Gene Symbol: AGO2
Description: Argonaute family protein
Alias: AtAGO2, T19E23.7, T19E23_7, argonaute 2, Argonaute family protein
Species: thale cress
Jaubert M, Bhattacharjee S, Mello A, Perry K, Moffett P. ARGONAUTE2 mediates RNA-silencing antiviral defenses against Potato virus X in Arabidopsis. Plant Physiol. 2011;156:1556-64 pubmed publisher
..Furthermore, we find that restriction of PVX on Arabidopsis also depends on AGO2, suggesting that this AGO protein has evolved to specialize in antiviral defenses.
Zhang X, Zhang X, Singh J, Li D, Qu F. Temperature-dependent survival of Turnip crinkle virus-infected arabidopsis plants relies on an RNA silencing-based defense that requires dcl2, AGO2, and HEN1. J Virol. 2012;86:6847-54 pubmed publisher
..virus (TCV) in Arabidopsis, plants containing loss-of-function mutations within the Dicer-like 2 (DCL2), Argonaute 2 (AGO2), and HEN1 RNA methyltransferase genes died of TCV infection, whereas the wild-type Col-0 plants survived ..
Harvey J, Lewsey M, Patel K, Westwood J, Heimstädt S, Carr J, et al
. An antiviral defense role of AGO2 in plants. PLoS ONE. 2011;6:e14639 pubmed publisher
..Plants encode multiple AGO proteins but, in Arabidopsis, only AGO1 is known to have an antiviral role...
Wang X, Jovel J, Udomporn P, Wang Y, Wu Q, Li W, et al
. The 21-nucleotide, but not 22-nucleotide, viral secondary small interfering RNAs direct potent antiviral defense by two cooperative argonautes in Arabidopsis thaliana. Plant Cell. 2011;23:1625-38 pubmed publisher
..AGO) genes combined with coimmunoprecipitation and deep sequencing identifies an essential function for AGO1 and AGO2 in defense against CMV-?2b, which act downstream the biogenesis of viral secondary siRNAs in a nonredundant and ..
Zhang X, Zhao H, Gao S, Wang W, Katiyar Agarwal S, Huang H, et al
. Arabidopsis Argonaute 2 regulates innate immunity via miRNA393(?)-mediated silencing of a Golgi-localized SNARE gene, MEMB12. Mol Cell. 2011;42:356-66 pubmed publisher
..We found that Arabidopsis AGO2 is highly induced by the bacterial pathogen Pseudomonas syringae pv. tomato (Pst)...
Garcia Ruiz H, Carbonell A, Hoyer J, Fahlgren N, Gilbert K, Takeda A, et al
. Roles and programming of Arabidopsis ARGONAUTE proteins during Turnip mosaic virus infection. PLoS Pathog. 2015;11:e1004755 pubmed publisher
..Arabidopsis thaliana has ten AGO genes of which AGO1, AGO2, and AGO7 have been shown to play roles in antiviral defense...
Pontier D, Picart C, Roudier F, Garcia D, Lahmy S, Azevedo J, et al
. NERD, a plant-specific GW protein, defines an additional RNAi-dependent chromatin-based pathway in Arabidopsis. Mol Cell. 2012;48:121-32 pubmed publisher
..chromatin signals in transcriptional silencing is supported by data showing that it binds both to histone H3 and AGO2 proteins and contributes to siRNA accumulation at a NERD-targeted locus...
Ma X, Nicole M, Meteignier L, Hong N, Wang G, Moffett P. Different roles for RNA silencing and RNA processing components in virus recovery and virus-induced gene silencing in plants. J Exp Bot. 2015;66:919-32 pubmed publisher
..Our results demonstrated roles for AGO2 and AGO4 in susceptibility to TRV, whereas VIGS of endogenous genes appeared to be largely mediated by AGO1...
Brosseau C, El Oirdi M, Adurogbangba A, Ma X, Moffett P. Antiviral Defense Involves AGO4 in an Arabidopsis-Potexvirus Interaction. Mol Plant Microbe Interact. 2016;29:878-888 pubmed
..Plants encode multiple AGO proteins with specialized functions, including AGO4-like proteins that affect RdDM and AGO2, AGO5, and AGO1, which have antiviral activities...