ABA3

Summary

Gene Symbol: ABA3
Description: molybdenum cofactor sulfurase (LOS5) (ABA3)
Alias: ABA DEFICIENT 3, ACI2, ALTERED CHLOROPLAST IMPORT 2, ATABA3, AtLOS5, F19K19.13, F19K19_13, LOS5, LOW OSMOTIC STRESS 5, MOLYBDENUM COFACTOR SULFURASE, SIR3, SIRTINOL RESISTANT 3, molybdenum cofactor sulfurase (LOS5) (ABA3)
Species: thale cress

Top Publications

  1. Léon Kloosterziel K, Gil M, Ruijs G, Jacobsen S, Olszewski N, Schwartz S, et al. Isolation and characterization of abscisic acid-deficient Arabidopsis mutants at two new loci. Plant J. 1996;10:655-61 pubmed
    ..The ABA-deficiency was caused by two monogenic, recessive mutations, aba2 and aba3, that were both located on chromosome 1...
  2. Xiong L, Ishitani M, Lee H, Zhu J. The Arabidopsis LOS5/ABA3 locus encodes a molybdenum cofactor sulfurase and modulates cold stress- and osmotic stress-responsive gene expression. Plant Cell. 2001;13:2063-83 pubmed
    ..temperature and osmotic stress signaling in plants, we isolated and characterized two allelic Arabidopsis mutants, los5-1 and los5-2, which are impaired in gene induction by cold and osmotic stresses...
  3. Yue Y, Zhang M, Zhang J, Duan L, Li Z. Arabidopsis LOS5/ABA3 overexpression in transgenic tobacco (Nicotiana tabacum cv. Xanthi-nc) results in enhanced drought tolerance. Plant Sci. 2011;181:405-11 pubmed publisher
    ..LOS5/ABA3 (LOS5) encodes molybdenum-cofactor sulfurase, which is a key regulator of ABA biosynthesis...
  4. Bittner F, Oreb M, Mendel R. ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana. J Biol Chem. 2001;276:40381-4 pubmed
    ..Previous analyses of mutants in plants indicated that the genetic locus aba3 is involved in this step leading to activation of the molybdenum enzymes aldehyde oxidase and xanthine ..
  5. Leon P, Sheen J. Sugar and hormone connections. Trends Plant Sci. 2003;8:110-6 pubmed
    ..The effects of sugar and osmotic stress on morphogenesis and gene expression are distinct. The plasticity of plant growth and development are exemplified by the complex interplay of sugar and hormone signalling. ..
  6. Lehrke M, Rump S, Heidenreich T, Wissing J, Mendel R, Bittner F. Identification of persulfide-binding and disulfide-forming cysteine residues in the NifS-like domain of the molybdenum cofactor sulfurase ABA3 by cysteine-scanning mutagenesis. Biochem J. 2012;441:823-32 pubmed publisher
    The Moco (molybdenum cofactor) sulfurase ABA3 from Arabidopsis thaliana catalyses the sulfuration of the Moco of aldehyde oxidase and xanthine oxidoreductase, which represents the final activation step of these enzymes...
  7. Heidenreich T, Wollers S, Mendel R, Bittner F. Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration. J Biol Chem. 2005;280:4213-8 pubmed
    The molybdenum cofactor sulfurase ABA3 from Arabidopsis thaliana specifically regulates the activity of the molybdenum enzymes aldehyde oxidase and xanthine dehydrogenase by converting their molybdenum cofactor from the desulfo-form into ..
  8. Dai X, Hayashi K, Nozaki H, Cheng Y, Zhao Y. Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis. Proc Natl Acad Sci U S A. 2005;102:3129-34 pubmed
  9. Larkindale J, Hall J, Knight M, Vierling E. Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance. Plant Physiol. 2005;138:882-97 pubmed
    ..adenine dinucleotide phosphate oxidase homolog genes (atrbohB and D), ABA biosynthesis mutants (aba1, aba2, and aba3), and NahG transgenic lines (salicylic acid deficient) showed weaker defects...
  10. Melotto M, Underwood W, Koczan J, Nomura K, He S. Plant stomata function in innate immunity against bacterial invasion. Cell. 2006;126:969-80 pubmed
    ..We provide evidence that supports a model in which stomata, as part of an integral innate immune system, act as a barrier against bacterial infection. ..

Detail Information

Publications16

  1. Léon Kloosterziel K, Gil M, Ruijs G, Jacobsen S, Olszewski N, Schwartz S, et al. Isolation and characterization of abscisic acid-deficient Arabidopsis mutants at two new loci. Plant J. 1996;10:655-61 pubmed
    ..The ABA-deficiency was caused by two monogenic, recessive mutations, aba2 and aba3, that were both located on chromosome 1...
  2. Xiong L, Ishitani M, Lee H, Zhu J. The Arabidopsis LOS5/ABA3 locus encodes a molybdenum cofactor sulfurase and modulates cold stress- and osmotic stress-responsive gene expression. Plant Cell. 2001;13:2063-83 pubmed
    ..temperature and osmotic stress signaling in plants, we isolated and characterized two allelic Arabidopsis mutants, los5-1 and los5-2, which are impaired in gene induction by cold and osmotic stresses...
  3. Yue Y, Zhang M, Zhang J, Duan L, Li Z. Arabidopsis LOS5/ABA3 overexpression in transgenic tobacco (Nicotiana tabacum cv. Xanthi-nc) results in enhanced drought tolerance. Plant Sci. 2011;181:405-11 pubmed publisher
    ..LOS5/ABA3 (LOS5) encodes molybdenum-cofactor sulfurase, which is a key regulator of ABA biosynthesis...
  4. Bittner F, Oreb M, Mendel R. ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana. J Biol Chem. 2001;276:40381-4 pubmed
    ..Previous analyses of mutants in plants indicated that the genetic locus aba3 is involved in this step leading to activation of the molybdenum enzymes aldehyde oxidase and xanthine ..
  5. Leon P, Sheen J. Sugar and hormone connections. Trends Plant Sci. 2003;8:110-6 pubmed
    ..The effects of sugar and osmotic stress on morphogenesis and gene expression are distinct. The plasticity of plant growth and development are exemplified by the complex interplay of sugar and hormone signalling. ..
  6. Lehrke M, Rump S, Heidenreich T, Wissing J, Mendel R, Bittner F. Identification of persulfide-binding and disulfide-forming cysteine residues in the NifS-like domain of the molybdenum cofactor sulfurase ABA3 by cysteine-scanning mutagenesis. Biochem J. 2012;441:823-32 pubmed publisher
    The Moco (molybdenum cofactor) sulfurase ABA3 from Arabidopsis thaliana catalyses the sulfuration of the Moco of aldehyde oxidase and xanthine oxidoreductase, which represents the final activation step of these enzymes...
  7. Heidenreich T, Wollers S, Mendel R, Bittner F. Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration. J Biol Chem. 2005;280:4213-8 pubmed
    The molybdenum cofactor sulfurase ABA3 from Arabidopsis thaliana specifically regulates the activity of the molybdenum enzymes aldehyde oxidase and xanthine dehydrogenase by converting their molybdenum cofactor from the desulfo-form into ..
  8. Dai X, Hayashi K, Nozaki H, Cheng Y, Zhao Y. Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis. Proc Natl Acad Sci U S A. 2005;102:3129-34 pubmed
  9. Larkindale J, Hall J, Knight M, Vierling E. Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance. Plant Physiol. 2005;138:882-97 pubmed
    ..adenine dinucleotide phosphate oxidase homolog genes (atrbohB and D), ABA biosynthesis mutants (aba1, aba2, and aba3), and NahG transgenic lines (salicylic acid deficient) showed weaker defects...
  10. Melotto M, Underwood W, Koczan J, Nomura K, He S. Plant stomata function in innate immunity against bacterial invasion. Cell. 2006;126:969-80 pubmed
    ..We provide evidence that supports a model in which stomata, as part of an integral innate immune system, act as a barrier against bacterial infection. ..
  11. Lu Y, Li Y, Zhang J, Xiao Y, Yue Y, Duan L, et al. Overexpression of Arabidopsis molybdenum cofactor sulfurase gene confers drought tolerance in maize (Zea mays L.). PLoS ONE. 2013;8:e52126 pubmed publisher
    ..Overexpression of Arabidopsis molybdenum cofactor sulfurase gene (LOS5) in maize markedly enhanced the expression of ZmAO and aldehyde oxidase (AO) activity, ..
  12. Zhang J, Yu H, Zhang Y, Wang Y, Li M, Zhang J, et al. Increased abscisic acid levels in transgenic maize overexpressing AtLOS5 mediated root ion fluxes and leaf water status under salt stress. J Exp Bot. 2016;67:1339-55 pubmed publisher
    ..b>AtLOS5 encoding molybdenum cofactor sulphurase is a key regulator of ABA biosynthesis...
  13. Wollers S, Heidenreich T, Zarepour M, Zachmann D, Kraft C, Zhao Y, et al. Binding of sulfurated molybdenum cofactor to the C-terminal domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration. J Biol Chem. 2008;283:9642-50 pubmed publisher
    The molybdenum cofactor sulfurase ABA3 from Arabidopsis thaliana is needed for post-translational activation of aldehyde oxidase and xanthine dehydrogenase by transferring a sulfur atom to the desulfo-molybdenum cofactor of these enzymes...
  14. Li Y, Zhang J, Zhang J, Hao L, Hua J, Duan L, et al. Expression of an Arabidopsis molybdenum cofactor sulphurase gene in soybean enhances drought tolerance and increases yield under field conditions. Plant Biotechnol J. 2013;11:747-58 pubmed publisher
    LOS5/ABA3 gene encoding molybdenum cofactor sulphurase is involved in aldehyde oxidase (AO) activity in Arabidopsis, which indirectly regulates ABA biosynthesis and increased stress tolerance...
  15. Zhong R, Thompson J, Ottesen E, Lamppa G. A forward genetic screen to explore chloroplast protein import in vivo identifies Moco sulfurase, pivotal for ABA and IAA biosynthesis and purine turnover. Plant J. 2010;63:44-59 pubmed publisher
    ..b>aci2-1 was selected for further study...
  16. Yue Y, Zhang M, Zhang J, Tian X, Duan L, Li Z. Overexpression of the AtLOS5 gene increased abscisic acid level and drought tolerance in transgenic cotton. J Exp Bot. 2012;63:3741-8 pubmed publisher
    ..The transformation and overexpression of AtLOS5 were assessed by PCR and RT-PCR analysis...