Gene Symbol: BT2
Description: BTB and TAZ domain protein 2
Alias: ATBT2, BTB and TAZ domain protein 2, BTB and TAZ domain protein 2
Species: thale cress
Mandadi K, Misra A, Ren S, McKnight T. BT2, a BTB protein, mediates multiple responses to nutrients, stresses, and hormones in Arabidopsis. Plant Physiol. 2009;150:1930-9 pubmed publisher
The Arabidopsis (Arabidopsis thaliana) gene BT2 encodes a 41-kD protein that possesses an amino-terminal BTB domain, a central TAZ domain, and a carboxyl-terminal calmodulin-binding domain...
Sato T, Maekawa S, Konishi M, Yoshioka N, Sasaki Y, Maeda H, et al
. Direct transcriptional activation of BT genes by NLP transcription factors is a key component of the nitrate response in Arabidopsis. Biochem Biophys Res Commun. 2017;483:380-386 pubmed publisher
..which are key regulators of the nitrate response, directly activate the nitrate-inducible expression of BT1 and BT2 encoding putative scaffold proteins with a plant-specific domain structure in Arabidopsis...
Newton A, Sharpe B, Kwan A, Mackay J, Crossley M. The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules. J Biol Chem. 2000;275:15128-34 pubmed
..Our results indicate that CBP is a genuine zinc-binding protein and introduce zinc bundles as novel protein interaction domains. ..
Du L, Poovaiah B. A novel family of Ca2+/calmodulin-binding proteins involved in transcriptional regulation: interaction with fsh/Ring3 class transcription activators. Plant Mol Biol. 2004;54:549-69 pubmed
..AtBET10 also interacts with AtBT2 and AtBT4, and exhibited a transcriptional activation function in yeast cells...
Ren S, Mandadi K, Boedeker A, Rathore K, McKnight T. Regulation of telomerase in Arabidopsis by BT2, an apparent target of TELOMERASE ACTIVATOR1. Plant Cell. 2007;19:23-31 pubmed
..Here, we report that BT2, a protein with BTB, TAZ, and calmodulin binding domains, is an essential component of the TAC1-mediated telomerase ..
Robert H, Quint A, Brand D, Vivian Smith A, Offringa R. BTB and TAZ domain scaffold proteins perform a crucial function in Arabidopsis development. Plant J. 2009;58:109-21 pubmed publisher
..Expression pattern, gene structure and sequence analyses indicate that BT1 and BT2 are closely related...
Figueroa P, Gusmaroli G, Serino G, Habashi J, Ma L, Shen Y, et al
. Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo. Plant Cell. 2005;17:1180-95 pubmed
Misra A, McKnight T, Mandadi K. Bromodomain proteins GTE9 and GTE11 are essential for specific BT2-mediated sugar and ABA responses in Arabidopsis thaliana. Plant Mol Biol. 2018;96:393-402 pubmed publisher
Global Transcription Factor Group E proteins GTE9 and GTE11 interact with BT2 to mediate ABA and sugar responses in Arabidopsis thaliana...
Araus V, Vidal E, Puelma T, Alamos S, Mieulet D, Guiderdoni E, et al
. Members of BTB Gene Family of Scaffold Proteins Suppress Nitrate Uptake and Nitrogen Use Efficiency. Plant Physiol. 2016;171:1523-32 pubmed publisher
..Second, we identified BT2, a member of the Bric-a-Brac/Tramtrack/Broad gene family, as the most central and connected gene in the NUE network...