BRI1

Summary

Gene Symbol: BRI1
Description: Leucine-rich receptor-like protein kinase family protein
Alias: ATBRI1, BIN1, BR INSENSITIVE 1, BRASSINOSTEROID INSENSITIVE 1, CABBAGE 2, CBB2, DWARF 2, DWF2, F23K16.30, F23K16_30, Leucine-rich receptor-like protein kinase family protein
Species: thale cress
Products:     BRI1

Top Publications

  1. Tanaka K, Asami T, Yoshida S, Nakamura Y, Matsuo T, Okamoto S. Brassinosteroid homeostasis in Arabidopsis is ensured by feedback expressions of multiple genes involved in its metabolism. Plant Physiol. 2005;138:1117-25 pubmed
    ..their response to fluctuation of BR levels was highly reduced (DWF4) or nullified (the other eight genes) in a bri1 mutant...
  2. Tang W, Kim T, Oses Prieto J, Sun Y, Deng Z, Zhu S, et al. BSKs mediate signal transduction from the receptor kinase BRI1 in Arabidopsis. Science. 2008;321:557-60 pubmed publisher
    Brassinosteroids (BRs) bind to the extracellular domain of the receptor kinase BRI1 to activate a signal transduction cascade that regulates nuclear gene expression and plant development...
  3. Oh M, Sun J, Oh D, Zielinski R, Clouse S, Huber S. Enhancing Arabidopsis leaf growth by engineering the BRASSINOSTEROID INSENSITIVE1 receptor kinase. Plant Physiol. 2011;157:120-31 pubmed publisher
    The BRASSINOSTEROID INSENSITIVE1 (BRI1) receptor kinase has recently been shown to possess tyrosine kinase activity, and preventing autophosphorylation of the tyrosine-831 regulatory site by site-directed mutagenesis enhances shoot growth...
  4. Xu W, Huang J, Li B, Li J, Wang Y. Is kinase activity essential for biological functions of BRI1?. Cell Res. 2008;18:472-8 pubmed publisher
    Brassinosteroids (BRs) are a major group of plant hormones that regulate plant growth and development. BRI1, a protein localized to the plasma membrane, functions as a BR receptor and it has been proposed that its kinase activity has an ..
  5. Wang X, Kota U, He K, Blackburn K, Li J, Goshe M, et al. Sequential transphosphorylation of the BRI1/BAK1 receptor kinase complex impacts early events in brassinosteroid signaling. Dev Cell. 2008;15:220-35 pubmed publisher
    Brassinosteroids (BRs) regulate plant development through a signal transduction pathway involving the BRI1 and BAK1 transmembrane receptor kinases...
  6. Jin H, Hong Z, Su W, Li J. A plant-specific calreticulin is a key retention factor for a defective brassinosteroid receptor in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2009;106:13612-7 pubmed publisher
    ..However, little is known about their physiological functions. Here we report ebs2 (EMS-mutagenized bri1 suppressor 2) as an allele-specific suppressor of bri1-9, a dwarf Arabidopsis mutant caused by retention of a ..
  7. Hothorn M, Belkhadir Y, Dreux M, Dabi T, Noel J, Wilson I, et al. Structural basis of steroid hormone perception by the receptor kinase BRI1. Nature. 2011;474:467-71 pubmed publisher
    ..Plants, however, perceive steroids at membranes, using the membrane-integral receptor kinase BRASSINOSTEROID INSENSITIVE 1 (BRI1)...
  8. Wang X, Goshe M, Soderblom E, Phinney B, Kuchar J, Li J, et al. Identification and functional analysis of in vivo phosphorylation sites of the Arabidopsis BRASSINOSTEROID-INSENSITIVE1 receptor kinase. Plant Cell. 2005;17:1685-703 pubmed
    ..BRs) regulate multiple aspects of plant growth and development and require an active BRASSINOSTEROID-INSENSITIVE1 (BRI1) and BRI1-ASSOCIATED RECEPTOR KINASE1 (BAK1) for hormone perception and signal transduction...
  9. Oh M, Wang X, Kota U, Goshe M, Clouse S, Huber S. Tyrosine phosphorylation of the BRI1 receptor kinase emerges as a component of brassinosteroid signaling in Arabidopsis. Proc Natl Acad Sci U S A. 2009;106:658-63 pubmed publisher
    ..repeat receptor-like kinases (LRR-RLKs) are involved in BR perception and signal transduction: brassinosteroid insensitive 1 (BRI1), which is the BR receptor, and its coreceptor BRI1-associated kinase 1 (BAK1)...

More Information

Publications72

  1. Wang X, Chory J. Brassinosteroids regulate dissociation of BKI1, a negative regulator of BRI1 signaling, from the plasma membrane. Science. 2006;313:1118-22 pubmed
    ..of plants, are perceived at the plasma membrane by a leucine-rich repeat receptor serine/threonine kinase called BRI1. We report a BRI1-interacting protein, BKI1, which is a negative regulator of brassinosteroid signaling...
  2. Li J, Wen J, Lease K, Doke J, Tax F, Walker J. BAK1, an Arabidopsis LRR receptor-like protein kinase, interacts with BRI1 and modulates brassinosteroid signaling. Cell. 2002;110:213-22 pubmed
    ..complex that includes the leucine-rich repeat receptor-like protein kinase (LRR-RLK) brassinosteroid-insensitive 1 (BRI1)...
  3. Nam K, Li J. BRI1/BAK1, a receptor kinase pair mediating brassinosteroid signaling. Cell. 2002;110:203-12 pubmed
    The Arabidopsis BAK1 (BRI1 Associated receptor Kinase 1) was identified by a yeast two-hybrid screen as a specific interactor for BRI1, a critical component of a membrane brassinosteroid (BR) receptor...
  4. Wang X, Li X, Meisenhelder J, Hunter T, Yoshida S, Asami T, et al. Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1. Dev Cell. 2005;8:855-65 pubmed
    The leucine-rich-repeat receptor serine/threonine kinase, BRI1, is a cell-surface receptor for brassinosteroids (BRs), the steroid hormones of plants, yet its activation mechanism is unknown...
  5. Kinoshita T, Caño Delgado A, Seto H, Hiranuma S, Fujioka S, Yoshida S, et al. Binding of brassinosteroids to the extracellular domain of plant receptor kinase BRI1. Nature. 2005;433:167-71 pubmed
    ..In plants, BRI1, a leucine-rich repeat (LRR) receptor kinase localized to the plasma membrane, is a critical component of a ..
  6. Kim T, Guan S, Burlingame A, Wang Z. The CDG1 kinase mediates brassinosteroid signal transduction from BRI1 receptor kinase to BSU1 phosphatase and GSK3-like kinase BIN2. Mol Cell. 2011;43:561-71 pubmed publisher
    The brassinosteroid (BR) signaling pathway includes two receptor-like kinases (BRI1 and BAK1), a plasma membrane-associated kinase (BSK1), two phosphatases (BSU1 and PP2A), a GSK3-like kinase (BIN2), and two homologous transcription ..
  7. Bücherl C, van Esse G, Kruis A, Luchtenberg J, Westphal A, Aker J, et al. Visualization of BRI1 and BAK1(SERK3) membrane receptor heterooligomers during brassinosteroid signaling. Plant Physiol. 2013;162:1911-25 pubmed publisher
    The leucine-rich repeat receptor-like kinase BRASSINOSTEROID-INSENSITIVE1 (BRI1) is the main ligand-perceiving receptor for brassinosteroids (BRs) in Arabidopsis (Arabidopsis thaliana)...
  8. Friedrichsen D, Joazeiro C, Li J, Hunter T, Chory J. Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase. Plant Physiol. 2000;123:1247-56 pubmed
    ..Screens for BR signaling mutants identified one locus, BRI1, which encodes a protein with homology to leucine-rich repeat receptor serine (Ser)/threonine (Thr) kinases...
  9. Sreeramulu S, Mostizky Y, Sunitha S, Shani E, Nahum H, Salomon D, et al. BSKs are partially redundant positive regulators of brassinosteroid signaling in Arabidopsis. Plant J. 2013;74:905-19 pubmed publisher
    ..In support of a redundant function in BR signaling, multiple BSKs interacted in vivo with the BR receptor BRI1, and served as its phosphorylation substrates in vitro...
  10. Li J, Chory J. A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. Cell. 1997;90:929-38 pubmed
    ..All 18 mutations define alleles of a single previously described gene, BRI1. We cloned BRI1 and examined its expression pattern. It encodes a ubiquitously expressed putative receptor kinase...
  11. Karlova R, Boeren S, Russinova E, Aker J, Vervoort J, de Vries S. The Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 protein complex includes BRASSINOSTEROID-INSENSITIVE1. Plant Cell. 2006;18:626-38 pubmed
    ..This approach identified two other LRR-RLKs, the BRASSINOSTEROID-INSENSITIVE1 (BRI1) receptor and its coreceptor, the SERK3 or BRI1-ASSOCIATED KINASE1 protein...
  12. He K, Gou X, Yuan T, Lin H, Asami T, Yoshida S, et al. BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell-death pathways. Curr Biol. 2007;17:1109-15 pubmed
    ..BRs are perceived by a protein complex containing two transmembrane receptor kinases, BRASSINOSTEROID INSENSITIVE 1 (BRI1) and BRI1-ASSOCIATED RECEPTOR KINASE 1 (BAK1) [1-3]...
  13. Karlova R, Boeren S, Van Dongen W, Kwaaitaal M, Aker J, Vervoort J, et al. Identification of in vitro phosphorylation sites in the Arabidopsis thaliana somatic embryogenesis receptor-like kinases. Proteomics. 2009;9:368-79 pubmed publisher
    ..consists of five leucine-rich repeat receptor-like kinases (LRR-RLKs) with diverse functions such as brassinosteroid insensitive 1 (BRI1)-mediated brassinosteroid perception, development and innate immunity...
  14. She J, Han Z, Kim T, Wang J, Cheng W, Chang J, et al. Structural insight into brassinosteroid perception by BRI1. Nature. 2011;474:472-6 pubmed publisher
    ..Perception of brassinosteroids requires an active complex of BRASSINOSTEROID-INSENSITIVE 1 (BRI1) and BRI1-ASSOCIATED KINASE 1 (BAK1)...
  15. Jaillais Y, Belkhadir Y, Balsemão Pires E, Dangl J, Chory J. Extracellular leucine-rich repeats as a platform for receptor/coreceptor complex formation. Proc Natl Acad Sci U S A. 2011;108:8503-7 pubmed publisher
    ..Here, we show that the extracellular LRR domain of BRI1-ASSOCIATED KINASE1 (BAK1), a coreceptor involved in the disparate processes of cell surface steroid signaling and ..
  16. Jaillais Y, Hothorn M, Belkhadir Y, Dabi T, NIMCHUK Z, Meyerowitz E, et al. Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase inhibitor. Genes Dev. 2011;25:232-7 pubmed publisher
    ..Recently, two Arabidopsis receptor kinases--BRASSINOSTEROID INSENSITIVE 1 (BRI1) and BRI1-ASSOCIATED KINASE1 (BAK1), the receptor and coreceptor for brassinosteroids--were ..
  17. Santiago J, Henzler C, Hothorn M. Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases. Science. 2013;341:889-92 pubmed publisher
    ..and development, are sensed by the leucine-rich repeat (LRR) domain of the membrane receptor kinase BRASSINOSTEROID INSENSITIVE 1 (BRI1), but it is unknown how steroid binding at the cell surface activates the cytoplasmic kinase ..
  18. Oh M, Wang X, Clouse S, Huber S. Deactivation of the Arabidopsis BRASSINOSTEROID INSENSITIVE 1 (BRI1) receptor kinase by autophosphorylation within the glycine-rich loop. Proc Natl Acad Sci U S A. 2012;109:327-32 pubmed publisher
    The activity of the dual-specificity receptor kinase, brassinosteroid insensitive 1 (BRI1), reflects the balance between phosphorylation-dependent activation and several potential mechanisms for deactivation of the receptor...
  19. Wheeler J, Wong A, Marondedze C, Groen A, Kwezi L, Freihat L, et al. The brassinosteroid receptor BRI1 can generate cGMP enabling cGMP-dependent downstream signaling. Plant J. 2017;91:590-600 pubmed publisher
    The brassinosteroid receptor brassinosteroid insensitive 1 (BRI1) is a member of the leucine-rich repeat receptor-like kinase family...
  20. Sun C, Yan K, Han J, Tao L, Lv M, Shi T, et al. Scanning for New BRI1 Mutations via TILLING Analysis. Plant Physiol. 2017;174:1881-1896 pubmed publisher
    ..BRASSINOSTEROID INSENSITIVE1 (BRI1), a multidomain transmembrane receptor-like kinase, is a major receptor of brassinosteroids in Arabidopsis (..
  21. Belkhadir Y, Durbak A, Wierzba M, Schmitz R, Aguirre A, Michel R, et al. Intragenic suppression of a trafficking-defective brassinosteroid receptor mutant in Arabidopsis. Genetics. 2010;185:1283-96 pubmed publisher
    The cell surface receptor kinase BRASSINOSTEROID-INSENSITIVE-1 (BRI1) is the major receptor for steroid hormones in Arabidopsis...
  22. Wang R, Liu M, Yuan M, Oses Prieto J, Cai X, Sun Y, et al. The Brassinosteroid-Activated BRI1 Receptor Kinase Is Switched off by Dephosphorylation Mediated by Cytoplasm-Localized PP2A B' Subunits. Mol Plant. 2016;9:148-157 pubmed publisher
    Brassinosteroid (BR) binding activates the receptor kinase BRI1 by inducing heterodimerization with its co-receptor kinase BAK1; however, the mechanisms that reversibly inactivate BRI1 remain unclear...
  23. Wang L, Li H, Lv X, Chen T, Li R, Xue Y, et al. Spatiotemporal Dynamics of the BRI1 Receptor and its Regulation by Membrane Microdomains in Living Arabidopsis Cells. Mol Plant. 2015;8:1334-49 pubmed publisher
    The major brassinosteroid (BR) receptor of Arabidopsis BRASSINOSTEROID INSENSITIVE1 (BRI1) plays fundamental roles in BR signaling, but the molecular mechanisms underlying the effects of BR on BRI1 internalization and assembly state ..
  24. Oh M, Kim H, Wu X, Clouse S, Zielinski R, Huber S. Calcium/calmodulin inhibition of the Arabidopsis BRASSINOSTEROID-INSENSITIVE 1 receptor kinase provides a possible link between calcium and brassinosteroid signalling. Biochem J. 2012;443:515-23 pubmed publisher
    The receptor kinase BRI1 (BRASSINOSTEROID-INSENSITIVE 1) is a key component in BR (brassinosteroid) perception and signal transduction, and has a broad impact on plant growth and development...
  25. Kim S, Kim B, Lim C, Lim C, Nam K. Constitutive activation of stress-inducible genes in a brassinosteroid-insensitive 1 (bri1) mutant results in higher tolerance to cold. Physiol Plant. 2010;138:191-204 pubmed publisher
    ..plant overcome the cold condition only when pretreated with less than 1 nM, and the brassinosteroid-insensitive 1 (bri1) mutation, which results in defective BR signaling and subsequent dwarfism, generates an increased tolerance to ..
  26. Wang J, Jiang J, Wang J, Chen L, Fan S, Wu J, et al. Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1. Cell Res. 2014;24:1328-41 pubmed publisher
    ..BRs are perceived by the cell-surface receptor-like kinase brassinosteroid insensitive 1 (BRI1)...
  27. Jung C, Hwang S, Park Y, Park H, Kim D, Park D, et al. Molecular characterization of the cold- and heat-induced Arabidopsis PXL1 gene and its potential role in transduction pathways under temperature fluctuations. J Plant Physiol. 2015;176:138-46 pubmed publisher
    ..These results provide an insight into the molecular function of AtPXL1 in the regulation of signal transduction pathways under temperature fluctuations. ..
  28. van Esse G, van Mourik S, Stigter H, Ten Hove C, Molenaar J, de Vries S. A mathematical model for BRASSINOSTEROID INSENSITIVE1-mediated signaling in root growth and hypocotyl elongation. Plant Physiol. 2012;160:523-32 pubmed publisher
    ..In Arabidopsis (Arabidopsis thaliana), BRs are perceived by the BRASSINOSTEROID INSENSITIVE1 (BRI1) receptor. Root growth and hypocotyl elongation are convenient downstream physiological outputs of BR signaling...
  29. Zhao B, Lv M, Feng Z, Campbell T, Liscum E, Li J. TWISTED DWARF 1 Associates with BRASSINOSTEROID-INSENSITIVE 1 to Regulate Early Events of the Brassinosteroid Signaling Pathway. Mol Plant. 2016;9:582-92 pubmed publisher
    A genome-wide screen for mutants showing altered brassinosteroid (BR) sensitivity or bri1-like phenotypes resulted in the identification of two new mutant alleles of TWISTED DWARF 1 (TWD1), twd1-4, and twd1-5...
  30. Wolf S, van der Does D, Ladwig F, Sticht C, Kolbeck A, Schürholz A, et al. A receptor-like protein mediates the response to pectin modification by activating brassinosteroid signaling. Proc Natl Acad Sci U S A. 2014;111:15261-6 pubmed publisher
    ..These findings corroborate a role for BR in controlling the sensitivity of a feedback signaling module involved in maintaining the physico-chemical homeostasis of the cell wall during cell expansion. ..
  31. van Esse G, Harter K, de Vries S. Computational modelling of the BRI1 receptor system. Plant Cell Environ. 2013;36:1728-37 pubmed publisher
    ..The brassinosteroid insensitive 1 (BRI1) receptor is one of the best-understood receptor systems in Arabidopsis with clearly described ..
  32. Hong Z, Kajiura H, Su W, Jin H, Kimura A, Fujiyama K, et al. Evolutionarily conserved glycan signal to degrade aberrant brassinosteroid receptors in Arabidopsis. Proc Natl Acad Sci U S A. 2012;109:11437-42 pubmed publisher
    ..Here, we show that a missense mutation in the Arabidopsis EMS-mutagenized bri1 suppressor 3 (EBS3) gene suppresses a dwarf mutant, bri1-9, the phenotypes of which are caused by ER retention and ..
  33. Song L, Shi Q, Yang X, Xu Z, Xue H. Membrane steroid-binding protein 1 (MSBP1) negatively regulates brassinosteroid signaling by enhancing the endocytosis of BAK1. Cell Res. 2009;19:864-76 pubmed publisher
    ..The transmembrane receptor BRI1 can directly bind to brassinolide (BL), and BAK1 interacts with BRI1 to enhance the BRI1-mediated BR signaling...
  34. Shang Y, Lee M, Li J, Nam K. Characterization of cp3 reveals a new bri1 allele, bri1-120, and the importance of the LRR domain of BRI1 mediating BR signaling. BMC Plant Biol. 2011;11:8 pubmed publisher
    Since the identification of BRI1 (BRASSINOSTEROID-INSENSITIVE1), a brassinosteroids (BRs) receptor, most of the critical roles of BR in plant development have been assessed using various bri1 mutant alleles...
  35. Hüttner S, Veit C, Schoberer J, Grass J, Strasser R. Unraveling the function of Arabidopsis thaliana OS9 in the endoplasmic reticulum-associated degradation of glycoproteins. Plant Mol Biol. 2012;79:21-33 pubmed publisher
    ..An A. thaliana OS9 loss-of-function line suppresses the severe growth phenotype of the bri1-5 and bri1-9 mutant plants, which harbour mutated forms of the brassinosteroid receptor BRI1...
  36. Wang Y, Li Z, Liu D, Xu J, Wei X, Yan L, et al. Assessment of BAK1 activity in different plant receptor-like kinase complexes by quantitative profiling of phosphorylation patterns. J Proteomics. 2014;108:484-93 pubmed publisher
    ..b>BRI1-ASSOCIATED KINASE 1 (BAK1), a member of the plant RLK family, forms receptor complexes with multiple RLK proteins ..
  37. Hategan L, Godza B, Kozma Bognar L, Bishop G, Szekeres M. Differential expression of the brassinosteroid receptor-encoding BRI1 gene in Arabidopsis. Planta. 2014;239:989-1001 pubmed publisher
    Brassinosteroid (BR)-regulated growth and development in Arabidopsis depends on BRASSINOSTEROID INSENSITIVE 1 (BRI1), the BR receptor that is responsible for initiating the events of BR signalling...
  38. Chaiwanon J, Garcia V, Cartwright H, Sun Y, Wang Z. Immunophilin-like FKBP42/TWISTED DWARF1 Interacts with the Receptor Kinase BRI1 to Regulate Brassinosteroid Signaling in Arabidopsis. Mol Plant. 2016;9:593-600 pubmed publisher
    ..vitro and in vivo assays showed that TWD1 interacts physically with the kinase domains of the BR receptor kinases BRI1 and BAK1...
  39. Schwessinger B, Roux M, Kadota Y, Ntoukakis V, Sklenar J, Jones A, et al. Phosphorylation-dependent differential regulation of plant growth, cell death, and innate immunity by the regulatory receptor-like kinase BAK1. PLoS Genet. 2011;7:e1002046 pubmed publisher
    ..We also show that, in contrast to the RD kinase BRI1, the non-RD kinases FLS2 and EFR have very low kinase activity, and we show that neither was able to trans-..
  40. Gonzalez N, De Bodt S, Sulpice R, Jikumaru Y, Chae E, Dhondt S, et al. Increased leaf size: different means to an end. Plant Physiol. 2010;153:1261-79 pubmed publisher
    ..belonging to different functional classes that all positively affect leaf size when overexpressed: AVP1, GRF5, JAW, BRI1, and GA20OX1...
  41. Martins S, Dohmann E, Cayrel A, Johnson A, Fischer W, Pojer F, et al. Internalization and vacuolar targeting of the brassinosteroid hormone receptor BRI1 are regulated by ubiquitination. Nat Commun. 2015;6:6151 pubmed publisher
    ..growth and development, and are perceived at the cell surface by the plasma membrane-localized receptor kinase BRI1. Here we show that BRI1 is post-translationally modified by K63 polyubiquitin chains in vivo...
  42. Li L, Yu X, Thompson A, Guo M, Yoshida S, Asami T, et al. Arabidopsis MYB30 is a direct target of BES1 and cooperates with BES1 to regulate brassinosteroid-induced gene expression. Plant J. 2009;58:275-86 pubmed publisher
    ..BRs signal through the BES1/BZR1 (bri1-Ethylmethane Sulphonate suppressor 1/brassinazole-resistant 1) family of transcription factors, which regulate ..
  43. Kleine Vehn J, Leitner J, Zwiewka M, Sauer M, Abas L, Luschnig C, et al. Differential degradation of PIN2 auxin efflux carrier by retromer-dependent vacuolar targeting. Proc Natl Acad Sci U S A. 2008;105:17812-7 pubmed publisher
  44. Sun Y, Han Z, Tang J, Hu Z, Chai C, Zhou B, et al. Structure reveals that BAK1 as a co-receptor recognizes the BRI1-bound brassinolide. Cell Res. 2013;23:1326-9 pubmed publisher
  45. Albrecht C, Boutrot F, Segonzac C, Schwessinger B, Gimenez Ibanez S, Chinchilla D, et al. Brassinosteroids inhibit pathogen-associated molecular pattern-triggered immune signaling independent of the receptor kinase BAK1. Proc Natl Acad Sci U S A. 2012;109:303-8 pubmed publisher
    ..the LRR-RLKs FLS2 and EFR in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and the LRR-RLK BRI1 in brassinosteroid (BR)-mediated growth...
  46. Bücherl C, Jarsch I, Schudoma C, Segonzac C, Mbengue M, Robatzek S, et al. Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains. elife. 2017;6: pubmed publisher
    ..In plants, prominent examples are the receptor kinases FLS2 and BRI1, which activate immunity and steroid-mediated growth, respectively...
  47. Wilma van Esse G, Westphal A, Surendran R, Albrecht C, van Veen B, Borst J, et al. Quantification of the brassinosteroid insensitive1 receptor in planta. Plant Physiol. 2011;156:1691-700 pubmed publisher
    ..As a proof of principle, we quantified the Brassinosteroid Insensitive1 (BRI1) receptor fused to GFP, under control of its own promoter...
  48. Lin W, Lu D, Gao X, Jiang S, Ma X, Wang Z, et al. Inverse modulation of plant immune and brassinosteroid signaling pathways by the receptor-like cytoplasmic kinase BIK1. Proc Natl Acad Sci U S A. 2013;110:12114-9 pubmed publisher
    ..receptor-like kinase BAK1 complexes with the receptor kinases FLS2 in bacterial flagellin-triggered immunity and BRI1 in brassinosteroid (BR)-mediated growth...
  49. Ivashikina N, Deeken R, Ache P, Kranz E, Pommerrenig B, Sauer N, et al. Isolation of AtSUC2 promoter-GFP-marked companion cells for patch-clamp studies and expression profiling. Plant J. 2003;36:931-45 pubmed
    ..These two dominant phloem K+ channel types provide a versatile mechanism to mediate K+ fluxes required for phloem action and potassium cycling. ..
  50. Yun H, Bae Y, Lee Y, Chang S, Kim S, Li J, et al. Analysis of phosphorylation of the BRI1/BAK1 complex in arabidopsis reveals amino acid residues critical for receptor formation and activation of BR signaling. Mol Cells. 2009;27:183-90 pubmed publisher
    The plasma membrane-localized BRASSINOSTEROID-INSENSITIVE1 (BRI1) and BRI1-ASSOCIATED KINASE1 (BAK1) are a well-known receptor pair involved in brassinosteroids (BR) signaling in Arabidposis...
  51. Witthöft J, Caesar K, Elgass K, Huppenberger P, Kilian J, Schleifenbaum F, et al. The activation of the Arabidopsis P-ATPase 1 by the brassinosteroid receptor BRI1 is independent of threonine 948 phosphorylation. Plant Signal Behav. 2011;6:1063-6 pubmed
    The plasma membrane-spanning receptor brassinosteroid insenstive 1 (BRI1) rapidly induces plant cell wall expansion in response to brassinosteroids such as brassinolide (BL)...
  52. van Esse W, van Mourik S, Albrecht C, van Leeuwen J, de Vries S. A mathematical model for the coreceptors SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 and SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE3 in BRASSINOSTEROID INSENSITIVE1-mediated signaling. Plant Physiol. 2013;163:1472-81 pubmed publisher
    ..The main BR-perceiving receptor in Arabidopsis (Arabidopsis thaliana) is BRASSINOSTEROID INSENSITIVE1 (BRI1)...
  53. Di Rubbo S, Irani N, Kim S, Xu Z, Gadeyne A, Dejonghe W, et al. The clathrin adaptor complex AP-2 mediates endocytosis of brassinosteroid insensitive1 in Arabidopsis. Plant Cell. 2013;25:2986-97 pubmed publisher
    ..Furthermore, endocytosis of the leucine-rich repeat receptor kinase, brassinosteroid insensitive1 (BRI1), was shown to depend on AP-2...
  54. Domagalska M, Schomburg F, Amasino R, Vierstra R, Nagy F, Davis S. Attenuation of brassinosteroid signaling enhances FLC expression and delays flowering. Development. 2007;134:2841-50 pubmed
    ..We isolated two alleles of brassinosteroid-insensitive 1 (bri1) as enhancers of the late-flowering autonomous-pathway mutant luminidependens (ld)...
  55. Ding Z, Wang H, Liang X, Morris E, Gallazzi F, Pandit S, et al. Phosphoprotein and phosphopeptide interactions with the FHA domain from Arabidopsis kinase-associated protein phosphatase. Biochemistry. 2007;46:2684-96 pubmed
    ..The brassinosteroid receptor BRI1 and KAPP are shown to associate in vivo and in vitro...
  56. Anne P, Azzopardi M, Gissot L, Beaubiat S, Hématy K, Palauqui J. OCTOPUS Negatively Regulates BIN2 to Control Phloem Differentiation in Arabidopsis thaliana. Curr Biol. 2015;25:2584-90 pubmed publisher
    ..Together, our data show that OPS antagonizes BIN2 to promote phloem differentiation. ..
  57. Ye Q, Zhu W, Li L, Zhang S, Yin Y, Ma H, et al. Brassinosteroids control male fertility by regulating the expression of key genes involved in Arabidopsis anther and pollen development. Proc Natl Acad Sci U S A. 2010;107:6100-5 pubmed publisher
    ..Our work provides a unique mechanism to explain how a phytohormone regulates an essential genetic program for plant development. ..
  58. Kir G, Ye H, Nelissen H, Neelakandan A, Kusnandar A, Luo A, et al. RNA Interference Knockdown of BRASSINOSTEROID INSENSITIVE1 in Maize Reveals Novel Functions for Brassinosteroid Signaling in Controlling Plant Architecture. Plant Physiol. 2015;169:826-39 pubmed publisher
    ..BRASSINOSTEROID INSENSITIVE1 (BRI1) is a BR receptor, and database searches and additional genomic sequencing identified five maize homologs including ..
  59. Shang Y, Dai C, Lee M, Kwak J, Nam K. BRI1-Associated Receptor Kinase 1 Regulates Guard Cell ABA Signaling Mediated by Open Stomata 1 in Arabidopsis. Mol Plant. 2016;9:447-460 pubmed publisher
    ..Taken together, our results suggest that BAK1 regulates ABA-induced stomatal closure in guard cells. ..
  60. Ye H, Li L, Guo H, Yin Y. MYBL2 is a substrate of GSK3-like kinase BIN2 and acts as a corepressor of BES1 in brassinosteroid signaling pathway in Arabidopsis. Proc Natl Acad Sci U S A. 2012;109:20142-7 pubmed publisher
    ..BRs signal through plasma membrane-localized receptor kinase brassinosteroid-insensitive 1 (BRI1), BRI1-associated receptor kinase (BAK1), and several intermediates to regulate the protein levels, cellular ..
  61. Liu Y, Zhang C, Wang D, Su W, Liu L, Wang M, et al. EBS7 is a plant-specific component of a highly conserved endoplasmic reticulum-associated degradation system in Arabidopsis. Proc Natl Acad Sci U S A. 2015;112:12205-10 pubmed publisher
    ..Loss-of-function ebs7 mutations prevent ERAD of brassinosteroid insensitive 1-9 (bri1-9) and bri1-5, two ER-retained mutant variants of the cell-surface receptor for ..
  62. Nam K, Li J. The Arabidopsis transthyretin-like protein is a potential substrate of BRASSINOSTEROID-INSENSITIVE 1. Plant Cell. 2004;16:2406-17 pubmed
    BRASSINOSTEROID-INSENSITIVE 1 (BRI1) is a Leu-rich-repeat (LRR) receptor kinase that functions as a critical component of a transmembrane brassinosteroid (BR) receptor...
  63. Russinova E, Borst J, Kwaaitaal M, Caño Delgado A, Yin Y, Chory J, et al. Heterodimerization and endocytosis of Arabidopsis brassinosteroid receptors BRI1 and AtSERK3 (BAK1). Plant Cell. 2004;16:3216-29 pubmed
    ..BR), perception is mediated by two Leu-rich repeat receptor-like kinases, BRASSINOSTEROID INSENSITIVE1 (BRI1) and BRI1-ASSOCIATED RECEPTOR KINASE1 (BAK1) (Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR-like KINASE3 [AtSERK3])...