Gene Symbol: SINVgp3
Description: p130 structural polyprotein
Alias: p130 structural polyprotein
Species: Sindbis virus

Top Publications

  1. Parrott M, Sitarski S, Arnold R, Picton L, Hill R, Mukhopadhyay S. Role of conserved cysteines in the alphavirus E3 protein. J Virol. 2009;83:2584-91 pubmed publisher
    ..Our data indicate that the role of the cysteine residues in E3 is not primarily structural. We hypothesize that E3 has an enzymatic or functional role in virus assembly, and these possibilities are further discussed...
  2. Jose J, Przybyla L, Edwards T, Perera R, Burgner J, Kuhn R. Interactions of the cytoplasmic domain of Sindbis virus E2 with nucleocapsid cores promote alphavirus budding. J Virol. 2012;86:2585-99 pubmed publisher
    ..We hypothesize that these cdE2 interactions induce a change in the organization of the nucleocapsid core upon binding leading to particle budding and priming of the nucleocapsid cores for disassembly that is required for virus infection...
  3. Ou J, Strauss E, Strauss J. The 5'-terminal sequences of the genomic RNAs of several alphaviruses. J Mol Biol. 1983;168:1-15 pubmed
  4. Li L, Jose J, Xiang Y, Kuhn R, Rossmann M. Structural changes of envelope proteins during alphavirus fusion. Nature. 2010;468:705-8 pubmed publisher
    ..The amino- and carboxy-terminal domains of E2 each form immunoglobulin-like folds, consistent with the receptor attachment properties of E2...
  5. Ou J, Strauss E, Strauss J. Comparative studies of the 3'-terminal sequences of several alpha virus RNAs. Virology. 1981;109:281-9 pubmed
  6. Strauss E, Rice C, Strauss J. Complete nucleotide sequence of the genomic RNA of Sindbis virus. Virology. 1984;133:92-110 pubmed
    ..A replication strategy for Sindbis virus based upon the complete nucleotide sequence, as well as prior data, is presented...
  7. Tang J, Jose J, Chipman P, Zhang W, Kuhn R, Baker T. Molecular links between the E2 envelope glycoprotein and nucleocapsid core in Sindbis virus. J Mol Biol. 2011;414:442-59 pubmed publisher
    ..The N-termini of the CPs form a contiguous network that interconnects 12 pentameric and 30 hexameric CP capsomers. A single glycoprotein spike cross-links three neighboring CP capsomers as might occur during initiation of virus budding...
  8. Snyder A, Sokoloski K, Mukhopadhyay S. Mutating conserved cysteines in the alphavirus e2 glycoprotein causes virus-specific assembly defects. J Virol. 2012;86:3100-11 pubmed publisher
    ..The nonconserved assembly defects suggest that E2 folding and function is species dependent, possibly due to interactions with a virus-specific chaperone...
  9. Monroe S, Ou J, Rice C, Schlesinger S, Strauss E, Strauss J. Sequence analysis of cDNA's derived from the RNA of Sindbis virions and of defective interfering particles. J Virol. 1982;41:153-62 pubmed

More Information


  1. Rice C, Strauss J. Nucleotide sequence of the 26S mRNA of Sindbis virus and deduced sequence of the encoded virus structural proteins. Proc Natl Acad Sci U S A. 1981;78:2062-6 pubmed
  2. Warrier R, Linger B, Golden B, Kuhn R. Role of sindbis virus capsid protein region II in nucleocapsid core assembly and encapsidation of genomic RNA. J Virol. 2008;82:4461-70 pubmed publisher
    ..The region that is responsible for nucleocapsid core accumulation has considerable overlap with the region that controls encapsidation specificity...
  3. Strauss E, Rice C, Strauss J. Sequence coding for the alphavirus nonstructural proteins is interrupted by an opal termination codon. Proc Natl Acad Sci U S A. 1983;80:5271-5 pubmed
  4. Rice C, Strauss J. Synthesis, cleavage and sequence analysis of DNA complementary to the 26 S messenger RNA of Sindbis virus. J Mol Biol. 1981;150:315-40 pubmed
  5. Zhu W, Wang L, Yang Y, Jia J, Fu S, Feng Y, et al. Interaction of E2 glycoprotein with heparan sulfate is crucial for cellular infection of Sindbis virus. PLoS ONE. 2010;5:e9656 pubmed publisher
    ..As a new dataset, these results clearly confirm an essential role of E2 glycoprotein, especially the domain of 145-150 aa, in SINV cellular infection through the interaction with HS...
  6. Ou J, Rice C, Dalgarno L, Strauss E, Strauss J. Sequence studies of several alphavirus genomic RNAs in the region containing the start of the subgenomic RNA. Proc Natl Acad Sci U S A. 1982;79:5235-9 pubmed
  7. Ou J, Trent D, Strauss J. The 3'-non-coding regions of alphavirus RNAs contain repeating sequences. J Mol Biol. 1982;156:719-30 pubmed
  8. Magliocca J, Vancini R, Hernandez R, Brown D. Single-Site Glycoprotein Mutants Inhibit a Late Event in Sindbis Virus Assembly. J Virol. 2016;90:8372-80 pubmed publisher
    ..These results allow us to conclude that these sites have essential roles in assembly, and E2_G209 shows us a new viral egress phenotype. ..