SCO6423

Summary

Gene Symbol: SCO6423
Description: lipoate-protein ligase
Alias: SC1A6.12c
Species: Streptomyces coelicolor A3(2)

Top Publications

  1. Cao X, Cronan J. The Streptomyces coelicolor lipoate-protein ligase is a circularly permuted version of the Escherichia coli enzyme composed of discrete interacting domains. J Biol Chem. 2015;290:7280-90 pubmed publisher
    ..However, only the large domain-containing protein was required for transfer of lipoate from the lipoyl-AMP intermediate to the acceptor proteins, whereas both domain-containing proteins were required to form lipoyl-AMP. ..
  2. Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P. A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway. Mol Gen Genet. 1996;251:113-20 pubmed
    ..nogalater minimal PKS genes produced auramycinone glycosides, demonstrating replacement of the starter unit for polyketide biosynthesis. The product of snoA seems to be needed for expression of at least the genes for the minimal PKS. ..
  3. Ylihonko K, Hakala J, Kunnari T, M nts l P. Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes. Microbiology. 1996;142 ( Pt 8):1965-72 pubmed publisher
    ..Cloning of the nogalamycin gene cluster should make possible a detailed study of the biosynthesis of this interesting antibiotic, as well as the production of novel anthracyclines of potential value as cytostatic drugs...
  4. Torkkell S, Ylihonko K, Hakala J, Skurnik M, Mantsala P. Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis. Mol Gen Genet. 1997;256:203-9 pubmed
    ..Interestingly, SnoA, a transcriptional activator for the sno minimal polyketide synthase, is also needed to express this cluster. ..