Gene Symbol: BIK1
Description: botrytis-induced kinase1
Alias: F12L6.32, F12L6_32, botrytis-induced kinase1, botrytis-induced kinase1
Species: thale cress

Top Publications

  1. Li L, Li M, Yu L, Zhou Z, Liang X, Liu Z, et al. The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity. Cell Host Microbe. 2014;15:329-38 pubmed publisher
    ..Here we show that the receptor-like cytoplasmic kinase BIK1, a component of the FLS2 immune receptor complex, not only positively regulates flg22-triggered calcium influx but ..
  2. Zhang J, Li W, Xiang T, Liu Z, Laluk K, Ding X, et al. Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host Microbe. 2010;7:290-301 pubmed publisher
    ..plants lacking RPS5, we find that AvrPphB can inhibit PTI by cleaving additional PBS1-like (PBL) kinases, including BIK1, PBL1, and PBL2...
  3. Feng F, Yang F, Rong W, Wu X, Zhang J, Chen S, et al. A Xanthomonas uridine 5'-monophosphate transferase inhibits plant immune kinases. Nature. 2012;485:114-8 pubmed publisher
    ..type III effector AvrAC enhances virulence and inhibits plant immunity by specifically targeting Arabidopsis BIK1 and RIPK, two receptor-like cytoplasmic kinases known to mediate immune signalling...
  4. Liu Z, Wu Y, Yang F, Zhang Y, Chen S, Xie Q, et al. BIK1 interacts with PEPRs to mediate ethylene-induced immunity. Proc Natl Acad Sci U S A. 2013;110:6205-10 pubmed publisher
    ..Here we show that PEPR1 specifically interacts with receptor-like cytoplasmic kinases botrytis-induced kinase 1 (BIK1) and PBS1-like 1 (PBL1) to mediate Pep1-induced defenses...
  5. Lin W, Lu D, Gao X, Jiang S, Ma X, Wang Z, et al. Inverse modulation of plant immune and brassinosteroid signaling pathways by the receptor-like cytoplasmic kinase BIK1. Proc Natl Acad Sci U S A. 2013;110:12114-9 pubmed publisher
    ..We have shown previously that BIK1, a receptor-like cytoplasmic kinase, is directly phosphorylated by BAK1 and associates with FLS2/BAK1 complex in ..
  6. Lu D, Wu S, Gao X, Zhang Y, Shan L, He P. A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity. Proc Natl Acad Sci U S A. 2010;107:496-501 pubmed publisher
    ..Here we identified the receptor-like cytoplasmic kinase BIK1 that is rapidly phosphorylated upon flagellin perception, depending on both FLS2 and BAK1...
  7. Laluk K, Luo H, Chai M, Dhawan R, Lai Z, Mengiste T. Biochemical and genetic requirements for function of the immune response regulator BOTRYTIS-INDUCED KINASE1 in plant growth, ethylene signaling, and PAMP-triggered immunity in Arabidopsis. Plant Cell. 2011;23:2831-49 pubmed publisher
    Arabidopsis thaliana BOTRYTIS-INDUCED KINASE1 (BIK1) regulates immune responses to a distinct class of pathogens. Here, mechanisms underlying BIK1 function and its interactions with other immune response regulators were determined...
  8. Lin W, Li B, Lu D, Chen S, Zhu N, He P, et al. Tyrosine phosphorylation of protein kinase complex BAK1/BIK1 mediates Arabidopsis innate immunity. Proc Natl Acad Sci U S A. 2014;111:3632-7 pubmed publisher
    ..2 and brassinosteroid insensitive 1-associated kinase 1 (BAK1), interact with RLCK Botrytis-induced kinase 1 (BIK1) to initiate plant immune responses to bacterial flagellin...
  9. Kadota Y, Sklenar J, Derbyshire P, Stransfeld L, Asai S, Ntoukakis V, et al. Direct regulation of the NADPH oxidase RBOHD by the PRR-associated kinase BIK1 during plant immunity. Mol Cell. 2014;54:43-55 pubmed publisher
    ..The plasma-membrane-associated kinase BIK1, which is a direct substrate of the PRR complex, directly interacts with and phosphorylates RBOHD upon PAMP ..

More Information


  1. Lu D, Wu S, He P, Shan L. Phosphorylation of receptor-like cytoplasmic kinases by bacterial flagellin. Plant Signal Behav. 2010;5:598-600 pubmed publisher
    ..We recently identified a receptor-like cytoplasmic kinase (RLCK) BIK1 that associates with flagellin receptor complex to initiate plant innate immunity...
  2. Ranf S, Eschen Lippold L, Fröhlich K, Westphal L, Scheel D, Lee J. Microbe-associated molecular pattern-induced calcium signaling requires the receptor-like cytoplasmic kinases, PBL1 and BIK1. BMC Plant Biol. 2014;14:374 pubmed publisher
    ..Validation with T-DNA mutants revealed that, besides PBL1, another RLCK, Botrytis-induced kinase 1 (BIK1), is also required for MAMP/DAMP-induced calcium elevations...
  3. Liu J, Chen S, Chen L, Zhou Q, Wang M, Feng D, et al. BIK1 cooperates with BAK1 to regulate constitutive immunity and cell death in Arabidopsis. J Integr Plant Biol. 2017;59:234-239 pubmed publisher
    ..both the membrane-anchored receptor-like kinase (RLK) BAK1 and the receptor-like cytoplasmic kinase (RLCK) BIK1 are important mediators of transmembrane signal transduction that regulate plant development and immunity...
  4. Monaghan J, Matschi S, Shorinola O, Rovenich H, Matei A, Segonzac C, et al. The calcium-dependent protein kinase CPK28 buffers plant immunity and regulates BIK1 turnover. Cell Host Microbe. 2014;16:605-15 pubmed publisher
    ..CPK28 interacts with and phosphorylates the plasma-membrane-associated cytoplasmic kinase BIK1, an important convergent substrate of multiple pattern recognition receptor (PRR) complexes...
  5. Kang G, Son S, Cho Y, Yoo S. Regulatory role of BOTRYTIS INDUCED KINASE1 in ETHYLENE INSENSITIVE3-dependent gene expression in Arabidopsis. Plant Cell Rep. 2015;34:1605-14 pubmed publisher
    ..b>BOTRYTIS INDUCED KINASE1 (BIK1) is a multifunctional receptor-like kinase that involves in ethylene-mediated plant defense ..
  6. Monaghan J, Matschi S, Romeis T, Zipfel C. The calcium-dependent protein kinase CPK28 negatively regulates the BIK1-mediated PAMP-induced calcium burst. Plant Signal Behav. 2015;10:e1018497 pubmed publisher
    ..The Arabidopsis plasma membrane-associated cytoplasmic kinase BIK1 is an immediate convergent substrate of multiple surface-localized immune receptors that is genetically required ..
  7. Cao Y, Aceti D, Sabat G, Song J, Makino S, Fox B, et al. Mutations in FLS2 Ser-938 dissect signaling activation in FLS2-mediated Arabidopsis immunity. PLoS Pathog. 2013;9:e1003313 pubmed publisher
    ..Previous work has shown that after flg22 binding, FLS2 releases BIK1 kinase and homologs and associates with BAK1 kinase, and that FLS2 kinase activity is critical for FLS2 function...
  8. Couto D, Niebergall R, Liang X, Bücherl C, Sklenar J, Macho A, et al. The Arabidopsis Protein Phosphatase PP2C38 Negatively Regulates the Central Immune Kinase BIK1. PLoS Pathog. 2016;12:e1005811 pubmed publisher
    ..The Arabidopsis cytoplasmic kinase BIK1 is a downstream substrate of several PRR complexes. How plant PTI is negatively regulated is not fully understood...
  9. Lal N, Fisher A, Dinesh Kumar S. Arabidopsis receptor-like cytoplasmic kinase BIK1: purification, crystallization and X-ray diffraction analysis. Acta Crystallogr F Struct Biol Commun. 2016;72:738-742 pubmed
    ..BOTRYTIS-INDUCED KINASE 1 (BIK1), belonging to the RLCK family, is an important player in defense against bacterial and fungal pathogens and in ..
  10. Veronese P, Nakagami H, Bluhm B, Abuqamar S, Chen X, Salmeron J, et al. The membrane-anchored BOTRYTIS-INDUCED KINASE1 plays distinct roles in Arabidopsis resistance to necrotrophic and biotrophic pathogens. Plant Cell. 2006;18:257-73 pubmed
    ..We identified the Arabidopsis thaliana BOTRYTIS-INDUCED KINASE1 (BIK1) gene that is transcriptionally regulated by Botrytis cinerea infection...
  11. Hou S, Wang X, Chen D, Yang X, Wang M, Turrà D, et al. The secreted peptide PIP1 amplifies immunity through receptor-like kinase 7. PLoS Pathog. 2014;10:e1004331 pubmed publisher
    ..PIP1 and PEP1 cooperate in amplifying the immune responses triggered by the PAMP flagellin. Collectively, these studies provide significant insights into immune modulation by Arabidopsis endogenous secreted peptides. ..
  12. Zhang H, Huang L, Hong Y, Song F. BOTRYTIS-INDUCED KINASE1, a plasma membrane-localized receptor-like protein kinase, is a negative regulator of phosphate homeostasis in Arabidopsis thaliana. BMC Plant Biol. 2016;16:152 pubmed publisher
    ..We report here that the involvement of Arabidopsis BIK1, a plasma membrane-localized receptor-like protein kinase that plays critical role in immunity, in Pi starvation ..
  13. Wang Y, Li Z, Liu D, Xu J, Wei X, Yan L, et al. Assessment of BAK1 activity in different plant receptor-like kinase complexes by quantitative profiling of phosphorylation patterns. J Proteomics. 2014;108:484-93 pubmed publisher
    ..a member of the plant RLK family, forms receptor complexes with multiple RLK proteins including BRI1, FLS2, EFR and BIK1 to regulate responses to growth hormones or PAMPs...
  14. Wang S, Sun J, Fan F, Tan Z, Zou Y, Lu D. A Xanthomonas oryzae pv. oryzae effector, XopR, associates with receptor-like cytoplasmic kinases and suppresses PAMP-triggered stomatal closure. Sci China Life Sci. 2016;59:897-905 pubmed publisher
    ..Here, we show that PXO99A XopR interacts with BIK1 at the plasma membrane...