Gene Symbol: CAK1AT
Description: CDK-activating kinase 1AT
Alias: CDK-activating kinase 1AT, CDKF;1, CYCLIN-DEPENDENT KINASE F;1, F19B15.10, F19B15_10, CDK-activating kinase 1AT
Species: thale cress
Products:     CAK1AT

Top Publications

  1. Umeda M, Bhalerao R, Schell J, Uchimiya H, Koncz C. A distinct cyclin-dependent kinase-activating kinase of Arabidopsis thaliana. Proc Natl Acad Sci U S A. 1998;95:5021-6 pubmed
    ..We screened an Arabidopsis cDNA expression library for complementation of a budding yeast CAK mutant. A cDNA, cak1At, was isolated that suppressed the CAK mutation in budding yeast, and it also complemented a fission yeast CAK ..
  2. Shimotohno A, Umeda Hara C, Bisova K, Uchimiya H, Umeda M. The plant-specific kinase CDKF;1 is involved in activating phosphorylation of cyclin-dependent kinase-activating kinases in Arabidopsis. Plant Cell. 2004;16:2954-66 pubmed
    ..b>CAK1At (CDKF;1) shows cyclin H-independent CDK-kinase activity and can activate a heterologous CAK, Mcs6, in fission ..
  3. Shimotohno A, Ohno R, Bisova K, Sakaguchi N, Huang J, Koncz C, et al. Diverse phosphoregulatory mechanisms controlling cyclin-dependent kinase-activating kinases in Arabidopsis. Plant J. 2006;47:701-10 pubmed
    ..We propose that two distinct types of CAK, namely CDKF;1 and CDKD;2, play a major role in CDK and CTD phosphorylation, respectively, in Arabidopsis. ..
  4. Umeda M, Umeda Hara C, Uchimiya H. A cyclin-dependent kinase-activating kinase regulates differentiation of root initial cells in Arabidopsis. Proc Natl Acad Sci U S A. 2000;97:13396-400 pubmed
    ..Here, we show that overexpression of sense or antisense gene for Cak1At in Arabidopsis by using the glucocorticoid-mediated transcriptional induction system resulted in a reduction of ..
  5. Hajheidari M, Farrona S, Huettel B, Koncz Z, Koncz C. CDKF;1 and CDKD protein kinases regulate phosphorylation of serine residues in the C-terminal domain of Arabidopsis RNA polymerase II. Plant Cell. 2012;24:1626-42 pubmed publisher
    ..Taken together, cotranscriptional processing and stability of a set of small RNAs and transcripts involved in their biogenesis are sensitive to changes in the phosphorylation of RNAPII CTD by CDKF;1 and CDKDs. ..
  6. Takatsuka H, Ohno R, Umeda M. The Arabidopsis cyclin-dependent kinase-activating kinase CDKF;1 is a major regulator of cell proliferation and cell expansion but is dispensable for CDKA activation. Plant J. 2009;59:475-87 pubmed publisher
    ..These results indicate that CDKF;1 is dispensable for CDKA;1 activation but is essential for maintaining a steady-state level of CDKD;2, thereby suggesting the quantitative regulation of a vertebrate-type CAK in a plant-specific manner. ..
  7. Umeda M, Shimotohno A, Yamaguchi M. Control of cell division and transcription by cyclin-dependent kinase-activating kinases in plants. Plant Cell Physiol. 2005;46:1437-42 pubmed
    ..We have introduced several transgenic studies in which CAK genes were used as a tool to modify the CDK activity and to analyze cell division and differentiation during organ development. ..