AOS

Summary

Gene Symbol: AOS
Description: allene oxide synthase
Alias: CYP74A, CYTOCHROME P450 74A, DDE2, DELAYED DEHISCENCE 2, allene oxide synthase, allene oxide synthase
Species: thale cress

Top Publications

  1. Pajerowska K, Parker J, Gebhardt C. Potato homologs of Arabidopsis thaliana genes functional in defense signaling--identification, genetic mapping, and molecular cloning. Mol Plant Microbe Interact. 2005;18:1107-19 pubmed
    ..Our results form the basis for further studies on the contributions of these candidate genes to natural variation of potato disease resistance. ..
  2. Laudert D, Weiler E. Allene oxide synthase: a major control point in Arabidopsis thaliana octadecanoid signalling. Plant J. 1998;15:675-84 pubmed
    The analysis of allene oxide synthase (AOS) mRNA levels, of AOS polypeptide levels and specific enzymatic activities, as well as the quantitative determination of the levels of the octadecanoids cis-12-oxophytodienoic acid (cis-OPDA) and ..
  3. Laudert D, Pfannschmidt U, Lottspeich F, Holländer Czytko H, Weiler E. Cloning, molecular and functional characterization of Arabidopsis thaliana allene oxide synthase (CYP 74), the first enzyme of the octadecanoid pathway to jasmonates. Plant Mol Biol. 1996;31:323-35 pubmed
    b>Allene oxide synthase, an enzyme of the octadecanoid pathway to jasmonates, was cloned from Arabidopsis thaliana as a full-length cDNA encoding a polypeptide of 517 amino acids with a calculated molecular mass of 58705 Da...
  4. Yan Y, Stolz S, Chételat A, Reymond P, Pagni M, Dubugnon L, et al. A downstream mediator in the growth repression limb of the jasmonate pathway. Plant Cell. 2007;19:2470-83 pubmed
    ..Both forms of JAS1 were found to localize to the nucleus in transient expression assays. Physiological tests of growth responses after wounding were consistent with the fact that JAS1 is a repressor of JA-regulated growth retardation. ..
  5. Song W, Funk C, Brash A. Molecular cloning of an allene oxide synthase: a cytochrome P450 specialized for the metabolism of fatty acid hydroperoxides. Proc Natl Acad Sci U S A. 1993;90:8519-23 pubmed
    ..Previously, we showed that an allene oxide synthase from flaxseed has the spectral properties of a cytochrome P450...
  6. Cho K, Lai W, Hamberg M, Raman C, Shaik S. The reaction mechanism of allene oxide synthase: Interplay of theoretical QM/MM calculations and experimental investigations. Arch Biochem Biophys. 2011;507:14-25 pubmed publisher
    A combined theoretical and experimental study highlights the reaction mechanism of allene oxide synthase (AOS) and its possible link to hydroperoxide lyase (HPL) pathway. A previously published study (Lee et al...
  7. Hughes R, Belfield E, Ashton R, Fairhurst S, Gobel C, Stumpe M, et al. Allene oxide synthase from Arabidopsis thaliana (CYP74A1) exhibits dual specificity that is regulated by monomer-micelle association. FEBS Lett. 2006;580:4188-94 pubmed
    We investigate the effects of detergent on the kinetics and oligomeric state of allene oxide synthase (AOS) from Arabidopsis thaliana (CYP74A1)...
  8. Bethke G, Thao A, Xiong G, Li B, Soltis N, Hatsugai N, et al. Pectin Biosynthesis Is Critical for Cell Wall Integrity and Immunity in Arabidopsis thaliana. Plant Cell. 2016;28:537-56 pubmed publisher
    ..Pectin is thus an important contributor to plant immunity, and this is due at least in part to the induction of immune responses by soluble pectin, likely OGs, that are released during plant-pathogen interactions. ..
  9. Kubigsteltig I, Laudert D, Weiler E. Structure and regulation of the Arabidopsis thaliana allene oxide synthase gene. Planta. 1999;208:463-71 pubmed
    b>Allene oxide synthase (AOS) is encoded by a single intronless gene in Arabidopsis thaliana (L.) Heynh...
  10. von Malek B, van der Graaff E, Schneitz K, Keller B. The Arabidopsis male-sterile mutant dde2-2 is defective in the ALLENE OXIDE SYNTHASE gene encoding one of the key enzymes of the jasmonic acid biosynthesis pathway. Planta. 2002;216:187-92 pubmed
    ..The combination of genetic mapping and a candidate-gene approach identified a frameshift mutation in the ALLENE OXIDE SYNTHASE (AOS) gene, encoding one of the key enzymes of jasmonic acid biosynthesis...

Detail Information

Publications13

  1. Pajerowska K, Parker J, Gebhardt C. Potato homologs of Arabidopsis thaliana genes functional in defense signaling--identification, genetic mapping, and molecular cloning. Mol Plant Microbe Interact. 2005;18:1107-19 pubmed
    ..Our results form the basis for further studies on the contributions of these candidate genes to natural variation of potato disease resistance. ..
  2. Laudert D, Weiler E. Allene oxide synthase: a major control point in Arabidopsis thaliana octadecanoid signalling. Plant J. 1998;15:675-84 pubmed
    The analysis of allene oxide synthase (AOS) mRNA levels, of AOS polypeptide levels and specific enzymatic activities, as well as the quantitative determination of the levels of the octadecanoids cis-12-oxophytodienoic acid (cis-OPDA) and ..
  3. Laudert D, Pfannschmidt U, Lottspeich F, Holländer Czytko H, Weiler E. Cloning, molecular and functional characterization of Arabidopsis thaliana allene oxide synthase (CYP 74), the first enzyme of the octadecanoid pathway to jasmonates. Plant Mol Biol. 1996;31:323-35 pubmed
    b>Allene oxide synthase, an enzyme of the octadecanoid pathway to jasmonates, was cloned from Arabidopsis thaliana as a full-length cDNA encoding a polypeptide of 517 amino acids with a calculated molecular mass of 58705 Da...
  4. Yan Y, Stolz S, Chételat A, Reymond P, Pagni M, Dubugnon L, et al. A downstream mediator in the growth repression limb of the jasmonate pathway. Plant Cell. 2007;19:2470-83 pubmed
    ..Both forms of JAS1 were found to localize to the nucleus in transient expression assays. Physiological tests of growth responses after wounding were consistent with the fact that JAS1 is a repressor of JA-regulated growth retardation. ..
  5. Song W, Funk C, Brash A. Molecular cloning of an allene oxide synthase: a cytochrome P450 specialized for the metabolism of fatty acid hydroperoxides. Proc Natl Acad Sci U S A. 1993;90:8519-23 pubmed
    ..Previously, we showed that an allene oxide synthase from flaxseed has the spectral properties of a cytochrome P450...
  6. Cho K, Lai W, Hamberg M, Raman C, Shaik S. The reaction mechanism of allene oxide synthase: Interplay of theoretical QM/MM calculations and experimental investigations. Arch Biochem Biophys. 2011;507:14-25 pubmed publisher
    A combined theoretical and experimental study highlights the reaction mechanism of allene oxide synthase (AOS) and its possible link to hydroperoxide lyase (HPL) pathway. A previously published study (Lee et al...
  7. Hughes R, Belfield E, Ashton R, Fairhurst S, Gobel C, Stumpe M, et al. Allene oxide synthase from Arabidopsis thaliana (CYP74A1) exhibits dual specificity that is regulated by monomer-micelle association. FEBS Lett. 2006;580:4188-94 pubmed
    We investigate the effects of detergent on the kinetics and oligomeric state of allene oxide synthase (AOS) from Arabidopsis thaliana (CYP74A1)...
  8. Bethke G, Thao A, Xiong G, Li B, Soltis N, Hatsugai N, et al. Pectin Biosynthesis Is Critical for Cell Wall Integrity and Immunity in Arabidopsis thaliana. Plant Cell. 2016;28:537-56 pubmed publisher
    ..Pectin is thus an important contributor to plant immunity, and this is due at least in part to the induction of immune responses by soluble pectin, likely OGs, that are released during plant-pathogen interactions. ..
  9. Kubigsteltig I, Laudert D, Weiler E. Structure and regulation of the Arabidopsis thaliana allene oxide synthase gene. Planta. 1999;208:463-71 pubmed
    b>Allene oxide synthase (AOS) is encoded by a single intronless gene in Arabidopsis thaliana (L.) Heynh...
  10. von Malek B, van der Graaff E, Schneitz K, Keller B. The Arabidopsis male-sterile mutant dde2-2 is defective in the ALLENE OXIDE SYNTHASE gene encoding one of the key enzymes of the jasmonic acid biosynthesis pathway. Planta. 2002;216:187-92 pubmed
    ..The combination of genetic mapping and a candidate-gene approach identified a frameshift mutation in the ALLENE OXIDE SYNTHASE (AOS) gene, encoding one of the key enzymes of jasmonic acid biosynthesis...
  11. Thatcher L, Manners J, Kazan K. Fusarium oxysporum hijacks COI1-mediated jasmonate signaling to promote disease development in Arabidopsis. Plant J. 2009;58:927-39 pubmed publisher
    ..Together, our results indicate that F. oxysporum hijacks non-defensive aspects of the JA-signaling pathway to cause wilt-disease symptoms that lead to plant death in Arabidopsis. ..
  12. Knopf R, Feder A, Mayer K, Lin A, Rozenberg M, Schaller A, et al. Rhomboid proteins in the chloroplast envelope affect the level of allene oxide synthase in Arabidopsis thaliana. Plant J. 2012;72:559-71 pubmed publisher
    ..One of the latter, allene oxide synthase, is involved in jasmonic acid biosynthesis...
  13. Lee D, Nioche P, Hamberg M, Raman C. Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes. Nature. 2008;455:363-8 pubmed publisher
    ..Although allene oxide synthase (AOS) and hydroperoxide lyase are atypical cytochrome P450 family members involved in the synthesis of ..