Gene Symbol: BZIP60
Description: basic region/leucine zipper motif 60
Alias: ATBZIP60, Bbasic region/leucine zipper motif 60, F13A11.5, F13A11_5, basic region/leucine zipper motif 60, basic region/leucine zipper motif 60
Species: thale cress

Top Publications

  1. Iwata Y, Koizumi N. An Arabidopsis transcription factor, AtbZIP60, regulates the endoplasmic reticulum stress response in a manner unique to plants. Proc Natl Acad Sci U S A. 2005;102:5280-5 pubmed
    ..75 genes encoding putative basic leucine zipper (bZIP) transcription factors in the Arabidopsis genome identified AtbZIP60, which was induced by tunicamycin...
  2. Lu D, Christopher D. Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana. Mol Genet Genomics. 2008;280:199-210 pubmed publisher
    ..tissues, in response to chemically induced UPR, and in null mutants of UPR signaling mediators (AtIRE1-2 and AtbZIP60)...
  3. Iwata Y, Fedoroff N, Koizumi N. Arabidopsis bZIP60 is a proteolysis-activated transcription factor involved in the endoplasmic reticulum stress response. Plant Cell. 2008;20:3107-21 pubmed publisher
    ..This phenomenon is known as the ER stress response. We report here that bZIP60, an Arabidopsis thaliana basic leucine zipper (bZIP) transcription factor with a transmembrane domain, is involved ..
  4. Iwata Y, Yoneda M, Yanagawa Y, Koizumi N. Characteristics of the nuclear form of the Arabidopsis transcription factor AtbZIP60 during the endoplasmic reticulum stress response. Biosci Biotechnol Biochem. 2009;73:865-9 pubmed
    ..Previously we isolated AtbZIP60, a membrane-bound transcription factor involved in the Arabidopsis ER stress response whose activity is ..
  5. Liu J, Howell S. bZIP28 and NF-Y transcription factors are activated by ER stress and assemble into a transcriptional complex to regulate stress response genes in Arabidopsis. Plant Cell. 2010;22:782-96 pubmed publisher
    ..Thus, in response to ER stress, bZIP28 is mobilized by proteolysis and recruits NF-Y subunits to form a transcriptional complex that upregulates the expression of ER stress-induced genes. ..
  6. Song Z, Sun L, Lu S, Tian Y, Ding Y, Liu J. Transcription factor interaction with COMPASS-like complex regulates histone H3K4 trimethylation for specific gene expression in plants. Proc Natl Acad Sci U S A. 2015;112:2900-5 pubmed publisher
    ..profiling analysis reveals that membrane-associated basic leucine zipper (bZIP) transcription factors bZIP28 and bZIP60 regulate most of the ER stress responsive genes...
  7. Nagashima Y, Mishiba K, Suzuki E, Shimada Y, Iwata Y, Koizumi N. Arabidopsis IRE1 catalyses unconventional splicing of bZIP60 mRNA to produce the active transcription factor. Sci Rep. 2011;1:29 pubmed publisher
    ..analysis revealed that genes whose induction was reduced in ire1a/ire1b largely overlapped those in the bzip60 mutant. We observed that the active form of bZIP60 protein detected in the wild-type was missing in ire1a/ire1b...
  8. Henriquez Valencia C, Moreno A, Sandoval Ibañez O, Mitina I, Blanco Herrera F, Cifuentes Esquivel N, et al. bZIP17 and bZIP60 Regulate the Expression of BiP3 and Other Salt Stress Responsive Genes in an UPR-Independent Manner in Arabidopsis thaliana. J Cell Biochem. 2015;116:1638-45 pubmed publisher
    ..Recently, it has been described that bZIP17 and bZIP60, two ER-located transcription factors, are involved in the cellular response to salt stress...
  9. Moreno A, Mukhtar M, Blanco F, Boatwright J, Moreno I, Jordan M, et al. IRE1/bZIP60-mediated unfolded protein response plays distinct roles in plant immunity and abiotic stress responses. PLoS ONE. 2012;7:e31944 pubmed publisher
    ..deficiency in ire1a is due to a defect in SA- and pathogen-triggered, IRE1-mediated cytoplasmic splicing of the bZIP60 mRNA, which encodes a transcription factor involved in the expression of UPR-responsive genes...

More Information


  1. Nagashima Y, Iwata Y, Mishiba K, Koizumi N. Arabidopsis tRNA ligase completes the cytoplasmic splicing of bZIP60 mRNA in the unfolded protein response. Biochem Biophys Res Commun. 2016;470:941-6 pubmed publisher
    Arabidopsis bZIP60 is a major transcription factor that activates the unfolded protein response and is regulated by cytoplasmic splicing...
  2. Tang W, Page M. Transcription factor AtbZIP60 regulates expression of Ca2+ -dependent protein kinase genes in transgenic cells. Mol Biol Rep. 2013;40:2723-32 pubmed publisher
    The Arabidopsis thaliana bZIP60 (AtbZIP60) transcription factor regulates stress signaling. However, its molecular mechanism remains to be elucidated...
  3. Sun L, Yang Z, Song Z, Wang M, Sun L, Lu S, et al. The plant-specific transcription factor gene NAC103 is induced by bZIP60 through a new cis-regulatory element to modulate the unfolded protein response in Arabidopsis. Plant J. 2013;76:274-86 pubmed publisher
    ..Previously bZIP28 and bZIP60 have been identified as important UPR regulators for mitigating the endoplasmic reticulum (ER) stress in ..