Gene Symbol: cpsFQ
Description: putative dTDP-glucose-4,6-dehydratase
Species: Streptococcus pyogenes M1 GAS
Morona J, Morona R, Paton J. Analysis of the 5' portion of the type 19A capsule locus identifies two classes of cpsC, cpsD, and cpsE genes in Streptococcus pneumoniae. J Bacteriol. 1999;181:3599-605 pubmed
..Whereas members within one class are greater than 95% identical to each other, the DNA sequence identity between the two classes is only approximately 70%...
Morona J, Morona R, Paton J. Comparative genetics of capsular polysaccharide biosynthesis in Streptococcus pneumoniae types belonging to serogroup 19. J Bacteriol. 1999;181:5355-64 pubmed
Yoshida Y, Ganguly S, Bush C, Cisar J. Carbohydrate engineering of the recognition motifs in streptococcal co-aggregation receptor polysaccharides. Mol Microbiol. 2005;58:244-56 pubmed publisher
..The reactions of these genetically modified polysaccharides as antigens and receptors provide further insight into the structural basis of RPS function...
Morona J, Morona R, Paton J. Characterization of the locus encoding the Streptococcus pneumoniae type 19F capsular polysaccharide biosynthetic pathway. Mol Microbiol. 1997;23:751-63 pubmed
..pneumoniae serotypes/groups tested. The region from cps19fG to cps19fK was found only in members of serogroup 19, and, within this, cps19fl was unique to type 19F...
Yoshida Y, Ganguly S, Bush C, Cisar J. Molecular basis of L-rhamnose branch formation in streptococcal coaggregation receptor polysaccharides. J Bacteriol. 2006;188:4125-30 pubmed publisher
..gordonii 38 and wefH in S. oralis 34. These genes were distinguished by the unique ability of WefC to act on the branched acceptor formed by the action of WefB...
Beis K, Allard S, Hegeman A, Murshudov G, Philp D, Naismith J. The structure of NADH in the enzyme dTDP-d-glucose dehydratase (RmlB). J Am Chem Soc. 2003;125:11872-8 pubmed
..These results demonstrate the ability of dehydratase enzymes to fine-tune the redox potential of NADH through conformational changes in the nicotinamide ring. ..