Genomes and Genes
Gene Symbol: clfB
Description: clumping factor B
Species: Staphylococcus aureus subsp. aureus Mu50
- Clumping factor B (ClfB), a new surface-located fibrinogen-binding adhesin of Staphylococcus aureusD Ni Eidhin
Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
Mol Microbiol 30:245-57. 1998..One of these loci is analysed here. It also encodes a fibrinogen-binding protein, which we have called ClfB. The overall organization of ClfB is very similar to that of ClfA, and the proteins have considerable sequence ..
- Crystallization of ClfA and ClfB fragments: the fibrinogen-binding surface proteins of Staphylococcus aureusC C Deivanayagam
Center for Macromolecular Crystallography, School of Optometry, 286 BHSB, 1918 University Boulevard, University of Alabama at Birmingham, Birmingham, AL 35205, USA
Acta Crystallogr D Biol Crystallogr 55:554-6. 1999Recombinant constructs encoding the fibrinogen-binding domains of ClfA and ClfB from Staphylococcus aureus have been crystallized. ClfA was crystallized in the orthorhombic space group P212121 with unit-cell parameters a = 39.58, b = 81...
- Loss of clumping factor B fibrinogen binding activity by Staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloproteaseF M McAleese
Microbiology Department, Moyne Institute for Preventive Medicine, Trinity College, Dublin 2, Ireland
J Biol Chem 276:29969-78. 2001The fibrinogen-binding protein clumping factor B (ClfB) of Staphylococcus aureus is present on the surface of cells from the early exponential phase of growth in greater amounts than on cells from late exponential phase and is barely ..
- Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein ALouise O'Brien
Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
Mol Microbiol 44:1033-44. 2002..aureus. Thus, S. aureus has multiple mechanisms for stimulating platelet aggregation. Such functional redundancy suggests that this phenomenon may be important in the pathogenesis of invasive diseases such as infective endocarditis...
- Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonizationLouise M O'Brien
Moyne Institute of Preventive Medicine, Department of Microbiology, Trinity College Dublin, Dublin 2, Ireland
Cell Microbiol 4:759-70. 2002..Here, we demonstrate for the first time that the S. aureus surface-expressed protein, clumping factor B (ClfB), promotes adherence to immobilized epidermal cytokeratins in vitro. By expressing a range of S...
- Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10Evelyn J Walsh
Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland
J Biol Chem 279:50691-9. 2004..We showed previously that S. aureus adheres to desquamated epithelial cells and that clumping factor B (ClfB), a surface-located MSCRAMM (microbial surface components recognizing adhesive matrix molecules) known for its ..