report the phosphorylation of cap binding protein 20 (CBP20) at Ser245 is regulated by ethylene, and the phosphorylation is involved in root growth...