Gene Symbol: AGG2
Description: G-protein gamma subunit 2
Alias: AtGG2, G-protein gamma subunit 2, G-protein gamma subunit 2
Species: thale cress

Top Publications

  1. Mason M, Botella J. Isolation of a novel G-protein gamma-subunit from Arabidopsis thaliana and its interaction with Gbeta. Biochim Biophys Acta. 2001;1520:147-53 pubmed
    ..Here we report the cloning of a second plant G-protein gamma-subunit (AGG2) from Arabidopsis thaliana...
  2. Adjobo Hermans M, Goedhart J, Gadella T. Plant G protein heterotrimers require dual lipidation motifs of Galpha and Ggamma and do not dissociate upon activation. J Cell Sci. 2006;119:5087-97 pubmed
    ..The second Ggamma subunit, AGG2, did not require AGbeta1 for localization to the plasma membrane...
  3. Zeng Q, Wang X, Running M. Dual lipid modification of Arabidopsis Ggamma-subunits is required for efficient plasma membrane targeting. Plant Physiol. 2007;143:1119-31 pubmed
    ..demonstrate that the two heterotrimeric G-protein gamma-subunits from Arabidopsis (Arabidopsis thaliana), AGG1 and AGG2, are prenylated, and AGG2 is S-acylated...
  4. Trusov Y, Zhang W, Assmann S, Botella J. Ggamma1 + Ggamma2 not equal to Gbeta: heterotrimeric G protein Ggamma-deficient mutants do not recapitulate all phenotypes of Gbeta-deficient mutants. Plant Physiol. 2008;147:636-49 pubmed publisher
    ..Arabidopsis thaliana) genome contains one Galpha (GPA1), one Gbeta (AGB1), and two Ggamma subunit (AGG1 and AGG2) genes...
  5. Aranda Sicilia M, Trusov Y, Maruta N, Chakravorty D, Zhang Y, Botella J. Heterotrimeric G proteins interact with defense-related receptor-like kinases in Arabidopsis. J Plant Physiol. 2015;188:44-8 pubmed publisher
    ..At the same time, no interaction was detected with the non-RD RLK FLS2. We hypothesize that G-proteins mediate signal transduction immediately downstream of the pathogenesis-related RLKs. ..
  6. Olejnik K, Bucholc M, Anielska Mazur A, Lipko A, Kujawa M, Modzelan M, et al. Arabidopsis thaliana Nudix hydrolase AtNUDT7 forms complexes with the regulatory RACK1A protein and Ggamma subunits of the signal transducing heterotrimeric G protein. Acta Biochim Pol. 2011;58:609-16 pubmed
    ..In vitro interaction between RACK1A and the AGG1 and AGG2 gamma subunits of the signal transducing heterotrimeric G protein was also detected and confirmed in BiFC assays...
  7. Maruta N, Trusov Y, Brenya E, Parekh U, Botella J. Membrane-localized extra-large G proteins and Gbg of the heterotrimeric G proteins form functional complexes engaged in plant immunity in Arabidopsis. Plant Physiol. 2015;167:1004-16 pubmed
    ..Accordingly, XLGs expand the repertoire of heterotrimeric G proteins in plants and reveal a higher level of diversity in heterotrimeric G protein signaling. ..
  8. Mudgil Y, Uhrig J, Zhou J, Temple B, Jiang K, Jones A. Arabidopsis N-MYC DOWNREGULATED-LIKE1, a positive regulator of auxin transport in a G protein-mediated pathway. Plant Cell. 2009;21:3591-609 pubmed publisher
    ..A null mutation in either the single beta (AGB1) or the two gamma (AGG1 and AGG2) subunits confers phenotypes that disrupt the proper architecture of Arabidopsis roots and are consistent with ..
  9. Delgado Cerezo M, Sánchez Rodríguez C, Escudero V, Miedes E, Fernández P, Jorda L, et al. Arabidopsis heterotrimeric G-protein regulates cell wall defense and resistance to necrotrophic fungi. Mol Plant. 2012;5:98-114 pubmed publisher
    ..G?/AGB1 forms an obligate dimer with either one of the Arabidopsis G? subunits (?1/AGG1 and ?2/AGG2)...

More Information


  1. Thung L, Chakravorty D, Trusov Y, Jones A, Botella J. Signaling specificity provided by the Arabidopsis thaliana heterotrimeric G-protein ? subunits AGG1 and AGG2 is partially but not exclusively provided through transcriptional regulation. PLoS ONE. 2013;8:e58503 pubmed publisher
    ..While two of the ? subunits, AGG1 and AGG2 have been shown to provide functional selectivity to the Gß? dimer in Arabidopsis, it is unclear if such ..