Gene Symbol: brpA
Description: transcriptional regulator
Alias: SMU.410
Species: Streptococcus mutans UA159
Products:     brpA

Top Publications

  1. Bitoun J, Liao S, McKey B, Yao X, Fan Y, Abranches J, et al. Psr is involved in regulation of glucan production, and double deficiency of BrpA and Psr is lethal in Streptococcus mutans. Microbiology. 2013;159:493-506 pubmed publisher
    ..primary causative agent of dental caries, contains two paralogues of the LytR-CpsA-Psr family proteins encoded by brpA and psr, respectively...
  2. Wen Z, Burne R. Functional genomics approach to identifying genes required for biofilm development by Streptococcus mutans. Appl Environ Microbiol. 2002;68:1196-203 pubmed
    ..In S. mutans UA159, the brpA gene (for biofilm regulatory protein) was found to encode a novel protein of 406 amino acid residues...
  3. Wen Z, Burne R. LuxS-mediated signaling in Streptococcus mutans is involved in regulation of acid and oxidative stress tolerance and biofilm formation. J Bacteriol. 2004;186:2682-91 pubmed
    ..Other down-regulated genes included ffh (a signal recognition particle subunit) and brpA (biofilm regulatory protein A)...
  4. De A, Liao S, Bitoun J, Roth R, Beatty W, Wu H, et al. Deficiency of RgpG Causes Major Defects in Cell Division and Biofilm Formation, and Deficiency of LytR-CpsA-Psr Family Proteins Leads to Accumulation of Cell Wall Antigens in Culture Medium by Streptococcus mutans. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..01). Double and triple mutants with deficiency in brpA and/or psr, genes coding for the LytR-CpsA-Psr family proteins BrpA and Psr, which were previously shown ..
  5. Chatfield C, Koo H, Quivey R. The putative autolysin regulator LytR in Streptococcus mutans plays a role in cell division and is growth-phase regulated. Microbiology. 2005;151:625-31 pubmed publisher
    ..No defect in cell-to-surface adherence or biofilm growth was seen in the LytR mutant. However, a connection between cell growth phase and transcription of lytR was found...
  6. Wen Z, Baker H, Burne R. Influence of BrpA on critical virulence attributes of Streptococcus mutans. J Bacteriol. 2006;188:2983-92 pubmed
    ..The brpA gene codes for a predicted surface-associated protein with apparent roles in biofilm formation, autolysis, and cell ..
  7. Nakano K, Fujita K, Nishimura K, Nomura R, Ooshima T. Contribution of biofilm regulatory protein A of Streptococcus mutans, to systemic virulence. Microbes Infect. 2005;7:1246-55 pubmed
    ..Recently, the brpA gene encoding biofilm regulatory protein A (BrpA) of S...