pSepCH_03

Summary

Gene Symbol: pSepCH_03
Description: ethidium bromide resistance determinant
Species: Staphylococcus epidermidis

Top Publications

  1. ncbi High-level resistance to ethidium bromide and antiseptics in Staphylococcus aureus
    M Sasatsu
    Department of Microbiology, Tokyo College of Pharmacy, Japan
    FEMS Microbiol Lett 72:109-13. 1992
  2. ncbi Plasmid-borne smr gene causes resistance to quaternary ammonium compounds in bovine Staphylococcus aureus
    J Bjorland
    Department of Reproduction and Forensic Medicine, National Veterinary Institute, Oslo, Norway
    J Clin Microbiol 39:3999-4004. 2001
  3. ncbi Molecular characterization of the staphylococcal multidrug resistance export protein QacC
    I T Paulsen
    School of Biological Sciences, University of Sydney, New South Wales, Australia
    J Bacteriol 177:2827-33. 1995
  4. ncbi Resistance to quaternary ammonium compounds in Staphylococcus spp. isolated from the food industry and nucleotide sequence of the resistance plasmid pST827
    E Heir
    MATFORSK, Norwegian Food Research Institute, As
    J Appl Bacteriol 79:149-56. 1995
  5. ncbi Multidrug resistance plasmid pSK108 from coagulase-negative staphylococci; relationships to Staphylococcus aureus qacC plasmids
    A Leelaporn
    School of Biological Sciences, University of Sydney, New South Wales, Australia
    Plasmid 34:62-7. 1995
  6. ncbi Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus
    J M Tennent
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    J Gen Microbiol 135:1-10. 1989
  7. ncbi Nucleotide sequence of a gene that encodes resistance to ethidium bromide from a transferable plasmid in Staphylococcus aureus
    M Sasatsu
    Department of Microbiology, Tokyo College of Pharmacy, Japan
    Nucleic Acids Res 17:10103. 1989
  8. ncbi Structure and evolution of a family of genes encoding antiseptic and disinfectant resistance in Staphylococcus aureus
    T G Littlejohn
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Gene 101:59-66. 1991
  9. ncbi A staphylococcal multidrug resistance gene product is a member of a new protein family
    L Grinius
    Department of Biochemistry and Biophysics, Vilnius University, Lithuania
    Plasmid 27:119-29. 1992
  10. ncbi The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to beta-lactam antibiotics in gram-positive and gram-negative bacteria
    Derie E Fuentes
    Laboratorio de Microbiologia Molecular, Departamento de Ciencias Biologicas, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Casilla 40, Correo 33, Santiago, Chile
    Res Microbiol 156:472-7. 2005

Scientific Experts

  • J Bjorland
  • Derie E Fuentes
  • Manuel A Araya
  • Claudio A Navarro
  • Phil A Youderian
  • Claudia P Saavedra
  • Guido C Mora
  • Claudio C Vásquez
  • Juan C Tantaleán
  • Jose M Perez
  • I T Paulsen
  • Iván L Calderón
  • R A Skurray
  • E Heir
  • A Leelaporn
  • M Sasatsu
  • M H Brown
  • N Firth
  • A Hettiaratchi
  • A L Holck
  • G Sundheim
  • S J Dunstan
  • L Grinius
  • Y Shibata
  • M Kono
  • J M Tennent
  • N Noguchi
  • S J Projan
  • C H Liao
  • E B Goldberg
  • T G Littlejohn
  • G Dreguniene
  • M Midgley
  • I G Jones
  • B R Lyon
  • D DiBerardino
  • L J Messerotti
  • A S Purewal
  • S J Spiers
  • K Shima

Detail Information

Publications10

  1. ncbi High-level resistance to ethidium bromide and antiseptics in Staphylococcus aureus
    M Sasatsu
    Department of Microbiology, Tokyo College of Pharmacy, Japan
    FEMS Microbiol Lett 72:109-13. 1992
    ..The efflux rate for EB of strains with duplicated ebr genes was twice the rate of strains with a single ebr gene. It was concluded that the duplication of ebr is responsible for the high-level resistance to EB and antiseptics...
  2. ncbi Plasmid-borne smr gene causes resistance to quaternary ammonium compounds in bovine Staphylococcus aureus
    J Bjorland
    Department of Reproduction and Forensic Medicine, National Veterinary Institute, Oslo, Norway
    J Clin Microbiol 39:3999-4004. 2001
    ..The study indicates that the occurrence and spread of QAC-resistant S. aureus among dairy cows may be a problem that needs further investigation...
  3. ncbi Molecular characterization of the staphylococcal multidrug resistance export protein QacC
    I T Paulsen
    School of Biological Sciences, University of Sydney, New South Wales, Australia
    J Bacteriol 177:2827-33. 1995
    ..Mutagenesis of conserved residues in QacC indicated that Tyr-59 and Trp-62 also play an essential structural or functional role in QacC...
  4. ncbi Resistance to quaternary ammonium compounds in Staphylococcus spp. isolated from the food industry and nucleotide sequence of the resistance plasmid pST827
    E Heir
    MATFORSK, Norwegian Food Research Institute, As
    J Appl Bacteriol 79:149-56. 1995
    ..The finding of resistant staphylococci in different areas of the food processing industry indicates that QAC resistance is a potential problem in the food processing industry...
  5. ncbi Multidrug resistance plasmid pSK108 from coagulase-negative staphylococci; relationships to Staphylococcus aureus qacC plasmids
    A Leelaporn
    School of Biological Sciences, University of Sydney, New South Wales, Australia
    Plasmid 34:62-7. 1995
    ....
  6. ncbi Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus
    J M Tennent
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    J Gen Microbiol 135:1-10. 1989
    ..Based on fluorimetric and isotopic assays used to determine the extent of accumulation of ethidium bromide by S. aureus strains harbouring pSK1, we propose that the basis of AcrEbrQarPirDdr in S. aureus is a qacA-mediated efflux system...
  7. ncbi Nucleotide sequence of a gene that encodes resistance to ethidium bromide from a transferable plasmid in Staphylococcus aureus
    M Sasatsu
    Department of Microbiology, Tokyo College of Pharmacy, Japan
    Nucleic Acids Res 17:10103. 1989
  8. ncbi Structure and evolution of a family of genes encoding antiseptic and disinfectant resistance in Staphylococcus aureus
    T G Littlejohn
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Gene 101:59-66. 1991
    ..The entire sequence of the 2.4-kb plasmid pSK89 (which contains qacC) was determined, and is compared with other plasmids from Gram + bacteria...
  9. ncbi A staphylococcal multidrug resistance gene product is a member of a new protein family
    L Grinius
    Department of Biochemistry and Biophysics, Vilnius University, Lithuania
    Plasmid 27:119-29. 1992
    ..This mechanism includes the idea that protons are transported to the Glu 13 via an appropriate chain of hydroxylic residues in the transmembrane segments of Smr...
  10. ncbi The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to beta-lactam antibiotics in gram-positive and gram-negative bacteria
    Derie E Fuentes
    Laboratorio de Microbiologia Molecular, Departamento de Ciencias Biologicas, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Casilla 40, Correo 33, Santiago, Chile
    Res Microbiol 156:472-7. 2005
    ..Experiments using tolC, ompW and ompD mutant strains of S. Typhimurium demonstrated that the beta-lactam antibiotic resistance conferred by this pump does not depend on these outer membrane proteins...