Gene Symbol: ATM
Description: Serine/Threonine-kinase ATM-like protein
Alias: ARABIDOPSIS THALIANA ATAXIA-TELANGIECTASIA MUTATED, ATATM, PIG1, ataxia-telangiectasia mutated, pcd in male gametogenesis 1, Serine/Threonine-kinase ATM-like protein
Species: thale cress

Top Publications

  1. Park S, Vaghchhipawala Z, Vasudevan B, Lee L, Shen Y, Singer K, et al. Agrobacterium T-DNA integration into the plant genome can occur without the activity of key non-homologous end-joining proteins. Plant J. 2015;81:934-46 pubmed publisher
    ..In animal cells, several proteins, including KU70, KU80, ARTEMIS, DNA-PKcs, DNA ligase IV (LIG4), Ataxia telangiectasia mutated (ATM), and ATM- and Rad3-related (ATR), play an important role in 'classical' (c)NHEJ...
  2. Culligan K, Robertson C, Foreman J, Doerner P, Britt A. ATR and ATM play both distinct and additive roles in response to ionizing radiation. Plant J. 2006;48:947-61 pubmed
    The ATR and ATM protein kinases are known to be involved in a wide variety of responses to DNA damage. The Arabidopsis thaliana genome includes both ATR and ATM orthologs, and plants with null alleles of these genes are viable...
  3. Vespa L, Warrington R, Mokros P, Siroky J, Shippen D. ATM regulates the length of individual telomere tracts in Arabidopsis. Proc Natl Acad Sci U S A. 2007;104:18145-50 pubmed
    ..We have previously shown that the absence of ataxia telangiectasia mutated (ATM), a central regulator of the DNA damage response, accelerates the onset of genome instability in ..
  4. Culligan K, Britt A. Both ATM and ATR promote the efficient and accurate processing of programmed meiotic double-strand breaks. Plant J. 2008;55:629-38 pubmed publisher
    The ATM and ATR protein kinases play central roles in the cellular response to double-strand breaks (DSBs) by regulating DNA repair, cell-cycle arrest and apoptosis...
  5. Vespa L, Couvillion M, Spangler E, Shippen D. ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in Arabidopsis. Genes Dev. 2005;19:2111-5 pubmed
    Here we examine the function of ATM and ATR at telomeres in Arabidopsis. Although plants lacking ATM or ATR display wild-type telomere length homeostasis, chromosome end protection is compromised in atm atr mutants...
  6. Adachi S, Minamisawa K, Okushima Y, Inagaki S, Yoshiyama K, Kondou Y, et al. Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis. Proc Natl Acad Sci U S A. 2011;108:10004-9 pubmed publisher
    ..b>ATM and ATR (ataxia-telangiectasia-mutated and -Rad3-related) are sensor kinases that relay the damage signal to ..
  7. Hisanaga T, Ferjani A, Horiguchi G, Ishikawa N, Fujikura U, Kubo M, et al. The ATM-dependent DNA damage response acts as an upstream trigger for compensation in the fas1 mutation during Arabidopsis leaf development. Plant Physiol. 2013;162:831-41 pubmed publisher
    ..activation of the DNA damage response and the accompanying decrease of cell number in fas1 depend on ATAXIA TELANGIECTASIA MUTATED (ATM) but not on ATM AND RAD3 RELATED...
  8. Curtis M, Hays J. Cooperative responses of DNA-damage-activated protein kinases ATR and ATM and DNA translesion polymerases to replication-blocking DNA damage in a stem-cell niche. DNA Repair (Amst). 2011;10:1272-81 pubmed publisher
    ..among DNA translesion synthesis (TLS) polymerases (Pol?, Pol?) and DNA-damage-activated protein kinases (ATR, ATM). Death was 100-fold higher in stem and progenitor (StPr) cells than in transiently amplifying cells...
  9. Garcia V, Bruchet H, Camescasse D, Granier F, Bouchez D, Tissier A. AtATM is essential for meiosis and the somatic response to DNA damage in plants. Plant Cell. 2003;15:119-32 pubmed
    ..We previously characterized AtATM, an Arabidopsis homolog of the human ATM gene, which is mutated in ataxia telangiectasia, a chromosome instability ..

More Information


  1. Waterworth W, Footitt S, Bray C, Finch Savage W, West C. DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds. Proc Natl Acad Sci U S A. 2016;113:9647-52 pubmed publisher
    ..The eukaryotic cellular response to DNA damage is orchestrated by the DNA damage checkpoint kinases ATAXIA TELANGIECTASIA MUTATED (ATM) and ATM AND RAD3-RELATED (ATR)...
  2. Friesner J, Liu B, Culligan K, Britt A. Ionizing radiation-dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related. Mol Biol Cell. 2005;16:2566-76 pubmed
    ..The dependency of this phosphorylation on the various PI3K-related protein kinases (in mammals, ataxia telangiectasia mutated and Rad3-related [ATR], ataxia telangiectasia mutated [ATM], and DNA-PKCs) has been a subject of ..
  3. Kurzbauer M, Pradillo M, Kerzendorfer C, Sims J, Ladurner R, Oliver C, et al. Arabidopsis thaliana FANCD2 Promotes Meiotic Crossover Formation. Plant Cell. 2018;30:415-428 pubmed publisher
    ..i>AtFANCD2 promotes noninterfering COs in a MUS81-independent manner and is therefore part of an uncharted meiotic CO-promoting mechanism, in addition to those described previously. ..
  4. Kenzior A, Folk W. Arabidopsis thaliana MSI4/FVE associates with members of a novel family of plant specific PWWP/RRM domain proteins. Plant Mol Biol. 2015;87:329-39 pubmed publisher
    ..We propose these novel ATMSI4-associated proteins help form nucleoprotein complexes that determine pleiotropic functional properties of AtMSI4/FVE/ACG1 involving plant development and responses to stress. ..
  5. Amiard S, Depeiges A, Allain E, White C, Gallego M. Arabidopsis ATM and ATR kinases prevent propagation of genome damage caused by telomere dysfunction. Plant Cell. 2011;23:4254-65 pubmed publisher
    ..We show that absence of telomerase in Arabidopsis thaliana elicits an ATAXIA-TELANGIECTASIA MUTATED (ATM) and ATM AND RAD3-RELATED (ATR)-dependent DDR at telomeres, principally through ATM...
  6. Zhang J, Teng C, Liang Y. Programmed cell death may act as a surveillance mechanism to safeguard male gametophyte development in Arabidopsis. Protein Cell. 2011;2:837-44 pubmed publisher
    ..The PIG1 gene was identified by map-based cloning, and was found to be identical to ATAXIA TELANGIECTASIA MUTATED (ATM), a highly conserved gene in eukaryotes and a key regulator of the DNA damage response...
  7. Yao Y, Bilichak A, Titov V, Golubov A, Kovalchuk I. Genome stability of Arabidopsis atm, ku80 and rad51b mutants: somatic and transgenerational responses to stress. Plant Cell Physiol. 2013;54:982-9 pubmed publisher
    ..To test this hypothesis, we analyzed the genome stability of the Arabidopsis thaliana mutants deficient in ATM (communication between DNA strand break recognition and the repair machinery), KU80 (deficient in NHEJ) and RAD51B (..
  8. Yuan D, Lai J, Xu P, Zhang S, Zhang J, Li C, et al. AtMMS21 regulates DNA damage response and homologous recombination repair in Arabidopsis. DNA Repair (Amst). 2014;21:140-7 pubmed publisher
    ..Depletion of ATAXIA-TELANGIECTASIA MUTATED (ATM) in mms21-1 enhances its root growth defect phenotype, indicating that ATM and AtMMS21 may play additive roles in ..
  9. Waterworth W, Altun C, Armstrong S, Roberts N, Dean P, Young K, et al. NBS1 is involved in DNA repair and plays a synergistic role with ATM in mediating meiotic homologous recombination in plants. Plant J. 2007;52:41-52 pubmed publisher
    ..Analysis of atnbs1-1 atatm double mutants revealed a role for AtNBS1 in meiotic recombination...