AGAMOUS

Summary

Gene Symbol: AGAMOUS
Description: K-box region and MADS-box transcription factor family protein
Alias: AGAMOUS, AGAMOUS PROTEIN, F13C5.130, F13C5_130, K-box region and MADS-box transcription factor family protein
Species: thale cress

Top Publications

  1. Yanofsky M, Ma H, Bowman J, Drews G, Feldmann K, Meyerowitz E. The protein encoded by the Arabidopsis homeotic gene agamous resembles transcription factors. Nature. 1990;346:35-9 pubmed
    Mutations in the homeotic gene agamous of the plant Arabidopsis cause the transformation of the floral sex organs...
  2. Honma T, Goto K. Complexes of MADS-box proteins are sufficient to convert leaves into floral organs. Nature. 2001;409:525-9 pubmed
    ..APETALA3 (AP3), interact with APETALA1 (AP1, a class A protein) and SEPALLATA3 (SEP3, previously AGL9), and with AGAMOUS (AG, a class C protein) through SEP3...
  3. Liu Z, Liu Z. The second intron of AGAMOUS drives carpel- and stamen-specific expression sufficient to induce complete sterility in Arabidopsis. Plant Cell Rep. 2008;27:855-63 pubmed publisher
    ..In this study, we isolated the enhancer element of Arabidopsis AGAMOUS that drives gene expression specifically in stamens and carpels...
  4. Ito T, Ng K, Lim T, Yu H, Meyerowitz E. The homeotic protein AGAMOUS controls late stamen development by regulating a jasmonate biosynthetic gene in Arabidopsis. Plant Cell. 2007;19:3516-29 pubmed
    The Arabidopsis thaliana floral homeotic gene AGAMOUS (AG) plays a central role in reproductive organ (stamen and carpel) development...
  5. Ito T, Wellmer F, Yu H, Das P, Ito N, Alves Ferreira M, et al. The homeotic protein AGAMOUS controls microsporogenesis by regulation of SPOROCYTELESS. Nature. 2004;430:356-60 pubmed
    The Arabidopsis homeotic gene AGAMOUS (AG) is necessary for the specification of reproductive organs (stamens and carpels) during the early steps of flower development...
  6. Gómez Mena C, de Folter S, Costa M, Angenent G, Sablowski R. Transcriptional program controlled by the floral homeotic gene AGAMOUS during early organogenesis. Development. 2005;132:429-38 pubmed
    ..In Arabidopsis, the homeotic gene AGAMOUS (AG) terminates meristem activity and promotes development of stamens and carpels...
  7. Bao X, Franks R, Levin J, Liu Z. Repression of AGAMOUS by BELLRINGER in floral and inflorescence meristems. Plant Cell. 2004;16:1478-89 pubmed
    ..To understand the mechanism of transcriptional repression of the floral homeotic gene AGAMOUS (AG), we identified two mutations in the BELLRINGER (BLR) gene based on a striking floral phenotype, in which ..
  8. Das P, Ito T, Wellmer F, Vernoux T, Dedieu A, Traas J, et al. Floral stem cell termination involves the direct regulation of AGAMOUS by PERIANTHIA. Development. 2009;136:1605-11 pubmed publisher
    ..The precisely timed repression of the stem cell identity gene WUSCHEL (WUS) by the floral homeotic protein AGAMOUS (AG) is a key part of this process...
  9. Mizukami Y, Ma H. Determination of Arabidopsis floral meristem identity by AGAMOUS. Plant Cell. 1997;9:393-408 pubmed
    Determinate growth of floral meristems in Arabidopsis requires the function of the floral regulatory gene AGAMOUS (AG)...

More Information

Publications37

  1. Smaczniak C, Immink R, Muiño J, Blanvillain R, Busscher M, Busscher Lange J, et al. Characterization of MADS-domain transcription factor complexes in Arabidopsis flower development. Proc Natl Acad Sci U S A. 2012;109:1560-5 pubmed publisher
    ..Furthermore, members of other transcription factor families were identified as interaction partners of floral MADS-domain proteins suggesting various specific combinatorial modes of action. ..
  2. Gamboa A, Paez Valencia J, Acevedo G, Vazquez Moreno L, Alvarez Buylla R. Floral transcription factor AGAMOUS interacts in vitro with a leucine-rich repeat and an acid phosphatase protein complex. Biochem Biophys Res Commun. 2001;288:1018-26 pubmed
    ..An affinity column with this motif and a few surrounding hypervariable amino acids derived from the AGAMOUS sequence was prepared and used to isolate potential interactors from floral crude extracts...
  3. Doyle M, Amasino R. A single amino acid change in the enhancer of zeste ortholog CURLY LEAF results in vernalization-independent, rapid flowering in Arabidopsis. Plant Physiol. 2009;151:1688-97 pubmed publisher
    ..Furthermore, FRI appears to affect CLF occupancy at FLC; thus, our work provides insight into the molecular role that FRI plays in delaying the onset of flowering. ..
  4. ÓMaoiléidigh D, Wuest S, Rae L, Raganelli A, Ryan P, Kwasniewska K, et al. Control of reproductive floral organ identity specification in Arabidopsis by the C function regulator AGAMOUS. Plant Cell. 2013;25:2482-503 pubmed publisher
    The floral organ identity factor AGAMOUS (AG) is a key regulator of Arabidopsis thaliana flower development, where it is involved in the formation of the reproductive floral organs as well as in the control of meristem determinacy...
  5. Ng K, Yu H, Ito T. AGAMOUS controls GIANT KILLER, a multifunctional chromatin modifier in reproductive organ patterning and differentiation. PLoS Biol. 2009;7:e1000251 pubmed publisher
    The Arabidopsis homeotic protein AGAMOUS (AG), a MADS domain transcription factor, specifies reproductive organ identity during flower development...
  6. Rodríguez Cazorla E, Ripoll J, Andújar A, Bailey L, Martínez Laborda A, Yanofsky M, et al. K-homology nuclear ribonucleoproteins regulate floral organ identity and determinacy in arabidopsis. PLoS Genet. 2015;11:e1004983 pubmed publisher
    ..C-function during floral organ identity by post-transcriptionally regulating the MADS-box floral homeotic gene AGAMOUS (AG)...
  7. Maizel A, Busch M, Tanahashi T, Perkovic J, Kato M, Hasebe M, et al. The floral regulator LEAFY evolves by substitutions in the DNA binding domain. Science. 2005;308:260-3 pubmed
    ..We report that the DNA binding domain of LEAFY, although largely conserved, has diverged in activity. On the contrary, other, more rapidly evolving portions of the protein have few effects on LEAFY activity. ..
  8. Kavaĭ ool U, Karpenko O, Ezhova T. [Interaction between the PINOID/ABRUPTUS gene with the AGAMOUS gene: the negative regulator of stem cells in the meristem of Arabidopsis thaliana flower]. Ontogenez. 2011;42:146-50 pubmed
    Complementary interaction between the AGAMOUS and PINOID/ABRUPTUS genes was revealed. In double mutant abr ag-1, there is a significant increasing proliferation of cells of the floral meristem and formation of branching bine-like flowers...
  9. Gregis V, Sessa A, Colombo L, Kater M. AGL24, SHORT VEGETATIVE PHASE, and APETALA1 redundantly control AGAMOUS during early stages of flower development in Arabidopsis. Plant Cell. 2006;18:1373-82 pubmed
    Loss-of-function alleles of AGAMOUS-LIKE24 (AGL24) and SHORT VEGETATIVE PHASE (SVP) revealed that these two similar MADS box genes have opposite functions in controlling the floral transition in Arabidopsis thaliana, with AGL24 ..
  10. Barrero J, González Bayón R, del Pozo J, Ponce M, Micol J. INCURVATA2 encodes the catalytic subunit of DNA Polymerase alpha and interacts with genes involved in chromatin-mediated cellular memory in Arabidopsis thaliana. Plant Cell. 2007;19:2822-38 pubmed
    ..Quantitative RT-PCR analyses indicated that a number of regulatory genes were derepressed in the icu2-1 mutant, including genes associated with flowering time, floral meristem, and floral organ identity. ..
  11. Hsu W, Yeh T, Huang K, Li J, Chen H, Yang C. AGAMOUS-LIKE13, a putative ancestor for the E functional genes, specifies male and female gametophyte morphogenesis. Plant J. 2014;77:1-15 pubmed publisher
    ..Our data suggest that AGL13 is likely a putative ancestor for the E functional genes which specifies male and female gametophyte morphogenesis in plants during evolution...
  12. Cartolano M, Efremova N, Kuckenberg M, Raman S, Schwarz Sommer Z. Enhanced AGAMOUS expression in the centre of the Arabidopsis flower causes ectopic expression over its outer expression boundaries. Planta. 2009;230:857-62 pubmed publisher
    ..and hence the principle of 'regulation by tuning' also applies to spatial regulation of the C-function gene AGAMOUS (AG) in Arabidopsis, we generated transgenic plants with enhanced central AG expression by using stem cell-..
  13. Riechmann J, Krizek B, Meyerowitz E. Dimerization specificity of Arabidopsis MADS domain homeotic proteins APETALA1, APETALA3, PISTILLATA, and AGAMOUS. Proc Natl Acad Sci U S A. 1996;93:4793-8 pubmed
    The MADS domain homeotic proteins APETALA1 (AP1), APETALA3 (AP3), PISTILLATA (PI), and AGAMOUS (AG) act in a combinatorial manner to specify the identity of Arabidopsis floral organs...
  14. Brambilla V, Battaglia R, Colombo M, Masiero S, Bencivenga S, Kater M, et al. Genetic and molecular interactions between BELL1 and MADS box factors support ovule development in Arabidopsis. Plant Cell. 2007;19:2544-56 pubmed
    ..the homeodomain factor BELL1 (BEL1) and MADS box family members SEEDSTICK (STK), SHATTERPROOF1 (SHP1), SHP2, and AGAMOUS. Both in the bel1 mutant and the stk shp1 shp2 triple mutant, integuments are transformed into carpelloid ..
  15. Zhao L, Kim Y, Dinh T, Chen X. miR172 regulates stem cell fate and defines the inner boundary of APETALA3 and PISTILLATA expression domain in Arabidopsis floral meristems. Plant J. 2007;51:840-9 pubmed
    In Arabidopsis, two floral homeotic genes APETALA2 (AP2) and AGAMOUS (AG) specify the identities of perianth and reproductive organs, respectively, in flower development...
  16. Liu X, Dinh T, Li D, Shi B, Li Y, Cao X, et al. AUXIN RESPONSE FACTOR 3 integrates the functions of AGAMOUS and APETALA2 in floral meristem determinacy. Plant J. 2014;80:629-41 pubmed publisher
    ..through the isolation and characterization of a mutant of ARF3 that enhanced the FM determinacy defects of agamous (ag)-10, a weak ag allele...
  17. Fan H, Hu Y, Tudor M, Ma H. Specific interactions between the K domains of AG and AGLs, members of the MADS domain family of DNA binding proteins. Plant J. 1997;12:999-1010 pubmed
    ..In vivo studies with the Arabidopsis AGAMOUS (AG) protein have indicated that the K domain is important for AG function...
  18. Saleh A, Al Abdallat A, Ndamukong I, Alvarez Venegas R, Avramova Z. The Arabidopsis homologs of trithorax (ATX1) and enhancer of zeste (CLF) establish 'bivalent chromatin marks' at the silent AGAMOUS locus. Nucleic Acids Res. 2007;35:6290-6 pubmed
    ..of zeste (EZ) and the ARABIDOPSIS HOMOLOG OF TRITHORAX (ATX1) control the expression of the flower homeotic gene AGAMOUS (AG)...
  19. Engelhorn J, Moreau F, Fletcher J, Carles C. ULTRAPETALA1 and LEAFY pathways function independently in specifying identity and determinacy at the Arabidopsis floral meristem. Ann Bot. 2014;114:1497-505 pubmed publisher
    ..In particular, the AGAMOUS (AG) MADS domain-containing transcription factor plays a major role in controlling floral determinacy in ..
  20. Bollier N, Sicard A, Leblond J, Latrasse D, Gonzalez N, Gévaudant F, et al. At-MINI ZINC FINGER2 and Sl-INHIBITOR OF MERISTEM ACTIVITY, a Conserved Missing Link in the Regulation of Floral Meristem Termination in Arabidopsis and Tomato. Plant Cell. 2018;30:83-100 pubmed publisher
    ..Direct repression mediated by the MADS domain transcription factor AGAMOUS (AG), followed by indirect repression requiring the C2H2 zinc-finger protein KNUCKLES (KNU), allow for the ..
  21. Liu X, Gao L, Dinh T, Shi T, Li D, Wang R, et al. DNA topoisomerase I affects polycomb group protein-mediated epigenetic regulation and plant development by altering nucleosome distribution in Arabidopsis. Plant Cell. 2014;26:2803-17 pubmed publisher
    ..nucleosome density, which probably allows the binding of factors that either recruit PcG, as we demonstrated for AGAMOUS at the WUS locus, or counteract PcG-mediated regulation...
  22. Wollmann H, Mica E, Todesco M, Long J, Weigel D. On reconciling the interactions between APETALA2, miR172 and AGAMOUS with the ABC model of flower development. Development. 2010;137:3633-42 pubmed publisher
    ..In Arabidopsis thaliana, APETALA2 (AP2) and AGAMOUS (AG) represent A- and C-class genes that act in an antagonistic fashion to specify perianth and reproductive ..
  23. Huang Z, Shi T, Zheng B, Yumul R, Liu X, You C, et al. APETALA2 antagonizes the transcriptional activity of AGAMOUS in regulating floral stem cells in Arabidopsis thaliana. New Phytol. 2017;215:1197-1209 pubmed publisher
    ..outer two floral whorls, where it specifies the identities of sepals and petals by restricting the expression of AGAMOUS (AG) to the inner two whorls in Arabidopsis thaliana...
  24. Liu X, Kim Y, Muller R, Yumul R, Liu C, Pan Y, et al. AGAMOUS terminates floral stem cell maintenance in Arabidopsis by directly repressing WUSCHEL through recruitment of Polycomb Group proteins. Plant Cell. 2011;23:3654-70 pubmed publisher
    ..b>AGAMOUS (AG), a MADS domain transcription factor essential for the termination of floral stem cell fate, has long been ..
  25. Favaro R, Pinyopich A, Battaglia R, Kooiker M, Borghi L, Ditta G, et al. MADS-box protein complexes control carpel and ovule development in Arabidopsis. Plant Cell. 2003;15:2603-11 pubmed
    The AGAMOUS (AG) gene is necessary for stamen and carpel development and is part of a monophyletic clade of MADS-box genes that also includes SHATTERPROOF1 (SHP1), SHP2, and SEEDSTICK (STK)...
  26. Yang Y, Jack T. Defining subdomains of the K domain important for protein-protein interactions of plant MADS proteins. Plant Mol Biol. 2004;55:45-59 pubmed
    The MADS proteins APETALA3 (AP3), PISTILLATA (PI), SEPALLATAI (SEPI), SEP2, SEP3, AGAMOUS, and APETALA are required for proper floral organ identity in Arabidopsis flowers...
  27. Wang X, Gingrich D, Deng Y, Hong Z. A nucleostemin-like GTPase required for normal apical and floral meristem development in Arabidopsis. Mol Biol Cell. 2012;23:1446-56 pubmed publisher
    ..stem cell activities have to be terminated during flower development, and this process requires the activation of AGAMOUS (AG) gene expression...
  28. Riechmann J, Wang M, Meyerowitz E. DNA-binding properties of Arabidopsis MADS domain homeotic proteins APETALA1, APETALA3, PISTILLATA and AGAMOUS. Nucleic Acids Res. 1996;24:3134-41 pubmed
    The MADS domain proteins APETALA1 (AP1), APETALA3 (AP3), PISTILLATA (PI), and AGAMOUS (AG) specify the identity of Arabidopsis floral organs. AP1 and AG homocomplexes and AP3-PI heterocomplexes bind to CArG-box sequences...