Research Topics
| TAF11SummaryGene Symbol: TAF11 Description: Taf11p Alias: TAF40 Species: Top Publications
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Publications
Yeast TFIID serves as a coactivator for Rap1p by direct protein-protein interactionKrassimira A Garbett
Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, TN 37232 0615, USA
Mol Cell Biol 27:297-311. 2007..We conclude that Rap1p and TFIID directly interact and that this interaction contributes importantly to RP gene transcription...
Autonomous function of the amino-terminal inhibitory domain of TAF1 in transcriptional regulationShinya Takahata
Division of Molecular and Cellular Biology, Graduate School of Integrated Science, Yokohama City University, Yokohama 230 0045, Japan
Mol Cell Biol 24:3089-99. 2004..These results indicate that there is no or minimal geometric constraint on the ability of the TAND to function normally in transcriptional regulation as long as TFIID assembly is secured...
Molecular genetic dissection of TAF25, an essential yeast gene encoding a subunit shared by TFIID and SAGA multiprotein transcription factorsJ Kirchner
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
Mol Cell Biol 21:6668-80. 2001..The results of these analyses show that TAF25p is comprised of multiple mutable elements which contribute importantly to RNA polymerase II-mediated mRNA gene transcription...
Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patternsDoris B Kirschner
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, F 67404 Illkirch Cedex, CU de Strasbourg, France
Mol Cell Biol 22:3178-93. 2002..Thus, different yTAF(II)25 mutations induce distinct phenotypes and affect the regulation of different subsets of genes, demonstrating that no individual TAF(II) mutant allele reflects the full range of its normal functions...
Molecular characterization of Saccharomyces cerevisiae TFIIDSteven L Sanders
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
Mol Cell Biol 22:6000-13. 2002..The results of direct biochemical exchange experiments confirmed this hypothesis. Together, our results represent a concise molecular characterization of the general transcription factor TFIID from S. cerevisiae...
Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assemblyWu Cheng Shen
Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
EMBO J 22:3395-402. 2003..Unexpectedly, these assembly experiments reveal that TAF11 and TAF13 appear to provide the critical functional contacts with TBP during PIC assembly...
Identification and characterization of a TFIID-like multiprotein complex from Saccharomyces cerevisiaeD Poon
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Proc Natl Acad Sci U S A 92:8224-8. 1995..In addition, by constructing null alleles of the cloned TAF-encoding genes, we show that normal function of the TAF-encoding genes is essential for yeast cell viability...
Purification of active TFIID from Saccharomyces cerevisiae. Extensive promoter contacts and co-activator functionRoy Auty
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
J Biol Chem 279:49973-81. 2004..TFIID supports basal transcription and activated transcription, both of which are enhanced by TFIIA...
Mapping and functional characterization of the TAF11 interaction with TFIIAM M Robinson
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 1870, USA
Mol Cell Biol 25:945-57. 2005TFIIA interacts with TFIID via association with TATA binding protein (TBP) and TBP-associated factor 11 (TAF11). We previously identified a mutation in the small subunit of TFIIA (toa2-I27K) that is defective for interaction with TAF11...
Genome-wide transcriptional dependence on TAF1 functional domainsJordan D Irvin
Department of Biochemistry and Molecular Biology, Center for Gene Regulation, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 281:6404-12. 2006....
Saccharomyces cerevisiae HMO1 interacts with TFIID and participates in start site selection by RNA polymerase IIKoji Kasahara
Division of Molecular and Cellular Biology, International Graduate School of Arts and Sciences, Yokohama City University, Yokohama, 230 0045, Japan
Nucleic Acids Res 36:1343-57. 2008....
Histone folds mediate selective heterodimerization of yeast TAF(II)25 with TFIID components yTAF(II)47 and yTAF(II)65 and with SAGA component ySPT7Y G Gangloff
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch Cedex, C U de Strasbourg, France
Mol Cell Biol 21:1841-53. 2001..Furthermore, our results indicate that ySPT7 has an HFD homologous to that of yTAF(II)47 which selectively heterodimerizes with yTAF(II)25, defining a novel histone-like pair in the SAGA complex...
TFIIA interacts with TFIID via association with TATA-binding protein and TAF40S M Kraemer
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523 1870, USA
Mol Cell Biol 21:1737-46. 2001..We show that in addition to making direct contacts with TBP, yeast TAF40 interacts directly and specifically with TFIIA...
TAF-Containing and TAF-independent forms of transcriptionally active TBP in vivoL Kuras
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Science 288:1244-8. 2000..Promoter-specific variations in the association of these distinct forms of TBP may explain why only some yeast genes require TFIID for transcriptional activity in vivo...
Yeast Taf170 is encoded by MOT1 and exists in a TATA box-binding protein (TBP)-TBP-associated factor complex distinct from transcription factor IIDD Poon
Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232 0615
J Biol Chem 269:23135-40. 1994..The significance of this unique TBP-Taf170 complex regarding transcriptional regulation is discussed...
Isolation and characterization of TAF25, an essential yeast gene that encodes an RNA polymerase II-specific TATA-binding protein-associated factorE R Klebanow
Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232 0615, USA
J Biol Chem 271:13706-15. 1996..Hence the protein encoded by TAF25 has been termed yTAFII25...
Yeast homologues of higher eukaryotic TFIID subunitsZ Moqtaderi
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 93:14654-8. 1996..Based on their predicted molecular weights, these genes have been designated TAF67, TAF61(68), TAF40, TAF23(25), TAF19(FUN81), and TAF17...
Cloning and characterization of an essential Saccharomyces cerevisiae gene, TAF40, which encodes yTAFII40, an RNA polymerase II-specific TATA-binding protein-associated factorE R Klebanow
Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232 0615, USA
J Biol Chem 272:9436-42. 1997In this report we describe the cloning and initial characterization of TAF40, a gene that encodes a yeast TATA-binding protein-associated factor (yTAF) of Mr = approximately 40,000...
Mapping the initiator binding Taf2 subunit in the structure of hydrated yeast TFIIDGabor Papai
Department of Structural Biology and Genomics, Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, 67404 Illkirch, France
Structure 17:363-73. 2009..Mapping the position of this crucial subunit in the vicinity of Taf1p and of TBP sheds new light on its role in promoter recognition...
yTAFII61 has a general role in RNA polymerase II transcription and is required by Gcn4p to recruit the SAGA coactivator complexK Natarajan
Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
Mol Cell 2:683-92. 1998..Our results provide strong evidence that recruitment of SAGA, in addition to holoenzyme, is crucial for activation by Gcn4p in vivo and that yTAFII61 plays a key role in this process...
TFIID-specific yeast TAF40 is essential for the majority of RNA polymerase II-mediated transcription in vivoP B Komarnitsky
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 13:2484-9. 1999..Here we show that mutations in the yeast TFIID-specific protein Taf40 lead to a general cessation of transcription, even in the presence of excess TBP, suggesting that the TFIID ..
Identification of two novel TAF subunits of the yeast Saccharomyces cerevisiae TFIID complexS L Sanders
Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232 0615, USA
J Biol Chem 275:13895-900. 2000..TAF complexes. The significance of these results in terms of TFIID structure, function, and organization is discussed...
Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth stateS S Walker
Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605, USA
Cell 90:607-14. 1997..Collectively, our results indicate that yTAF(II)145 and other TFIID components have a specialized role in transcriptional regulation of cell cycle progression and growth control...
Mechanism and regulation of yeast RNA polymerase II transcriptionR D Kornberg
Department of Structural Biology, Stanford School of Medicine, California 94305, USA
Cold Spring Harb Symp Quant Biol 63:229-32. 1998
TAFs: guilt by association?W P Tansey
Cold Spring Harbor Laboratory, New York 11724, USA
Cell 88:729-32. 1997
