AHBP-1B

Summary

Gene Symbol: AHBP-1B
Description: bZIP transcription factor family protein
Alias: AtTGA2, MOJ9.12, MOJ9_12, TGA2, TGACG sequence-specific binding protein 2, bZIP transcription factor family protein
Species: thale cress

Top Publications

  1. Fode B, Siemsen T, Thurow C, Weigel R, Gatz C. The Arabidopsis GRAS protein SCL14 interacts with class II TGA transcription factors and is essential for the activation of stress-inducible promoters. Plant Cell. 2008;20:3122-35 pubmed publisher
    ..Chromatin immunoprecipitation experiments revealed that class II TGA factors TGA2, TGA5, and/or TGA6 are needed to recruit SCL14 to promoters of selected SCL14 target genes identified by whole-..
  2. Zhang Y, Fan W, Kinkema M, Li X, Dong X. Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. Proc Natl Acad Sci U S A. 1999;96:6523-8 pubmed
    ..thaliana PR-1 gene. These data suggest that NPR1 may regulate PR-1 gene expression by interacting with a subclass of basic leucine zipper protein transcription factors. ..
  3. Li S, Lauri A, Ziemann M, Busch A, Bhave M, Zachgo S. Nuclear activity of ROXY1, a glutaredoxin interacting with TGA factors, is required for petal development in Arabidopsis thaliana. Plant Cell. 2009;21:429-41 pubmed publisher
    ..Additionally, ROXY1 affects later petal morphogenesis, probably by modulating other TGA factors that might act redundantly during differentiation of second whorl organs. ..
  4. Kesarwani M, Yoo J, Dong X. Genetic interactions of TGA transcription factors in the regulation of pathogenesis-related genes and disease resistance in Arabidopsis. Plant Physiol. 2007;144:336-46 pubmed
    ..A triple-knockout mutant tga2-1 tga5-1 tga6-1 was shown previously to be defective in the induction of PR genes and systemic acquired resistance, ..
  5. Spoel S, Mou Z, Tada Y, Spivey N, Genschik P, Dong X. Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity. Cell. 2009;137:860-72 pubmed publisher
    ..These in vivo data demonstrate dual roles for coactivator turnover in both preventing and stimulating gene transcription to regulate plant immunity. ..
  6. Despres C, Chubak C, Rochon A, Clark R, Bethune T, Desveaux D, et al. The Arabidopsis NPR1 disease resistance protein is a novel cofactor that confers redox regulation of DNA binding activity to the basic domain/leucine zipper transcription factor TGA1. Plant Cell. 2003;15:2181-91 pubmed
    ..Unlike its animal and yeast counterparts, the DNA binding activity of TGA1 is not redox regulated; however, this property is conferred by interaction with the NPR1 cofactor. ..
  7. Liu G, Holub E, Alonso J, Ecker J, Fobert P. An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance. Plant J. 2005;41:304-18 pubmed
    ..These results indicate that NPR4 is required for basal defense against pathogens, and that it may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways. ..
  8. Boyle P, Le Su E, Rochon A, Shearer H, Murmu J, Chu J, et al. The BTB/POZ domain of the Arabidopsis disease resistance protein NPR1 interacts with the repression domain of TGA2 to negate its function. Plant Cell. 2009;21:3700-13 pubmed publisher
    b>TGA2 and NONEXPRESSER OF PR GENES1 (NPR1) are activators of systemic acquired resistance (SAR) and of the SAR marker gene pathogenesis-related-1 (PR-1) in Arabidopsis thaliana...
  9. Zhang Y, Cheng Y, Qu N, Zhao Q, Bi D, Li X. Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs. Plant J. 2006;48:647-56 pubmed
    ..NPR3 and NPR4 interact with TGA2, TGA3, TGA5 and TGA6 in yeast two-hybrid assays...
  10. Hepworth S, Zhang Y, McKim S, Li X, Haughn G. BLADE-ON-PETIOLE-dependent signaling controls leaf and floral patterning in Arabidopsis. Plant Cell. 2005;17:1434-48 pubmed

Detail Information

Publications32

  1. Fode B, Siemsen T, Thurow C, Weigel R, Gatz C. The Arabidopsis GRAS protein SCL14 interacts with class II TGA transcription factors and is essential for the activation of stress-inducible promoters. Plant Cell. 2008;20:3122-35 pubmed publisher
    ..Chromatin immunoprecipitation experiments revealed that class II TGA factors TGA2, TGA5, and/or TGA6 are needed to recruit SCL14 to promoters of selected SCL14 target genes identified by whole-..
  2. Zhang Y, Fan W, Kinkema M, Li X, Dong X. Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. Proc Natl Acad Sci U S A. 1999;96:6523-8 pubmed
    ..thaliana PR-1 gene. These data suggest that NPR1 may regulate PR-1 gene expression by interacting with a subclass of basic leucine zipper protein transcription factors. ..
  3. Li S, Lauri A, Ziemann M, Busch A, Bhave M, Zachgo S. Nuclear activity of ROXY1, a glutaredoxin interacting with TGA factors, is required for petal development in Arabidopsis thaliana. Plant Cell. 2009;21:429-41 pubmed publisher
    ..Additionally, ROXY1 affects later petal morphogenesis, probably by modulating other TGA factors that might act redundantly during differentiation of second whorl organs. ..
  4. Kesarwani M, Yoo J, Dong X. Genetic interactions of TGA transcription factors in the regulation of pathogenesis-related genes and disease resistance in Arabidopsis. Plant Physiol. 2007;144:336-46 pubmed
    ..A triple-knockout mutant tga2-1 tga5-1 tga6-1 was shown previously to be defective in the induction of PR genes and systemic acquired resistance, ..
  5. Spoel S, Mou Z, Tada Y, Spivey N, Genschik P, Dong X. Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity. Cell. 2009;137:860-72 pubmed publisher
    ..These in vivo data demonstrate dual roles for coactivator turnover in both preventing and stimulating gene transcription to regulate plant immunity. ..
  6. Despres C, Chubak C, Rochon A, Clark R, Bethune T, Desveaux D, et al. The Arabidopsis NPR1 disease resistance protein is a novel cofactor that confers redox regulation of DNA binding activity to the basic domain/leucine zipper transcription factor TGA1. Plant Cell. 2003;15:2181-91 pubmed
    ..Unlike its animal and yeast counterparts, the DNA binding activity of TGA1 is not redox regulated; however, this property is conferred by interaction with the NPR1 cofactor. ..
  7. Liu G, Holub E, Alonso J, Ecker J, Fobert P. An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance. Plant J. 2005;41:304-18 pubmed
    ..These results indicate that NPR4 is required for basal defense against pathogens, and that it may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways. ..
  8. Boyle P, Le Su E, Rochon A, Shearer H, Murmu J, Chu J, et al. The BTB/POZ domain of the Arabidopsis disease resistance protein NPR1 interacts with the repression domain of TGA2 to negate its function. Plant Cell. 2009;21:3700-13 pubmed publisher
    b>TGA2 and NONEXPRESSER OF PR GENES1 (NPR1) are activators of systemic acquired resistance (SAR) and of the SAR marker gene pathogenesis-related-1 (PR-1) in Arabidopsis thaliana...
  9. Zhang Y, Cheng Y, Qu N, Zhao Q, Bi D, Li X. Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs. Plant J. 2006;48:647-56 pubmed
    ..NPR3 and NPR4 interact with TGA2, TGA3, TGA5 and TGA6 in yeast two-hybrid assays...
  10. Hepworth S, Zhang Y, McKim S, Li X, Haughn G. BLADE-ON-PETIOLE-dependent signaling controls leaf and floral patterning in Arabidopsis. Plant Cell. 2005;17:1434-48 pubmed
  11. Rochon A, Boyle P, Wignes T, Fobert P, Despres C. The coactivator function of Arabidopsis NPR1 requires the core of its BTB/POZ domain and the oxidation of C-terminal cysteines. Plant Cell. 2006;18:3670-85 pubmed
    ..We show that TGA2 and NPR1 are recruited to PR-1 independently of each other and of SA treatment...
  12. Zander M, La Camera S, Lamotte O, Metraux J, Gatz C. Arabidopsis thaliana class-II TGA transcription factors are essential activators of jasmonic acid/ethylene-induced defense responses. Plant J. 2010;61:200-10 pubmed publisher
    The three closely related Arabidopsis basic leucine zipper (bZIP) transcription factors TGA2, TGA5 and TGA6 are required for the establishment of the salicylic acid (SA)-dependent plant defense response systemic acquired resistance, which ..
  13. Ndamukong I, Abdallat A, Thurow C, Fode B, Zander M, Weigel R, et al. SA-inducible Arabidopsis glutaredoxin interacts with TGA factors and suppresses JA-responsive PDF1.2 transcription. Plant J. 2007;50:128-39 pubmed
    ..further regulatory proteins of SA-dependent signaling pathways, a yeast protein interaction screen with tobacco TGA2.2 as bait and an Arabidopsis thaliana cDNA prey library was performed and led to the identification of a member of ..
  14. Despres C, Delong C, Glaze S, Liu E, Fobert P. The Arabidopsis NPR1/NIM1 protein enhances the DNA binding activity of a subgroup of the TGA family of bZIP transcription factors. Plant Cell. 2000;12:279-90 pubmed
    ..In the electrophoretic mobility shift assay, NPR1 substantially increased the binding of TGA2 to its cognate promoter element (as-1) as well as to a positive salicylic acid-inducible element (LS7) and a ..
  15. Subramaniam R, Desveaux D, Spickler C, Michnick S, Brisson N. Direct visualization of protein interactions in plant cells. Nat Biotechnol. 2001;19:769-72 pubmed
    ..We demonstrate that the interaction between Arabidopsis NPR1/NIM1 and the bZIP factor TGA2 is induced by the regulators of SAR, salicylic acid (SA), and its analog 2,6-dichloroisonicotinic acid (INA) with ..
  16. Deppmann C, Alvania R, Taparowsky E. Cross-species annotation of basic leucine zipper factor interactions: Insight into the evolution of closed interaction networks. Mol Biol Evol. 2006;23:1480-92 pubmed
    ..Finally, we discuss the fundamental similarities and differences between dimerization networks within the context of bZIP factor evolution. ..
  17. Stotz H, Findling S, Nukarinen E, Weckwerth W, Mueller M, Berger S. A tandem affinity purification tag of TGA2 for isolation of interacting proteins in Arabidopsis thaliana. Plant Signal Behav. 2014;9:e972794 pubmed publisher
    ..Type II bZIP transcription factors (TGA2, TGA5 and TGA6) play key roles in pathways that control salicylic acid, ethylene, xenobiotic and reactive oxylipin ..
  18. Canet J, Dobon A, Fajmonov√° J, Tornero P. The BLADE-ON-PETIOLE genes of Arabidopsis are essential for resistance induced by methyl jasmonate. BMC Plant Biol. 2012;12:199 pubmed publisher
  19. Johnson C, Mhatre A, Arias J. NPR1 preferentially binds to the DNA-inactive form of Arabidopsis TGA2. Biochim Biophys Acta. 2008;1779:583-9 pubmed publisher
    ..case of PR-1, transcriptional activation involves promoter-specific recruitment of transcription factors such as TGA2 through a mechanism that may involve transient physical interaction with the NPR1 protein...
  20. Zhou J, Trifa Y, Silva H, Pontier D, Lam E, Shah J, et al. NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid. Mol Plant Microbe Interact. 2000;13:191-202 pubmed
    ..Six TGA family members were tested and shown to differentially interact with NPR1: TGA2 and TGA3 showed strong affinity for NPR1; TGA5 and TGA6 exhibited weaker affinity; and TGA1 and TGA4 displayed ..
  21. Kang H, Klessig D. Salicylic acid-inducible Arabidopsis CK2-like activity phosphorylates TGA2. Plant Mol Biol. 2005;57:541-57 pubmed
    We demonstrate that TGA2, TGA5 and TGA6, and TGA3 to a lesser extent, are phosphorylated by an activity in rabbit reticulocytes...
  22. Fan W, Dong X. In vivo interaction between NPR1 and transcription factor TGA2 leads to salicylic acid-mediated gene activation in Arabidopsis. Plant Cell. 2002;14:1377-89 pubmed
    ..analysis, NPR1 has been suggested to interact with members of the TGA family of transcription factors, including TGA2 (AHBP-1b)...
  23. Matthews B, Beard H, Brewer E, Kabir S, MacDonald M, Youssef R. Arabidopsis genes, AtNPR1, AtTGA2 and AtPR-5, confer partial resistance to soybean cyst nematode (Heterodera glycines) when overexpressed in transgenic soybean roots. BMC Plant Biol. 2014;14:96 pubmed publisher
    ..decreased the number of cysts formed by SCN to less than 50% of those found on control roots, namely AtNPR1(33%), AtTGA2 (38%), and AtPR-5 (38%)...
  24. Weigel R, Bäuscher C, Pfitzner A, Pfitzner U. NIMIN-1, NIMIN-2 and NIMIN-3, members of a novel family of proteins from Arabidopsis that interact with NPR1/NIM1, a key regulator of systemic acquired resistance in plants. Plant Mol Biol. 2001;46:143-60 pubmed
    ..Taken together, these data indicate that the NIMIN proteins, via physical interaction with NPR1/NIM1, are part of the signal transduction pathway leading to SAR gene expression in Arabidopsis. ..
  25. Kim H, Delaney T. Over-expression of TGA5, which encodes a bZIP transcription factor that interacts with NIM1/NPR1, confers SAR-independent resistance in Arabidopsis thaliana to Peronospora parasitica. Plant J. 2002;32:151-63 pubmed
    ..We identified, in a yeast two-hybrid screen, two NIM1/NPR1 interacting proteins, TGA2 and TGA5, which belong to the basic region, leucine zipper (bZIP) family of transcription factors...
  26. Shi Z, Maximova S, Liu Y, Verica J, Guiltinan M. The salicylic acid receptor NPR3 is a negative regulator of the transcriptional defense response during early flower development in Arabidopsis. Mol Plant. 2013;6:802-16 pubmed publisher
    ..The physical interaction between NPR3 and NPR1/TGA2 was explored using bimolecular fluorescence complementation analysis in onion epidermal cells...
  27. de Pater S, Pham K, Memelink J, Kijne J. Binding specificity and tissue-specific expression pattern of the Arabidopsis bZIP transcription factor TGA2. Mol Gen Genet. 1996;250:237-9 pubmed
    The binding specificity and tissue-specific expression pattern of TGA2 (AHBP-1b), an Arabidopsis bZIP transcription factor have been determined...
  28. Fonseca J, Menossi M, Thibaud Nissen F, Town C. Functional analysis of a TGA factor-binding site located in the promoter region controlling salicylic acid-induced NIMIN-1 expression in Arabidopsis. Genet Mol Res. 2010;9:167-75 pubmed publisher
    ..We investigated whether the TGA2-binding motif TGACG located upstream of the NIMIN-1 gene is necessary for SA induction of NIMIN-1 expression...
  29. Zander M, Chen S, Imkampe J, Thurow C, Gatz C. Repression of the Arabidopsis thaliana jasmonic acid/ethylene-induced defense pathway by TGA-interacting glutaredoxins depends on their C-terminal ALWL motif. Mol Plant. 2012;5:831-40 pubmed publisher
    ..JA)/ethylene (ET)-induced defense genes through an unknown mechanism that requires clade II transcription factors TGA2, TGA5, and/or TGA6...
  30. Murmu J, Bush M, DeLong C, Li S, Xu M, Khan M, et al. Arabidopsis basic leucine-zipper transcription factors TGA9 and TGA10 interact with floral glutaredoxins ROXY1 and ROXY2 and are redundantly required for anther development. Plant Physiol. 2010;154:1492-504 pubmed publisher
  31. Weigel R, Pfitzner U, Gatz C. Interaction of NIMIN1 with NPR1 modulates PR gene expression in Arabidopsis. Plant Cell. 2005;17:1279-91 pubmed
    ..Our results strongly suggest that NIMIN1 negatively regulates distinct functions of NPR1, providing a mechanism to modulate specific features of SAR. ..
  32. Stotz H, Mueller S, Zoeller M, Mueller M, Berger S. TGA transcription factors and jasmonate-independent COI1 signalling regulate specific plant responses to reactive oxylipins. J Exp Bot. 2013;64:963-75 pubmed publisher
    ..Whereas JA-isoleucine signals through binding to COI1, the bZIP transcription factors TGA2, TGA5, and TGA6 are involved in regulation of gene expression in response to phytoprostanes...