Description: homeobox knotted-like protein
Alias: BP1, BREVIPEDICELLUS, BREVIPEDICELLUS 1, F9M13.2, F9M13_2, KNOTTED-LIKE HOMEOBOX PROTEIN, KNOTTED-like from Arabidopsis thaliana, homeobox knotted-like protein
Species: thale cress

Top Publications

  1. Smith H, Hake S. The interaction of two homeobox genes, BREVIPEDICELLUS and PENNYWISE, regulates internode patterning in the Arabidopsis inflorescence. Plant Cell. 2003;15:1717-27 pubmed one of the Arabidopsis BELL genes, PENNYWISE (PNY), that appears phenotypically similar to the KNOX mutant brevipedicellus (bp)...
  2. Kanrar S, Onguka O, Smith H. Arabidopsis inflorescence architecture requires the activities of KNOX-BELL homeodomain heterodimers. Planta. 2006;224:1163-73 pubmed
    ..studies show that PNY associates with the knotted1-like homeobox (KNOX) proteins, SHOOTMERISTEMLESS (STM) and BREVIPEDICELLUS (BP)...
  3. Douglas S, Riggs C. Pedicel development in Arabidopsis thaliana: contribution of vascular positioning and the role of the BREVIPEDICELLUS and ERECTA genes. Dev Biol. 2005;284:451-63 pubmed
    ..Distal pedicel growth is controlled by the KNOTTED1-like homeobox gene BREVIPEDICELLUS (BP), as 35S::BP plants show excessive proliferation of pedicel tissue, while loss of BP conditions a radial ..
  4. Kumar R, Kushalappa K, Godt D, Pidkowich M, Pastorelli S, Hepworth S, et al. The Arabidopsis BEL1-LIKE HOMEODOMAIN proteins SAW1 and SAW2 act redundantly to regulate KNOX expression spatially in leaf margins. Plant Cell. 2007;19:2719-35 pubmed
    ..complexes with the Class 1 KNOX TALE homeodomain proteins, including SHOOTMERISTEMLESS (STM) and BREVIPEDICELLUS (BP)...
  5. Lincoln C, Long J, Yamaguchi J, Serikawa K, Hake S. A knotted1-like homeobox gene in Arabidopsis is expressed in the vegetative meristem and dramatically alters leaf morphology when overexpressed in transgenic plants. Plant Cell. 1994;6:1859-76 pubmed
    ..The expression pattern of KNAT1 in the shoot meristem combined with the results of transgenic overexpression experiments supports the hypothesis that class 1 kn1-like genes play a role in morphogenesis. ..
  6. Bellaoui M, Pidkowich M, Samach A, Kushalappa K, Kohalmi S, Modrusan Z, et al. The Arabidopsis BELL1 and KNOX TALE homeodomain proteins interact through a domain conserved between plants and animals. Plant Cell. 2001;13:2455-70 pubmed
    ..Finally, overlapping patterns of BEL1 and SHOOT MERISTEMLESS (STM) expression within the inflorescence meristem suggest a role for the BEL1-STM complex in maintaining the indeterminacy of the inflorescence meristem. ..
  7. Ragni L, Belles Boix E, Günl M, Pautot V. Interaction of KNAT6 and KNAT2 with BREVIPEDICELLUS and PENNYWISE in Arabidopsis inflorescences. Plant Cell. 2008;20:888-900 pubmed publisher
    ..development, we examined their interactions with two TALE genes that regulate internode patterning, BREVIPEDICELLUS (BP) and PENNYWISE (PNY)...
  8. Venglat S, Dumonceaux T, Rozwadowski K, Parnell L, Babic V, Keller W, et al. The homeobox gene BREVIPEDICELLUS is a key regulator of inflorescence architecture in Arabidopsis. Proc Natl Acad Sci U S A. 2002;99:4730-5 pubmed
    ..However, very little is known about the genes or the pathways that regulate pedicel development. The brevipedicellus (bp) mutant of Arabidopsis thaliana displays a unique phenotype with defects in pedicel development causing ..
  9. Cole M, Nolte C, Werr W. Nuclear import of the transcription factor SHOOT MERISTEMLESS depends on heterodimerization with BLH proteins expressed in discrete sub-domains of the shoot apical meristem of Arabidopsis thaliana. Nucleic Acids Res. 2006;34:1281-92 pubmed
    ..These results contribute to our understanding of the STM transcription factor function in the SAM and also shed new light on the evolution of the TALE-HD super gene family in animal and plant lineages. ..

More Information


  1. Bhatt A, Etchells J, Canales C, Lagodienko A, Dickinson H. VAAMANA--a BEL1-like homeodomain protein, interacts with KNOX proteins BP and STM and regulates inflorescence stem growth in Arabidopsis. Gene. 2004;328:103-11 pubmed
    ..VAN interacts specifically with the class I KNOX proteins SHOOTMERISTEMLESS (STM), BREVIPEDICELLUS (BP), and KNAT6 (K6), and nuclear localisation of a VAN-GFP fusion depends on co-expression of STM or BP in ..
  2. Douglas S, Li B, Kliebenstein D, Nambara E, Riggs C. A novel Filamentous Flower mutant suppresses brevipedicellus developmental defects and modulates glucosinolate and auxin levels. PLoS ONE. 2017;12:e0177045 pubmed publisher
    b>BREVIPEDICELLUS (BP) encodes a class-I KNOTTED1-like homeobox (KNOX) transcription factor that plays a critical role in conditioning a replication competent state in the apical meristem, and it also governs growth and cellular ..
  3. Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, et al. Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events. Plant J. 2010;61:70-82 pubmed publisher
    ..These features must, therefore, be controlled by other genes in which expression is enhanced in the as1 and as2 mutants. ..
  4. Shi C, Stenvik G, Vie A, Bones A, Pautot V, Proveniers M, et al. Arabidopsis class I KNOTTED-like homeobox proteins act downstream in the IDA-HAE/HSL2 floral abscission signaling pathway. Plant Cell. 2011;23:2553-67 pubmed publisher
    ..organ abscission in ida mutants, we identified three new mutant alleles of the KNOTTED-LIKE HOMEOBOX gene BREVIPEDICELLUS (BP)/KNOTTED-LIKE FROM ARABIDOPSIS THALIANA1 (KNAT1)...
  5. Zhao M, Yang S, Chen C, Li C, Shan W, Lu W, et al. Arabidopsis BREVIPEDICELLUS interacts with the SWI2/SNF2 chromatin remodeling ATPase BRAHMA to regulate KNAT2 and KNAT6 expression in control of inflorescence architecture. PLoS Genet. 2015;11:e1005125 pubmed publisher
    b>BREVIPEDICELLUS (BP or KNAT1), a class-I KNOTTED1-like homeobox (KNOX) transcription factor in Arabidopsis thaliana, contributes to shaping the normal inflorescence architecture through negatively regulating other two class-I KNOX genes, ..
  6. Li Y, Pi L, Huang H, Xu L. ATH1 and KNAT2 proteins act together in regulation of plant inflorescence architecture. J Exp Bot. 2012;63:1423-33 pubmed publisher
    ..Previous studies have revealed that the class-I KNOTTED1-like homeobox (KNOX) genes BREVIPEDICELLUS (BP or KNAT1), KNAT2, and KNAT6 play essential roles in inflorescence architecture...
  7. Qi B, Zheng H. Modulation of root-skewing responses by KNAT1 in Arabidopsis thaliana. Plant J. 2013;76:380-92 pubmed publisher
    ..Together, these results demonstrate that KNAT1 negatively modulates root skewing, possibly by regulating auxin transport...
  8. Ding L, Yan S, Jiang L, Zhao W, Ning K, Zhao J, et al. HANABA TARANU (HAN) Bridges Meristem and Organ Primordia Boundaries through PINHEAD, JAGGED, BLADE-ON-PETIOLE2 and CYTOKININ OXIDASE 3 during Flower Development in Arabidopsis. PLoS Genet. 2015;11:e1005479 pubmed publisher to explore interactions between the boundary gene HANABA TARANU (HAN) and two meristem regulators BREVIPEDICELLUS (BP) and PINHEAD (PNH), and three primordia-specific genes PETAL LOSS (PTL), JAGGED (JAG) and BLADE-ON-..
  9. Furumizu C, Alvarez J, Sakakibara K, Bowman J. Antagonistic roles for KNOX1 and KNOX2 genes in patterning the land plant body plan following an ancient gene duplication. PLoS Genet. 2015;11:e1004980 pubmed publisher
  10. Truernit E, Haseloff J. Arabidopsis thaliana outer ovule integument morphogenesis: ectopic expression of KNAT1 reveals a compensation mechanism. BMC Plant Biol. 2008;8:35 pubmed publisher
    ..This work provides new insights into its development and opens new possibilities for the identification of factors involved in the regulation of cell division and elongation during plant organ growth. ..
  11. Lodha M, Marco C, Timmermans M. The ASYMMETRIC LEAVES complex maintains repression of KNOX homeobox genes via direct recruitment of Polycomb-repressive complex2. Genes Dev. 2013;27:596-601 pubmed publisher
    ..ASYMMETRIC LEAVES complex physically interacts with PRC2 and recruits this complex to the homeobox genes BREVIPEDICELLUS and KNAT2 to stably silence these stem cell regulators in differentiating leaves...
  12. Scofield S, Dewitte W, Nieuwland J, Murray J. The Arabidopsis homeobox gene SHOOT MERISTEMLESS has cellular and meristem-organisational roles with differential requirements for cytokinin and CYCD3 activity. Plant J. 2013;75:53-66 pubmed publisher
    ..We propose that STM has dual cellular and meristem-organisational functions that are differentially represented in the class-1 KNOX gene family and have differing requirements for CK and CYCD3. ..
  13. Li Z, Li B, Liu J, Guo Z, Liu Y, Li Y, et al. Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis. J Integr Plant Biol. 2016;58:959-970 pubmed publisher
    ..establish the H3K27me3 modification at the chromatin regions of Class-I KNOTTED1-like homeobox (KNOX) genes BREVIPEDICELLUS and KNAT2 via direct interactions with LHP1...
  14. Xu X, Wang J, Xuan Z, Goldshmidt A, Borrill P, Hariharan N, et al. Chaperonins facilitate KNOTTED1 cell-to-cell trafficking and stem cell function. Science. 2011;333:1141-4 pubmed publisher
    ..Our study shows that chaperonins are essential for the cell-to-cell trafficking of a subset of mobile transcription factors and demonstrates the importance of chaperonin-dependent protein trafficking for plant stem cell function...
  15. Marsch Martinez N, Zúñiga Mayo V, Herrera Ubaldo H, Ouwerkerk P, Pablo Villa J, Lozano Sotomayor P, et al. The NTT transcription factor promotes replum development in Arabidopsis fruits. Plant J. 2014;80:69-81 pubmed publisher
    ..Moreover, its genetic interactions provide further evidence about its biological relevance in replum development. ..
  16. Liebsch D, Sunaryo W, Holmlund M, Norberg M, Zhang J, Hall H, et al. Class I KNOX transcription factors promote differentiation of cambial derivatives into xylem fibers in the Arabidopsis hypocotyl. Development. 2014;141:4311-9 pubmed publisher
    ..Together, these data indicate that, in the cambium, KNAT1 and STM, contrary to their function in the shoot apical meristem, promote cell differentiation through repression of BOP genes. ..
  17. Etchells J, Moore L, Jiang W, Prescott H, Capper R, Saunders N, et al. A role for BELLRINGER in cell wall development is supported by loss-of-function phenotypes. BMC Plant Biol. 2012;12:212 pubmed publisher
    ..and gene expression in a series of plants over-expressing BLR, and generating combinatorial mutants with blr, brevipedicellus (bp), a member of the KNOX1 family of transcription factors that has previously been shown to interact with ..