Gene Symbol: BBI
Description: Bowman-Birk proteinase inhibitor
Alias: Bowman-Birk type proteinase inhibitor, Bowman-Birk protease inhibitor
Species: soybean
Products:     BBI

Top Publications

  1. Werner M, Wemmer D. 1H assignments and secondary structure determination of the soybean trypsin/chymotrypsin Bowman-Birk inhibitor. Biochemistry. 1991;30:3356-64 pubmed
    ..These structural elements are compared to those found in other Bowman-Birk inhibitors. ..
  2. Odani S, Ikenaka T. Scission of soybean Bowman-Birk proteinase inhibitor into two small fragments having either trypsin or chymotrypsin inhibitory activity. J Biochem. 1973;74:857-60 pubmed
  3. Baek J, Kim S. Nucleotide sequence of a cDNA encoding soybean Bowman-Birk proteinase inhibitor. Plant Physiol. 1993;102:687 pubmed
  4. Baek J, Song J, Choi Y, Kim S. Nucleotide sequence homology of cDNAs encoding soybean Bowman-Birk type proteinase inhibitor and its isoinhibitors. Biosci Biotechnol Biochem. 1994;58:843-6 pubmed
    ..It was assumed from these results that isoinhibitor D-II was the most primordial type of these inhibitors. ..
  5. Koepke J, Ermler U, Warkentin E, Wenzl G, Flecker P. Crystal structure of cancer chemopreventive Bowman-Birk inhibitor in ternary complex with bovine trypsin at 2.3 A resolution. Structural basis of Janus-faced serine protease inhibitor specificity. J Mol Biol. 2000;298:477-91 pubmed publisher
    ..The triple-stranded beta-hairpin unique to the BBI-family and the surface loops surrounding the active site of the enzyme formed a protein-protein-interface far ..
  6. Odani S, Ikenaka T. Studies on soybean trypsin inhibitors. IV. Complete amino acid sequence and the anti-proteinase sites of Bowman-Birk soybean proteinase inhibitor. J Biochem. 1972;71:839-48 pubmed
  7. Odani S, Ikenaka T. Studies on soybean trypsin inhibitors. 8. Disulfide bridges in soybean Bowman-Birk proteinase inhibitor. J Biochem. 1973;74:697-715 pubmed
  8. Hammond R, Foard D, Larkins B. Molecular cloning and analysis of a gene coding for the Bowman-Birk protease inhibitor in soybean. J Biol Chem. 1984;259:9883-90 pubmed
    ..DNA sequence analysis of the genomic clone reveals that it is similar, although not identical, to the cDNA clone and that it contains no intervening sequences. ..
  9. Voss R, Ermler U, Essen L, Wenzl G, Kim Y, Flecker P. Crystal structure of the bifunctional soybean Bowman-Birk inhibitor at 0.28-nm resolution. Structural peculiarities in a folded protein conformation. Eur J Biochem. 1996;242:122-31 pubmed
    ..Exposed hydrophobic patches, the presence of charged amino acid residues, and the presence of water molecules in the protein interior are in contrast to standard proteins that comprise a hydrophobic core and exposed polar amino acids. ..