Gene Symbol: ABI4
Description: Integrase-type DNA-binding superfamily protein
Species: thale cress

Top Publications

  1. Ramon M, Rolland F, Thevelein J, Van Dijck P, Leyman B. ABI4 mediates the effects of exogenous trehalose on Arabidopsis growth and starch breakdown. Plant Mol Biol. 2007;63:195-206 pubmed
    ..Here we show that the ABI4 transcription factor mediates the effects of trehalose on starch metabolism and growth, independently of abscisic ..
  2. Van Oosten J, Gerbaud A, Huijser C, Dijkwel P, Chua N, Smeekens S. An Arabidopsis mutant showing reduced feedback inhibition of photosynthesis. Plant J. 1997;12:1011-20 pubmed
    ..It was found that the sun6 mutation makes plants unresponsive to these 2DG-induced effects...
  3. Penfield S, Li Y, Gilday A, Graham S, Graham I. Arabidopsis ABA INSENSITIVE4 regulates lipid mobilization in the embryo and reveals repression of seed germination by the endosperm. Plant Cell. 2006;18:1887-99 pubmed
    ..We also show that ABA INSENSITIVE4 (ABI4) expression is confined to the embryo, accounts for the major differences in embryo response to ABA, and defines a ..
  4. Bossi F, Cordoba E, Dupré P, Mendoza M, Román C, Leon P. The Arabidopsis ABA-INSENSITIVE (ABI) 4 factor acts as a central transcription activator of the expression of its own gene, and for the induction of ABI5 and SBE2.2 genes during sugar signaling. Plant J. 2009;59:359-74 pubmed publisher
    The transcription factor ABA INSENSITIVE 4 (ABI4), discovered nearly 10 years ago, plays a central role in a variety of functions in plants, including sugar responses...
  5. Shu K, Zhang H, Wang S, Chen M, Wu Y, Tang S, et al. ABI4 regulates primary seed dormancy by regulating the biogenesis of abscisic acid and gibberellins in arabidopsis. PLoS Genet. 2013;9:e1003577 pubmed publisher
    ..Here, we report that ABI4 positively regulates primary seed dormancy, while negatively regulating cotyledon greening, by mediating the ..
  6. Arenas Huertero F, Arroyo A, Zhou L, Sheen J, Leon P. Analysis of Arabidopsis glucose insensitive mutants, gin5 and gin6, reveals a central role of the plant hormone ABA in the regulation of plant vegetative development by sugar. Genes Dev. 2000;14:2085-96 pubmed
    ..The T-DNA-tagged gin6 mutant abrogates the glucose-induced expression of a putative transcription factor, ABI4, previously shown to be involved in seed-specific abscisic acid (ABA) responses...
  7. Leon P, Sheen J. Sugar and hormone connections. Trends Plant Sci. 2003;8:110-6 pubmed
    ..The effects of sugar and osmotic stress on morphogenesis and gene expression are distinct. The plasticity of plant growth and development are exemplified by the complex interplay of sugar and hormone signalling. ..
  8. Reeves W, Lynch T, Mobin R, Finkelstein R. Direct targets of the transcription factors ABA-Insensitive(ABI)4 and ABI5 reveal synergistic action by ABI4 and several bZIP ABA response factors. Plant Mol Biol. 2011;75:347-63 pubmed publisher
    ..The direct effects of ABI4 and ABI5 in ABA response remain largely undefined...
  9. Brady S, Sarkar S, Bonetta D, McCourt P. The ABSCISIC ACID INSENSITIVE 3 (ABI3) gene is modulated by farnesylation and is involved in auxin signaling and lateral root development in Arabidopsis. Plant J. 2003;34:67-75 pubmed
    ..In contrast with ABI3 and ABI5, the ABI4 transcription factor appears to act at or upstream of ERA1...

More Information


  1. Finkelstein R, Lynch T, Reeves W, Petitfils M, Mostachetti M. Accumulation of the transcription factor ABA-insensitive (ABI)4 is tightly regulated post-transcriptionally. J Exp Bot. 2011;62:3971-9 pubmed publisher
    ..Previous studies have shown that ABI4 transcripts are high in seeds and in seedlings exposed to high concentrations of glucose and, to a lesser extent, ..
  2. Cui H, Hao Y, Kong D. SCARECROW has a SHORT-ROOT-independent role in modulating the sugar response. Plant Physiol. 2012;158:1769-78 pubmed publisher
    ..and reverse transcription-PCR assays as well as transgenic studies with an ABA-INSENSITIVE2 (ABI4)-?-glucuronidase reporter construct revealed that in root, SCR, but not SHR, repressed ABI4 and ABI5 directly and ..
  3. Quesada V, Ponce M, Micol J. Genetic analysis of salt-tolerant mutants in Arabidopsis thaliana. Genetics. 2000;154:421-36 pubmed
    ..germination was displayed by sañ5, whose genetic and molecular characterization indicates that it carries an extremely hypomorphic or null allele of the ABI4 gene, its deduced protein product lacking the APETALA2 DNA binding domain.
  4. Shkolnik Inbar D, Bar Zvi D. ABI4 mediates abscisic acid and cytokinin inhibition of lateral root formation by reducing polar auxin transport in Arabidopsis. Plant Cell. 2010;22:3560-73 pubmed publisher
    ..Here, we show that mutating ABSCISIC ACID INSENSITIVE4 (ABI4), which encodes an ABA-regulated AP2 domain transcription factor, results in an increased number of LRs...
  5. Kaliff M, Staal J, Myrenås M, Dixelius C. ABA is required for Leptosphaeria maculans resistance via ABI1- and ABI4-dependent signaling. Mol Plant Microbe Interact. 2007;20:335-45 pubmed
    ..Highly induced camalexin levels made ABA mutants in Col-0 background (aba2-1, aba3-1, and abi4-1) appear resistant, but displayed enhanced susceptibility as double mutants with pad3-1, impaired in camalexin ..
  6. Kerchev P, Pellny T, Vivancos P, Kiddle G, Hedden P, Driscoll S, et al. The transcription factor ABI4 Is required for the ascorbic acid-dependent regulation of growth and regulation of jasmonate-dependent defense signaling pathways in Arabidopsis. Plant Cell. 2011;23:3319-34 pubmed publisher
    ..Interactions between redox metabolism and the ABSCISIC ACID-INSENSITIVE-4 (ABI4) transcription factor were characterized in the Arabidopsis thaliana vitamin c defective1 (vtc1) and vtc2 mutants, ..
  7. Yang Y, Yu X, Song L, An C. ABI4 activates DGAT1 expression in Arabidopsis seedlings during nitrogen deficiency. Plant Physiol. 2011;156:873-83 pubmed publisher
    ..Yeast one-hybrid and electrophoretic mobility shift assays demonstrated that ABSCISIC ACID INSENSITIVE4 (ABI4), an important transcriptional factor in the abscisic acid signaling pathway, bound directly to the CE1-like ..
  8. Acevedo Hernández G, Leon P, Herrera Estrella L. Sugar and ABA responsiveness of a minimal RBCS light-responsive unit is mediated by direct binding of ABI4. Plant J. 2005;43:506-19 pubmed
    ..The latter responses were found to be impaired in the abi4 mutant, indicating that ABSCISIC ACID INSENSITIVE-4 (ABI4) is a regulator involved in sugar and ABA repression of ..
  9. Finkelstein R, Wang M, Lynch T, Rao S, Goodman H. The Arabidopsis abscisic acid response locus ABI4 encodes an APETALA 2 domain protein. Plant Cell. 1998;10:1043-54 pubmed
    Arabidopsis abscisic acid (ABA)-insensitive abi4 mutants have pleiotropic defects in seed development, including decreased sensitivity to ABA inhibition of germination and altered seed-specific gene expression...
  10. Nakamura S, Lynch T, Finkelstein R. Physical interactions between ABA response loci of Arabidopsis. Plant J. 2001;26:627-35 pubmed
    ..Yeast one-hybrid assays with a lacZ reporter gene under control of the late embryogenesis-abundant AtEm6 promoter show that only ABI5 binds directly to this promoter fragment. ..
  11. Koussevitzky S, Nott A, Mockler T, Hong F, Sachetto Martins G, Surpin M, et al. Signals from chloroplasts converge to regulate nuclear gene expression. Science. 2007;316:715-9 pubmed
    ..We show here that GUN1, a chloroplast-localized pentatricopeptide-repeat protein, and ABI4, an Apetala 2 (AP2)-type transcription factor, are common to all three pathways...
  12. Giraud E, Van Aken O, Ho L, Whelan J. The transcription factor ABI4 is a regulator of mitochondrial retrograde expression of ALTERNATIVE OXIDASE1a. Plant Physiol. 2009;150:1286-96 pubmed publisher
    ..with a previously identified potential binding site for the transcription factor ABSCISIC ACID INSENSITIVE4 (ABI4). AOX1a promoter activity was fully derepressed in abi4 mutants and was unresponsive to rotenone...
  13. Xie Y, Mao Y, Duan X, Zhou H, Lai D, Zhang Y, et al. Arabidopsis HY1-Modulated Stomatal Movement: An Integrative Hub Is Functionally Associated with ABI4 in Dehydration-Induced ABA Responsiveness. Plant Physiol. 2016;170:1699-713 pubmed publisher
    ..In agreement, ABA-induced ABSCISIC ACID-INSENSITIVE4 (ABI4) transcript accumulation was strengthened in the hy1 mutant...
  14. Shu K, Chen Q, Wu Y, Liu R, Zhang H, Wang S, et al. ABSCISIC ACID-INSENSITIVE 4 negatively regulates flowering through directly promoting Arabidopsis FLOWERING LOCUS C transcription. J Exp Bot. 2016;67:195-205 pubmed publisher
    ..Here, we report that ABSCISIC ACID-INSENSITIVE 4 (ABI4), a key component in the ABA signalling pathway, negatively regulates floral transition by directly promoting ..
  15. Zhang Z, Feng L, Cheng J, Tang H, Xu F, Zhu F, et al. The roles of two transcription factors, ABI4 and CBFA, in ABA and plastid signalling and stress responses. Plant Mol Biol. 2013;83:445-58 pubmed publisher
    ..b>ABI4, a master Apetala 2 (AP2)-type transcription factor (TF), is targeted by multiple signalling pathways in plant ..
  16. Kong Y, Chen S, Yang Y, An C. ABA-insensitive (ABI) 4 and ABI5 synergistically regulate DGAT1 expression in Arabidopsis seedlings under stress. FEBS Lett. 2013;587:3076-82 pubmed publisher
    ..study, we show that TAG accumulation in Arabidopsis seedlings is correlated with environmental stress, and both ABI4 and ABI5 play important roles in regulating DGAT1 expression...
  17. Huang X, Zhang X, Gong Z, Yang S, Shi Y. ABI4 represses the expression of type-A ARRs to inhibit seed germination in Arabidopsis. Plant J. 2017;89:354-365 pubmed publisher
    ..ABSCISIC ACID INSENSITIVE4 (ABI4), an APETALA2 (AP2)-type transcription factor, is required for the ABA-mediated inhibition of seed germination...
  18. Shkolnik Inbar D, Adler G, Bar Zvi D. ABI4 downregulates expression of the sodium transporter HKT1;1 in Arabidopsis roots and affects salt tolerance. Plant J. 2013;73:993-1005 pubmed publisher
    ..mutants affected in the ABSCISIC ACID INSENSITIVE (ABI) 4 gene display increased salt tolerance, whereas ABI4-overexpressors are hypersensitive to salinity from seed germination to late vegetative developmental stages...
  19. Waszczak C, Kerchev P, Mühlenbock P, Hoeberichts F, Van Der Kelen K, Mhamdi A, et al. SHORT-ROOT Deficiency Alleviates the Cell Death Phenotype of the Arabidopsis catalase2 Mutant under Photorespiration-Promoting Conditions. Plant Cell. 2016;28:1844-59 pubmed publisher
    ..Our findings reveal a link between SHR and photorespiratory H2O2 production that has implications for the integration of developmental and stress responses. ..
  20. Xu X, Chi W, Sun X, Feng P, Guo H, Li J, et al. Convergence of light and chloroplast signals for de-etiolation through ABI4-HY5 and COP1. Nat Plants. 2016;2:16066 pubmed publisher
    ..developmental and physiological responses associated with de-etiolation through a transcriptional module of ABA INSENSITIVE 4 (ABI4) and ELONGATED HYPOCOTYL 5 (HY5)...
  21. Riechmann J, Ratcliffe O. A genomic perspective on plant transcription factors. Curr Opin Plant Biol. 2000;3:423-34 pubmed
  22. Feng C, Chen Y, Wang C, Kong Y, Wu W, Chen Y. Arabidopsis RAV1 transcription factor, phosphorylated by SnRK2 kinases, regulates the expression of ABI3, ABI4, and ABI5 during seed germination and early seedling development. Plant J. 2014;80:654-68 pubmed publisher
    ..Overexpression of RAV1 repressed ABI3, ABI4, and ABI5 expression, and RAV1 bound to the ABI3, ABI4, and ABI5 promoters in vitro and in vivo, indicating that ..
  23. Mu Y, Zou M, Sun X, He B, Xu X, Liu Y, et al. BASIC PENTACYSTEINE Proteins Repress ABSCISIC ACID INSENSITIVE4 Expression via Direct Recruitment of the Polycomb-Repressive Complex 2 in Arabidopsis Root Development. Plant Cell Physiol. 2017;58:607-621 pubmed publisher
    ..investigated the molecular and functional relationships of the transcription factors ABSCISIC ACID INSENSITIVE 4 (ABI4) and members of the BASIC PENTACYSTEINE (BPC) family in lateral root (LR) development of Arabidopsis thaliana...
  24. Katagiri T, Ishiyama K, Kato T, Tabata S, Kobayashi M, Shinozaki K. An important role of phosphatidic acid in ABA signaling during germination in Arabidopsis thaliana. Plant J. 2005;43:107-17 pubmed
    ..Furthermore, double-mutant analysis showed that ABA-insensitive 4 (ABI4) is epistatic to AtLPP2 but ABA-insensitive 3 (ABI3) is not...
  25. Jakab G, Ton J, Flors V, Zimmerli L, Metraux J, Mauch Mani B. Enhancing Arabidopsis salt and drought stress tolerance by chemical priming for its abscisic acid responses. Plant Physiol. 2005;139:267-74 pubmed
    ..On the contrary, the ABA deficient 1 and ABA insensitive 4 mutants, both impaired in the ABA-signaling pathway, could not be protected by BABA application...
  26. Dong Z, Yu Y, Li S, Wang J, Tang S, Huang R. Abscisic Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis. Mol Plant. 2016;9:126-135 pubmed publisher
    ..A dominant allele of ABI4, abi4-152, which produces a putative protein with a 16-amino-acid truncation at the C-terminus of ABI4, reduces ..
  27. Daszkowska Golec A, Wojnar W, Rosikiewicz M, Szarejko I, Maluszynski M, Szweykowska Kulinska Z, et al. Arabidopsis suppressor mutant of abh1 shows a new face of the already known players: ABH1 (CBP80) and ABI4-in response to ABA and abiotic stresses during seed germination. Plant Mol Biol. 2013;81:189-209 pubmed publisher
    ..The molecular analysis revealed that mutation causing the phenotype of soa1 occurred in the ABI4 (ABA insensitive 4) gene...
  28. Uhrig J, Mutondo M, Zimmermann I, Deeks M, Machesky L, Thomas P, et al. The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis. Development. 2007;134:967-77 pubmed
  29. Yao X, Li J, Liu J, Liu K. An Arabidopsis mitochondria-localized RRL protein mediates abscisic acid signal transduction through mitochondrial retrograde regulation involving ABI4. J Exp Bot. 2015;66:6431-45 pubmed publisher
    ..The APETALA2 (AP2)-type transcription factor ABI4 is a regulator of ALTERNATIVE OXIDASE1a (AOX1a) in mitochondrial retrograde signalling...
  30. Shu K, Chen Q, Wu Y, Liu R, Zhang H, Wang P, et al. ABI4 mediates antagonistic effects of abscisic acid and gibberellins at transcript and protein levels. Plant J. 2016;85:348-61 pubmed publisher
    ..Here, we report that ABA-INSENSITIVE 4 (ABI4) is a central factor in GA/ABA homeostasis and antagonism in post-germination stages...
  31. Shkolnik D, Bar Zvi D. Tomato ASR1 abrogates the response to abscisic acid and glucose in Arabidopsis by competing with ABI4 for DNA binding. Plant Biotechnol J. 2008;6:368-78 pubmed publisher
    ..ASR1-overexpressing (ASR1-OE) plants display an abscisic acid-insensitive 4 (abi4) phenotype: seed germination is not sensitive to inhibition by abscisic acid (ABA), glucose, NaCl and paclobutrazol...
  32. Lee K, Lee H, Yoon S, Kim H, Seo P. The Arabidopsis MYB96 Transcription Factor Is a Positive Regulator of ABSCISIC ACID-INSENSITIVE4 in the Control of Seed Germination. Plant Physiol. 2015;168:677-89 pubmed publisher
    ..highly expressed in embryo, regulates seed germination by controlling the expression of abscisic acid-insensitive4 (ABI4) in Arabidopsis (Arabidopsis thaliana)...
  33. Shkolnik Inbar D, Bar Zvi D. Expression of ABSCISIC ACID INSENSITIVE 4 (ABI4) in developing Arabidopsis seedlings. Plant Signal Behav. 2011;6:694-6 pubmed
    We have recently demonstrated that the transcription factor ABSCISIC ACID INSENSITIVE 4 (ABI4) mediates abscisic acid and cytokinin inhibition of lateral root formation by reducing polar auxin transport in Arabidopsis thaliana...
  34. Lai Z, Schluttenhofer C, Bhide K, Shreve J, Thimmapuram J, Lee S, et al. MED18 interaction with distinct transcription factors regulates multiple plant functions. Nat Commun. 2014;5:3064 pubmed publisher
    ..In addition, MED18 interacts with ABA INSENSITIVE 4 and SUPPRESSOR OF FRIGIDA4 to regulate abscisic acid responses and flowering time, respectively...
  35. Li P, Zhou H, Shi X, Yu B, Zhou Y, Chen S, et al. The ABI4-induced Arabidopsis ANAC060 transcription factor attenuates ABA signaling and renders seedlings sugar insensitive when present in the nucleus. PLoS Genet. 2014;10:e1004213 pubmed publisher
    ..Chromatin immunoprecipitation-qPCR and transient expression analysis showed that ABI4 directly binds to the GSQ11/ANAC060 promoter to activate transcription...
  36. Zhao J, Zhou H, Zhang M, Gao Y, Li L, Gao Y, et al. Ubiquitin-specific protease 24 negatively regulates abscisic acid signalling in Arabidopsis thaliana. Plant Cell Environ. 2016;39:427-40 pubmed publisher
    ..These results uncover an important regulatory role for the ubiquitin-specific protease in response to ABA and salt stress in plant. ..
  37. Gregorio J, Hernández Bernal A, Cordoba E, Leon P. Characterization of evolutionarily conserved motifs involved in activity and regulation of the ABA-INSENSITIVE (ABI) 4 transcription factor. Mol Plant. 2014;7:422-36 pubmed publisher
    In recent years, the transcription factor ABI4 has emerged as an important node of integration for external and internal signals such as nutrient status and hormone signaling that modulates critical transitions during the growth and ..