Gene Symbol: ARGONAUTE1
Description: Stabilizer of iron transporter SufD / Polynucleotidyl transferase
Alias: ARGONAUTE 1, AtAGO1, ICU9, T1N15.2, T1N15_2, Stabilizer of iron transporter SufD / Polynucleotidyl transferase
Species: thale cress
Products:     ARGONAUTE1

Top Publications

  1. Kidner C, Martienssen R. The role of ARGONAUTE1 (AGO1) in meristem formation and identity. Dev Biol. 2005;280:504-17 pubmed
    ..b>ARGONAUTE1 (AGO1) is required for stem cell function and organ polarity, as is the closely related protein PINHEAD/ZWILLE (..
  2. Bortolamiol D, Pazhouhandeh M, Marrocco K, Genschik P, Ziegler Graff V. The Polerovirus F box protein P0 targets ARGONAUTE1 to suppress RNA silencing. Curr Biol. 2007;17:1615-21 pubmed
    ..b>ARGONAUTE1 (AGO1) is a key component of RISC: it carries the RNA slicer activity...
  3. Bohmert K, Camus I, Bellini C, Bouchez D, Caboche M, Benning C. AGO1 defines a novel locus of Arabidopsis controlling leaf development. EMBO J. 1998;17:170-80 pubmed
    ..No specific function has been assigned to these genes. Similar proteins are not encoded by the genomes of yeast or bacteria, suggesting that AGO1 belongs to a novel class of genes with a function specific to multicellular organisms. ..
  4. Sorin C, Bussell J, Camus I, Ljung K, Kowalczyk M, Geiss G, et al. Auxin and light control of adventitious rooting in Arabidopsis require ARGONAUTE1. Plant Cell. 2005;17:1343-59 pubmed adventitious root formation: the superroot mutants, which spontaneously make adventitious roots, and the argonaute1 (ago1) mutants, which unlike superroot are barely able to form adventitious roots...
  5. Mallory A, Hinze A, Tucker M, Bouche N, Gasciolli V, Elmayan T, et al. Redundant and specific roles of the ARGONAUTE proteins AGO1 and ZLL in development and small RNA-directed gene silencing. PLoS Genet. 2009;5:e1000646 pubmed publisher
    The Arabidopsis ARGONAUTE1 (AGO1) and ZWILLE/PINHEAD/AGO10 (ZLL) proteins act in the miRNA and siRNA pathways and are essential for multiple processes in development...
  6. Baumberger N, Baulcombe D. Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs. Proc Natl Acad Sci U S A. 2005;102:11928-33 pubmed
    ..Based on sequence similarity, we predict that other Arabidopsis AGOs might have a similar catalytic activity but recruit different subsets of siRNAs or miRNAs. ..
  7. Mallory A, Vaucheret H. ARGONAUTE 1 homeostasis invokes the coordinate action of the microRNA and siRNA pathways. EMBO Rep. 2009;10:521-6 pubmed publisher
    b>ARGONAUTE 1 (AGO1) slices endogenous messenger RNAs (mRNAs) during both microRNA (miRNA)- and short interfering RNA (siRNA)-guided post-transcriptional silencing...
  8. Vaucheret H, Vazquez F, Crété P, Bartel D. The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development. Genes Dev. 2004;18:1187-97 pubmed
  9. Lynn K, Fernandez A, Aida M, Sedbrook J, Tasaka M, Masson P, et al. The PINHEAD/ZWILLE gene acts pleiotropically in Arabidopsis development and has overlapping functions with the ARGONAUTE1 gene. Development. 1999;126:469-81 pubmed
    ..In addition, we find that embryos doubly mutant for PINHEAD and ARGONAUTE1, a related, ubiquitously expressed family member, fail to progress to bilateral symmetry and do not accumulate ..

More Information


  1. Jover Gil S, Candela H, Robles P, Aguilera V, Barrero J, Micol J, et al. The microRNA pathway genes AGO1, HEN1 and HYL1 participate in leaf proximal-distal, venation and stomatal patterning in Arabidopsis. Plant Cell Physiol. 2012;53:1322-33 pubmed publisher
    ..icu8), icu9 and icu15 has identified them as new loss-of-function alleles of the HYPONASTIC LEAVES1 (HYL1), ARGONAUTE1 (AGO1) and HUA ENHANCER1 (HEN1) genes, respectively, which encode known components of the microRNA pathway...
  2. Montgomery T, Yoo S, Fahlgren N, Gilbert S, Howell M, Sullivan C, et al. AGO1-miR173 complex initiates phased siRNA formation in plants. Proc Natl Acad Sci U S A. 2008;105:20055-62 pubmed publisher
    ..We also show that miR173 functions in association with ARGONAUTE 1 (AGO1) during TAS1 and TAS2 tasiRNA formation, and we provide data indicating that the miR173-AGO1 complex ..
  3. Zhang X, Yuan Y, Pei Y, Lin S, Tuschl T, Patel D, et al. Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense. Genes Dev. 2006;20:3255-68 pubmed
    ..In contrast to most characterized suppressors, 2b directly interacts with Argonaute1 (AGO1) in vitro and in vivo, and this interaction occurs primarily on one surface of the PAZ-containing module ..
  4. Derrien B, Baumberger N, Schepetilnikov M, Viotti C, De Cillia J, Ziegler Graff V, et al. Degradation of the antiviral component ARGONAUTE1 by the autophagy pathway. Proc Natl Acad Sci U S A. 2012;109:15942-6 pubmed
    ..In Arabidopsis, a key component of RISC is ARGONAUTE1 (AGO1), which not only binds to siRNAs but also carries the RNA slicer activity...
  5. Wang H, Zhang X, Liu J, Kiba T, Woo J, Ojo T, et al. Deep sequencing of small RNAs specifically associated with Arabidopsis AGO1 and AGO4 uncovers new AGO functions. Plant J. 2011;67:292-304 pubmed publisher
  6. Schott G, Marí Ordóñez A, Himber C, Alioua A, Voinnet O, Dunoyer P. Differential effects of viral silencing suppressors on siRNA and miRNA loading support the existence of two distinct cellular pools of ARGONAUTE1. EMBO J. 2012;31:2553-65 pubmed publisher
    ..These findings have important implications for our current understanding of RNA silencing and of its suppression in plants. ..
  7. Tucker M, Hinze A, Tucker E, Takada S, Jurgens G, Laux T. Vascular signalling mediated by ZWILLE potentiates WUSCHEL function during shoot meristem stem cell development in the Arabidopsis embryo. Development. 2008;135:2839-43 pubmed publisher
    ..Thus, WUS-dependent OC signalling to the stem cells is promoted by AGO1 and subsequently maintained by a provascular ZLL-dependent signalling pathway. ..
  8. Morel J, Godon C, Mourrain P, Beclin C, Boutet S, Feuerbach F, et al. Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance. Plant Cell. 2002;14:629-39 pubmed
    ..Finally, we show that hypomorphic ago1 mutants are hypersensitive to virus infection, confirming the hypothesis that in plants PTGS is a mechanism of defense against viruses. ..
  9. Azevedo J, Garcia D, Pontier D, Ohnesorge S, Yu A, Garcia S, et al. Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein. Genes Dev. 2010;24:904-15 pubmed publisher
    ..The likely widespread occurrence and expected consequences of GW protein mimicry on host silencing pathways are discussed in the context of innate and adaptive immunity in plants and metazoans. ..
  10. Qu F, Ye X, Morris T. Arabidopsis DRB4, AGO1, AGO7, and RDR6 participate in a DCL4-initiated antiviral RNA silencing pathway negatively regulated by DCL1. Proc Natl Acad Sci U S A. 2008;105:14732-7 pubmed publisher
    ..Our results resolve several key steps in the antiviral RNA silencing pathway and provide a basis for further in-depth analysis...
  11. Wang X, Jovel J, Udomporn P, Wang Y, Wu Q, Li W, et al. The 21-nucleotide, but not 22-nucleotide, viral secondary small interfering RNAs direct potent antiviral defense by two cooperative argonautes in Arabidopsis thaliana. Plant Cell. 2011;23:1625-38 pubmed publisher
    ..Possible mechanisms for the observed qualitative difference in RNA silencing between 21- and 22-nucleotide secondary siRNAs are discussed. ..
  12. Dolata J, Bajczyk M, Bielewicz D, Niedojadlo K, Niedojadlo J, Pietrykowska H, et al. Salt Stress Reveals a New Role for ARGONAUTE1 in miRNA Biogenesis at the Transcriptional and Posttranscriptional Levels. Plant Physiol. 2016;172:297-312 pubmed publisher
    ..b>ARGONAUTE1 (AGO1) participated in both processes...
  13. Manavella P, Koenig D, Rubio Somoza I, Burbano H, Becker C, Weigel D. Tissue-specific silencing of Arabidopsis SU(VAR)3-9 HOMOLOG8 by miR171a. Plant Physiol. 2013;161:805-12 pubmed publisher
    ..Our study demonstrates that each miR171a strand can be loaded onto RISC with separate regulatory outcomes. ..
  14. Li S, Liu L, Zhuang X, Yu Y, Liu X, Cui X, et al. MicroRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis. Cell. 2013;153:562-74 pubmed publisher
    ..AMP1 encodes an integral membrane protein associated with endoplasmic reticulum (ER) and ARGONAUTE1, the miRNA effector and a peripheral ER membrane protein...
  15. Wang W, Ye R, Xin Y, Fang X, Li C, Shi H, et al. An importin ? protein negatively regulates MicroRNA activity in Arabidopsis. Plant Cell. 2011;23:3565-76 pubmed publisher
    ..SAD2/EMA1 encodes an Importin ? protein. The ema1 mutation had no effects on the accumulation of miRNAs and ARGONAUTE1 (AGO1) or on their cytoplasmic and nuclear distributions...
  16. Fang Y, Spector D. Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants. Curr Biol. 2007;17:818-23 pubmed
    ..Furthermore, plant miRNAs are methylated by Hua Enhancer (HEN1) at their 3' ends and loaded onto Argonaute1 (AGO1). However, little is known about the cellular basis of miRNA biogenesis...
  17. Maunoury N, Vaucheret H. AGO1 and AGO2 act redundantly in miR408-mediated Plantacyanin regulation. PLoS ONE. 2011;6:e28729 pubmed publisher
  18. Zhang X, Niu D, Carbonell A, Wang A, Lee A, Tun V, et al. ARGONAUTE PIWI domain and microRNA duplex structure regulate small RNA sorting in Arabidopsis. Nat Commun. 2014;5:5468 pubmed publisher
    ..Finally, we rescued the adaxialized phenotype of ago1-12, which is largely due to miR165 loss-of-function, by changing miR165 duplex structure which we predict redirects it to AGO2. ..
  19. Ren G, Xie M, Zhang S, Vinovskis C, Chen X, Yu B. Methylation protects microRNAs from an AGO1-associated activity that uridylates 5' RNA fragments generated by AGO1 cleavage. Proc Natl Acad Sci U S A. 2014;111:6365-70 pubmed publisher
    ..We also show that Argonaute 1 (AGO1), the effector protein of miRNAs, interacts with HESO1 through its Piwi/Argonaute/Zwille and PIWI domains,..
  20. Micol Ponce R, Aguilera V, Ponce M. A genetic screen for suppressors of a hypomorphic allele of Arabidopsis ARGONAUTE1. Sci Rep. 2014;4:5533 pubmed publisher
    b>ARGONAUTE1 (AGO1) encodes a key component of the complexes mediating microRNA (miRNA) function in Arabidopsis...
  21. Garcia Ruiz H, Carbonell A, Hoyer J, Fahlgren N, Gilbert K, Takeda A, et al. Roles and programming of Arabidopsis ARGONAUTE proteins during Turnip mosaic virus infection. PLoS Pathog. 2015;11:e1004755 pubmed publisher
    ..These findings indicate that distinct AGO proteins function as antiviral modules, and provide a molecular explanation for the silencing suppressor activity of HC-Pro. ..
  22. Ronemus M, Vaughn M, Martienssen R. MicroRNA-targeted and small interfering RNA-mediated mRNA degradation is regulated by argonaute, dicer, and RNA-dependent RNA polymerase in Arabidopsis. Plant Cell. 2006;18:1559-74 pubmed
    b>ARGONAUTE1 (AGO1) of Arabidopsis thaliana mediates the cleavage of microRNA (miRNA)-targeted mRNAs, and it has also been implicated in the posttranscriptional silencing of transgenes and the maintenance of chromatin structure...
  23. Arribas Hernández L, Kielpinski L, Brodersen P. mRNA Decay of Most Arabidopsis miRNA Targets Requires Slicer Activity of AGO1. Plant Physiol. 2016;171:2620-32 pubmed publisher
    ..A set of genes exhibiting up-regulation specifically in ago1 null, but not in ago1 slicer-deficient mutants was also identified, leaving open the possibility that AGO1 may have functions in gene regulation independent of small RNAs. ..
  24. Fernández Nohales P, Domenech M, Martínez de Alba A, Micol J, Ponce M, Madueno F. AGO1 controls arabidopsis inflorescence architecture possibly by regulating TFL1 expression. Ann Bot. 2014;114:1471-81 pubmed publisher
    ..Cloning of the mutated gene showed that both phenotypes were caused by a mutation in the ARGONAUTE1 (AGO1) gene, which encodes a key component of the RNA silencing machinery...
  25. Ji L, Liu X, Yan J, Wang W, Yumul R, Kim Y, et al. ARGONAUTE10 and ARGONAUTE1 regulate the termination of floral stem cells through two microRNAs in Arabidopsis. PLoS Genet. 2011;7:e1001358 pubmed publisher
    ..We also show that both the ubiquitously expressed ARGONAUTE1 (AGO1) gene and its homolog AGO10, which exhibits highly restricted spatial expression patterns, are required to ..
  26. Cui Y, Fang X, Qi Y. TRANSPORTIN1 Promotes the Association of MicroRNA with ARGONAUTE1 in Arabidopsis. Plant Cell. 2016;28:2576-2585 pubmed
    In Arabidopsis thaliana, microRNAs (miRNAs) are mainly loaded into ARGONAUTE1 (AGO1) to posttranscriptionally regulate gene expression...
  27. Yang L, Huang W, Wang H, Cai R, Xu Y, Huang H. Characterizations of a hypomorphic argonaute1 mutant reveal novel AGO1 functions in Arabidopsis lateral organ development. Plant Mol Biol. 2006;61:63-78 pubmed
    ..Our results demonstrate several important AGO1 functions in plant lateral organ development. ..
  28. Speth C, Willing E, Rausch S, Schneeberger K, Laubinger S. RACK1 scaffold proteins influence miRNA abundance in Arabidopsis. Plant J. 2013;76:433-45 pubmed publisher
    ..In conclusion, our study identified complex functioning of RACK1 proteins in the Arabidopsis miRNA pathway; these proteins are important for miRNA production and therefore plant development. ..
  29. Wang B, Duan C, Wang X, Hou Y, Yan J, Gao C, et al. HOS1 regulates Argonaute1 by promoting transcription of the microRNA gene MIR168b in Arabidopsis. Plant J. 2015;81:861-70 pubmed publisher
    ..Of Osmotically Responsive Genes1 (HOS1) is a regulator of an important miRNA, mi168a/b, that targets the Argonaute1 (AGO1) gene in Arabidopsis...
  30. Vaucheret H. AGO1 homeostasis involves differential production of 21-nt and 22-nt miR168 species by MIR168a and MIR168b. PLoS ONE. 2009;4:e6442 pubmed publisher
    ..These results suggest that 22-nt miR168 ensures basal cleavage of AGO1 mRNA whereas 21-nt miR168 permits an effective response to endogenous or environmental fluctuations owing to its preferential stabilization by AGO1. ..
  31. Brosseau C, Moffett P. Functional and Genetic Analysis Identify a Role for Arabidopsis ARGONAUTE5 in Antiviral RNA Silencing. Plant Cell. 2015;27:1742-54 pubmed publisher
    ..In agreement with functional assays, we show that Potexvirus infection induces AGO5 expression and that both AGO2 and AGO5 are required for full restriction of PVX infection in systemic tissues of Arabidopsis. ..
  32. Duan C, Fang Y, Zhou B, Zhao J, Hou W, Zhu H, et al. Suppression of Arabidopsis ARGONAUTE1-mediated slicing, transgene-induced RNA silencing, and DNA methylation by distinct domains of the Cucumber mosaic virus 2b protein. Plant Cell. 2012;24:259-74 pubmed publisher
    ..suppressors of RNA silencing, the 2b protein interacts directly with both small interfering RNA (siRNA) and ARGONAUTE1 (AGO1) and AGO4 proteins and is targeted to the nucleolus...
  33. Li Y, Zhang Q, Zhang J, Wu L, Qi Y, Zhou J. Identification of microRNAs involved in pathogen-associated molecular pattern-triggered plant innate immunity. Plant Physiol. 2010;152:2222-31 pubmed publisher
    ..Here we show that the Arabidopsis (Arabidopsis thaliana) miRNA effector protein, Argonaute1 (AGO1), is required for a number of PTI responses including PAMP-induced callose deposition, gene expression, ..
  34. Miyashima S, Hashimoto T, Nakajima K. ARGONAUTE1 acts in Arabidopsis root radial pattern formation independently of the SHR/SCR pathway. Plant Cell Physiol. 2009;50:626-34 pubmed publisher
    ..In this study, we identified a novel root radial pattern mutant and found that it is a new argonaute1 (ago1) allele...
  35. Kenesi E, Carbonell A, Lózsa R, Vértessy B, Lakatos L. A viral suppressor of RNA silencing inhibits ARGONAUTE 1 function by precluding target RNA binding to pre-assembled RISC. Nucleic Acids Res. 2017;45:7736-7750 pubmed publisher
    ..Our results describe the negative regulation of RISC, the small RNA containing molecular machine. ..
  36. Mason G, Lemus T, Queitsch C. The Mechanistic Underpinnings of an ago1-Mediated, Environmentally Dependent, and Stochastic Phenotype. Plant Physiol. 2016;170:2420-31 pubmed publisher
    ..Here, we describe a novel, environmentally dependent phenotype in hypomorphic argonaute1 (ago1) mutants and uncover its mechanistic underpinnings in Arabidopsis (Arabidopsis thaliana)...
  37. Brodersen P, Sakvarelidze Achard L, Schaller H, Khafif M, Schott G, Bendahmane A, et al. Isoprenoid biosynthesis is required for miRNA function and affects membrane association of ARGONAUTE 1 in Arabidopsis. Proc Natl Acad Sci U S A. 2012;109:1778-83 pubmed publisher
    ..These results suggest a possible basis for the requirement of isoprenoid biosynthesis for the activity of plant miRNAs, and unravel mechanistic features shared with their metazoan counterparts. ..
  38. Zhai J, Zhao Y, Simon S, Huang S, Petsch K, Arikit S, et al. Plant microRNAs display differential 3' truncation and tailing modifications that are ARGONAUTE1 dependent and conserved across species. Plant Cell. 2013;25:2417-28 pubmed publisher
    ..Our results showed AGO1-bound miRNAs are actively 3' truncated and tailed, possibly reflecting the activity of cofactors acting in conserved patterns in miRNA degradation...
  39. Garcia D, Garcia S, Pontier D, Marchais A, Renou J, Lagrange T, et al. Ago hook and RNA helicase motifs underpin dual roles for SDE3 in antiviral defense and silencing of nonconserved intergenic regions. Mol Cell. 2012;48:109-20 pubmed publisher
    ..We identified endogenous SDE3 targets corresponding to nonconserved intergenic regions, transposons and recently evolved pseudogenes, unraveling striking functional convergences among plant and metazoan SDE3 pathways. ..
  40. Qu D, Yan F, Li M, Varotto C, Zhao Z. Comparative analysis of MIR168 promoters in three plant species. Genet Mol Res. 2016;15: pubmed publisher
    ..miR168 is a key miRNA because it regulates the expression of the slicer protein ARGONAUTE1 (AGO1), which catalyzes mRNA cleavage...
  41. Yang K, Jiang M, Le J. A new loss-of-function allele 28y reveals a role of ARGONAUTE1 in limiting asymmetric division of stomatal lineage ground cell. J Integr Plant Biol. 2014;56:539-49 pubmed publisher
    ..Using map-based cloning, we identified mutation in ARGONAUTE1 (AGO1) as the cause of 28y phenotypes...
  42. Dunoyer P, Himber C, Ruiz Ferrer V, Alioua A, Voinnet O. Intra- and intercellular RNA interference in Arabidopsis thaliana requires components of the microRNA and heterochromatic silencing pathways. Nat Genet. 2007;39:848-56 pubmed
    ..Finally, we show that the genetics of RNAi is distinct from that of antiviral silencing and propose that this experimental silencing pathway has a direct endogenous plant counterpart. ..
  43. Lecampion C, Lanet E, Robaglia C. Detection of Argonaute 1 Association with Polysomes in Arabidopsis thaliana. Methods Mol Biol. 2017;1640:137-143 pubmed publisher
    ..In this chapter, we describe the identification of AGO1 association with polysomes through polysome fractionation on sucrose gradient, preparation of proteins by filtration and concentration, and immunoblotting. ..
  44. Kumar V, Mishra S, Rahman J, Taneja J, Sundaresan G, Mishra N, et al. Mungbean yellow mosaic Indian virus encoded AC2 protein suppresses RNA silencing by inhibiting Arabidopsis RDR6 and AGO1 activities. Virology. 2015;486:158-72 pubmed publisher
    ..Thus the study identifies dual sites of MYMIV-AC2 interference and probably accounts for its strong RNA silencing suppression activity. ..
  45. Li W, Cui X, Meng Z, Huang X, Xie Q, Wu H, et al. Transcriptional regulation of Arabidopsis MIR168a and argonaute1 homeostasis in abscisic acid and abiotic stress responses. Plant Physiol. 2012;158:1279-92 pubmed publisher
    ..The miR168-mediated feedback regulatory loop regulates ARGONAUTE1 (AGO1) homeostasis, which is crucial for gene expression modulation and plant development...
  46. Carbonell A, Fahlgren N, Garcia Ruiz H, Gilbert K, Montgomery T, Nguyen T, et al. Functional analysis of three Arabidopsis ARGONAUTES using slicer-defective mutants. Plant Cell. 2012;24:3613-29 pubmed publisher
    ..These data not only reveal functional roles for AGO1, AGO2, and AGO7 slicer activity, but also indicate an approach to capture ternary complexes more efficiently for genome-wide analyses. ..
  47. Qin J, Ma X, Yi Z, Tang Z, Meng Y. A transcriptome-wide study on the microRNA- and the Argonaute 1-enriched small RNA-mediated regulatory networks involved in plant leaf senescence. Plant Biol (Stuttg). 2016;18:197-205 pubmed publisher
    ..Besides, whether other Argonaute 1 (AGO1)-enriched small RNAs (sRNAs) play regulatory roles in leaf senescence remains unclear...
  48. Sánchez García A, Aguilera V, Micol Ponce R, Jover Gil S, Ponce M. Arabidopsis MAS2, an Essential Gene That Encodes a Homolog of Animal NF-κ B Activating Protein, Is Involved in 45S Ribosomal DNA Silencing. Plant Cell. 2015;27:1999-2015 pubmed publisher
    ..for ethyl methanesulfonate-induced suppressors of Arabidopsis thaliana ago1-52, a hypomorphic allele of AGO1 (ARGONAUTE1), a key gene in microRNA pathways...
  49. Manavella P, Hagmann J, Ott F, Laubinger S, Franz M, Macek B, et al. Fast-forward genetics identifies plant CPL phosphatases as regulators of miRNA processing factor HYL1. Cell. 2012;151:859-870 pubmed publisher
    ..In the absence of CPL1, HYL1 dephosphorylation and hence accurate processing and strand selection from miRNA duplexes are compromised. Our findings thus define a new regulatory step in plant miRNA biogenesis. ..
  50. Lackey E, Ng D, Chen Z. RNAi-mediated down-regulation of DCL1 and AGO1 induces developmental changes in resynthesized Arabidopsis allotetraploids. New Phytol. 2010;186:207-15 pubmed publisher
    ..These lines will be useful for studying the effects of miRNA biogenesis genes on growth and developmental variation in the allopolyploids. ..
  51. Dunoyer P, Voinnet O. Movement of RNA silencing between plant cells: is the question now behind us?. Trends Plant Sci. 2009;14:643-4 pubmed publisher
  52. Fusaro A, Corrêa R, Nakasugi K, Jackson C, Kawchuk L, Vaslin M, et al. The Enamovirus P0 protein is a silencing suppressor which inhibits local and systemic RNA silencing through AGO1 degradation. Virology. 2012;426:178-87 pubmed publisher
    ..Therefore, despite the lack of any sequence similarity, the poleroviral and enamoviral SSPs have a conserved mode of action upon the RNA silencing machinery...