ABI1

Summary

Gene Symbol: ABI1
Description: Protein phosphatase 2C family protein
Alias: ABA INSENSITIVE 1, AtABI1, F20B18.190, F20B18_190, PROTEIN PHOSPHATASE 2C ABI1, Protein phosphatase 2C family protein
Species: thale cress
Products:     ABI1

Top Publications

  1. Yoshida R, Umezawa T, Mizoguchi T, Takahashi S, Takahashi F, Shinozaki K. The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates abscisic acid (ABA) and osmotic stress signals controlling stomatal closure in Arabidopsis. J Biol Chem. 2006;281:5310-8 pubmed
    b>ABI1 and ABI2 encode PP2C-type protein phosphatases and are thought to negatively regulate many aspects of abscisic acid (ABA) signaling, including stomatal closure in Arabidopsis. In contrast, SRK2E/OST1/SnRK2...
  2. Watanabe N, Lam E. BAX inhibitor-1 modulates endoplasmic reticulum stress-mediated programmed cell death in Arabidopsis. J Biol Chem. 2008;283:3200-10 pubmed
    ..We propose that AtBI1 plays a pivotal role as a highly conserved survival factor during ER stress that acts in parallel to the unfolded protein response pathway. ..
  3. Szostkiewicz I, Richter K, Kepka M, Demmel S, Ma Y, Korte A, et al. Closely related receptor complexes differ in their ABA selectivity and sensitivity. Plant J. 2010;61:25-35 pubmed publisher
    ..RCAR3 was identified in a screen for interactors of the PP2Cs ABI1 and ABI2, which are key regulators of ABA responses...
  4. Ludwikow A, Cieśla A, Kasprowicz Maluśki A, Mituła F, Tajdel M, Gałgański Ł, et al. Arabidopsis protein phosphatase 2C ABI1 interacts with type I ACC synthases and is involved in the regulation of ozone-induced ethylene biosynthesis. Mol Plant. 2014;7:960-76 pubmed publisher
    ..Here, we show that the Arabidopsis thaliana protein phosphatase type 2C, ABI1, a negative regulator of abscisic acid signaling, is involved in the regulation of ethylene biosynthesis under ..
  5. Miyazono K, Miyakawa T, Sawano Y, Kubota K, Kang H, Asano A, et al. Structural basis of abscisic acid signalling. Nature. 2009;462:609-14 pubmed publisher
    ..PYL1 bound with (+)-ABA, and the complex formed by the further binding of (+)-ABA-bound PYL1 with the PP2C protein ABI1. PYL1 binds (+)-ABA using the START-protein-specific ligand-binding site, thereby forming a hydrophobic pocket on ..
  6. Melcher K, Ng L, Zhou X, Soon F, Xu Y, Suino Powell K, et al. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 2009;462:602-8 pubmed publisher
    ..Together, our results identify a conserved gate-latch-lock mechanism underlying ABA signalling. ..
  7. Vlad F, Rubio S, Rodrigues A, Sirichandra C, Belin C, Robert N, et al. Protein phosphatases 2C regulate the activation of the Snf1-related kinase OST1 by abscisic acid in Arabidopsis. Plant Cell. 2009;21:3170-84 pubmed publisher
    ..Furthermore, HAB1 and the related PP2Cs ABI1 and ABI2 interact with OST1 in vivo, and mutations in the corresponding genes strongly affect OST1 activation by ..
  8. Himmelbach A, Hoffmann T, Leube M, Höhener B, Grill E. Homeodomain protein ATHB6 is a target of the protein phosphatase ABI1 and regulates hormone responses in Arabidopsis. EMBO J. 2002;21:3029-38 pubmed
    b>ABI1, a protein phosphatase 2C, is a key component of signal transduction in Arabidopsis. It regulates diverse responses to the phytohormone abscisic acid (ABA) such as stomatal closure, seed dormancy and inhibition of vegetative growth...
  9. Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, et al. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009;16:1230-6 pubmed publisher
    ..Upon binding to ABA, a PYL protein associates with type 2C protein phosphatases (PP2Cs) such as ABI1 and ABI2, inhibiting their activity; the molecular mechanisms by which PYLs mediate ABA signaling remain unknown, ..
  10. Nishimura N, Sarkeshik A, Nito K, Park S, Wang A, Carvalho P, et al. PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J. 2010;61:290-9 pubmed publisher
    ..The group-A PP2Cs, of which ABI1 is the prototypical member, are protein phosphatases that play critical roles as negative regulators very early in ..

Detail Information

Publications66

  1. Yoshida R, Umezawa T, Mizoguchi T, Takahashi S, Takahashi F, Shinozaki K. The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates abscisic acid (ABA) and osmotic stress signals controlling stomatal closure in Arabidopsis. J Biol Chem. 2006;281:5310-8 pubmed
    b>ABI1 and ABI2 encode PP2C-type protein phosphatases and are thought to negatively regulate many aspects of abscisic acid (ABA) signaling, including stomatal closure in Arabidopsis. In contrast, SRK2E/OST1/SnRK2...
  2. Watanabe N, Lam E. BAX inhibitor-1 modulates endoplasmic reticulum stress-mediated programmed cell death in Arabidopsis. J Biol Chem. 2008;283:3200-10 pubmed
    ..We propose that AtBI1 plays a pivotal role as a highly conserved survival factor during ER stress that acts in parallel to the unfolded protein response pathway. ..
  3. Szostkiewicz I, Richter K, Kepka M, Demmel S, Ma Y, Korte A, et al. Closely related receptor complexes differ in their ABA selectivity and sensitivity. Plant J. 2010;61:25-35 pubmed publisher
    ..RCAR3 was identified in a screen for interactors of the PP2Cs ABI1 and ABI2, which are key regulators of ABA responses...
  4. Ludwikow A, Cieśla A, Kasprowicz Maluśki A, Mituła F, Tajdel M, Gałgański Ł, et al. Arabidopsis protein phosphatase 2C ABI1 interacts with type I ACC synthases and is involved in the regulation of ozone-induced ethylene biosynthesis. Mol Plant. 2014;7:960-76 pubmed publisher
    ..Here, we show that the Arabidopsis thaliana protein phosphatase type 2C, ABI1, a negative regulator of abscisic acid signaling, is involved in the regulation of ethylene biosynthesis under ..
  5. Miyazono K, Miyakawa T, Sawano Y, Kubota K, Kang H, Asano A, et al. Structural basis of abscisic acid signalling. Nature. 2009;462:609-14 pubmed publisher
    ..PYL1 bound with (+)-ABA, and the complex formed by the further binding of (+)-ABA-bound PYL1 with the PP2C protein ABI1. PYL1 binds (+)-ABA using the START-protein-specific ligand-binding site, thereby forming a hydrophobic pocket on ..
  6. Melcher K, Ng L, Zhou X, Soon F, Xu Y, Suino Powell K, et al. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 2009;462:602-8 pubmed publisher
    ..Together, our results identify a conserved gate-latch-lock mechanism underlying ABA signalling. ..
  7. Vlad F, Rubio S, Rodrigues A, Sirichandra C, Belin C, Robert N, et al. Protein phosphatases 2C regulate the activation of the Snf1-related kinase OST1 by abscisic acid in Arabidopsis. Plant Cell. 2009;21:3170-84 pubmed publisher
    ..Furthermore, HAB1 and the related PP2Cs ABI1 and ABI2 interact with OST1 in vivo, and mutations in the corresponding genes strongly affect OST1 activation by ..
  8. Himmelbach A, Hoffmann T, Leube M, Höhener B, Grill E. Homeodomain protein ATHB6 is a target of the protein phosphatase ABI1 and regulates hormone responses in Arabidopsis. EMBO J. 2002;21:3029-38 pubmed
    b>ABI1, a protein phosphatase 2C, is a key component of signal transduction in Arabidopsis. It regulates diverse responses to the phytohormone abscisic acid (ABA) such as stomatal closure, seed dormancy and inhibition of vegetative growth...
  9. Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, et al. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009;16:1230-6 pubmed publisher
    ..Upon binding to ABA, a PYL protein associates with type 2C protein phosphatases (PP2Cs) such as ABI1 and ABI2, inhibiting their activity; the molecular mechanisms by which PYLs mediate ABA signaling remain unknown, ..
  10. Nishimura N, Sarkeshik A, Nito K, Park S, Wang A, Carvalho P, et al. PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J. 2010;61:290-9 pubmed publisher
    ..The group-A PP2Cs, of which ABI1 is the prototypical member, are protein phosphatases that play critical roles as negative regulators very early in ..
  11. Moes D, Himmelbach A, Korte A, Haberer G, Grill E. Nuclear localization of the mutant protein phosphatase abi1 is required for insensitivity towards ABA responses in Arabidopsis. Plant J. 2008;54:806-19 pubmed publisher
    b>ABI1, a protein phosphatase 2C, is a key component of ABA signal transduction in Arabidopsis that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth...
  12. Hao Q, Yin P, Li W, Wang L, Yan C, Lin Z, et al. The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins. Mol Cell. 2011;42:662-72 pubmed publisher
    ..These findings provide an important framework for understanding the complex regulation of ABA signaling by PYL proteins. ..
  13. Guo Y, Xiong L, Song C, Gong D, Halfter U, Zhu J. A calcium sensor and its interacting protein kinase are global regulators of abscisic acid signaling in Arabidopsis. Dev Cell. 2002;3:233-44 pubmed
    ..interacts with the 2C-type protein phosphatase ABI2 (ABA-insensitive 2) and to a lesser extent with the homologous ABI1 (ABA-insensitive 1) protein...
  14. Saez A, Robert N, Maktabi M, Schroeder J, Serrano R, Rodriguez P. Enhancement of abscisic acid sensitivity and reduction of water consumption in Arabidopsis by combined inactivation of the protein phosphatases type 2C ABI1 and HAB1. Plant Physiol. 2006;141:1389-99 pubmed
    ..e. the protein phosphatases type 2C (PP2Cs) ABA-INSENSITIVE1 (ABI1) and HYPERSENSITIVE TO ABA1 (HAB1)...
  15. Soon F, Ng L, Zhou X, West G, Kovach A, Tan M, et al. Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science. 2012;335:85-8 pubmed publisher
    ..These structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites. ..
  16. Meyer K, Leube M, Grill E. A protein phosphatase 2C involved in ABA signal transduction in Arabidopsis thaliana. Science. 1994;264:1452-5 pubmed
    ..All three responses are affected in the ABA-insensitive mutant abi1 of Arabidopsis thaliana, suggesting that an early step in the signaling of ABA is controlled by the ABI1 locus...
  17. Fujii H, Chinnusamy V, Rodrigues A, Rubio S, Antoni R, Park S, et al. In vitro reconstitution of an abscisic acid signalling pathway. Nature. 2009;462:660-4 pubmed publisher
    ..we show that by combining the recently identified ABA receptor PYR1 with the type 2C protein phosphatase (PP2C) ABI1, the serine/threonine protein kinase SnRK2...
  18. Park S, Fung P, Nishimura N, Jensen D, Fujii H, Zhao Y, et al. Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. 2009;324:1068-71 pubmed publisher
    ..Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy. ..
  19. Vlad F, Droillard M, Valot B, Khafif M, Rodrigues A, Brault M, et al. Phospho-site mapping, genetic and in planta activation studies reveal key aspects of the different phosphorylation mechanisms involved in activation of SnRK2s. Plant J. 2010;63:778-90 pubmed publisher
    ..6 and SnRK2.10, which may be conserved between the two subgroups of SnRK2s depending on their ABA-responsiveness. ..
  20. Nishimura N, Hitomi K, Arvai A, Rambo R, Hitomi C, Cutler S, et al. Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science. 2009;326:1373-9 pubmed publisher
    ..Site-directed PYR1 mutants designed to disrupt hormone binding lose ABA-triggered interactions with type 2C protein phosphatase partners in planta. ..
  21. Ludwikow A, Kierzek D, Gallois P, Zeef L, Sadowski J. Gene expression profiling of ozone-treated Arabidopsis abi1td insertional mutant: protein phosphatase 2C ABI1 modulates biosynthesis ratio of ABA and ethylene. Planta. 2009;230:1003-17 pubmed publisher
    ..possible cross-talk controlled by an ABA-negative regulator, the protein phosphatase 2C abscisic acid insensitive1 (ABI1), we performed a genome-wide transcription profiling of O(3)-treated wild-type and ABI1 knockout (abi1td) plants...
  22. Leung J, Bouvier Durand M, Morris P, Guerrier D, Chefdor F, Giraudat J. Arabidopsis ABA response gene ABI1: features of a calcium-modulated protein phosphatase. Science. 1994;264:1448-52 pubmed
    The Arabidopsis ABI1 locus is essential for a wide spectrum of abscisic acid (ABA) responses throughout plant development. Here, ABI1 was shown to regulate stomatal aperture in leaves and mitotic activity in root meristems...
  23. Umezawa T, Sugiyama N, Mizoguchi M, Hayashi S, Myouga F, Yamaguchi Shinozaki K, et al. Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis. Proc Natl Acad Sci U S A. 2009;106:17588-93 pubmed publisher
    ..This step was suppressed by the RCAR/PYR ABA receptors in response to ABA. However the abi1-1 mutated PP2C did not respond to the receptors and constitutively inactivated SnRK2...
  24. Lynch T, Erickson B, Finkelstein R. Direct interactions of ABA-insensitive(ABI)-clade protein phosphatase(PP)2Cs with calcium-dependent protein kinases and ABA response element-binding bZIPs may contribute to turning off ABA response. Plant Mol Biol. 2012;80:647-58 pubmed publisher
    ..These studies support specific interactions among kinases, phosphatases and transcription factors that are co-expressed in early seedling development. ..
  25. Saez A, Rodrigues A, Santiago J, Rubio S, Rodriguez P. HAB1-SWI3B interaction reveals a link between abscisic acid signaling and putative SWI/SNF chromatin-remodeling complexes in Arabidopsis. Plant Cell. 2008;20:2972-88 pubmed publisher
    ..Additionally, our results uncover SWI3B as a novel positive regulator of ABA signaling and suggest that HAB1 modulates ABA response through the regulation of a putative SWI/SNF chromatin-remodeling complex. ..
  26. Ma Y, Szostkiewicz I, Korte A, Moes D, Yang Y, Christmann A, et al. Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science. 2009;324:1064-8 pubmed publisher
    ..Key players in ABA signal transduction include the type 2C protein phosphatases (PP2Cs) ABI1 and ABI2, which act by negatively regulating ABA responses...
  27. Bertauche N, Leung J, Giraudat J. Protein phosphatase activity of abscisic acid insensitive 1 (ABI1) protein from Arabidopsis thaliana. Eur J Biochem. 1996;241:193-200 pubmed
    Mutations at the ABI1 (abscisic acid insensitive 1) locus of the plant Arabidopsis thaliana cause a reduction in sensitivity to the plant hormone abscisic acid...
  28. Miao Y, Lv D, Wang P, Wang X, Chen J, Miao C, et al. An Arabidopsis glutathione peroxidase functions as both a redox transducer and a scavenger in abscisic acid and drought stress responses. Plant Cell. 2006;18:2749-66 pubmed
    ..physically interacted with the 2C-type protein phosphatase ABA INSENSITIVE2 (ABI2) and, to a lesser extent, with ABI1. In addition, the redox states of both ATGPX3 and ABI2 were found to be regulated by H(2)O(2)...
  29. Duan L, Dietrich D, Ng C, Chan P, Bhalerao R, Bennett M, et al. Endodermal ABA signaling promotes lateral root quiescence during salt stress in Arabidopsis seedlings. Plant Cell. 2013;25:324-41 pubmed publisher
    ..Our results identify the endodermis as a gateway with an ABA-dependent guard, which prevents root growth into saline environments...
  30. Ohta M, Guo Y, Halfter U, Zhu J. A novel domain in the protein kinase SOS2 mediates interaction with the protein phosphatase 2C ABI2. Proc Natl Acad Sci U S A. 2003;100:11771-6 pubmed
    ..We found that some PKSs interact strongly with ABI2 whereas others interact preferentially with ABI1. The interaction between SOS2 and ABI2 was disrupted by the abi2-1 mutation, which causes increased tolerance to ..
  31. Uhrig J, Mutondo M, Zimmermann I, Deeks M, Machesky L, Thomas P, et al. The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis. Development. 2007;134:967-77 pubmed
  32. Rodrigues A, Adamo M, Crozet P, Margalha L, Confraria A, Martinho C, et al. ABI1 and PP2CA phosphatases are negative regulators of Snf1-related protein kinase1 signaling in Arabidopsis. Plant Cell. 2013;25:3871-84 pubmed publisher
    ..Hence, the PP2C hub allows the coordinated activation of ABA and energy signaling, strengthening the stress response through the cooperation of two key and complementary pathways. ..
  33. Zhou X, Soon F, Ng L, Kovach A, Suino Powell K, Li J, et al. Catalytic mechanism and kinase interactions of ABA-signaling PP2C phosphatases. Plant Signal Behav. 2012;7:581-8 pubmed publisher
    ..6-HAB1 complex, we present the catalytic mechanism of PP2C and provide new insight into PP2C-SnRK2 interactions and possible roles of other SnRK2 kinases in ABA signaling. ..
  34. Kaliff M, Staal J, Myrenås M, Dixelius C. ABA is required for Leptosphaeria maculans resistance via ABI1- and ABI4-dependent signaling. Mol Plant Microbe Interact. 2007;20:335-45 pubmed
    ..Similar treatments enhanced callose depositions and induced resistance to L. maculans in oilseed rape, and BABA-induced resistance was found to be independent of salicylic acid. ..
  35. Mitula F, Tajdel M, Cieśla A, Kasprowicz Maluśki A, Kulik A, Babula Skowrońska D, et al. Arabidopsis ABA-Activated Kinase MAPKKK18 is Regulated by Protein Phosphatase 2C ABI1 and the Ubiquitin-Proteasome Pathway. Plant Cell Physiol. 2015;56:2351-67 pubmed publisher
    ..Notably, we identified abscisic acid insensitive 1 (ABI1) PP2C as a MKKK18-interacting protein, and demonstrated that ABI1 inhibited its activity...
  36. Rodriguez P. Protein phosphatase 2C (PP2C) function in higher plants. Plant Mol Biol. 1998;38:919-27 pubmed
    ..For instance, the ABI1/ABI2 PP2Cs are central components in abscisic acid (ABA) signal transduction...
  37. Antoni R, Gonzalez Guzman M, Rodriguez L, Peirats Llobet M, Pizzio G, Fernandez M, et al. PYRABACTIN RESISTANCE1-LIKE8 plays an important role for the regulation of abscisic acid signaling in root. Plant Physiol. 2013;161:931-41 pubmed publisher
    ..PYL8 interacted in vivo with at least five PP2Cs, namely HYPERSENSITIVE TO ABA1 (HAB1), HAB2, ABA-INSENSITIVE1 (ABI1), ABI2, and PP2CA/ABA-HYPERSENSITIVE GERMINATION3 as revealed by tandem affinity purification and mass spectrometry ..
  38. Melcher K, Xu Y, Ng L, Zhou X, Soon F, Chinnusamy V, et al. Identification and mechanism of ABA receptor antagonism. Nat Struct Mol Biol. 2010;17:1102-8 pubmed publisher
    ..ABA activates these receptors to inhibit type 2C protein phosphatases, such as ABI1, yet it remains unclear whether these receptors can be antagonized...
  39. Kong L, Cheng J, Zhu Y, Ding Y, Meng J, Chen Z, et al. Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases. Nat Commun. 2015;6:8630 pubmed publisher
    ..However, whether these PP2Cs are regulated by other factors remains unknown. Here, we report that ABI1 (ABA-INSENSITIVE 1) can interact with the U-box E3 ligases PUB12 and PUB13, but is ubiquitinated only when it ..
  40. Tajdel M, Mituła F, Ludwików A. Regulation of Arabidopsis MAPKKK18 by ABI1 and SnRK2, components of the ABA signaling pathway. Plant Signal Behav. 2016;11:e1139277 pubmed publisher
    ..recently discovered that MAPKKK18, an ABA-activated kinase, is regulated by the protein phosphatase type 2C (PP2C) ABI1 and the kinase SnRK2.6, both components of the ABA core signaling pathway...
  41. Larkindale J, Hall J, Knight M, Vierling E. Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance. Plant Physiol. 2005;138:882-97 pubmed
    ..Fifteen mutants showed significant phenotypes. Abscisic acid (ABA) signaling mutants (abi1 and abi2) and the UV-sensitive mutant, uvh6, showed the strongest defects in acquired thermotolerance of root ..
  42. Li Z, Li Z, Gao X, Chinnusamy V, Bressan R, Wang Z, et al. ROP11 GTPase negatively regulates ABA signaling by protecting ABI1 phosphatase activity from inhibition by the ABA receptor RCAR1/PYL9 in Arabidopsis. J Integr Plant Biol. 2012;54:180-8 pubmed publisher
    ..and bimolecular fluorescence complementation assays, we demonstrated that CA-ROP11 directly interacts with ABI1, a signaling component downstream of RCAR1/PYL9...
  43. Yamburenko M, Zubo Y, Börner T. Abscisic acid affects transcription of chloroplast genes via protein phosphatase 2C-dependent activation of nuclear genes: repression by guanosine-3'-5'-bisdiphosphate and activation by sigma factor 5. Plant J. 2015;82:1030-41 pubmed publisher
    ..Abscisic acid does not influence chloroplast transcription in the mutant lines abi1-1 and abi2-1 with constitutive protein phosphatase 2C (PP2C) activity, suggesting that ABA affects chloroplast gene ..
  44. Lu Y, Sasaki Y, Li X, Mori I, Matsuura T, Hirayama T, et al. ABI1 regulates carbon/nitrogen-nutrient signal transduction independent of ABA biosynthesis and canonical ABA signalling pathways in Arabidopsis. J Exp Bot. 2015;66:2763-71 pubmed publisher
    ..The CNI2 gene encodes ABI1, a phosphatase type 2C protein, which negatively regulates abscisic acid (ABA) signal transduction...
  45. Lackman P, Gonzalez Guzman M, Tilleman S, Carqueijeiro I, Pérez A, Moses T, et al. Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco. Proc Natl Acad Sci U S A. 2011;108:5891-6 pubmed publisher
    ..These findings define a connection between a component of the core ABA signaling pathway and the JA responses and contribute to the understanding of the role of JAs in balancing tradeoffs between growth and defense. ..
  46. Hua D, Wang C, He J, Liao H, Duan Y, Zhu Z, et al. A plasma membrane receptor kinase, GHR1, mediates abscisic acid- and hydrogen peroxide-regulated stomatal movement in Arabidopsis. Plant Cell. 2012;24:2546-61 pubmed publisher
    ..when coexpressed in Xenopus laevis oocytes, and this activation was inhibited by ABA-INSENSITIVE2 (ABI2) but not ABI1. Our study identifies a critical component in ABA and H2O2 signaling that is involved in stomatal movement and ..
  47. Li W, Wang L, Sheng X, Yan C, Zhou R, Hang J, et al. Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13. Cell Res. 2013;23:1369-79 pubmed publisher
    ..The biochemical and structural studies provide important insights into the function of PYL13 in the stress response of plant and set up a foundation for future biotechnological applications of PYL13...
  48. Zhang Y, Xu W, Li Z, Deng X, Wu W, Xue Y. F-box protein DOR functions as a novel inhibitory factor for abscisic acid-induced stomatal closure under drought stress in Arabidopsis,. Plant Physiol. 2008;148:2121-33 pubmed publisher
    ..Double-mutant analyses of dor with ABA-insensitive mutant abi1-1 showed that abi1-1 is epistatic to dor, but no apparent change of phospholipase Dalpha1 was detected between the ..
  49. Liang F, Ho W, Crabtree G. Engineering the ABA plant stress pathway for regulation of induced proximity. Sci Signal. 2011;4:rs2 pubmed publisher
    ..These properties, along with its lack of toxicity and low cost, suggest that ABA may be well suited for therapeutic applications and as an experimental tool to control diverse cellular activities in vivo. ..
  50. Mogami J, Fujita Y, Yoshida T, Tsukiori Y, Nakagami H, Nomura Y, et al. Two distinct families of protein kinases are required for plant growth under high external Mg2+ concentrations in Arabidopsis. Plant Physiol. 2015;167:1039-57 pubmed publisher
    ..These results suggested that SRK2D/E/I- and CIPK26/3/9/23-mediated phosphorylation signaling pathways maintain cellular Mg(2+) homeostasis. ..
  51. Li Z, Waadt R, Schroeder J. Release of GTP Exchange Factor Mediated Down-Regulation of Abscisic Acid Signal Transduction through ABA-Induced Rapid Degradation of RopGEFs. PLoS Biol. 2016;14:e1002461 pubmed publisher
    ..RopGEF1 directly interacts with several clade A PP2C protein phosphatases, including ABI1. Interestingly, RopGEF1 undergoes constitutive degradation in pp2c quadruple abi1/abi2/hab1/pp2ca mutant plants, ..
  52. Krzywinska E, Bucholc M, Kulik A, Ciesielski A, Lichocka M, Debski J, et al. Phosphatase ABI1 and okadaic acid-sensitive phosphoprotein phosphatases inhibit salt stress-activated SnRK2.4 kinase. BMC Plant Biol. 2016;16:136 pubmed publisher
    ..Here, we show that ABI1, a PP2C clade A phosphatase, interacts with SnRK2...
  53. Finkelstein R. Abscisic acid-insensitive mutations provide evidence for stage-specific signal pathways regulating expression of an Arabidopsis late embryogenesis-abundant (lea) gene. Mol Gen Genet. 1993;238:401-8 pubmed
    ..in seeds of aba mutants and approximately ten-fold in abi3 mutants, but seed expression was not decreased in either abi1 or abi2 monogenic mutants...
  54. Xie T, Ren R, Zhang Y, Pang Y, Yan C, Gong X, et al. Molecular mechanism for inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by protein phosphatase ABI1. J Biol Chem. 2012;287:794-802 pubmed publisher
    ..6-Å resolution. Structure-guided biochemical analyses identified two distinct interfaces between SnRK2.6 and ABI1, a member of group A PP2Cs. Structural modeling suggested that the two interfaces lock SnRK2...
  55. Gilmour S, Thomashow M. Cold acclimation and cold-regulated gene expression in ABA mutants of Arabidopsis thaliana. Plant Mol Biol. 1991;17:1233-40 pubmed
    ..Arabidopsis cor genes was unaffected in the abi2, abi3, and aba-1 mutants, but was dramatically impaired in the abi1 mutant...
  56. Matsuoka D, Yasufuku T, Furuya T, Nanmori T. An abscisic acid inducible Arabidopsis MAPKKK, MAPKKK18 regulates leaf senescence via its kinase activity. Plant Mol Biol. 2015;87:565-75 pubmed publisher
    ..Furthermore, ABA-induced leaf senescence was accelerated in 35S:MAPKKK18. These results suggest that MAPKKK18 controls the plant growth by adjusting the timing of senescence via its protein kinase activity in ABA dependent manners. ..
  57. Yang Y, Sulpice R, Himmelbach A, Meinhard M, Christmann A, Grill E. Fibrillin expression is regulated by abscisic acid response regulators and is involved in abscisic acid-mediated photoprotection. Proc Natl Acad Sci U S A. 2006;103:6061-6 pubmed
    ..ABA induces fibrillin accumulation, and the ABA response regulators ABI1 and ABI2 regulate fibrillin expression...
  58. Leube M, Grill E, Amrhein N. ABI1 of Arabidopsis is a protein serine/threonine phosphatase highly regulated by the proton and magnesium ion concentration. FEBS Lett. 1998;424:100-4 pubmed
    ..All three responses are regulated by the ABI1 gene product...
  59. Mäntylä E, Lang V, Palva E. Role of Abscisic Acid in Drought-Induced Freezing Tolerance, Cold Acclimation, and Accumulation of LT178 and RAB18 Proteins in Arabidopsis thaliana. Plant Physiol. 1995;107:141-148 pubmed
    ..development of freezing tolerance of Arabidopsis thaliana, we exposed wild-type plants, the ABA-insensitive mutant abi1, and the ABA-deficient mutant aba-1 to low temperature (LT), exogenous ABA, and drought. Exposure of A...
  60. Arend M, Schnitzler J, Ehlting B, Hansch R, Lange T, Rennenberg H, et al. Expression of the Arabidopsis mutant ABI1 gene alters abscisic acid sensitivity, stomatal development, and growth morphology in gray poplars. Plant Physiol. 2009;151:2110-9 pubmed publisher
    ..Sm.) development were examined by ectopic expression of the Arabidopsis (Arabidopsis thaliana) mutant abi1 (for abscisic acid insensitive1) gene...
  61. He J, Duan Y, Hua D, Fan G, Wang L, Liu Y, et al. DEXH box RNA helicase-mediated mitochondrial reactive oxygen species production in Arabidopsis mediates crosstalk between abscisic acid and auxin signaling. Plant Cell. 2012;24:1815-33 pubmed publisher
    ..Two dominant-negative mutations in ABA insensitive1 (abi1-1) and abi2-1 greatly reduced ROS production in mitochondria...
  62. Zhao Y, Chan Z, Xing L, Liu X, Hou Y, Chinnusamy V, et al. The unique mode of action of a divergent member of the ABA-receptor protein family in ABA and stress signaling. Cell Res. 2013;23:1380-95 pubmed publisher
    ..Our results show that PYL13 is not an ABA receptor but can modulate the ABA pathway by interacting with and inhibiting both the PYL receptors and the PP2C co-receptors...
  63. Mishra G, Zhang W, Deng F, Zhao J, Wang X. A bifurcating pathway directs abscisic acid effects on stomatal closure and opening in Arabidopsis. Science. 2006;312:264-6 pubmed
    ..PLDalpha1-produced phosphatidic acid (PA) binds to the ABI1 PP2C to signal ABA-promoted stomatal closure, whereas PLDalpha1 and PA interact with the Galpha subunit of ..
  64. Kumar D, Kumar R, Baek D, Hyun T, Chung W, Yun D, et al. Arabidopsis thaliana RECEPTOR DEAD KINASE1 Functions as a Positive Regulator in Plant Responses to ABA. Mol Plant. 2017;10:223-243 pubmed publisher
    ..Accordingly, RDK1 interacted in the plasma membrane with type 2C protein phosphatase ABSCISIC ACID INSENSITIVE1 (ABI1); this interaction was further enhanced by exogenous application of ABA, suggesting that RDK1-mediated recruitment ..
  65. Geiger D, Scherzer S, Mumm P, Marten I, Ache P, Matschi S, et al. Guard cell anion channel SLAC1 is regulated by CDPK protein kinases with distinct Ca2+ affinities. Proc Natl Acad Sci U S A. 2010;107:8023-8 pubmed publisher
    ..Open stomata 1 protein kinase (OST1) and ABI1 protein phosphatase (ABA insensitive 1) represent key components of calcium-independent ABA signaling...
  66. Ye Y, Zhou L, Liu X, Liu H, Li D, Cao M, et al. A Novel Chemical Inhibitor of ABA Signaling Targets All ABA Receptors. Plant Physiol. 2017;173:2356-2369 pubmed publisher