Gene Symbol: AGO6
Description: Argonaute family protein
Alias: ARGONAUTE 6, T21L14.12, T21L14_12, Argonaute family protein
Species: thale cress
Havecker E, Wallbridge L, Hardcastle T, Bush M, Kelly K, Dunn R, et al
. The Arabidopsis RNA-directed DNA methylation argonautes functionally diverge based on their expression and interaction with target loci. Plant Cell. 2010;22:321-34 pubmed publisher
..basis of AGO functional diversification, we characterized three closely related Arabidopsis thaliana AGOs (AGO4, AGO6, and AGO9) implicated in RNA-directed DNA methylation...
Brosseau C, Moffett P. Functional and Genetic Analysis Identify a Role for Arabidopsis ARGONAUTE5 in Antiviral RNA Silencing. Plant Cell. 2015;27:1742-54 pubmed publisher
..In agreement with functional assays, we show that Potexvirus infection induces AGO5 expression and that both AGO2 and AGO5 are required for full restriction of PVX infection in systemic tissues of Arabidopsis. ..
Zheng X, Zhu J, Kapoor A, Zhu J. Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing. EMBO J. 2007;26:1691-701 pubmed
..We found that a mutation in AGO6 partially suppresses transcriptional gene silencing in the DNA demethylase mutant ros1-1...
Eun C, Lorkovic Z, Naumann U, Long Q, Havecker E, Simon S, et al
. AGO6 functions in RNA-mediated transcriptional gene silencing in shoot and root meristems in Arabidopsis thaliana. PLoS ONE. 2011;6:e25730 pubmed publisher
..AGO4 is the main AGO protein implicated in the RdDM pathway. Here we report the identification of the related AGO6 in a forward genetic screen for mutants defective in RdDM and transcriptional gene silencing in shoot and root ..
McCue A, Panda K, Nuthikattu S, Choudury S, Thomas E, Slotkin R. ARGONAUTE 6 bridges transposable element mRNA-derived siRNAs to the establishment of DNA methylation. EMBO J. 2015;34:20-35 pubmed publisher
..21-22 nucleotide (nt) siRNA degradation products from the RNAi of TE mRNAs are directly incorporated into the ARGONAUTE 6 (AGO6) protein and direct AGO6 to TE chromatin to guide its function in RdDM...
Duan C, Zhang H, Tang K, Zhu X, Qian W, Hou Y, et al
. Specific but interdependent functions for Arabidopsis AGO4 and AGO6 in RNA-directed DNA methylation. EMBO J. 2015;34:581-92 pubmed publisher
..In the RNA-directed DNA methylation (RdDM) pathway in Arabidopsis, AGO6 is generally considered to be redundant with AGO4...