Gene Symbol: BZR1
Description: Brassinosteroid signaling positive regulator (BZR1) family protein
Alias: BRASSINAZOLE-RESISTANT 1, F9E10.7, F9E10_7, Brassinosteroid signaling positive regulator (BZR1) family protein
Species: thale cress
Products:     BZR1

Top Publications

  1. Ryu H, Kim K, Cho H, Park J, Choe S, Hwang I. Nucleocytoplasmic shuttling of BZR1 mediated by phosphorylation is essential in Arabidopsis brassinosteroid signaling. Plant Cell. 2007;19:2749-62 pubmed
    ..the phosphorylation status of two key transcriptional factors, BRI1 EMS SUPPRESSOR1 and BRASSINAZOLE RESISTANT1 (BZR1), through the action of BRASSINOSTEROID INSENSITIVE1/BRI1 ASSOCIATED RECEPTOR KINASE1 receptors and a GSK3 kinase, ..
  2. Wang Z, Nakano T, Gendron J, He J, Chen M, Vafeados D, et al. Nuclear-localized BZR1 mediates brassinosteroid-induced growth and feedback suppression of brassinosteroid biosynthesis. Dev Cell. 2002;2:505-13 pubmed
    ..Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway...
  3. Sun Y, Fan X, Cao D, Tang W, He K, Zhu J, et al. Integration of brassinosteroid signal transduction with the transcription network for plant growth regulation in Arabidopsis. Dev Cell. 2010;19:765-77 pubmed publisher
    ..profiling and chromatin-immunoprecipitation microarray (ChIP-chip) experiments to identify 953 BR-regulated BZR1 target (BRBT) genes...
  4. Tang W, Yuan M, Wang R, Yang Y, Wang C, Oses Prieto J, et al. PP2A activates brassinosteroid-responsive gene expression and plant growth by dephosphorylating BZR1. Nat Cell Biol. 2011;13:124-31 pubmed publisher
    When brassinosteroid levels are low, the GSK3-like kinase BIN2 phosphorylates and inactivates the BZR1 transcription factor to inhibit growth in plants...
  5. He J, Gendron J, Yang Y, Li J, Wang Z. The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis. Proc Natl Acad Sci U S A. 2002;99:10185-90 pubmed
    ..receptor BRI1, the glycogen synthase kinase-3-like kinase BIN2 as a negative regulator, and nuclear proteins BZR1 and BZR2/BES1 as positive regulators. The interactions among these components remain unclear...
  6. Wang Y, Sun S, Zhu W, Jia K, Yang H, Wang X. Strigolactone/MAX2-induced degradation of brassinosteroid transcriptional effector BES1 regulates shoot branching. Dev Cell. 2013;27:681-8 pubmed publisher
    ..In addition, we demonstrate that the SL and brassinosteroid (BR) signaling pathways distinctly regulate the same transcription factor, BES1, to control specific developmental processes. ..
  7. Oh E, Zhu J, Wang Z. Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses. Nat Cell Biol. 2012;14:802-9 pubmed publisher
    ..transcription factor phytochrome-interacting factor 4 (PIF4) and the BR-activated transcription factor BZR1 integrates the hormonal and environmental signals...
  8. Gampala S, Kim T, He J, Tang W, Deng Z, Bai M, et al. An essential role for 14-3-3 proteins in brassinosteroid signal transduction in Arabidopsis. Dev Cell. 2007;13:177-89 pubmed
    ..BRs regulate gene expression by inducing dephosphorylation of two key transcription factors, BZR1 and BZR2/BES1, through a signal transduction pathway that involves cell-surface receptors (BRI1 and BAK1) and a ..
  9. Li Q, Wang C, Jiang L, Li S, Sun S, He J. An interaction between BZR1 and DELLAs mediates direct signaling crosstalk between brassinosteroids and gibberellins in Arabidopsis. Sci Signal. 2012;5:ra72 pubmed publisher
    ..We report that BZR1, a key transcription factor activated by BR signaling, interacts in vitro and in vivo with REPRESSOR OF ga1-3 (RGA),..

More Information


  1. Gallego Bartolome J, Minguet E, Grau Enguix F, Abbas M, Locascio A, Thomas S, et al. Molecular mechanism for the interaction between gibberellin and brassinosteroid signaling pathways in Arabidopsis. Proc Natl Acad Sci U S A. 2012;109:13446-51 pubmed publisher
    ..between the DELLA protein GAI, which is a major negative regulator of the GA pathway, and BRASSINAZOLE RESISTANT1 (BZR1), a transcription factor that broadly regulates gene expression in response to BRs...
  2. Peng P, Zhao J, Zhu Y, Asami T, Li J. A direct docking mechanism for a plant GSK3-like kinase to phosphorylate its substrates. J Biol Chem. 2010;285:24646-53 pubmed publisher
    ..kinase that negatively regulates brassinosteroid (BR) signaling by phosphorylating BES1 (bri1 EMS suppressor 1) and BZR1 (brassinazole-resistant 1), two highly similar transcription factors critical for bringing about characteristic BR ..
  3. Kim T, Michniewicz M, Bergmann D, Wang Z. Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathway. Nature. 2012;482:419-22 pubmed publisher
  4. He J, Gendron J, Sun Y, Gampala S, Gendron N, Sun C, et al. BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses. Science. 2005;307:1634-8 pubmed
    ..receptor kinases and intracellular components leads to dephosphorylation and accumulation of the nuclear protein BZR1. How BR signaling regulates gene expression, however, remains unknown...
  5. Wu P, Gao H, Zhang L, Xue H, Lin W. Phosphatidic acid regulates BZR1 activity and brassinosteroid signal of Arabidopsis. Mol Plant. 2014;7:445-7 pubmed publisher
  6. Huang H, Jiang W, Hu Y, Wu P, Zhu J, Liang W, et al. BR signal influences Arabidopsis ovule and seed number through regulating related genes expression by BZR1. Mol Plant. 2013;6:456-69 pubmed publisher
    ..either directly by targeting the promoter sequences or indirectly via regulation by BR-induced transcription factor BZR1. Also, Western blot demonstrates that the dephosphorylation level of BZR1 is consistent with ovule and seed number...
  7. Zhang Y, Li B, Xu Y, Li H, Li S, Zhang D, et al. The cyclophilin CYP20-2 modulates the conformation of BRASSINAZOLE-RESISTANT1, which binds the promoter of FLOWERING LOCUS D to regulate flowering in Arabidopsis. Plant Cell. 2013;25:2504-21 pubmed publisher
    ..Here, we report that BRASSINAZOLE-RESISTANT1 (BZR1), the conformation of which is altered by a cyclophilin (CYP20-2), binds cis-elements in the FLOWERING LOCUS D (FLD)..
  8. Li Q, He J. BZR1 Interacts with HY5 to Mediate Brassinosteroid- and Light-Regulated Cotyledon Opening in Arabidopsis in Darkness. Mol Plant. 2016;9:113-125 pubmed publisher
    ..connection between the BR and light signaling pathways, which was mediated by the BR-regulated transcription factor BZR1 and light-regulated transcription factor HY5 in Arabidopsis thaliana...
  9. Lozano Dur n R, Macho A, Boutrot F, Segonzac C, Somssich I, Zipfel C. The transcriptional regulator BZR1 mediates trade-off between plant innate immunity and growth. elife. 2013;2:e00983 pubmed publisher
    ..Here, we report that activation of the transcription factor BZR1 is required and sufficient for suppression of immune signaling by brassinosteroids (BR)...
  10. Zhao J, Peng P, Schmitz R, Decker A, Tax F, Li J. Two putative BIN2 substrates are nuclear components of brassinosteroid signaling. Plant Physiol. 2002;130:1221-9 pubmed
    ..BES1 and its closest homolog, BZR1, which was also uncovered as a potential BR-signaling protein, display specific interactions with BIN2 in yeast...
  11. Li Q, Huang L, Wei K, Yu J, Zhang C, Liu Q. Light involved regulation of BZR1 stability and phosphorylation status to coordinate plant growth in Arabidopsis. Biosci Rep. 2017;37: pubmed publisher
    ..However, little is known about how BZR1, the pivotal integration node, is regulated by light and dark...
  12. Oh E, Zhu J, Ryu H, Hwang I, Wang Z. TOPLESS mediates brassinosteroid-induced transcriptional repression through interaction with BZR1. Nat Commun. 2014;5:4140 pubmed publisher
    Brassinosteroid (BR) regulates plant development by activating the transcription factor brassinazole resistant 1 (BZR1), which activates and represses different target genes to switch cellular programmes...
  13. Singh A, Fridman Y, Friedlander Shani L, Tarkowska D, Strnad M, Savaldi Goldstein S. Activity of the brassinosteroid transcription factors BRASSINAZOLE RESISTANT1 and BRASSINOSTEROID INSENSITIVE1-ETHYL METHANESULFONATE-SUPPRESSOR1/BRASSINAZOLE RESISTANT2 blocks developmental reprogramming in response to low phosphate availability. Plant Physiol. 2014;166:678-88 pubmed publisher that the activity of two homologous brassinosteroid (BR) transcriptional effectors, BRASSINAZOLE RESISTANT1 (BZR1) and BRASSINOSTEROID INSENSITIVE1-ETHYL METHANESULFONATE-SUPPRESSOR1 (BES1)/BZR2, blocks these responses, ..
  14. Chung Y, Maharjan P, Lee O, Fujioka S, Jang S, Kim B, et al. Auxin stimulates DWARF4 expression and brassinosteroid biosynthesis in Arabidopsis. Plant J. 2011;66:564-78 pubmed publisher
    ..chromatin immunoprecipitation assays confirmed that auxin inhibits the binding of the transcriptional repressor, BZR1, to the DWF4 promoter...
  15. Bai M, Shang J, Oh E, Fan M, Bai Y, Zentella R, et al. Brassinosteroid, gibberellin and phytochrome impinge on a common transcription module in Arabidopsis. Nat Cell Biol. 2012;14:810-7 pubmed publisher
    ..Here we show that BR and GA act interdependently through a direct interaction between the BR-activated BZR1 and GA-inactivated DELLA transcription regulators...
  16. Miyaji T, Yamagami A, Kume N, Sakuta M, Osada H, Asami T, et al. Brassinosteroid-related transcription factor BIL1/BZR1 increases plant resistance to insect feeding. Biosci Biotechnol Biochem. 2014;78:960-8 pubmed publisher
    ..BIL1/BZR1 is a BR master transcription factor known to be involved in the regulation of plant development through work ..
  17. Shigeta T, Zaizen Y, Sugimoto Y, Nakamura Y, Matsuo T, Okamoto S. Heat shock protein 90 acts in brassinosteroid signaling through interaction with BES1/BZR1 transcription factor. J Plant Physiol. 2015;178:69-73 pubmed publisher
    ..Two highly homologous transcription factors, brassinosteroid insensitive 1-EMS-SUPRESSOR 1 (BES1) and brassinazole resistant 1 (BZR1), act downstream of BR signaling to control several thousands of putative target genes...
  18. Lee H, Kim Y, Pham G, Kim J, Song J, Lee Y, et al. Brassinazole resistant 1 (BZR1)-dependent brassinosteroid signalling pathway leads to ectopic activation of quiescent cell division and suppresses columella stem cell differentiation. J Exp Bot. 2015;66:4835-49 pubmed publisher
    ..Here, it is demonstrated that BZR1, a BES1 homologue, also promotes cell divisions in the QC, but it suppresses columella stem cell differentiation, ..
  19. Tsugama D, Liu S, Takano T. Arabidopsis heterotrimeric G protein ? subunit, AGB1, regulates brassinosteroid signalling independently of BZR1. J Exp Bot. 2013;64:3213-23 pubmed publisher
    ..A key transcription factor downstream of BR, BZR1, and its gain-of-function mutant, bzr1-1, were overexpressed in an AGB1-null mutant, agb1-1, to examine their ..
  20. Guo R, Qian H, Shen W, Liu L, Zhang M, Cai C, et al. BZR1 and BES1 participate in regulation of glucosinolate biosynthesis by brassinosteroids in Arabidopsis. J Exp Bot. 2013;64:2401-12 pubmed publisher
    ..of reduced content of glucosinolates and lower expression levels of glucosinolate biosynthetic genes in 35S-BZR1/bzr1-1D and bes1-D plants compared with the corresponding wild-types suggested that BZR1 and BES1, two important ..
  21. Shimada S, Komatsu T, Yamagami A, Nakazawa M, Matsui M, Kawaide H, et al. Formation and dissociation of the BSS1 protein complex regulates plant development via brassinosteroid signaling. Plant Cell. 2015;27:375-90 pubmed publisher
    Brassinosteroids (BRs) play important roles in plant development and the response to environmental cues. BIL1/BZR1 is a master transcription factor in BR signaling, but the mechanisms that lead to the finely tuned targeting of BIL1/BZR1 ..
  22. Ryu H, Cho H, Kim K, Hwang I. Phosphorylation dependent nucleocytoplasmic shuttling of BES1 is a key regulatory event in brassinosteroid signaling. Mol Cells. 2010;29:283-90 pubmed publisher
    ..phosphorylation status of two crucial transcription factors, BRI1 EMS SUPPRESSOR1 BES1)and BRASSINAZOLE RESISTANT1 (BZR1)...
  23. Oh E, Zhu J, Bai M, Arenhart R, Sun Y, Wang Z. Cell elongation is regulated through a central circuit of interacting transcription factors in the Arabidopsis hypocotyl. elife. 2014;3: pubmed publisher
    ..the light/temperature-regulated transcription factor PIF4, and the brassinosteroid-signaling transcription factor BZR1, interact with each other and cooperatively regulate large numbers of common target genes, but their DNA-binding ..
  24. Yang X, Bai Y, Shang J, Xin R, Tang W. The antagonistic regulation of abscisic acid-inhibited root growth by brassinosteroids is partially mediated via direct suppression of ABSCISIC ACID INSENSITIVE 5 expression by BRASSINAZOLE RESISTANT 1. Plant Cell Environ. 2016;39:1994-2003 pubmed publisher
    ..BRs regulate plant growth and development by activating BRASSINAZOLE RESISTANT 1 (BZR1) family transcription factors...
  25. Nolan T, Liu S, Guo H, Li L, Schnable P, Yin Y. Identification of Brassinosteroid Target Genes by Chromatin Immunoprecipitation Followed by High-Throughput Sequencing (ChIP-seq) and RNA-Sequencing. Methods Mol Biol. 2017;1564:63-79 pubmed publisher
    ..BRs signal to regulate BR-INSENSITIVE1-ETHYL METHANESULFONATE-SUPPRESSOR1 (BES1) and BRASSINAZOLE-RESISTANT1 (BZR1) transcription factors (TFs), which, in turn, regulate several hundreds of transcription factors (termed BES1/BZR1-..