Gene Symbol: ATR
Description: Ataxia telangiectasia-mutated and RAD3-like protein
Alias: ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, ATATR, ATRAD3, Ataxia telangiectasia-mutated and RAD3-related, MHK7.5, MHK7_5, Ataxia telangiectasia-mutated and RAD3-like protein
Species: thale cress
- Nezames C, Sjogren C, Barajas J, Larsen P. The Arabidopsis cell cycle checkpoint regulators TANMEI/ALT2 and ATR mediate the active process of aluminum-dependent root growth inhibition. Plant Cell. 2012;24:608-21 pubmed publisher..alt2-1 and atr loss-of-function mutants, the latter of which affects the cell cycle checkpoint ATAXIA TELANGIECTASIA-MUTATED AND ..
- Waterworth W, Footitt S, Bray C, Finch Savage W, West C. DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds. Proc Natl Acad Sci U S A. 2016;113:9647-52 pubmed publisher..is orchestrated by the DNA damage checkpoint kinases ATAXIA TELANGIECTASIA MUTATED (ATM) and ATM AND RAD3-RELATED (ATR). Here we identify important physiological roles for these sensor kinases in control of seed germination...
- Curtis M, Hays J. Cooperative responses of DNA-damage-activated protein kinases ATR and ATM and DNA translesion polymerases to replication-blocking DNA damage in a stem-cell niche. DNA Repair (Amst). 2011;10:1272-81 pubmed publisher..among DNA translesion synthesis (TLS) polymerases (Pol?, Pol?) and DNA-damage-activated protein kinases (ATR, ATM). Death was 100-fold higher in stem and progenitor (StPr) cells than in transiently amplifying cells...
- Boltz K, Leehy K, Song X, Nelson A, Shippen D. ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis. Mol Biol Cell. 2012;23:1558-68 pubmed publisher..Here we show that CST and ATR (ataxia telangiectasia mutated [ATM] and Rad3-related) act synergistically to maintain telomere length and genome ..
- Kwok C, Ding Y, Shahid S, Assmann S, Bevilacqua P. A stable RNA G-quadruplex within the 5'-UTR of Arabidopsis thaliana ATR mRNA inhibits translation. Biochem J. 2015;467:91-102 pubmed publisher..This GQS is located within the 5'-UTR of the ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED (ATR) mRNA of Arabidopsis thaliana (mouse-ear cress)...
- González Besteiro M, Ulm R. ATR and MKP1 play distinct roles in response to UV-B stress in Arabidopsis. Plant J. 2013;73:1034-43 pubmed publisher..This is not due to a block in replication, as, in contrast to atr, the mkp1 mutant is not hypersensitive to the replication-inhibiting drug hydroxyurea, hydroxyurea does not ..
- Culligan K, Britt A. Both ATM and ATR promote the efficient and accurate processing of programmed meiotic double-strand breaks. Plant J. 2008;55:629-38 pubmed publisherThe ATM and ATR protein kinases play central roles in the cellular response to double-strand breaks (DSBs) by regulating DNA repair, cell-cycle arrest and apoptosis...
- Yan S, Wang W, Marques J, Mohan R, Saleh A, Durrant W, et al. Salicylic acid activates DNA damage responses to potentiate plant immunity. Mol Cell. 2013;52:602-10 pubmed publisher..The DNA damage sensor proteins RAD17 and ATR are required for effective immune responses...