Gene Symbol: SSO_RS05210
Description: translation initiation factor IF-2 subunit alpha
Species: Sulfolobus solfataricus P2
Yatime L, Mechulam Y, Blanquet S, Schmitt E. Structural switch of the gamma subunit in an archaeal aIF2 alpha gamma heterodimer. Structure. 2006;14:119-28 pubmed
..Because the alpha subunit markedly reinforces the affinity of tRNA for the gamma subunit, a contribution of the alpha subunit to the switch movements observed in the gamma structure is considered. ..
Satpati P, Simonson T. Conformational selection by the aIF2 GTPase: a molecular dynamics study of functional pathways. Biochemistry. 2012;51:353-61 pubmed publisher
..This suggests that the MIXED state could be a functional intermediate. ..
Schmitt E, Panvert M, Lazennec Schurdevin C, Coureux P, Perez J, Thompson A, et al
. Structure of the ternary initiation complex aIF2-GDPNP-methionylated initiator tRNA. Nat Struct Mol Biol. 2012;19:450-4 pubmed publisher
..We conclude that despite considerable structural homology between the core ? subunit of aIF2 and the elongation factor EF1A, these two G proteins of the translation apparatus use very different tRNA-binding strategies...
Yatime L, Mechulam Y, Blanquet S, Schmitt E. Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states. Proc Natl Acad Sci U S A. 2007;104:18445-50 pubmed publisher
..The nucleotide state of aIF2 shown here is indicative of a similar mechanism in archaea. Finally, we consider the possibility that release of Pi takes place after e/aIF2gamma has been informed of e/aIF1 dissociation by e/aIF2beta...