Gene Symbol: cpsN
Description: dTDP-glucose-4,6-dehydratase
Species: Streptococcus pneumoniae R6

Top Publications

  1. Morona J, Morona R, Paton J. Characterization of the locus encoding the Streptococcus pneumoniae type 19F capsular polysaccharide biosynthetic pathway. Mol Microbiol. 1997;23:751-63 pubmed
    ..pneumoniae serotypes/groups tested. The region from cps19fG to cps19fK was found only in members of serogroup 19, and, within this, cps19fl was unique to type 19F...
  2. Iannelli F, Pearce B, Pozzi G. The type 2 capsule locus of Streptococcus pneumoniae. J Bacteriol. 1999;181:2652-4 pubmed
    ..It was also shown that R36A and R6, which are unencapsulated (rough) derivatives of D39, carry a 7,504-bp deletion involving nine capsule genes...
  3. Morona J, Morona R, Paton J. Analysis of the 5' portion of the type 19A capsule locus identifies two classes of cpsC, cpsD, and cpsE genes in Streptococcus pneumoniae. J Bacteriol. 1999;181:3599-605 pubmed
    ..Whereas members within one class are greater than 95% identical to each other, the DNA sequence identity between the two classes is only approximately 70%...
  4. Morona J, Morona R, Paton J. Comparative genetics of capsular polysaccharide biosynthesis in Streptococcus pneumoniae types belonging to serogroup 19. J Bacteriol. 1999;181:5355-64 pubmed
  5. Yoshida Y, Ganguly S, Bush C, Cisar J. Molecular basis of L-rhamnose branch formation in streptococcal coaggregation receptor polysaccharides. J Bacteriol. 2006;188:4125-30 pubmed publisher
    ..gordonii 38 and wefH in S. oralis 34. These genes were distinguished by the unique ability of WefC to act on the branched acceptor formed by the action of WefB...
  6. Ramirez M, Tomasz A. Molecular characterization of the complete 23F capsular polysaccharide locus of Streptococcus pneumoniae. J Bacteriol. 1998;180:5273-8 pubmed
    ..The 18.6-kb cps23f locus is composed of 18 open reading frames flanked at the 5' and 3' ends by the genes dexB and aliA, an arrangement similar to those of some of the other identified cps loci. ..
  7. Yoshida Y, Ganguly S, Bush C, Cisar J. Carbohydrate engineering of the recognition motifs in streptococcal co-aggregation receptor polysaccharides. Mol Microbiol. 2005;58:244-56 pubmed publisher
    ..The reactions of these genetically modified polysaccharides as antigens and receptors provide further insight into the structural basis of RPS function...